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British Journal of Haematology, ISSN 0007-1048, 04/2011, Volume 153, Issue 1, pp. 92 - 104
Summary Red blood cell (RBC) hydration is regulated in part by the Ca2+‐activated K+ efflux (Gardos) channel. Senicapoc selectively blocks potassium efflux... 
Gardos channel | KCa3·1 | senicapoc | sickle cell disease | red blood cell | Red blood cell | Senicapoc | Sickle cell disease | ION-TRANSPORT | CLOTRIMAZOLE | SAD MICE | ADHESION | KCa3 center dot 1 | DEHYDRATION | K+ TRANSPORT | HEMATOLOGY | BLOOD-CELLS | Hemolysis - drug effects | Antisickling Agents - therapeutic use | Antisickling Agents - adverse effects | Humans | Middle Aged | Hematocrit | Trityl Compounds - adverse effects | Erythrocyte Aging - drug effects | Male | Anemia, Sickle Cell - drug therapy | Antisickling Agents - blood | Acetamides - blood | Young Adult | Acetamides - therapeutic use | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Acetamides - adverse effects | Pain - etiology | Adult | Female | Trityl Compounds - administration & dosage | Trityl Compounds - blood | Double-Blind Method | Drug Administration Schedule | Pain - prevention & control | Anemia, Sickle Cell - complications | Treatment Outcome | Antisickling Agents - administration & dosage | Adolescent | Trityl Compounds - therapeutic use | Aged | Anemia, Sickle Cell - blood | Acetamides - administration & dosage | Medical colleges | Medical research | Complications and side effects | Care and treatment | Sickle cell anemia | Analysis | Patient outcomes | Hemoglobin | Medicine, Experimental | Clinical trials | Urinary tract infections | Dehydration (Physiology)
Journal Article
Blood, ISSN 0006-4971, 05/2017, Volume 129, Issue 20, pp. 2719 - 2726
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 795, pp. 1 - 7
Neuropathic pain is a debilitating, chronic condition with a significant unmet need for effective treatment options. Recent studies have demonstrated that in... 
Tactile allodynia | Gabapentin | Calcium-activated potassium channel | KCa3.1 | Chronic constriction injury | Senicapoc | Von Frey | KCNN4 | ICA-17043 | Neuropathic pain | Microglia | 3.1 | K
Journal Article
GLIA, ISSN 0894-1491, 10/2016, Volume 64, Issue 10, pp. 1733 - 1741
Over the past decade, glial cells have attracted attention for harboring unexploited targets for drug discovery. Several glial targets have attracted de novo... 
NCATS | ASSOCIATION/AMERICAN-STROKE-ASSOCIATION | CA2+-ACTIVATED K+ CHANNEL | ACUTE MYELOID-LEUKEMIA | SENICAPOC ICA-17043 | NEUROSCIENCES | drug repurposing | KCa3.1 | GARDOS CHANNEL | THERAPEUTIC TARGETS | ACTIVATED POTASSIUM CHANNEL | SICKLE-CELL-DISEASE | ION CHANNELS | microglia | ISCHEMIC-STROKE | drug target
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 01/2017, Volume 795, pp. 1 - 7
Neuropathic pain is a debilitating, chronic condition with a significant unmet need for effective treatment options. Recent studies have demonstrated that in... 
Tactile allodynia | ACTIVATION | Chronic constriction injury | MECHANISMS | KCNN4/KCA3.1 | Neuropathic pain | Microglia | BLOCKERS | IMMUNE | Calcium-activated potassium channel | K(Ca)3.1 | Senicapoc | Von Frey | PHARMACOLOGY & PHARMACY | KCNN4 | ICA-17043 | K+ CHANNELS | BRAIN | MONONEUROPATHY
Journal Article
Stroke, ISSN 0039-2499, 01/2015, Volume 46, Issue 1, pp. 237 - 244
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 12/2011, Volume 31, Issue 12, pp. 2363 - 2374
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 02/2013, Volume 48, Issue 2, pp. 212 - 219
Key features of asthma include bronchial hyperresponsiveness (BHR), eosinophilic airway inflammation, and bronchial remodeling, characterized by subepithelial... 
Smooth muscle | Ion channel | Remodeling | 3.1 | Asthma | MODERATE ASTHMA | LUNG | remodeling | POTASSIUM CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | smooth muscle | UNRESTRAINED PLETHYSMOGRAPHY | asthma | BRONCHIAL SMOOTH-MUSCLE | SENICAPOC ICA-17043 | MAST-CELL MIGRATION | CELL BIOLOGY | ion channel | RESPIRATORY SYSTEM | INFLAMMATION | K(Ca)3.1 | MICE | KCa3.1
Journal Article
Journal Article