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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2018, Volume 115, Issue 18, pp. 4755 - 4760
The susceptibility to autoimmune diseases is affected by genetic and environmental factors. In rheumatoid arthritis (RA), the shared epitope (SE), a five-amino... 
Aryl hydrocarbon receptor | Signaling | Gene–environment interaction | Shared epitope | Nuclear factor kappa B | RHEUMATOID-ARTHRITIS | ACTIVATION | shared epitope | signaling | CALRETICULIN | MULTIDISCIPLINARY SCIENCES | gene-environment interaction | nuclear factor kappa B | SUSCEPTIBILITY | RISK | SMOKING | INDUCTION | aryl hydrocarbon receptor | NATIONAL INSTITUTE | DIFFERENTIATION | NF-KAPPA-B | Arthritis, Experimental - genetics | Humans | Receptors, Aryl Hydrocarbon - genetics | Mice, Transgenic | Arthritis, Experimental - immunology | Signal Transduction - genetics | Gene-Environment Interaction | Environmental Pollutants - immunology | Arthritis, Experimental - pathology | Epitopes - immunology | Signal Transduction - immunology | Animals | Alleles | Th17 Cells - immunology | Mice | Environmental Pollutants - toxicity | Receptors, Aryl Hydrocarbon - immunology | Th17 Cells - pathology | Environmental aspects | Arthritis | Genetic aspects | Autoimmune diseases | Gene expression | Health aspects | Crosstalk | Helper cells | Combustion products | Hydrocarbons | Lymphocytes T | Smoke | Lymph nodes | Risk factors | Ecological risk assessment | Signal transduction | Biological effects | Biomedical materials | Pathways | Aromatic compounds | Rodents | Interleukin 1 | Drb1 protein | Genetics | Biocompatibility | Pollutants | Transgenic mice | Amino acid sequence | Environmental factors | Exposure | Inflammation | Risk analysis | Joint diseases | Interleukin 17 | Studies | Osteoclastogenesis | Drainage | Tobacco | Rheumatoid arthritis | Osteoclasts | Transduction | Histocompatibility antigen HLA | Differentiation | Cigarette smoke | Index Medicus | Biological Sciences | gene–environment interaction
Journal Article
Journal Article
Clinical and Experimental Immunology, ISSN 0009-9104, 04/2017, Volume 188, Issue 1, pp. 53 - 62
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2006, Volume 65, Issue 7, pp. 905 - 909
Objective: To evaluate a possible association between wrist and periodontal destruction in rheumatoid arthritis, and between periodontal destruction, dry... 
GENOTYPE | IL-1 | INTERLEUKIN-1-BETA | SUSCEPTIBILITY | TISSUE | RHEUMATOLOGY | GENE POLYMORPHISMS | ADULT PERIODONTITIS | Bone and Bones - pathology | Epitope Mapping | Interleukin-1 - genetics | Salivary Glands - pathology | Sjogren's Syndrome - pathology | Humans | Mandible - pathology | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Joints - pathology | Logistic Models | Male | Reverse Transcriptase Polymerase Chain Reaction | Alveolar Bone Loss - pathology | Alveolar Bone Loss - immunology | Arthritis, Rheumatoid - pathology | Epitopes - immunology | Joints - immunology | Female | Aged | HLA-DR Antigens - immunology | Polymorphism, Single Nucleotide | Arthritis, Rheumatoid - immunology | Carpal Bones - pathology | Periodontal disease | Rheumatoid arthritis | Development and progression | Genetic aspects | Bone diseases | Research | Joint diseases | Antigenic determinants | Studies | Confidence intervals | Disease | Cytokines | Biopsy | Rheumatism | Amino acids | Agreements | Deoxyribonucleic acid--DNA | Index Medicus | Bone and Bones | Interleukin-1 | HLA-DR Antigens | Rhumatology and musculoskeletal system | Sjogren's Syndrome | Life Sciences | Immunology | Alveolar Bone Loss | Joints | Salivary Glands | Mandible | Epitopes | Tumor Necrosis Factor-alpha | Arthritis, Rheumatoid | Human health and pathology | Carpal Bones | Extended Report | cytokines | shared epitope | rheumatoid arthritis | destruction | periodontal disease
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 01/2018, Volume 19, Issue 1
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 11/2010, Volume 12, Issue 6, pp. R213 - R213
Journal Article
American Journal of Epidemiology, ISSN 0002-9262, 2017, Volume 186, Issue 2, pp. 245 - 254
Specific alleles of the human leukocyte antigen (HLA)-DRB1 gene (HLA-DRB1) encode a "shared epitope" (SE) associated with rheumatoid arthritis (RA), especially... 
HLA-DRB1 gene | Shared epitope | Human leukocyte antigen | Mortality | Rheumatoid arthritis | Cardiovascular disease | Cancer | ANTIBODIES | cardiovascular disease | POPULATION | shared epitope | EVENTS | CYCLIC CITRULLINATED PEPTIDE | human leukocyte antigen | DEATH | rheumatoid arthritis | HEART-DISEASE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RISK-FACTOR | mortality | cancer | ASSOCIATION | HLA-DRB1 | SEVERITY | Prevalence | Humans | Middle Aged | Coronary Disease - epidemiology | HLA Antigens - genetics | Cardiovascular Diseases - genetics | Incidence | Neoplasms - genetics | Women's Health - statistics & numerical data | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Postmenopause | Female | Genetic Predisposition to Disease | Coronary Disease - immunology | Comorbidity | Arthritis, Rheumatoid - epidemiology | Proportional Hazards Models | HLA Antigens - immunology | Inflammation - immunology | Inflammation - epidemiology | Epitopes - genetics | Cardiovascular Diseases - immunology | Arthritis, Rheumatoid - genetics | Coronary Disease - genetics | Alleles | Biomarkers | Inflammation - genetics | Aged | Arthritis, Rheumatoid - immunology | Longitudinal Studies | Neoplasms - epidemiology | Women | Usage | Inflammation | Postmenopausal women | Research | Histocompatibility testing | Analysis | Cardiovascular diseases | Health aspects | Antigenic determinants | Index Medicus | Original Contributions
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 01/2017, Volume 16, Issue 1, pp. 355 - 365
Proteolysis of autoantigens can alter normal MHC class II antigen processing and has been implicated in the induction of autoimmune diseases. Many autoantigens... 
hydrogen-deuterium exchange | shared epitope | antigen presentation | autoimmunity | peptidylarginine deiminase | mass spectrometry | antigen processing | epitope | autoantigen | rheumatoid arthritis | CITRULLINATION | BIOCHEMICAL RESEARCH METHODS | T-CELL EPITOPES | CLEAVAGE | CYTOTOXIC-CELLS | PEPTIDES | DISEASE | IMMUNODOMINANT EPITOPES | antigen pressing | EXCHANGE | ASSOCIATION | Hydrolases - genetics | Humans | Middle Aged | Substrate Specificity | Epitopes, T-Lymphocyte - genetics | Male | Granzymes - genetics | Autoantibodies - biosynthesis | CD4-Positive T-Lymphocytes - pathology | Autoantigens - genetics | Case-Control Studies | CD4-Positive T-Lymphocytes - immunology | Granzymes - chemistry | Deuterium Exchange Measurement | Antigen Presentation | Proteolysis | Escherichia coli - metabolism | Female | Granzymes - immunology | Protein Interaction Domains and Motifs | Epitopes, T-Lymphocyte - immunology | Binding Sites | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Autoantigens - chemistry | Arthritis, Rheumatoid - pathology | Epitopes, T-Lymphocyte - chemistry | Arthritis, Rheumatoid - genetics | Protein Conformation, beta-Strand | Recombinant Proteins - immunology | Escherichia coli - genetics | Hydrolases - immunology | Autoantigens - immunology | Protein Binding | Aged | Hydrolases - chemistry | Arthritis, Rheumatoid - immunology | Protein-Arginine Deiminases | Index Medicus | hydrogen–deuterium exchange
Journal Article
International Journal of Rheumatic Diseases, ISSN 1756-1841, 10/2017, Volume 20, Issue 10, pp. 1492 - 1498
Journal Article