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BMB Reports, ISSN 1976-6696, 2019, Volume 52, Issue 2, p. 139
Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems,... 
SETDB1 | Breast cancer | Metastasis
Journal Article
Cell Reports, ISSN 2211-1247, 01/2020, Volume 30, Issue 1, pp. 25 - 36.e6
Known as a histone H3K9 methyltransferase, SETDB1 is essential for embryonic development and pluripotent inner cell mass (ICM) establishment. However, its... 
2C-like totipotency | Setdb1 | H3K9 methylation | necroptosis | ENDOGENOUS RETROVIRUSES | MAINTENANCE | H3K9 METHYLATION | NECROPTOSIS | DNA METHYLATION | ROLES | EMBRYONIC STEM-CELLS | GENES | ESET | HISTONE METHYLTRANSFERASE SETDB1 | CELL BIOLOGY
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 11/2017, Volume 216, Issue 11, pp. 3535 - 3549
A propensity for rewiring genetic and epigenetic regulatory networks, thus enabling sustained cell proliferation, suppression of apoptosis, and the ability to... 
ENDOGENOUS RETROVIRUSES | VULNERABILITIES | DNA METHYLATION | VIRAL MIMICRY | EMBRYONIC STEM-CELLS | GENES | RETROELEMENTS | CANCER | HISTONE METHYLTRANSFERASE SETDB1 | HYPOMETHYLATION | CELL BIOLOGY
Journal Article
Development (Cambridge), ISSN 0950-1991, 02/2013, Volume 140, Issue 3, pp. 519 - 529
Endogenous retroviruses (ERVs) undergo de novo DNA methylation during the first few days of mammalian embryogenesis, although the factors that control the... 
TIF1β | TRIM28 | ESET (SETDB1) | KRAB-associated protein 1 (KAP1) | KRAB zinc-finger protein (KRAB-ZFP) | De novo DNA methylation | Endogenous retroviral silencing | RETROTRANSPOSON | DNMT3A | MURINE LEUKEMIA-VIRUS | DEVELOPMENTAL BIOLOGY | LYSINE METHYLTRANSFERASE G9A | MAINTENANCE | EPIGENETIC INHERITANCE | REPRESSION | EMBRYONIC STEM-CELLS | REQUIRES | TIF1 beta | EXPRESSION | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Endogenous Retroviruses - enzymology | Humans | Transcriptome | Endogenous Retroviruses - genetics | Tripartite Motif-Containing Protein 28 | Embryo, Mammalian - metabolism | Lentivirus - metabolism | DNA Methylation | Transfection | Endogenous Retroviruses - metabolism | Gene Expression Regulation, Developmental | HEK293 Cells | Embryo, Mammalian - virology | Lentivirus - genetics | Embryonic Stem Cells - virology | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Gene Transfer Techniques | Promoter Regions, Genetic | Histone-Lysine N-Methyltransferase - genetics | Animals, Genetically Modified | DNA, Viral - metabolism | Gene Silencing | Genetic Vectors - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Gene Knockout Techniques | Genetic Vectors - genetics | Animals | Histones - genetics | Histone-Lysine N-Methyltransferase - metabolism | Embryo, Mammalian - cytology | Mice | Histones - metabolism | DNA, Viral - genetics | de novo DNA methylation | SETDB1 | endogenous retroviral silencing | KRAB-zinc finger protein (KRAB-ZFP) | ESET
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 474 - 478
Journal Article
EMBO reports, ISSN 1469-221X, 10/2018, Volume 19, Issue 10, p. n/a
Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during... 
KAP1 (KRAB‐associated protein 1) | endogenous retroviruses | SETDB1 | adult human cells | epigenetic control | retrotransposons | innate immune genes | 5‐azacytidine | KAP1 (KRAB-associated protein 1) | 5-azacytidine | DNA METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | TRANSPOSABLE ELEMENTS | LARGE GENE LISTS | I INTERFERON | CELL BIOLOGY | INTERFERON RESPONSE | EMBRYONIC STEM-CELLS | EXPRESSION | HISTONE METHYLTRANSFERASE SETDB1 | Endogenous Retroviruses - pathogenicity | Promoter Regions, Genetic | Histones - immunology | Gene Expression Regulation - immunology | Humans | Immunity, Innate - genetics | Repressor Proteins - genetics | DNA Methylation - genetics | Endogenous Retroviruses - genetics | Binding Sites - genetics | Tripartite Motif-Containing Protein 28 - genetics | Gene Knockout Techniques | Leukocytes, Mononuclear - virology | Histones - genetics | Leukocytes, Mononuclear - immunology | Endogenous Retroviruses - immunology | Genome, Human - immunology | Regulations | Deactivation | Genes | Gene regulation | Leukocytes (mononuclear) | Genomes | Inactivation | Gene expression | Ribonucleic acid--RNA | Zinc | Proteins | Signal transduction | Signaling | Human performance | Peripheral blood mononuclear cells | Endogenous retroviruses | Control stability | Interferon | Cytosine | Zinc finger proteins | Methylation | Binding sites | Immunology | Transcription | Chromatin, Epigenetics, Genomics & Functional Genomics
Journal Article
by Lee, S and Lee, C and Hwang, CY and Kim, D and Han, Y and Hong, SN and Kim, SH and Cho, KH
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 01/2020, Volume 18, Issue 1, pp. 118 - 129
Cancer cells exhibit properties of cells in a less differentiated state than the adjacent normal cells in the tissue. We explored whether cancer cells can be... 
VISUALIZATION | STEM-CELLS | THERAPY | ONCOLOGY | BIOLOGY | EXPRESSION | SIGNATURE | PROMOTES | HISTONE METHYLTRANSFERASE SETDB1 | PROGRESSION | BIOCONDUCTOR | CELL BIOLOGY
Journal Article
by Batham, J and Lim, PS and Rao, S
CANCERS, ISSN 2072-6694, 08/2019, Volume 11, Issue 8, p. 1143
The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain... 
PROGENITOR CELLS | STEM-CELLS | EPITHELIAL-MESENCHYMAL PLASTICITY | PROTEIN | SETDB1 | DNA METHYLATION | therapy | breast cancer | resistance | epigenetics | recurrence | ONCOLOGY | GENE-EXPRESSION | SELECTIVE INHIBITORS | cancer stem cells | ESET | HISTONE METHYLTRANSFERASE SETDB1 | HEMATOPOIETIC STEM
Journal Article
Cancers, ISSN 2072-6694, 08/2019, Volume 11, Issue 8, p. 1134
SETDB1 is a key histone lysine methyltransferase involved in gene silencing. The gene is amplified in human lung cancer, where the protein plays a driver role.... 
Life Sciences | Quantitative Methods | Biochemistry, Molecular Biology | Genomics | Cancer | non-small cell lung cancer | meta-analysis | lysine methyltransferase | SETDB1/KMT1E
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2019, Volume 18, Issue 8, pp. 889 - 897
This study was to investigate the biological function and underlying mechanisms of FENDRR in cholangiocarcinoma (CCA) cell proliferation, migration and... 
survivin | proliferation | LncRNA FENDRR | cholangiocarcinoma | APOPTOSIS | SETDB1 | PROGNOSIS | NONCODING RNA FENDRR | CANCER | CELL BIOLOGY | THERAPY | TARGETING SURVIVIN | EXPRESSION
Journal Article
TURKISH JOURNAL OF BIOLOGY, ISSN 1300-0152, 2019, Volume 43, Issue 5, pp. 281 - 292
Head and neck cancer (HNC) is the sixth most common cancer worldwide and therefore presents a global public health problem. There are no standard algorithms... 
APOPTOSIS | SETDB1 | MECHANISM | caspase-3 activity | SUV39H1 | qRT-PCR | siRNA | PROLIFERATION | western blot | LYSINE METHYLTRANSFERASES | EPIGENETICS | cell viability | INHIBITION | scratch wound-healing | BIOLOGY | Head and neck cancer | EXPRESSION | TUMORIGENESIS | HISTONE METHYLTRANSFERASE SETDB1
Journal Article
The Journal of pathology, ISSN 0022-3417, 3/2015, Volume 235, Issue 4, pp. 559 - 570
We investigated the oncogenic role of SETDB1 focusing on non-small cell lung cancer (NSCLC) having high expression of this protein. A total of 387 lung cancer... 
lung | tumorigenesis | SETDB1 | WNT
Journal Article
Journal Article