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sgi-1776 (28) 28
humans (18) 18
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cell line, tumor (13) 13
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atp binding cassette transporter, sub-family b (2) 2
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Journal of Medicinal Chemistry, ISSN 0022-2623, 2019, Volume 62, Issue 4, pp. 2140 - 2153
Pim kinases have been targets of interest for a number of therapeutic areas. Evidence of durable single-agent efficacy in human clinical trials validated Pim... 
POTENT | DESIGN | TRANSPORT | CHEMISTRY, MEDICINAL | THERAPY | SGI-1776 | GROWTH | SELECTIVE INHIBITORS | MECHANISMS | IDENTIFICATION | DISCOVERY
Journal Article
Anti-cancer agents in medicinal chemistry, ISSN 1871-5206, 2018, Volume 18, Issue 8, pp. 1100 - 1114
Pim kinases, also known as Serine/Threonine kinases, are intensively studied protein drug targets in cancer research. They play crucial role in the regulation... 
haematological malignancies | Pim kinase inhibitors | apoptosis | clinical trials | solid cancers | X-ray crystallographic studies | TARGET | CHEMISTRY, MEDICINAL | SGI-1776 | EFFICACY | MECHANISM | AZD1208 | COMBINATION | FEATURES | ONCOLOGY | GROWTH | LEUKEMIA | INSIGHTS
Journal Article
JOURNAL OF CELL COMMUNICATION AND SIGNALING, ISSN 1873-9601, 06/2019, Volume 13, Issue 2, pp. 163 - 177
Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late... 
Cell survival | SGI-1776 | PROTEIN | Phosphoproteomics | EFFICACY | Gastrointestinal cancer | Targeted therapy | PHOSPHORYLATION | TYROSINE KINASE | POTENTIAL THERAPEUTIC TARGET | mTOR signaling | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | SIGNALING PATHWAY | ENRICHMENT
Journal Article
Journal of Central South University (Medical Sciences), ISSN 1672-7347, 2014, Volume 39, Issue 7, pp. 649 - 657
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 02/2016, Volume 57, Issue 2, pp. 436 - 444
The Pim proteins are Ser/Thr kinases over-expressed in several hematological malignancies such as chronic lymphocytic leukemia (CLL) and some solid cancers... 
Pim kinase | CLL | SMI-4a | AZD1208 | SGI-1776 | ABT-199 | PHOSPHORYLATES BAD | APOPTOSIS | ACUTE MYELOID-LEUKEMIA | FAMILY PROTEINS | ONCOLOGY | PROSTATE-CANCER CELLS | GROWTH | LYMPHOMA | TARGETS | HEMATOLOGY | PHASE-I | EXPRESSION
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2015, Volume 6, Issue 1, pp. 63 - 67
Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein... 
BAD phosphorylation | 2-dimensional colony formation | hERG inhibition | kinase selectivity | Pyrazolo[1 5- a ]pyrimidine | Pim-1 inhibitor | DESIGN | CHEMISTRY, MEDICINAL | SGI-1776 | CANCER | DISCOVERY | MANTLE CELL LYMPHOMA | Pyrazolo[1,5-a]pyrimidine | TARGETS | KINASES
Journal Article
Journal of Cell Communication and Signaling, ISSN 1873-9601, 06/2019, Volume 13, Issue 2, pp. 163 - 177
Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late... 
Cell survival | SGI-1776 | Phosphoproteomics | mTOR signaling | Gastrointestinal cancer | Targeted therapy | Prevention | Proline | Analysis | Gallbladder cancer | Cancer
Journal Article
Neoplasia, ISSN 1476-5586, 2014, Volume 16, Issue 5, pp. 403 - 412
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2017, Volume 25, Issue 9, pp. 2657 - 2665
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2013, Volume 85, Issue 4, pp. 514 - 524
Overexpression of the ATP-binding cassette (ABC) drug efflux proteins P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on malignant cells is... 
SGI-1776 | ABCB1 | Pim-1 kinase | Multidrug resistance | Leukemia | ABCG2 | ONCOLOGY-GROUP | BCR-ABL | ACUTE MYELOID-LEUKEMIA | POTENT INHIBITOR | CYCLOSPORINE-A | MYELOGENOUS LEUKEMIA | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | BRAIN ACCUMULATION | GROUP-B | IMATINIB MESYLATE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Proto-Oncogene Proteins c-pim-1 - metabolism | Drug Resistance, Neoplasm | Imidazoles - pharmacology | Pyridazines - pharmacology | Neoplasm Proteins - metabolism | Breast Neoplasms - metabolism | Gene Knockdown Techniques | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-pim-1 - genetics | Female | ATP Binding Cassette Transporter, Sub-Family B | Antineoplastic Agents - pharmacology | Biological Transport - drug effects | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Drug resistance in microorganisms | Care and treatment | Oncology, Experimental | Breast cancer | Research | Drug therapy | Cancer | multidrug resistance | leukemia
Journal Article
Pharmaceutical Chemistry Journal, ISSN 0091-150X, 1/2018, Volume 51, Issue 10, pp. 893 - 901
Systemic toxicity associated with drug resistance continues to be the major obstacle to curative therapy of cancer. Tumor cell resistance to chemotherapeutic... 
Pharmacy | apoptosis | tumor cells | Pharmacology/Toxicology | Pyridazin-3(2H)-one derivatives | MTT assay | cytotoxicity | Organic Chemistry | CHEMISTRY, MEDICINAL | SGI-1776 | PIM KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | MECHANISMS | NEPHROTOXICITY | ABCG2 | Care and treatment | Drug resistance | Health aspects | Analysis | Apoptosis | Cancer
Journal Article
Pharmacological Research, ISSN 1043-6618, 04/2013, Volume 70, Issue 1, pp. 90 - 101
Journal Article
Clinical lymphoma, myeloma & leukemia, ISSN 2152-2650, 9/2013, Volume 13, Issue 2, pp. S355 - S362
SGI-1776 is a small molecule Pim kinase inhibitor that primarily targets c-Myc-driven transcription and cap-dependent translation in mantle cell lymphoma (MCL)... 
Pim kinase | mantle cell lymphoma | SGI-1776 | Bendamustine | combination strategy
Journal Article