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1. Full Text Essay - Dendritic cells in a mature age
by Sousa, CR
NATURE REVIEWS IMMUNOLOGY, ISSN 1474-1733, 06/2006, Volume 6, Issue 6, pp. 476 - 483
A common view supposes that dendritic cells (DCs) exist in two basic functional states: immature DCs induce tolerance to self, whereas mature DCs induce... 
ADAPTIVE IMMUNITY | EPIDERMAL LANGERHANS CELLS | REGULATE ANTIGEN PRESENTATION | TUMOR-NECROSIS-FACTOR | IN-VIVO REQUIRES | LYMPH-NODE | PERIPHERAL TOLERANCE | STEADY-STATE | IMMUNOLOGY | PRESENT SELF-ANTIGENS | CD8 T-CELLS
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2. Full Text Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis
by Jelcic, Ilijas and Jelcic, Ivan and Al Nimer, Faiez and Wang, Jian and Lentsch, Verena and Planas, Raquel and Madjovski, Aleksandar and Ruhrmann, Sabrina and Faigle, Wolfgang and Frauenknecht, Katrin and Pinilla, Clemencia and Santos, Radleigh and Hammer, Christian and Ortiz, Yaneth and Opitz, Lennart and Grönlund, Hans and Rogler, Gerhard and Boyman, Onur and Reynolds, Richard and Lutterotti, Andreas and Khademi, Mohsen and Olsson, Tomas and Piehl, Fredrik and Sospedra, Mireia and Martin, Roland
Cell, ISSN 0092-8674, 09/2018, Volume 175, Issue 1, pp. 85 - 100.e23
Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic, particularly the HLA-DR15 haplotype, and environmental risk factors.... 
pathogenesis | HLA-DR15 | T cell receptor | multiple sclerosis | B cells | autoproliferation | T cells | brain | RASGRP2 | ANTIBODIES | TCR | HOMEOSTASIS | AUTOIMMUNITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | MECHANISMS | SELF-ANTIGENS | INDUCTION | LESIONS | REPERTOIRES | CELL BIOLOGY
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3. Full Text Diabetogenic T cells recognize insulin bound to IA(g7) in an unexpected, weakly binding register
by Stadinski, BD and Zhang, L and Crawford, F and Marrack, P and Eisenbarth, GS and Kappler, JW
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2010, Volume 107, Issue 24, pp. 10978 - 10983
A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4(+) T cells in the NOD mouse model of type 1 diabetes (T1D). This... 
antigen presentation | SPECIFICITY | MOLECULE | MULTIDISCIPLINARY SCIENCES | self-antigens | UNIQUE | AUTOANTIGEN | MAJOR HISTOCOMPATIBILITY COMPLEX | NOD MOUSE | PEPTIDES | autoimmunity | NONOBESE DIABETIC MICE | RECEPTORS | diabetes | tolerance | CLONES
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4. Full Text Cross-priming in health and disease
by Kurts, Christian and Robinson, Bruce W. S and Knolle, Percy A
Nature Reviews Immunology, ISSN 1474-1733, 06/2010, Volume 10, Issue 6, pp. 403 - 414
Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for immune defence against viruses and tumours. Although it was discovered... 
MHC CLASS-I | LISTERIA-MONOCYTOGENES | HEPATITIS-C VIRUS | TUMOR-SPECIFIC CTL | ENDOTHELIAL-CELLS | PERIPHERAL TOLERANCE | SELF-ANTIGENS | IMMUNOLOGY | CD8(+) T-CELLS | CD8-ALPHA(+) DENDRITIC CELLS | CUTTING EDGE | T-Lymphocytes, Cytotoxic - immunology | Neoplasms - therapy | Animals | Virus Diseases - immunology | Bacterial Infections - immunology | Neoplasms - immunology | Dendritic Cells - immunology | Humans | Cross-Priming | Physiological aspects | Immune response | Research | T cells
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5. Full Text Cutting Edge: Programed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens
by Martin-Orozco, Natalia and Wang, Yi-Hong and Yagita, Hideo and Dong, Chen
The Journal of Immunology, ISSN 0022-1767, 12/2006, Volume 177, Issue 12, pp. 8291 - 8295
Constitutive presentation of tissue Ags by dendritic cells results in tolerance of autoreactive CD8+ T cells; however, the underlying molecular mechanisms are... 
RESPONSES | LIGANDS | AUTOIMMUNITY | MICE | SELF-ANTIGENS | DILATED CARDIOMYOPATHY | IMMUNOLOGY | EXPRESSION | CROSS-PRESENTATION | LYMPHOCYTES | DELETION
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6. Full Text Mechanisms maintaining peripheral tolerance
by Mueller, Daniel L
Nature Immunology, ISSN 1529-2908, 01/2010, Volume 11, Issue 1, pp. 21 - 27
The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an... 
MYELIN BASIC-PROTEIN | DENDRITIC CELLS | 7 COMMON DISEASES | IN-VIVO | CLONAL ANERGY | SELF-ANTIGENS | IMMUNOLOGY | T-CELL TOLERANCE | GENOME-WIDE ASSOCIATION | CROSS-PRESENTATION | TRANSGENIC MICE | Models, Immunological | Animals | Apoptosis - immunology | Immune Tolerance - immunology | Dendritic Cells - immunology | Humans | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Major Histocompatibility Complex - immunology | Antigen Presentation - immunology | Genetic aspects | Research | T cells | Autoimmune diseases | Gene expression | Health aspects | Risk factors
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7. Full Text Direct stimulation of T cells by type IIFN enhances the CD8(+) T cell response during cross-priming
by Le Bon, A and Durand, V and Kamphuis, E and Thompson, C and Bulfone-Paus, S and Rossmann, C and Kalinke, U and Tough, DF
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2006, Volume 176, Issue 8, pp. 4682 - 4689
Type I IFN (IFN-alpha beta), which is produced rapidly in response to infection, plays a key role in innate immunity and also acts as a stimulus for the... 
VIRUS-INFECTION | DENDRITIC CELLS | KILLER-CELL | IMMUNE-RESPONSES | CLONAL EXPANSION | IN-VIVO | SELF-ANTIGENS | IMMUNOLOGY | IL-15 AUGMENTS | CUTTING EDGE | IFN-ALPHA
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8. Full Text Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
by Brian D. Stadinski and Li Zhang and Frances Crawford and Philippa Marrack and George S. Eisenbarth and John W. Kappler
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2010, Volume 107, Issue 24, pp. 10978 - 10983
A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4 + T cells in the NOD mouse model of type 1 diabetes (T1D). This... 
Autoimmunity | Tolerance | Antigen presentation | Diabetes | Self-antigens | Amino Acid Sequence | Epitopes - metabolism | Insulin - immunology | Models, Molecular | Molecular Sequence Data | Cysteine - chemistry | CD4-Positive T-Lymphocytes - immunology | Insulin - metabolism | Animals | Antigen Presentation | Insulin - chemistry | Hybridomas - immunology | Protein Binding | Histocompatibility Antigens Class II - metabolism | Mice, Inbred NOD | Epitopes - chemistry | Mice | Diabetes Mellitus, Type 1 - immunology | Insulin - genetics | Binding Sites | Biological Sciences | autoimmunity | antigen presentation | diabetes | tolerance | self-antigens
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9. Full Text CD8 + T cell efficacy in vaccination and disease
by Appay, Victor and Price, David A and Douek, Daniel C
Nature Medicine, ISSN 1078-8956, 06/2008, Volume 14, Issue 6, pp. 623 - 628
Much effort has been devoted to the design of vaccines that induce adaptive cellular immunity, in particular CD8(+) T cells, which have a central role in the... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | MELANOMA PATIENTS | SELF-ANTIGENS | BLOOD MONONUCLEAR-CELLS | CELL BIOLOGY | TUMOR REACTIVITY | PRIME-BOOST IMMUNIZATION | CANCER REGRESSION | IN-VIVO | HIGH-FREQUENCY | HIGH-AVIDITY CTL | PD-1 EXPRESSION | Communicable Diseases - pathology | Humans | Vaccination | Histocompatibility Antigens Class I - immunology | HIV Infections - immunology | Models, Immunological | HIV Infections - pathology | Virus Replication | Neoplasms - immunology | Communicable Diseases - immunology | HIV Infections - physiopathology | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Medical research | Immunology | Infectious diseases | Vaccines | Cellular biology | Tumors
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10. Full Text In vivo function of Langerhans cells and dermal dendritic cells
by Kaplan, Daniel H
Trends in Immunology, ISSN 1471-4906, 2010, Volume 31, Issue 12, pp. 446 - 451
In the past few years there has been an explosion in the characterization of skin-resident dendritic cells (DCs). This is largely because of the development of... 
Allergy and Immunology | TOLERANCE | LYMPH-NODES | DISTINCT | CONTACT HYPERSENSITIVITY | ABLATION | STEADY-STATE | MICE | SELF-ANTIGENS | IMMUNOLOGY | T-CELLS | SKIN IMMUNE-RESPONSES | Dermatitis, Contact - immunology | Animals | Antigen Presentation | Humans | Langerhans Cells - immunology | Biomarkers | Skin - immunology | Bone marrow | Population | Microorganisms | Lymphocytes
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11. Full Text Dynamic programming of CD8 + T lymphocyte responses
by Bijker, Martijn S and Green, Douglas R and van Stipdonk, Marianne J.B and Droin, Nathalie M and Schoenberger, Stephen P and Lemmens, Edward E and Hardenberg, Gijs
Nature Immunology, ISSN 1529-2908, 04/2003, Volume 4, Issue 4, pp. 361 - 365
The initial encounter with an antigen-presenting cell (APC) is the primary force behind the expansion, differentiation and survival of naive T cells. Using an... 
EFFECTOR | DENDRITIC CELLS | TOLERANCE | EXPANSION | RECEPTOR | INFECTION | SELF-ANTIGENS | DIFFERENTIATION | IMMUNOLOGY | CROSS-PRESENTATION | DELETION | Cell Movement - immunology | Interleukin-2 - metabolism | Mice | Animals | CD8-Positive T-Lymphocytes - immunology | Cell Division - immunology
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12. Full Text T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology
by King, Carolyn G and Koehli, Sabrina and Hausmann, Barbara and Schmaler, Mathias and Zehn, Dietmar and Palmer, Ed
Immunity, ISSN 1074-7613, 10/2012, Volume 37, Issue 4, pp. 709 - 720
The strength of interactions between T cell receptors and the peptide-major histocompatibility complex (pMHC) directly modulates T cell fitness, clonal... 
BET | TCR | MEMORY | AUTOIMMUNITY | INTEGRIN | CD8 | PROLIFERATION | SELF-ANTIGENS | IMMUNOLOGY | LYMPHOCYTE-RESPONSES | TRANSCRIPTION FACTOR | Phenotype | Animals | T-Lymphocytes - cytology | Lymphocyte Activation | Cell Division | Mice, Inbred C57BL | Cells, Cultured | Ligands | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Cell Differentiation | Mice | Antigens | Universities and colleges | T cells | Integrins | Daughters | Pathology | Peptides | Microscopy | Listeria | Lymphocytes | Cell division | T cell receptors | Diabetes | Immune system | Cell adhesion & migration
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