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Current topics in medicinal chemistry, ISSN 1568-0266, 10/2016, Volume 16, Issue 25, pp. 2779 - 2791
Background. The high sequence and structural homology among the hsp90 paralogs - Hsp90 alpha, Hsp90 beta, Grp94, and Trap-1 - has made the development of paralog-specific inhibitors a challenging proposition. Objective... 
Hsp90 | Screening | Trap-1 | Paralog-selective inhibitor | Structure-based design | Grp94 | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Sequence Homology, Amino Acid | HSP90 Heat-Shock Proteins - chemistry | Amino Acid Sequence | Resorcinols - chemistry | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Humans
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Journal Article