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03/2010
Src homology 3 (SH3) domains are one family of the peptide recognition modules (PRMs), which bind peptides rich in proline or positively charged residues in... 
SH3 domain | worm | proteomics | yeast | 0369 | 0379 | pooling | 0410 | yeast two-hybrid | protein-protein interaction | interactome | 0307 | 0715
Dissertation
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 07/2017, Volume 85, Issue 7, pp. 1336 - 1350
The molecular details of the association between the human Fyn‐SH3 domain, and the fragment of 18.5‐kDa myelin basic protein (MBP) spanning residues S38–S107... 
molecular recognition fragment (MoRF) | poly‐proline type II (PPII) | Fyn‐SH3 | amphipathic α‐helix | myelin basic protein (MBP) | intrinsically disordered protein (IDP) | molecular dynamics (MD) simulations | GROMACS | amphipathic α-helix | poly-proline type II (PPII) | Fyn-SH3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNODOMINANT EPITOPE | POSTTRANSLATIONAL MODIFICATIONS | amphipathic -helix | AZE AZETIDINE-2-CARBOXYLIC ACID | INTRINSICALLY DISORDERED PROTEINS | FYN TYROSINE KINASE | BIOPHYSICS | MULTIPLE-SCLEROSIS | CRK N-SH3 DOMAIN | STATE NMR-SPECTROSCOPY | CENTRAL-NERVOUS-SYSTEM | MESSENGER-RNA TRANSPORT | Protein Structure, Tertiary | Amino Acid Sequence | Protein Conformation, alpha-Helical | Peptides - chemistry | Humans | Phosphorylcholine - analogs & derivatives | Molecular Dynamics Simulation | Proline - chemistry | src Homology Domains | Thermodynamics | Animals | Protein Conformation, beta-Strand | Myelin Basic Protein - chemistry | Water - chemistry | Phosphorylcholine - chemistry | Protein Binding | Mice | Molecular Docking Simulation | Proto-Oncogene Proteins c-fyn - chemistry | Lipid Bilayers - chemistry | Binding Sites | Dimyristoylphosphatidylcholine - chemistry | Unithiol - chemistry | Molecular dynamics | Proline | Phospholipids | Myelin proteins | Proteins | Peptides | Myelin | Docking | Fuzzy | Myelin basic protein | Sheets | Fyn protein | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2005, Volume 280, Issue 24, pp. 23147 - 23156
Journal Article
Molecular & Cellular Proteomics, ISSN 1535-9476, 04/2009, Volume 8, Issue 4, pp. 639 - 649
Extensive efforts have been devoted to determining the binding specificity of Src homology 3 (SH3) domains usually in a case-by-case manner. A generic... 
PROTEIN | LIGANDS | SPECIFICITY | BIOCHEMICAL RESEARCH METHODS | RECOGNITION MODULES | ABL-SH3 DOMAIN | FREE-ENERGIES | MULTIPLE SEQUENCE ALIGNMENT | MOLECULAR-MECHANICS | ABL SH3 DOMAIN | PREDICTION
Journal Article
11/2011
Protein interactions are often mediated through binding of protein interaction domains to short peptide motifs. However, how the specificity of interactions is... 
SH3 domain | Nbp2p | Bem1p | specificity | 0307
Dissertation
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2003, Volume 100, Issue 23, pp. 13298 - 13302
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2002, Volume 21, Issue 19, pp. 5057 - 5068
p47 phox is a key cytosolic subunit required for activation of phagocyte NADPH oxidase. The X‐ray structure of the p47 phox PX domain revealed two distinct... 
SH3 domains | phosphatidic acid | p40 | phagocyte | NADPH oxidase | phosphoinositide | Phosphoinositide | Phagocyte | Phosphatidic acid
Journal Article
06/2014
Protein-protein interactions are an integral part of virtually all aspects of cellular function. Many of these interactions are mediated by small modular units... 
Intrinsic Specificity | 0487 | SH3 Domain
Dissertation
EMBO reports, ISSN 1469-221X, 11/2017, Volume 18, Issue 11, pp. 2051 - 2066
Endocytic processes are facilitated by both curvature‐generating BAR ‐domain proteins and the coordinated polymerization of actin filaments. Under... 
protein Bin1 | tau | BAR | Alzheimer's disease | actin binding | genetic risk factor | N-BAR protein Bin1 | PROTEIN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING | FILAMENT TURNOVER | TAU PATHOLOGY | CELL BIOLOGY | SKELETAL-MUSCLE | STRUCTURAL BASIS | SYNAPTIC VESICLE ENDOCYTOSIS | MEMBRANE CURVATURE | SH3 DOMAIN | Tauopathies - genetics | Humans | Actins - metabolism | Tauopathies - pathology | tau Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Actins - genetics | Drosophila melanogaster - metabolism | Protein Isoforms - metabolism | tau Proteins - genetics | Tumor Suppressor Proteins - genetics | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Binding Sites | Actin Cytoskeleton - genetics | Disease Models, Animal | Recombinant Proteins - metabolism | Gene Expression | Tumor Suppressor Proteins - metabolism | Actin Cytoskeleton - metabolism | Genetic Vectors - chemistry | Gene Expression Regulation | Genetic Vectors - metabolism | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Tauopathies - metabolism | Animals | Carrier Proteins - metabolism | Escherichia coli - genetics | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Protein Isoforms - genetics | Membranes | Neurodegenerative diseases | Drosophila | Health risks | Polymerization | Rods | Bundles | Risk factors | Membrane proteins | Bundling | Proteins | Depolymerization | Insects | Tau protein | Filaments | Neurodegeneration | Actin | Isoforms | BAR protein | Cytoskeleton | Alzheimers disease | Curvature | Index Medicus | N‐BAR protein Bin1 | Neuroscience | Cell Adhesion, Polarity & Cytoskeleton
Journal Article