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1. Full Text Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
by Kiguli, Sarah and Maitland, Kathryn and George, Elizabeth C and Olupot-Olupot, Peter and Opoka, Robert O and Engoru, Charles and Akech, Samuel O and Nyeko, Richard and Mtove, George and Reyburn, Hugh and Levin, Michael and Babiker, Abdel G and Gibb, Diana M and Crawley, Jane
BMC Medicine, ISSN 1741-7015, 02/2015, Volume 13, Issue 1, pp. 21 - 21
Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited... 
Anaemia | Malaria | Africa | Sepsis | Children | Blood transfusion | FEAST trial | MORTALITY | MANAGEMENT | FLUID-BOLUS | INDICATOR | CHILDHOOD | DISTRICT HOSPITALS | SEVERE MALARIAL ANEMIA | TRIAL | MEDICINE, GENERAL & INTERNAL | BURDEN | Anemia - mortality | Prevalence | Time-to-Treatment | Anemia - epidemiology | Humans | Child, Preschool | Anemia - therapy | Infant | Male | Sepsis - complications | Hospitalization | Blood Transfusion - statistics & numerical data | Fluid Therapy - adverse effects | Guideline Adherence | Female | Malaria - complications | Africa, Eastern - epidemiology | Child | Anemia - etiology | Practice Guidelines as Topic | Infection | Anemia | Mortality
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2. Full Text Defining Falciparum-Malaria-Attributable Severe Febrile Illness in Moderate-to-High Transmission Settings on the Basis of Plasma PfHRP2 Concentration
by Ilse C. E. Hendriksen and Lisa J. White and Jacobien Veenemans and George Mtove and Charles Woodrow and Ben Amos and Somporn Saiwaew and Samwel Gesase and Behzad Nadjm and Kamolrat Silamut and Sarah Joseph and Kesinee Chotivanich and Nicholas P. J. Day and Lorenz von Seidlein and Hans Verhoef and Hugh Reyburn and Nicholas J. White and Arjen M. Dondorp
The Journal of Infectious Diseases, ISSN 0022-1899, 1/2013, Volume 207, Issue 2, pp. 351 - 361
Background. In malaria-endemic settings, asymptomatic parasitemia complicates the diagnosis of malaria. Histidine-rich protein 2 (HRP2) is produced by... 
Disease transmission | Malaria | Disease models | Parasitic diseases | Children | Parasites | Parasitemia | Blood | Blood plasma | Diseases | Plasmodium falciparum | severe malaria | case definition | malaria-attributable disease | Tanzania | asymptomatic parasitemia | bacteremia | histidine-rich protein 2 | SYSTEMATIC ANALYSIS | INFECTIOUS DISEASES | MALAWIAN CHILDREN | SUB-SAHARAN AFRICA | CLINICAL-DIAGNOSIS | MICROBIOLOGY | IMMUNOLOGY | HISTIDINE-RICH PROTEIN-2 | CASE DEFINITIONS | PLASMODIUM-FALCIPARUM | NORTH-EASTERN TANZANIA | ENDEMIC AREAS | CEREBRAL MALARIA | Malaria, Falciparum - physiopathology | Severity of Illness Index | Tanzania - epidemiology | Fever - parasitology | Protozoan Proteins - blood | Humans | Child, Preschool | Infant | Male | Fever - epidemiology | Malaria, Falciparum - parasitology | Malaria, Falciparum - transmission | Fever - etiology | Malaria, Falciparum - epidemiology | Parasitemia - parasitology | Plasmodium falciparum - pathogenicity | Antigens, Protozoan - blood | Female | Parasitemia - epidemiology | Measurement | Parasite antigens | Diagnosis | Research | Major and Brief Reports
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3. Full Text Integrated fever management: Disease severity markers to triage children with malaria and non-malarial febrile illness
by McDonald, Chloe R and Weckman, Andrea and Richard-Greenblatt, Melissa and Leligdowicz, Aleksandra and Kain, Kevin C
Malaria Journal, ISSN 1475-2875, 10/2018, Volume 17, Issue 1, pp. 353 - 7
Febrile symptoms in children are a leading cause of health-care seeking behaviour worldwide. The majority of febrile illnesses are uncomplicated and... 
Disease severity | Severe malaria | Innate immunity | Inflammation | Malaria | Endothelial activation | MORTALITY | INFECTIOUS DISEASES | INFECTIONS | FALCIPARUM-MALARIA | SEPSIS | ANGIOPOIETIN-2 | CARE | TROPICAL MEDICINE | DYSREGULATION | DYSFUNCTION | PARASITOLOGY | Therapy | Diagnostic tests | Infections | Parasites | Density stratification | Aetiology | Risks | Illnesses | At risk youth | Children | Stratification | Public health | Vector-borne diseases | Pathogens | Human diseases | Integrated approach | Mortality | Health risks | Antimicrobial agents | Patients | Fever | Children & youth | Diseases | Hospitals | Health care expenditures | Antibiotics | Biomarkers | Sepsis | Detection | Symptoms
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4. Full Text A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial
by Keitel, Kristina and Kagoro, Frank and Samaka, Josephine and Masimba, John and Said, Zamzam and Temba, Hosiana and Mlaganile, Tarsis and Sangu, Willy and Rambaud-Althaus, Clotilde and Gervaix, Alain and Genton, Blaise and D’Acremont, Valérie
PLoS Medicine, ISSN 1549-1277, 10/2017, Volume 14, Issue 10, p. e1002411
Background The management of childhood infections remains inadequate in resource-limited countries, resulting in high mortality and irrational use of... 
C-REACTIVE PROTEIN | AGED 2-59 MONTHS | MEDICINE, GENERAL & INTERNAL | INFECTIONS | PROCALCITONIN | HOSPITALS | MALARIA | OUTCOMES | PRIMARY-HEALTH-CARE | SEVERE PNEUMONIA | TREATMENT FAILURE | Predictive Value of Tests | Patient Readmission | Point-of-Care Testing | Humans | Child, Preschool | Fever - mortality | Infant | Male | Fever - physiopathology | Patient Selection | Anti-Bacterial Agents - therapeutic use | Communicable Diseases - drug therapy | Communicable Diseases - physiopathology | Mobile Applications | Clinical Decision-Making | Communicable Diseases - diagnosis | Female | Nutritional Status | Communicable Diseases - mortality | Diagnosis, Computer-Assisted - instrumentation | Severity of Illness Index | Heart Rate | Diagnosis, Differential | Reproducibility of Results | Risk Factors | Decision Support Techniques | Tanzania | Fever - diagnosis | Biomarkers - blood | Algorithms | Point-of-Care Systems | Age of Onset | Respiration | Fever - drug therapy | Smartphone | Treatment outcome | Usage | Care and treatment | Analysis | Medical tests | Children | Research | Diseases | Pneumonia | C-reactive protein | Funding | Procalcitonin | Medical services | Risk | Infections | Clinical outcomes | Subgroups | Proteins | Randomization | Reduction | Illnesses | Consultation | Control algorithms | Hemoglobin | Bioindicators | Prescriptions | Public health | Supervision | Failure | Vector-borne diseases | Malaria | Anemia | Mortality | Case management | Antimicrobial agents | Management tools | Management | Patients | Disease control | Children & youth | Medicine | Population (statistical) | Hospitals | Antibiotics | Biomarkers | Diagnostic systems | Control theory | Resource management | Ambulatory care
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5. Full Text Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations
by Potts, James A and Rothman, Alan L
Tropical Medicine & International Health, ISSN 1360-2276, 11/2008, Volume 13, Issue 11, pp. 1328 - 1340
Summary Objective  Clinicians in resource‐poor countries need to identify patients with dengue using readily‐available data. The objective of this systematic... 
revisión | dengue haemorrhagic fever | revue | sistemática | signs and symptoms | maladies transmissibles | communicable diseases | diagnosis | enfermedades transmisibles | systematic | dengue | fièvre hémorragique de la dengue | systématique | signos y síntomas | signes et symptômes | review | diagnóstico | diagnostic | fiebre hemorrágica | Signs and symptoms | Systematic | Communicable diseases | Dengue | Diagnosis | Review | Dengue haemorrhagic fever | VIRUS-INFECTION | LEPTOSPIROSIS | ADULTS | CLASSIFICATION | TROPICAL MEDICINE | CHILDREN | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEMORRHAGIC-FEVER | EPIDEMIC | OUTBREAK | MANIFESTATIONS | Predictive Value of Tests | Diagnosis, Differential | Humans | Biomarkers - analysis | Male | Clinical Trials as Topic | Developed Countries - economics | Severe Dengue - transmission | Severe Dengue - diagnosis | Fever - etiology | Adult | Biomedical Research | Dengue - transmission | Female | Dengue Virus - isolation & purification | Child | Dengue - diagnosis | Medical diagnosis | Tropical diseases | Developing countries--LDCs
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6. Full Text Severe febrile illness in adult hospital admissions in Tanzania: a prospective study in an area of high malaria transmission
by Nadjm, Behzad and Mtove, George and Amos, Ben and Walker, Naomi F and Diefendal, Helmut and Reyburn, Hugh and Whitty, Christopher J.M
Transactions of the Royal Society of Tropical Medicine and Hygiene, ISSN 0035-9203, 11/2012, Volume 106, Issue 11, pp. 688 - 695
Severe febrile illness is a major cause of adult hospital admission in Africa. Studies of non-malarial fever come largely from children or from high HIV... 
Radiography, thoracic | Salmonella | Adult | Bacterial infections | Malaria | HIV infection | SYSTEMATIC ANALYSIS | MORTALITY | NORTHERN TANZANIA | MANAGEMENT | GUIDELINES | CARE | TROPICAL MEDICINE | CHILDREN | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | BACTEREMIA | BLOOD-STREAM INFECTIONS | SEVERE SEPSIS | Tanzania - epidemiology | Coinfection | Prevalence | Prospective Studies | Fever - microbiology | Humans | Middle Aged | Hospitalization - statistics & numerical data | Male | Fever - epidemiology | Malaria - microbiology | Bacteremia - microbiology | Acquired Immunodeficiency Syndrome - immunology | Malaria - epidemiology | Aged, 80 and over | Female | Fever - immunology | Hospital Mortality | AIDS-Related Opportunistic Infections - immunology | Malaria - immunology | Bacteremia - complications | Bacteremia - diagnosis | CD4 Lymphocyte Count | AIDS-Related Opportunistic Infections - microbiology | AIDS-Related Opportunistic Infections - epidemiology | Adolescent | Acquired Immunodeficiency Syndrome - epidemiology | Bacteremia - epidemiology | Aged | Medical research | Pneumonia | Medical examination | Bacterial pneumonia | Escherichia coli | HIV (Viruses) | Blood | Admission and discharge | Plasmodium falciparum | Anopheles | Hospitals | Disease transmission | Medicine, Experimental | HIV testing | Adults
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7. Full Text Differential Diagnosis of Chikungunya, Dengue Viral Infection and Other Acute Febrile Illnesses in Children
by Laoprasopwattana, Kamolwish and Kaewjungwad, Lamy and Jarumanokul, Roongrueng and Geater, Alan
The Pediatric Infectious Disease Journal, ISSN 0891-3668, 05/2012, Volume 31, Issue 5, pp. 459 - 463
BACKGROUND:Clinical manifestations of chikungunya (CHIK) are similar to those of dengue. It would be useful to be able to identify clinical manifestations that... 
Chikungunya | Dengue viral infection | INFECTIOUS DISEASES | SEVERE DISEASE | REUNION ISLAND | LABORATORY FEATURES | IMMUNOLOGY | chikungunya | dengue viral infection | THAILAND | PEDIATRICS | VIRUS-INFECTIONS | OUTBREAK | FEVER | MANIFESTATIONS | Alphavirus Infections - diagnosis | Arthralgia - etiology | Alphavirus Infections - physiopathology | Coinfection | Prospective Studies | Chikungunya virus - genetics | Humans | Thailand - epidemiology | Child, Preschool | Infant | Male | Disease Outbreaks | Female | Chikungunya virus - isolation & purification | Child | Real-Time Polymerase Chain Reaction | Infant, Newborn | Chikungunya Fever | Acute Disease | Diagnosis, Differential | Alphavirus Infections - epidemiology | Dengue - epidemiology | Fever - diagnosis | Arthralgia - diagnosis | Dengue - virology | Alphavirus Infections - virology | Chikungunya virus - classification | Adolescent | Fever - etiology | Cohort Studies | Dengue - diagnosis
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8. Full Text High frequency of blackwater fever among children presenting to hospital with severe febrile illnesses in eastern Uganda
by Olupot-Olupot, Peter and Engoru, Charles and Uyoga, Sophie and Muhindo, Rita and Macharia, Alex and Kiguli, Sarah and Opoka, Robert O and Akech, Samuel and Ndila, Carolyne and Nyeko, Richard and Mtove, George and Nteziyaremye, Julius and Chebet, Martin and George, Elizabeth C and Babiker, Abdel G and Gibb, Diana M and Williams, Thomas N and Maitland, Kathryn
Clinical Infectious Diseases, ISSN 1058-4838, 04/2017, Volume 64, Issue 7, pp. 939 - 946
Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with... 
Hemoglobinuria | African child | Malaria | Haemoglobinopathies | Blackwater fever | INFECTIOUS DISEASES | PARENTERAL ARTESUNATE | DELAYED HEMOLYSIS | SEVERE FALCIPARUM-MALARIA | MICROBIOLOGY | ACUTE-RENAL-FAILURE | hemoglobinuria | IMMUNOLOGY | malaria | FEATURES | AFRICAN CHILDREN | haemoglobinopathies | blackwater fever | Prevalence | Age Factors | Urinalysis | Humans | Symptom Assessment | Child, Preschool | Uganda - epidemiology | Infant | Male | Blackwater Fever - parasitology | Blackwater Fever - epidemiology | Blackwater Fever - complications | Blackwater Fever - diagnosis | Hemoglobinopathies - genetics | Female | Severity of Illness Index | Patient Outcome Assessment | Polymorphism, Genetic | Hemoglobinopathies - complications | Phenotype | Erythrocytes - metabolism | Biomarkers | Glucosephosphate Dehydrogenase - genetics | Mutation | Erythrocytes - parasitology | Care and treatment | Children | Research | Health aspects | Risk factors | Genetic polymorphisms | Major
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9. Full Text Use of a rapid test to assess plasma Plasmodium falciparum HRP2 and guide management of severe febrile illness
by Sinha, Ipsita and Ekapirat, Nattwut and Dondorp, Arjen M and Woodrow, Charles J
Malaria Journal, ISSN 1475-2875, 09/2015, Volume 14, Issue 1, p. 362
Background: Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP2) is the most accurate biomarker for severe malaria, but its measurement by ELISA has... 
PfHRP2 | Plasma | Rapid test | Severe febrile illness | Falciparum malaria | ENCEPHALOPATHIES | DIAGNOSIS | INFECTIOUS DISEASES | TROPICAL MEDICINE | HISTIDINE-RICH PROTEIN-2 | AFRICAN CHILDREN | RETINOPATHY | PARASITOLOGY | CEREBRAL MALARIA | Malaria, Falciparum - drug therapy | Protozoan Proteins - blood | Parasitemia - diagnosis | Diagnostic Tests, Routine - methods | Humans | Malaria, Falciparum - diagnosis | Child, Preschool | Antigens, Protozoan - blood | Biomarkers - blood | Drug Monitoring - methods | Child | Malaria | Comparative analysis | Enzyme-linked immunosorbent assay
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10. Full Text Blood glucose as a predictor of mortality in children admitted to the hospital with febrile illness in Tanzania
by Nadjm, Behzad and Mtove, George and Amos, Ben and Hildenwall, Helena and Najjuka, Anne and Mtei, Frank and Todd, Jim and Reyburn, Hugh
American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, 08/2013, Volume 89, Issue 2, pp. 232 - 237
Data from a prospective study of 3,319 children ages 2 months to 5 years admitted with febrile illness to a Tanzanian district hospital were analyzed to... 
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ADMISSION | SEVERE MALARIA | INDICATORS | BACTEREMIA | HYPOGLYCEMIA | CARE | TROPICAL MEDICINE | Tanzania - epidemiology | Hypoglycemia - epidemiology | Prospective Studies | Humans | Child, Preschool | Blood Glucose | Infant | Male | Malaria, Falciparum - blood | Malaria, Falciparum - mortality | Fever - blood | Malaria, Falciparum - epidemiology | Hypoglycemia - complications | Female | ROC Curve | Hypoglycemia - blood
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11. Full Text Complicated malaria and other severe febrile illness in a pediatric ward in Libreville, Gabon
by Bouyou-Akotet, Marielle Karine and Bouyou-Akotet, Marielle K and Mawili-Mboumba, Denise Patricia and Mawili-Mboumba, Denise P and Kendjo, Eric and Eyang Ekouma, Ariane and Abdou Raouf, Omar and Engohan Allogho, Edouard and Engohang Allogho, Edouard and Kombila, Maryvonne
BMC infectious diseases, ISSN 1471-2334, 2012, Volume 12, Issue 1, pp. 216 - 216
Background: Although a substantial decline of Plasmodium falciparum infection is observed in Africa following implementation of new control strategies, malaria... 
INFECTIOUS DISEASES | MANAGEMENT | SUB-SAHARAN AFRICA | SEVERE FALCIPARUM-MALARIA | NORTHERN GHANA | AGE-PATTERNS | TRANSMISSION INTENSITY | TANZANIA | KENYA | SEVERE ANEMIA | CHILDREN | Prospective Studies | Humans | Child, Preschool | Infant | Male | Fever - epidemiology | Pilot Projects | Malaria - epidemiology | Child, Hospitalized | Adolescent | Fever - etiology | Gabon - epidemiology | Survival Analysis | Female | Child | Care and treatment | Fever in children | Research | Diagnosis | Malaria | Analysis | Medical personnel | Pediatrics | Medical research | Bacterial infections | Child care | Diseases | Plasmodium falciparum | Control | Medicine, Experimental | Children | Health aspects | Kenya | Gabon | Health facilities | Infections | Illnesses
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