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shk toxin (63) 63
index medicus (62) 62
animals (49) 49
biochemistry & molecular biology (32) 32
amino acid sequence (30) 30
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models, molecular (27) 27
potassium channels (26) 26
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memory t-cells (16) 16
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potassium channel blockers - pharmacology (15) 15
kv1.3 potassium channel - antagonists & inhibitors (14) 14
multiple-sclerosis (14) 14
protein conformation (14) 14
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toxin (10) 10
amino-acid-sequence (9) 9
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protein structure, secondary (9) 9
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sequence homology, amino acid (9) 9
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t-lymphocytes - drug effects (9) 9
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cell biology (8) 8
complex mixtures (8) 8
ion channels (8) 8
kv1.3 (8) 8
magnetic resonance spectroscopy (8) 8
nmr (8) 8
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protein binding (8) 8
autoimmune diseases - drug therapy (7) 7
charybdotoxin (7) 7
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cnidarian venoms - metabolism (7) 7
gated potassium channel (7) 7
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FEBS Journal, ISSN 1742-464X, 06/2015, Volume 282, Issue 12, pp. 2247 - 2259
The voltage‐gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone... 
electrophysiology | molecular dynamics | N‐terminal extension | potassium channels | ShK | Electrophysiology | Molecular dynamics | Potassium channels | N-terminal extension | RHEUMATOID-ARTHRITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | SHK TOXIN | MULTIPLE-SCLEROSIS | AUTOIMMUNE-DISEASES | THERAPEUTIC TARGETS | FORCE-FIELD | INHIBITOR | MEMORY T-CELLS | LYMPHOCYTES | Recombinant Fusion Proteins - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Neurotoxins - genetics | Isoenzymes - chemistry | Structure-Activity Relationship | Cnidarian Venoms | Kv1.3 Potassium Channel - genetics | Potassium Channel Blockers - metabolism | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mutant Proteins - pharmacology | Sea Anemones | Kv1.3 Potassium Channel - chemistry | Isoenzymes - metabolism | Drug Design | Kv1.3 Potassium Channel - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Oligopeptides - chemistry | Potassium Channel Blockers - pharmacology | Recombinant Proteins - metabolism | Cell Line | Neurotoxins - chemistry | Oligopeptides - genetics | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Recombinant Proteins - genetics | Kv1.3 Potassium Channel - antagonists & inhibitors | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Molecular Dynamics Simulation | Neurotoxins - pharmacology | Patch-Clamp Techniques | Animals | Mutant Proteins - chemistry | Neurotoxins - metabolism | Protein Conformation | Mice | Kinetics | Oligopeptides - pharmacology | Isoenzymes - antagonists & inhibitors | Potassium Channel Blockers - chemistry | Proteins | Amino acids | Toxins | Autoimmune diseases | Lymphocytes | Asthma | Index Medicus
Journal Article
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 3/2017, Volume 56, Issue 12, pp. 3324 - 3328
ShK toxin is a cysteine-rich 35 residue protein ion channel ligand isolated from the sea anemone Stichodactyla helianthus. In this work, we studied the impact... 
Kv1.3 ion channel | quasi-racemic protein crystallography | alloisoleucine | ShK toxin | folding | allothreonine | chemical protein synthesis
Journal Article
Chinese Chemical Letters, ISSN 1001-8417, 07/2019, Volume 30, Issue 7, pp. 1369 - 1373
Venom toxins are receiving growing interests as novel therapeutics and biophysical probes. This review briefly discusses recent advances in the chemical... 
Racemic protein crystallography | Chemical protein synthesis | Protein foldin | Venom toxins | Structure determination | X-RAY-STRUCTURE | BRIDGES | LIGATION | CRYSTALLOGRAPHY | PHASE PEPTIDE-SYNTHESIS | HUMAN HEPCIDIN | PROTEIN-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | SHK TOXIN | DISULFIDE-BOND FORMATION | RESOLUTION STRUCTURE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 17, pp. 6784 - 6802
Journal Article
Journal of Proteomics, ISSN 1874-3919, 10/2016, Volume 148, pp. 57 - 64
Jellyfish sting has become a worldwide issue of critical concern to human health and safety in coastal areas in recent decades. is one of the dominant blooming... 
Toxin | Jellyfish | Cyanea nozakii | Transcriptomics | Venom | Proteomics | THAI WATERS | ENVENOMATION SYNDROMES | HEMOLYTIC-ACTIVITY | BIOCHEMICAL RESEARCH METHODS | NEMATOCYST VENOM | CHIROPSALMUS-QUADRIGATUS | SHK TOXIN | HABU-KURAGE | STOMOLOPHUS-MELEAGRIS | PARTIAL-PURIFICATION | PROTEINS | Proteins | Protease inhibitors | Proteases | Analysis | Bites and stings | Thrombin
Journal Article
Toxicon, ISSN 0041-0101, 10/2012, Volume 60, Issue 5, pp. 840 - 850
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2006, Volume 348, Issue 2, pp. 514 - 523
Journal Article
TOXICON, ISSN 0041-0101, 07/2018, Volume 149, pp. 100 - 101
Conference Proceeding
Journal Article
Journal Article