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Biomedicine & Pharmacotherapy, ISSN 0753-3322, 11/2019, Volume 119, p. 109414
Breast cancer ranks first among female malignancies worldwide, and estrogen receptor-positive (ER+) breast cancer is the leading cause of cancer death in... 
Ubiquitination | Breast cancer | SHARPIN | ER ɑ | P53
Journal Article
NATURE, ISSN 0028-0836, 01/2016, Volume 529, Issue 7587, pp. 546 - 546
Ubiquitination is a central process affecting all facets of cellular signalling and function(1). A critical step in ubiquitination is the transfer of ubiquitin... 
REFINEMENT | SYSTEM | PARKIN | ACTIVATION | LINEAR UBIQUITIN CHAINS | SHARPIN | MULTIDISCIPLINARY SCIENCES | RING DOMAIN | CONJUGATING ENZYME | NF-KAPPA-B | INSIGHTS
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 3/2015, Volume 194, Issue 5, pp. 2064 - 2067
The NLRP3 inflammasome is a multimeric protein complex assembled in response to a wide array of pathogens and danger-associated molecular patterns. Despite the... 
NLRP3 | SHARPIN | caspase-1 | inflammasome
Journal Article
BBA Clinical, ISSN 2214-6474, 12/2017, Volume 8, pp. 56 - 65
We report three signatures produced from gene copy number increase (GCN-Increase) and their effects on patients with breast cancer (BC). In the Metabric... 
SIPL1/SHARPIN | Breast cancer | Overall survival | Cancer
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2019, Volume 202, Issue 1, pp. 218 - 227
NOD-like receptors (NLR) are critical regulators of innate immune signaling. The NLR family consists of 22 human proteins with a conserved structure containing... 
SHIGELLA-FLEXNERI | IMMUNITY | ACTIVATION | PROTEIN | SHARPIN | IMMUNOLOGY | NF-KAPPA-B | BINDING | EXPRESSION | A20-BINDING INHIBITOR | A20
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 07/2016, Volume 22, Issue 7, pp. 545 - 564
Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial... 
autoimmune | IL-1 | inflammasome | Sharpin | inflammatory | NLRP3 | Ptpn6 | CAPS | FMF
Journal Article
Molecular Medicine, ISSN 1076-1551, 12/2019, Volume 25, Issue 1, pp. 1 - 9
Abstract Background Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental... 
Genetic risk factor | Inflammation | SHARPIN | Alzheimer’s disease | Rare functional variant
Journal Article
Oncotarget, ISSN 1949-2553, 09/2017, Volume 8, Issue 44, p. 77137
Estrogen receptor α is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. In our study, we identified the novel E3... 
Journal Article
ELIFE, ISSN 2050-084X, 01/2015, Volume 4
Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors. Patients with mutations in HOIL1 (RBCK1)... 
IMMUNE | GAMMA-HERPESVIRUS | KAPPA-B ACTIVATION | COMPLEX | SHARPIN | UBIQUITIN LIGASE | INFLAMMATION | LINEAR UBIQUITINATION | BIOLOGY | LATENCY | LUBAC
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 2019, Volume 141, Issue 6, pp. 2703 - 2712
Modification of proteins with polyubiquitin chains is a key regulatory mechanism to control cellular behavior and alterations in the ubiquitin system are... 
SYSTEM | REGULATOR | DOMAIN | SHARPIN | LINEAR UBIQUITINATION | CHAIN ASSEMBLY COMPLEX | GLIOTOXIN | SUPPRESSES | NF-KAPPA-B | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 03/2019, Volume 10, p. 479
Background: HOIP is the catalytic subunit of the linear ubiquitination chain assembly complex (LUBAC) that is essential for NF-kappa B signaling and thus... 
CVID | ACTIVATION | SHARPIN | AMYLOPECTINOSIS | primary immunodeficiency | autoinflammation | HUMANS | IMMUNOLOGY | HOIL1 | LUBAC | IMMUNODEFICIENCY | HOIP
Journal Article
Cell, ISSN 0092-8674, 08/2016, Volume 166, Issue 5, pp. 1215 - 1230.e20
Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators... 
MET1-LINKED UBIQUITINATION | ACTIVATION | LINEAR UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE | SHARPIN CONTROLS | NF-KAPPA-B | LUBAC | IMMUNODEFICIENCY | HOIP | AUTOINFLAMMATION | CELL BIOLOGY | Ubiquitin | Autoimmunity | Viral antibodies | Analysis | Medical genetics | Antibodies | Inflammation | T cells | Molecular biology | Resveratrol
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2012, Volume 46, Issue 6, pp. 746 - 758
Journal Article