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Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2014, Volume 14, Issue 1, pp. 54 - 65
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2004, Volume 47, Issue 14, pp. 3546 - 3560
New 5α-reductase 1 (5αR-1) inhibitors were designed to complete a consistent set of analogues suitable for a 3D QSAR study. These compounds were synthesized by... 
BENIGN PROSTATIC HYPERPLASIA | 19-NOR-10-AZASTEROIDS | POTENT | CHEMISTRY, MEDICINAL | MALE PATTERN BALDNESS | SELECTIVE INHIBITORS | FINASTERIDE | 5 ALPHA-REDUCTASE | TYPE-1 5-ALPHA-REDUCTASE | MOLECULAR MECHANICS | DEFICIENCY
Journal Article
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760, 05/2011, Volume 125, Issue 1-2, pp. 66 - 82
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 21, pp. 6660 - 6671
Many breast tumors are hormone-dependent, and estrogens, especially estradiol (E2), have a pivotal role in their growth and development. 17β-Hydroxysteroid... 
ESTROGEN-DEPENDENT DISEASES | HUMAN BREAST-CARCINOMA | CHEMISTRY, MEDICINAL | SELECTIVE NONSTEROIDAL INHIBITORS | STEROID DEHYDROGENASE | ACTIVE-SITE | ENZYME MODULATORS | CARBONYL-COMPOUNDS | SITE-DIRECTED MUTAGENESIS | POTENT INHIBITORS | AROMATASE INHIBITORS
Journal Article
BREAST CANCER RESEARCH AND TREATMENT, ISSN 0167-6806, 1994, Volume 30, Issue 1, pp. 43 - 55
The conversion of androgens to estrogens occurs in a variety of cells and tissues, such as ovarian granulosa and testicular cells, placenta, adipose tissue,... 
SELECTIVE-INHIBITION | PLACENTAL AROMATASE | P450 19 | VOROZOLE | ENDOCRINE THERAPY | BIOSYNTHESIS INHIBITORS | SIDE-CHAIN-CLEAVAGE | CGS 47465 | SITE-DIRECTED MUTAGENESIS | FADROZOLE | ENDOCRINE TREATMENT | BREAST-CANCER | ONCOLOGY | AMINOGLUTETHIMIDE | CGS 20267 | ROGLETIMIDE | ESTROGEN BIOSYNTHESIS | POSTMENOPAUSAL WOMEN | AROMATASE INHIBITORS | MICROSOMAL CYTOCHROME-P-450
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 07/2017, Volume 171, pp. 157 - 177
Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play fundamental roles in adrenal and gonadal steroidogenesis as well as in the... 
Virtual screening | Hydroxysteroid dehydrogenase | Drug development | Short-chain dehydrogenase/reductase | Endocrine disrupting chemicals | CARBONYL REDUCTASE SNIFFER | SELECTIVE NONSTEROIDAL INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | BETA-HYDROXYSTEROID DEHYDROGENASE | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1 17-BETA-HSD1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE | ENDOCRINOLOGY & METABOLISM | BICYCLIC SUBSTITUTED HYDROXYPHENYLMETHANONES | 11-BETA-HSD1 INHIBITORS | (-)-GOSSYPOLS POTENTLY INHIBIT | STRUCTURE-BASED DESIGN | Chemistry, Pharmaceutical - methods | Hydroxysteroid Dehydrogenases - chemistry | Expert Systems | Humans | Substrate Specificity | Isoenzymes - chemistry | Machine Learning | Endocrine Disruptors - pharmacology | Isoenzymes - metabolism | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Drug Design | Hydroxysteroid Dehydrogenases - metabolism | Toxicology - methods | Computer-Aided Design - trends | Binding Sites | Chemistry, Pharmaceutical - trends | Endocrine Disruptors - metabolism | Enzyme Inhibitors - metabolism | Endocrine Disruptors - chemistry | Computational Biology | Enzyme Inhibitors - pharmacology | Toxicology - trends | Molecular Docking Simulation - trends | High-Throughput Screening Assays - trends | Endocrine Disruptors - toxicity | Animals | Validation Studies as Topic | Databases, Chemical | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Protein Conformation | Isoenzymes - antagonists & inhibitors | Enzymes | Dehydroepiandrosterone | Corticosteroids | Bile acids | Estrogen | Cytochrome P-450 | Physiological aspects | Alcoholic beverages | Drug discovery | Retinoids | Progesterone | Index Medicus
Journal Article
EXPERT OPINION ON THERAPEUTIC PATENTS, ISSN 1354-3776, 09/2010, Volume 20, Issue 9, pp. 1123 - 1145
Journal Article