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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2011, Volume 589, Issue 21, pp. 5109 - 5123
Non‐Technical Summary  Cardiovascular disease and high blood pressure (hypertension) are frequent in the human population. Amiloride is commonly given as a... 
INACTIVATION | SELECTIVE INHIBITOR | ZONIPORIDE | PHYSIOLOGY | NERVE-TERMINALS | NEUROTRANSMISSION | AMILORIDE | SODIUM-CHANNEL | EXPRESSION | NEUROSCIENCES | BLOCKER | MODULATION | Xenopus | Nerve Tissue Proteins - deficiency | Amiloride - analogs & derivatives | Guanidines - pharmacology | Sodium Channels - physiology | Brain - physiology | Nicotine - pharmacology | Neurons - physiology | Oocytes - drug effects | Synaptic Transmission - drug effects | Neurons - drug effects | Nicotinic Agonists - pharmacology | Sodium Channels - deficiency | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Pyrazoles - pharmacology | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - physiology | Acid Sensing Ion Channels | Sodium-Hydrogen Exchangers - physiology | Mice, Inbred C57BL | Sodium Channel Blockers - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Brain - drug effects | Animals | Oocytes - physiology | Receptors, Nicotinic - physiology | Amiloride - pharmacology | Mice | Sodium Channels - genetics | In Vitro Techniques | Hypertension | Cardiovascular disease | Potassium | Investigations | Drugs | Brain | Brain slice preparation | Nervous system | Antagonists | Oocytes | Potassium channels (calcium-gated) | Antagonism | Amiloride | Synaptic transmission | Habenula | Cardiorespiratory | Medications | Blood pressure | Communication | Peripheral nervous system | Sodium channels | gamma -Aminobutyric acid receptors | Cross-reactivity | Excitability | Acidity | Acetylcholine receptors (nicotinic) | Glutamatergic transmission | Blood diseases | Cardiovascular diseases | Animal subjects | Neuroscience
Journal Article
Brain Research, ISSN 0006-8993, 2018
The orexin system includes the neuropeptides orexin A and B and the cognate receptors of orexin-1 (OX1) and -2 (OX2) and has been indicated in a number of... 
Antagonist | Addiction | Selective | Hypocretin | Orexin
Journal Article
Journal Article