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Molecular & Cellular Proteomics, ISSN 1535-9476, 04/2008, Volume 7, Issue 4, pp. 768 - 784
Journal Article
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2003, Volume 171, Issue 11, pp. 6072 - 6079
Curcumin has been strongly implicated as an anti-inflammatory agent, but the precise mechanisms of its action are largely unknown. In this study, we show that... 
SH2 DOMAIN | MEMBRANE RAFTS | CELLS | JAK/STAT PATHWAY | SHP-2 | PROTEIN | PHOSPHORYLATION | GENE-EXPRESSION | IMMUNOLOGY | NITRIC-OXIDE MECHANISM | NF-KAPPA-B | Prostaglandin-Endoperoxide Synthases - biosynthesis | Microglia - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Protein-Tyrosine Kinases - metabolism | Regulatory Sequences, Nucleic Acid | Brain - enzymology | Protein Tyrosine Phosphatases - metabolism | Interferon-gamma - metabolism | Nitric Oxide Synthase Type II | Trans-Activators - physiology | Brain - metabolism | Protein-Tyrosine Kinases - physiology | Inflammation - metabolism | Microglia - pathology | Phosphorylation - drug effects | Protein Phosphatase 2 | DNA-Binding Proteins - physiology | DNA-Binding Proteins - antagonists & inhibitors | Curcumin - pharmacology | Microglia - enzymology | Rats | src Homology Domains - physiology | Rats, Sprague-Dawley | Janus Kinase 1 | Brain - drug effects | Signal Transduction - drug effects | SH2 Domain-Containing Protein Tyrosine Phosphatases | Brain - pathology | STAT1 Transcription Factor | Inflammation - prevention & control | Protein-Tyrosine Kinases - antagonists & inhibitors | Cyclooxygenase 2 | Nitric Oxide Synthase - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | DNA-Binding Proteins - metabolism | Janus Kinase 2 | Interferon-gamma - antagonists & inhibitors | Nitric Oxide Synthase - biosynthesis | Proto-Oncogene Proteins | Microglia - drug effects | Cells, Cultured | Intracellular Signaling Peptides and Proteins | Down-Regulation - drug effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Animals | Inflammation - genetics | Signal Transduction - physiology | Trans-Activators - metabolism | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Isoenzymes - biosynthesis | Interferon-gamma - pharmacology | Isoenzymes - antagonists & inhibitors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2014, Volume 289, Issue 51, pp. 35397 - 35408
Journal Article
Journal Article
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 08/2012, Volume 51, Issue 15, pp. 8284 - 8291
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2005, Volume 102, Issue 12, pp. 4276 - 4281
Phospholipase C-gamma 1 (PLC-gamma 1) contains two tandem Src homology 2 (SH2) domains. The NH2-terminal SH2 domain has been known to mediate the binding of... 
GAMMA | affinity chromatography | STIMULATION | MECHANISM | C-GAMMA-1 | MULTIDISCIPLINARY SCIENCES | platelet-derived growth factor | SH2 DOMAINS | GROWTH-FACTOR RECEPTOR | AFFINITY | ASSOCIATION | EXPRESSION | RESIDUES
Journal Article
Journal Article
Journal Article
MedChemComm, ISSN 2040-2503, 07/2012, Volume 3, Issue 7, pp. 763 - 770
SH2 domains are the paradigm of phosphotyrosine protein recognition modules and are involved in mediating numerous cancer-promoting protein-protein complexes.... 
SH2 DOMAIN | BINDING-DOMAINS | CHEMISTRY, MEDICINAL | ACTIVATOR | INHIBITION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-PROTEIN INTERACTIONS | TRANSCRIPTION-3 | DIMERIZATION | SIGNAL TRANSDUCER
Journal Article