Science, ISSN 0036-8075, 2014, Volume 345, Issue 6193, pp. 222 - 225
During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of...
DYNAMICS | SOMITOGENESIS | VERTEBRATE SEGMENTATION | SEGMENTATION CLOCK | MULTIDISCIPLINARY SCIENCES | Genetic research | Embryonic development | Genetic aspects | Research | Growth | Zebra fish | Doppler effect | Vertebrates | Embryos | Segmentation | Oscillations | Genetics | Segments | Rhythm | Formations | Time measurements
DYNAMICS | SOMITOGENESIS | VERTEBRATE SEGMENTATION | SEGMENTATION CLOCK | MULTIDISCIPLINARY SCIENCES | Genetic research | Embryonic development | Genetic aspects | Research | Growth | Zebra fish | Doppler effect | Vertebrates | Embryos | Segmentation | Oscillations | Genetics | Segments | Rhythm | Formations | Time measurements
Journal Article
Geophysical Research Letters, ISSN 0094-8276, 03/2014, Volume 41, Issue 6, pp. 2204 - 2211
Dart‐stepped‐leader step formation in triggered lightning is documented with high‐speed video recorded at 648 kiloframes per second (1.16 µs exposure time, 380...
step formation | lightning | atmospheric electricity | dart‐stepped leader | leader step | triggered lightning | dart-stepped leader | GEOSCIENCES, MULTIDISCIPLINARY | GAP | Lightning | Meteorology | Triggered lightning | Bidirectional | Streak | High speed | Segments | Motion pictures | Channels | Noise threshold
step formation | lightning | atmospheric electricity | dart‐stepped leader | leader step | triggered lightning | dart-stepped leader | GEOSCIENCES, MULTIDISCIPLINARY | GAP | Lightning | Meteorology | Triggered lightning | Bidirectional | Streak | High speed | Segments | Motion pictures | Channels | Noise threshold
Journal Article
3.
Full Text
Progressive Bone Formation After Cervical Disc Replacement: Minimum of 5-Year Follow-up
SPINE, ISSN 0362-2436, 02/2018, Volume 43, Issue 3, pp. E163 - E170
STUDY DESIGN.Retrospective review. OBJECTIVE.Our objective was to examine the prevalence, clinical significance, ramifications, and possible etiology of...
Bryan | Cervical disc replacement | Range of motion | Kellgren | Cervical spondylotic radiculopathy | Heterotopic ossification | McAfee | Adjacent segment degeneration | Disc arthroplasty | Cervical spondylotic myelopathy | adjacent segment degeneration | cervical spondylotic radiculopathy | LEVEL INTRADISCAL PRESSURE | FUSION | cervical disc replacement | cervical spondylotic myelopathy | ARTHROPLASTY | heterotopic ossification | FOLLOW-UP | BRYAN DISC | ANTERIOR DISKECTOMY | CLINICAL NEUROLOGY | ARTIFICIAL DISC | DEVICE EXEMPTION | range of motion | disc arthroplasty | ORTHOPEDICS | CLINICAL-OUTCOMES | Disability Evaluation | Cervical Vertebrae | Postoperative Complications - etiology | Prevalence | Follow-Up Studies | Humans | Middle Aged | Ossification, Heterotopic - etiology | Male | Treatment Outcome | Neck Pain - etiology | Young Adult | Ossification, Heterotopic - epidemiology | Radiculopathy - surgery | Total Disc Replacement - adverse effects | Adult | Female | Retrospective Studies | Spondylosis - surgery | Osteogenesis | Patient Reported Outcome Measures
Bryan | Cervical disc replacement | Range of motion | Kellgren | Cervical spondylotic radiculopathy | Heterotopic ossification | McAfee | Adjacent segment degeneration | Disc arthroplasty | Cervical spondylotic myelopathy | adjacent segment degeneration | cervical spondylotic radiculopathy | LEVEL INTRADISCAL PRESSURE | FUSION | cervical disc replacement | cervical spondylotic myelopathy | ARTHROPLASTY | heterotopic ossification | FOLLOW-UP | BRYAN DISC | ANTERIOR DISKECTOMY | CLINICAL NEUROLOGY | ARTIFICIAL DISC | DEVICE EXEMPTION | range of motion | disc arthroplasty | ORTHOPEDICS | CLINICAL-OUTCOMES | Disability Evaluation | Cervical Vertebrae | Postoperative Complications - etiology | Prevalence | Follow-Up Studies | Humans | Middle Aged | Ossification, Heterotopic - etiology | Male | Treatment Outcome | Neck Pain - etiology | Young Adult | Ossification, Heterotopic - epidemiology | Radiculopathy - surgery | Total Disc Replacement - adverse effects | Adult | Female | Retrospective Studies | Spondylosis - surgery | Osteogenesis | Patient Reported Outcome Measures
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 50, pp. 81975 - 81976
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2013, Volume 202, Issue 6, pp. 837 - 848
Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and...
POLARITY ORIENTATION | RETINAL GANGLION-CELLS | NEURONAL POLARIZATION | IN-VIVO | MICROTUBULE-ASSOCIATED PROTEIN-1B | INITIAL SEGMENT | TARGET RECOGNITION | SYNAPSE FORMATION | DIFFUSION BARRIER | HIPPOCAMPAL-NEURONS | CELL BIOLOGY | Proteins | Growth | Cells | Reviews
POLARITY ORIENTATION | RETINAL GANGLION-CELLS | NEURONAL POLARIZATION | IN-VIVO | MICROTUBULE-ASSOCIATED PROTEIN-1B | INITIAL SEGMENT | TARGET RECOGNITION | SYNAPSE FORMATION | DIFFUSION BARRIER | HIPPOCAMPAL-NEURONS | CELL BIOLOGY | Proteins | Growth | Cells | Reviews
Journal Article
Experimental Eye Research, ISSN 0014-4835, 02/2017, Volume 155, pp. 121 - 127
The accumulation of lipofuscin in the cells of the retinal pigment epithelium (RPE) is thought to play an important role in the development and progression of...
NADPH | Photoreceptor | ABCA4 | Fluorescence | Lipofuscin | Retinal | Retinol | CELLS | MACULAR DEGENERATION | FLUOROPHORE | A2E | METABOLISM | PIGMENT EPITHELIUM | IN-VIVO | OPHTHALMOLOGY | ACCUMULATION | STARGARDTS-DISEASE | BISRETINOIDS | Optical Imaging | Rod Cell Outer Segment - metabolism | Cells, Cultured | Mice, Transgenic | Retinal Degeneration - metabolism | DNA - genetics | Animals | Ultraviolet Rays | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Mice | Mutation | Retinal Degeneration - pathology | Lipofuscin - metabolism | Rod Cell Outer Segment - radiation effects | Disease Models, Animal | retinol | retinal | fluorescence | photoreceptor | lipofuscin
NADPH | Photoreceptor | ABCA4 | Fluorescence | Lipofuscin | Retinal | Retinol | CELLS | MACULAR DEGENERATION | FLUOROPHORE | A2E | METABOLISM | PIGMENT EPITHELIUM | IN-VIVO | OPHTHALMOLOGY | ACCUMULATION | STARGARDTS-DISEASE | BISRETINOIDS | Optical Imaging | Rod Cell Outer Segment - metabolism | Cells, Cultured | Mice, Transgenic | Retinal Degeneration - metabolism | DNA - genetics | Animals | Ultraviolet Rays | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Mice | Mutation | Retinal Degeneration - pathology | Lipofuscin - metabolism | Rod Cell Outer Segment - radiation effects | Disease Models, Animal | retinol | retinal | fluorescence | photoreceptor | lipofuscin
Journal Article
Circulation Research, ISSN 0009-7330, 05/2007, Volume 100, Issue 9, pp. 1261 - 1275
The platelet, once thought to be solely involved in clot formation, is now known to be a key mediator in various others processes such as inflammation,...
Antiplatelet therapy | Cardiovascular disease | Platelets | Thrombosis | Atherosclerosis | atherosclerosis | cardiovascular disease | CARDIAC & CARDIOVASCULAR SYSTEMS | RANDOMIZED-TRIAL | antiplatelet therapy | GLYCOPROTEIN IIB/IIIA INHIBITION | platelets | RECEPTOR ANTAGONIST | PERCUTANEOUS CORONARY INTERVENTION | thrombosis | LOW-DOSE ASPIRIN | ACUTE MYOCARDIAL-INFARCTION | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | UNSTABLE ANGINA | ST-SEGMENT ELEVATION | HEMATOLOGY | Receptor, PAR-1 - antagonists & inhibitors | Ticlopidine - therapeutic use | Thromboxanes - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Purinergic P2 Receptor Antagonists | Blood Platelets - physiology | Ticlopidine - analogs & derivatives | Platelet Adhesiveness - drug effects | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Atherosclerosis - etiology | Thrombosis - etiology | Pentanoic Acids - therapeutic use | Tetrazoles - therapeutic use | Aspirin - therapeutic use | Thrombosis - prevention & control | Platelet Aggregation Inhibitors - therapeutic use | Stents - adverse effects | Dipyridamole - therapeutic use | Atherosclerosis - prevention & control | Drug Resistance | Pyridines - therapeutic use
Antiplatelet therapy | Cardiovascular disease | Platelets | Thrombosis | Atherosclerosis | atherosclerosis | cardiovascular disease | CARDIAC & CARDIOVASCULAR SYSTEMS | RANDOMIZED-TRIAL | antiplatelet therapy | GLYCOPROTEIN IIB/IIIA INHIBITION | platelets | RECEPTOR ANTAGONIST | PERCUTANEOUS CORONARY INTERVENTION | thrombosis | LOW-DOSE ASPIRIN | ACUTE MYOCARDIAL-INFARCTION | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | UNSTABLE ANGINA | ST-SEGMENT ELEVATION | HEMATOLOGY | Receptor, PAR-1 - antagonists & inhibitors | Ticlopidine - therapeutic use | Thromboxanes - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Purinergic P2 Receptor Antagonists | Blood Platelets - physiology | Ticlopidine - analogs & derivatives | Platelet Adhesiveness - drug effects | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Atherosclerosis - etiology | Thrombosis - etiology | Pentanoic Acids - therapeutic use | Tetrazoles - therapeutic use | Aspirin - therapeutic use | Thrombosis - prevention & control | Platelet Aggregation Inhibitors - therapeutic use | Stents - adverse effects | Dipyridamole - therapeutic use | Atherosclerosis - prevention & control | Drug Resistance | Pyridines - therapeutic use
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2016, Volume 138, Issue 43, pp. 14246 - 14249
Diverse hydrogen-mediated C–C couplings enable construction of the actin-binding marine polyketide swinholide A in only 15 steps (longest linear sequence),...
CATALYZED CARBONYL ALLYLATION | A STEREOCONTROLLED SYNTHESIS | ABSOLUTE STEREOSTRUCTURE | CYTOTOXIC DIMERIC MACROLIDE | MUKAIYAMA ALDOL REACTION | SPONGE THEONELLA-SWINHOEI | ALDEHYDE OXIDATION LEVEL | CHEMISTRY, MULTIDISCIPLINARY | MARINE NATURAL-PRODUCTS | CARBOCYCLIC COMPOUNDS | C-11-C23 SEGMENT | Chemistry Techniques, Synthetic | Marine Toxins - chemistry | Hydrogen - chemistry | Carbon - chemistry | Marine Toxins - chemical synthesis | Chemical bonds | Usage | Chemical properties | Chemical synthesis | Hydrogen | Analysis
CATALYZED CARBONYL ALLYLATION | A STEREOCONTROLLED SYNTHESIS | ABSOLUTE STEREOSTRUCTURE | CYTOTOXIC DIMERIC MACROLIDE | MUKAIYAMA ALDOL REACTION | SPONGE THEONELLA-SWINHOEI | ALDEHYDE OXIDATION LEVEL | CHEMISTRY, MULTIDISCIPLINARY | MARINE NATURAL-PRODUCTS | CARBOCYCLIC COMPOUNDS | C-11-C23 SEGMENT | Chemistry Techniques, Synthetic | Marine Toxins - chemistry | Hydrogen - chemistry | Carbon - chemistry | Marine Toxins - chemical synthesis | Chemical bonds | Usage | Chemical properties | Chemical synthesis | Hydrogen | Analysis
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2018, Volume 38, Issue 27, pp. 6063 - 6075
Action potential conduction along myelinated axons depends on high densities of voltage-gated Na+ channels at the nodes of Ranvier. Flanking each node,...
Spectrin | Node of Ranvier | Myelin | Paranode | myelin | RANVIER | BRAIN-INJURY | NA+ CHANNELS | node of Ranvier | NEUROSCIENCES | AXOGLIAL JUNCTIONS | PERIPHERAL-NERVE | paranode | MYELINATED AXONS | MULTIPLE-SCLEROSIS | AXON INITIAL SEGMENT | spectrin | CENTRAL-NERVOUS-SYSTEM | DOMAIN ORGANIZATION
Spectrin | Node of Ranvier | Myelin | Paranode | myelin | RANVIER | BRAIN-INJURY | NA+ CHANNELS | node of Ranvier | NEUROSCIENCES | AXOGLIAL JUNCTIONS | PERIPHERAL-NERVE | paranode | MYELINATED AXONS | MULTIPLE-SCLEROSIS | AXON INITIAL SEGMENT | spectrin | CENTRAL-NERVOUS-SYSTEM | DOMAIN ORGANIZATION
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2008, Volume 20, Issue 6, pp. 616 - 623
Action potential propagation along myelinated nerve fibers requires high-density protein complexes that include voltage-gated Na+ channels at the nodes of...
Internal Medicine | MYELINATED AXONS | AXON INITIAL SEGMENTS | DIFFERENTIAL EXPRESSION | PERIPHERAL NERVOUS-SYSTEM | SODIUM-CHANNELS | BETA-IV-SPECTRIN | POLARIZED DOMAINS | CELL-ADHESION MOLECULES | EXTRACELLULAR-MATRIX | ANKYRIN-BINDING | CELL BIOLOGY | Nerve Fibers, Myelinated - metabolism | Nerve Tissue Proteins - metabolism | Peripheral Nervous System - physiology | Animals | Central Nervous System - metabolism | Models, Biological | Humans | Ankyrins - metabolism | Extracellular Matrix - metabolism | Ranvier's Nodes - physiology | Cell Adhesion Molecules, Neuronal - metabolism | Spectrin - metabolism
Internal Medicine | MYELINATED AXONS | AXON INITIAL SEGMENTS | DIFFERENTIAL EXPRESSION | PERIPHERAL NERVOUS-SYSTEM | SODIUM-CHANNELS | BETA-IV-SPECTRIN | POLARIZED DOMAINS | CELL-ADHESION MOLECULES | EXTRACELLULAR-MATRIX | ANKYRIN-BINDING | CELL BIOLOGY | Nerve Fibers, Myelinated - metabolism | Nerve Tissue Proteins - metabolism | Peripheral Nervous System - physiology | Animals | Central Nervous System - metabolism | Models, Biological | Humans | Ankyrins - metabolism | Extracellular Matrix - metabolism | Ranvier's Nodes - physiology | Cell Adhesion Molecules, Neuronal - metabolism | Spectrin - metabolism
Journal Article
Neuron, ISSN 0896-6273, 12/2015, Volume 88, Issue 6, pp. 1208 - 1226
Axon formation, the initial step in establishing neuronal polarity, critically depends on local microtubule reorganization and is characterized by the...
microtubule | axon initial segment | cytoskeleton | TRIM | parallel bundles | neuronal polarity | transport | fascicles | cross-bridges | axon formation | Cytoskeleton | Axon formation | Microtubule | Parallel bundles | Axon initial segment | Neuronal polarity | Transport | Fascicles | Cross-bridges | MAINTENANCE | TRANSPORT | DENDRITE | DROSOPHILA NEURONS | MOTOR | GROWTH | INITIAL SEGMENT | DYNAMICS | E3 UBIQUITIN LIGASES | END-BINDING-PROTEIN | NEUROSCIENCES | Humans | Repressor Proteins - ultrastructure | Cercopithecus aethiops | Molecular Sequence Data | Axons - physiology | Cerebral Cortex - ultrastructure | Repressor Proteins - physiology | Neurons - ultrastructure | Axons - ultrastructure | HEK293 Cells | Microtubules - ultrastructure | Neurons - physiology | Female | Nerve Tissue Proteins - ultrastructure | Amino Acid Sequence | Nerve Tissue Proteins - physiology | Mice, Inbred C57BL | Cells, Cultured | Microtubules - physiology | Rats | Pregnancy | Animals | Cerebral Cortex - embryology | Cell Polarity - physiology | Cerebral Cortex - physiology | Mice | HeLa Cells | COS Cells | Neurons | Mass spectrometry | Neurosciences | Antigens | Immunoglobulins | Research & development--R&D | Cloning | Experiments | Proteins | Studies | Microscopy | Scientific imaging | Deoxyribonucleic acid--DNA
microtubule | axon initial segment | cytoskeleton | TRIM | parallel bundles | neuronal polarity | transport | fascicles | cross-bridges | axon formation | Cytoskeleton | Axon formation | Microtubule | Parallel bundles | Axon initial segment | Neuronal polarity | Transport | Fascicles | Cross-bridges | MAINTENANCE | TRANSPORT | DENDRITE | DROSOPHILA NEURONS | MOTOR | GROWTH | INITIAL SEGMENT | DYNAMICS | E3 UBIQUITIN LIGASES | END-BINDING-PROTEIN | NEUROSCIENCES | Humans | Repressor Proteins - ultrastructure | Cercopithecus aethiops | Molecular Sequence Data | Axons - physiology | Cerebral Cortex - ultrastructure | Repressor Proteins - physiology | Neurons - ultrastructure | Axons - ultrastructure | HEK293 Cells | Microtubules - ultrastructure | Neurons - physiology | Female | Nerve Tissue Proteins - ultrastructure | Amino Acid Sequence | Nerve Tissue Proteins - physiology | Mice, Inbred C57BL | Cells, Cultured | Microtubules - physiology | Rats | Pregnancy | Animals | Cerebral Cortex - embryology | Cell Polarity - physiology | Cerebral Cortex - physiology | Mice | HeLa Cells | COS Cells | Neurons | Mass spectrometry | Neurosciences | Antigens | Immunoglobulins | Research & development--R&D | Cloning | Experiments | Proteins | Studies | Microscopy | Scientific imaging | Deoxyribonucleic acid--DNA
Journal Article
EMBO reports, ISSN 1469-221X, 07/2012, Volume 13, Issue 7, pp. 608 - 618
Both the basal body and the microtubule‐based axoneme it nucleates have evolutionarily conserved subdomains crucial for cilium biogenesis, function and...
basal body | cilium | transition fibre | transition zone | ciliopathy | RETINAL DEGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMA-MEMBRANE | SOLUBLE-PROTEIN | IMPORTIN-ALPHA | CELL BIOLOGY | JOUBERT-SYNDROME | FREEZE-FRACTURE | DIFFUSION BARRIER | OUTER SEGMENT FORMATION | INTRAFLAGELLAR TRANSPORT | MECKEL-GRUBER-SYNDROME | Cell Compartmentation | Cilia - physiology | Animals | Axoneme - metabolism | Axoneme - ultrastructure | Humans | Cilia - ultrastructure | Cytoplasmic Streaming | Cytoskeletal Proteins - metabolism | Axoneme - chemistry | Cilia - chemistry | Evolutionary biology | Biogeochemistry | Review
basal body | cilium | transition fibre | transition zone | ciliopathy | RETINAL DEGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMA-MEMBRANE | SOLUBLE-PROTEIN | IMPORTIN-ALPHA | CELL BIOLOGY | JOUBERT-SYNDROME | FREEZE-FRACTURE | DIFFUSION BARRIER | OUTER SEGMENT FORMATION | INTRAFLAGELLAR TRANSPORT | MECKEL-GRUBER-SYNDROME | Cell Compartmentation | Cilia - physiology | Animals | Axoneme - metabolism | Axoneme - ultrastructure | Humans | Cilia - ultrastructure | Cytoplasmic Streaming | Cytoskeletal Proteins - metabolism | Axoneme - chemistry | Cilia - chemistry | Evolutionary biology | Biogeochemistry | Review
Journal Article
Soft matter, ISSN 1744-683X, 06/2019, Volume 15, Issue 26, pp. 5255 - 5263
Complex DNA topological structures, including polymer loops, are frequently observed in biological processes when protein molecules simultaneously bind to...
Journal Article