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CELL METABOLISM, ISSN 1550-4131, 01/2015, Volume 21, Issue 1, pp. 33 - 38
Increasing energy expenditure through activation of endogenous brown adipose tissue (BAT) is a potential approach to treat obesity and diabetes. The class of... 
SELECTIVE BETA-ADRENOCEPTOR AGONIST | THERMOGENESIS | ADRENOCEPTOR AGONIST | ENERGY-EXPENDITURE | COLD-EXPOSURE | METABOLISM | MIRABEGRON | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | FAT | ADULT HUMANS | CELL BIOLOGY
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 01/2013, Volume 699, Issue 1-3, pp. 101 - 105
beta(3)-Adrenoceptors are major players in detrusor relaxation and have been suggested as a new putative target for the treatment of overactive bladder... 
beta-Adrenoceptor | SELECTIVE BETA-2 | EFFICACY | BETA-3-ADRENOCEPTOR AGONISTS | Lower urinary tract symptom | Overactive bladder syndrome | MUSCLE | RELAXATION | HYPERREFLEXIA | Benign prostatic hyperplasia | PHARMACOLOGY & PHARMACY | Mirabegron | EXPRESSION
Journal Article
BJU INTERNATIONAL, ISSN 1464-4096, 06/2018, Volume 121, Issue 6, pp. 959 - 970
Objective To test if carbachol (CCh)-evoked Ca2+ oscillations in freshly isolated murine detrusor myocytes are affected by beta 3-adrenoceptor (beta-AR)... 
SELECTIVE BETA-ADRENOCEPTOR AGONIST | ACTIVATION | BLADDER SMOOTH-MUSCLE | RAT | ACETYLCHOLINE | RELAXATION | RECEPTOR | HUMAN URINARY-BLADDER | RELEASE | beta 3-adrenoceptor agonists | CONTRACTIONS | cholinergic | bladder | UROLOGY & NEPHROLOGY | Ca2+ oscillations | detrusor
Journal Article
Neurourology and Urodynamics, ISSN 0733-2467, 08/2017, Volume 36, Issue 6, pp. 1511 - 1518
Aims To evaluate the effects of the beta‐3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity. Methods C57BL/6 male... 
detrusor | overactivity | cAMP | obesity | SELECTIVE BETA-ADRENOCEPTOR AGONIST | NON-VOIDING ACTIVITY | BROWN ADIPOSE-TISSUE | RAT URINARY-BLADDER | CONTRACTILE ACTIVITY | SMOOTH-MUSCLE | MESSENGER-RNA | IN-VIVO | OUTFLOW OBSTRUCTION | UROLOGY & NEPHROLOGY | PHARMACOLOGICAL PROFILE | Body Weight - drug effects | Male | Thiazoles - therapeutic use | Adrenergic beta-3 Receptor Agonists - pharmacology | Muscle, Smooth - drug effects | Urinary Bladder, Overactive - drug therapy | Urinary Bladder, Overactive - physiopathology | Urination - drug effects | Acetanilides - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Acetanilides - pharmacology | Urinary Bladder - metabolism | Mice, Inbred C57BL | Obesity - physiopathology | Urinary Bladder, Overactive - metabolism | Muscle, Smooth - metabolism | Obesity - metabolism | Carbachol - pharmacology | Adrenergic beta-3 Receptor Agonists - therapeutic use | Animals | Muscle Contraction - drug effects | Muscle, Smooth - physiopathology | Urinary Bladder - physiopathology | Mice, Obese | Urinary Bladder - drug effects | Mice | Thiazoles - pharmacology | Obesity | Carbachol | Analysis | Low density lipoproteins | Body weight | Cyclic adenylic acid | Adenylic acid | Lipoproteins (low density) | Adenosine | Fasting | Body fat | Intracellular levels | Contractility | Bladder | Cyclic AMP | Smooth muscle | Muscle contraction | Potassium chloride | High fat diet | Urinary bladder | Rodents | Protein expression | Adrenergic receptors | Urination | Lipoproteins (high density) | Phosphodiesterase
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 09/2019, Volume 858, p. 172447
Mirabegron is the first β3-adrenoceptor agonist approved on the market and may offer beneficial pharmacological action in patients with overactive bladder and... 
Cyclic AMP | Tadalafil | Intracavernous pressure | Erectile dysfunction | Mirabegron | Cyclic GMP | SELECTIVE BETA-ADRENOCEPTOR AGONIST | ACTIVATION | NITRIC-OXIDE SYNTHASE | ADRENERGIC-RECEPTOR SUBTYPES | SMOOTH-MUSCLE | OVERACTIVE BLADDER | CYCLIC-GMP | URINARY-TRACT SYMPTOMS | BETA-3 ADRENOCEPTOR AGONIST | PHARMACOLOGY & PHARMACY | DYSFUNCTION
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 04/2018, Volume 93, Issue 4, pp. 259 - 265
Journal Article
by Shan, WJ and Huang, L and Zhou, Q and Jiang, HL and Luo, ZH and Lai, KF and Li, XS
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 02/2012, Volume 22, Issue 4, pp. 1523 - 1526
We designed and synthesized a novel class of dual pharmacology bronchodilators targeting both beta 2-adrenoceptor and PDE4 by applying a multivalent approach.... 
SELECTIVE PDE4 INHIBITORS | TARGET | ADRENOCEPTOR | CHEMISTRY, MEDICINAL | EFFICACY | Asthma and COPD | Bronchodilator | beta-Adrenoceptor agonist | CHEMISTRY, ORGANIC | IN-VITRO | PDE4 inhibitor | CIS-HEXAHYDROPHTHALAZINONES | PHOSPHODIESTERASE-4
Journal Article
Molecular Aspects of Medicine, ISSN 0098-2997, 08/2019, Volume 68, pp. 82 - 89
The present “obesogenic’ environment has favored excessive energy intake resulting in the current obesity epidemic and its associated diseases. The epidemic... 
Obesity | Thermogenesis | Lipid homeostasis | Glucose homeostasis | Cold exposure | SELECTIVE BETA-ADRENOCEPTOR AGONIST | MEDICINE, RESEARCH & EXPERIMENTAL | COLD-INDUCED THERMOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | WEIGHT-LOSS | ADULT HUMANS | INSULIN SENSITIVITY | OXIDATIVE-METABOLISM | DOUBLE-BLIND | BODY-MASS | SKELETAL-MUSCLES | PROTEIN LEVERAGE
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2001, Volume 133, Issue 8, pp. 1201 - 1212
The spasmolytic and anti‐spasmogenic activity of β‐adrenoceptor agonists on airways smooth muscle is thought to involve activation of the cyclic AMP/cyclic... 
β‐Adrenoceptor agonist | cyclic AMP | protein kinase A | isoprenaline | airways tone | Protein kinase A | Cyclic AMP | Airways tone | Isoprenaline | β-Adrenoceptor agonist | CROSS-ACTIVATION | air-ways tone | beta-adrenoceptor agonist | RELAXATION | ACTIVATED POTASSIUM CHANNELS | ADRENERGIC AGONISTS | FAMILY | SELECTIVE INHIBITOR | BINDING PROTEINS | PHARMACOLOGY & PHARMACY | AIRWAY SMOOTH-MUSCLE | RECEPTORS | CAMP | Cyclic GMP - pharmacology | Trachea - drug effects | Trachea - metabolism | Pyridazines - pharmacology | Cyclic GMP-Dependent Protein Kinases - metabolism | Muscle, Smooth - drug effects | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - analogs & derivatives | Cyclic GMP - analogs & derivatives | Isoenzymes - metabolism | Cyclic AMP-Dependent Protein Kinase Type II | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guinea Pigs | Acetylcholine - pharmacology | Adrenergic beta-Agonists - pharmacology | Muscle Tonus - drug effects | Muscle, Smooth - metabolism | Cyclic AMP - pharmacology | Animals | Cyclic GMP - metabolism | Muscle Contraction - drug effects | Isoproterenol - pharmacology | Isoenzymes - antagonists & inhibitors | Trachea - enzymology | Muscle, Smooth - enzymology | Papers
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 01/2016, Volume 26, Issue 1, pp. 55 - 59
The paper will describe the synthesis and SAR studies that led to the discovery of benzamide ( reverse amide) as potent and selective human beta(3)-adrenergic... 
SELECTIVE BETA-ADRENOCEPTOR AGONIST | DETRUSOR MUSCLE | CHEMISTRY, MEDICINAL | Bioisostere | URINARY-BLADDER | CLINICAL DEVELOPMENT | DRUG DESIGN | RATS | CHEMISTRY, ORGANIC | HYPERREFLEXIA | Reverse amide | Pyrrolidine scaffold | beta adrenergic receptor agonist | BETA-3-ADRENOCEPTOR | Overactive bladder | HIGHLY POTENT
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 02/2017, Volume 27, Issue 4, pp. 1094 - 1098
The synthesis of a novel class of piperazine benzamide (reverse amides) targeting the human beta(3)-adrenergic receptor for the treatment of overactive bladder... 
SELECTIVE BETA-ADRENOCEPTOR AGONIST | ADRENOCEPTOR | CHEMISTRY, MEDICINAL | RAT | NOREPINEPHRINE | URINARY-BLADDER | MIRABEGRON | CHEMISTRY, ORGANIC | Norepinephrine transporter | Reverse amide | Pyrrolidine scaffold | DISCOVERY | CONTRACTIONS | POTENT | ANTIDEPRESSANTS | beta-Adrenergic receptor agonist | Overactive bladder
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 02/2016, Volume 173, Issue 3, pp. 415 - 428
Linked ArticleThis article is commented on by Michel, M. C., pp. 429-430 of this issue. To view this commentary visit . Background and PurposeMirabegron is the... 
SELECTIVE BETA-ADRENOCEPTOR AGONIST | DETRUSOR MUSCLE | IN-VITRO | OVERACTIVE BLADDER | VAS-DEFERENS | CONCISE GUIDE | BETA-ADRENOCEPTOR SUBTYPES | URINARY-TRACT SYMPTOMS | DOUBLE-BLIND | FUNCTIONAL-ROLE | PHARMACOLOGY & PHARMACY
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 09/2017, Volume 54, Issue 5, pp. 2703 - 2707
Mirabegron is a muscle relaxing drug for the treatment of overactive bladder. The existing synthetic methods for mirabegron produced intermediate product... 
SELECTIVE BETA-ADRENOCEPTOR AGONIST | CHEMISTRY, ORGANIC | OVERACTIVE BLADDER | REDUCTION | YM178
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2015, Volume 10, Issue 1
Acting on the glucocorticoid receptor (NR3C1), glucocorticoids are widely used to treat inflammatory diseases. However, glucocorticoid resistance often leads... 
BETA-ADRENOCEPTOR AGONISTS | INFLAMMATORY GENE-EXPRESSION | PULMONARY EPITHELIAL-CELLS | SELECTIVE INHIBITOR | ACTIVATED PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | AIRWAY INFLAMMATION | NECROSIS-FACTOR-ALPHA | SMOOTH-MUSCLE-CELLS | STEROID RESISTANCE
Journal Article