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Cellular and Molecular Life Sciences, ISSN 1420-682X, 3/2016, Volume 73, Issue 5, pp. 985 - 1001
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 06/2015, Volume 15, Issue 9, pp. 762 - 775
The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles... 
1,3,4-thiadiazoles | Cyclooxygenase inhibitors | Leishmanicidal agents | Metalloproteinases inhibitors | Anticonvulsant activity | Diuretics | Carbonic anhydrase inhibitors | Anticancer agents | VITRO ANTITUBERCULOSIS ACTIVITY | CHEMISTRY, MEDICINAL | leishmanicidal agents | GYNECOLOGIC-ONCOLOGY-GROUP | SELECTIVE PDE7 INHIBITORS | HELICOBACTER-PYLORI ACTIVITY | HUMAN ISOFORM-II | IN-VITRO | metalloproteinases inhibitors | anticonvulsant activity | carbonic anhydrase inhibitors | diuretics | AMINOPEPTIDASE-N INHIBITORS | cyclooxygenase inhibitors | SUBSTITUTED 1,3,4-THIADIAZOLES | CARBONIC-ANHYDRASE INHIBITORS | Phosphodiesterase Inhibitors - therapeutic use | Carbonic Anhydrase Inhibitors - chemistry | Humans | Matrix Metalloproteinase Inhibitors - chemistry | Antineoplastic Agents - therapeutic use | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Matrix Metalloproteinase Inhibitors - metabolism | Matrix Metalloproteinase Inhibitors - therapeutic use | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Animals | Phosphodiesterase Inhibitors - metabolism | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Protein Binding | Phosphodiesterase Inhibitors - chemistry | Thiadiazoles - metabolism | Carbonic Anhydrase Inhibitors - metabolism | Cyclooxygenase Inhibitors - therapeutic use | Quantitative Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - therapeutic use
Journal Article
Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, 10/2017, Volume 26, Issue 10, pp. 1141 - 1148
PurposeTo assess the risk of gastrointestinal perforation, ulcers, or bleeding (PUB) associated with the use of conventional nonsteroidal anti-inflammatory... 
proton pump inhibitors | bleeding | gastrointestinal toxicity | perforation | selective COX‐2 inhibitors | ulcers | conventional NSAIDs | selective COX-2 inhibitors | RHEUMATOID-ARTHRITIS | CARDIOVASCULAR EVENTS | NONSELECTIVE NSAIDS | CELECOXIB | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CONTROLLED TRIALS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HIGH-RISK | CYCLOOXYGENASE-2 INHIBITORS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | OSTEOARTHRITIS | Age Factors | Humans | Middle Aged | Peptic Ulcer - prevention & control | Male | Peptic Ulcer - epidemiology | Gastrointestinal Hemorrhage - epidemiology | Case-Control Studies | Cyclooxygenase 2 Inhibitors - adverse effects | Peptic Ulcer Perforation - epidemiology | Pain - drug therapy | Pain Management - adverse effects | Aged, 80 and over | Female | Odds Ratio | Peptic Ulcer - complications | Risk Factors | Pain Management - methods | Proton Pump Inhibitors - therapeutic use | Gastrointestinal Hemorrhage - chemically induced | Gastrointestinal Hemorrhage - prevention & control | Peptic Ulcer Perforation - prevention & control | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Aged | Peptic Ulcer - chemically induced | Peptic Ulcer Perforation - etiology | COX-2 inhibitors | Proton pump inhibitors | Nonsteroidal anti-inflammatory drugs | Drugs | Antiinflammatory agents | Control methods | Adjustment | Toxicity | Perforation | Pharmacology | Inflammation | Regression analysis | Patients | Risk factors | Bleeding | Confidence intervals | Inhibitors | Ulcers | Cyclooxygenase-2 | Health risk assessment | Index Medicus | Original Report | Original Reports
Journal Article
Journal Article