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International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2019, Volume 854, pp. 62 - 69
Journal Article
by Cho, DH and Park, JH and Lee, EJ and Won, KJ and Lee, SH and Kim, YH and Hwang, S and Kwon, KJ and Shin, CY and Song, KH and Jo, I and Han, SH
FREE RADICAL BIOLOGY AND MEDICINE, ISSN 0891-5849, 11/2014, Volume 76, pp. 96 - 106
Valproic acid (VPA) with its inhibitory activity of histone deacetylase has been used in the treatment of epilepsy and bipolar disorder associated with... 
PHOSPHATASE SHP-1 | MORTALITY | Histone deacetylase | Free radicals | ANGIOGENESIS | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Valproic acid | Cyclin-dependent kinase 5 | SH2 domain-containing protein tyrosine | BIPOLAR | RESPONSES | Endothelial nitric oxide synthase | Nitric oxide | phosphatase 1 | ENDOCRINOLOGY & METABOLISM | DEGRADATION | INHIBITORS | Endothelium, Vascular - cytology | Surface Plasmon Resonance | Immunoprecipitation | Reactive Oxygen Species - metabolism | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Immunoenzyme Techniques | Cyclin-Dependent Kinase 5 - genetics | Cattle | Nitric Oxide Synthase Type III - metabolism | Phosphorylation - drug effects | Real-Time Polymerase Chain Reaction | Aorta - drug effects | RNA, Messenger - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Nitric Oxide Synthase Type III - genetics | Serine - metabolism | Blotting, Western | Mice, Inbred ICR | Cyclin-Dependent Kinase 5 - metabolism | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Endothelium, Vascular - metabolism | Fluorescent Antibody Technique | SH2 Domain-Containing Protein Tyrosine Phosphatases | Cell Proliferation - drug effects | Mice | Aorta - cytology | Nitric Oxide - metabolism
Journal Article
MATRIX BIOLOGY, ISSN 0945-053X, 05/2008, Volume 27, Issue 4, pp. 282 - 294
Arterial smooth muscle cells (SMCs) are present in the elastic lamina-containing media, suggesting that the elastic laminae may regulate the development of... 
PROGENITOR CELLS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CD34+bone marrow cells | PROLIFERATION | SHP-1 | FAMILY | CELL BIOLOGY | protein tyrosine phosphatase SHP-1 | NEGATIVE REGULATION | DIFFERENTIATION | vascular smooth muscle cells | EXPRESSION | NEOINTIMA | extracellular matrix | MOLECULAR-MECHANISMS
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2018, Volume 37, Issue 5, p. n/a
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e28706
Background: The aim of this study is to determine anti-cancer effect of Icariside II purified from the root of Epimedium koreanum Nakai on human acute myeloid... 
TYROSINE-PHOSPHATASE SHP-1 | STAT3 ACTIVATION | INHIBITION | PATHWAY | BIOLOGY | Plant Extracts - chemistry | Epimedium - chemistry | Phosphorylation | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Caspase 3 - metabolism | bcl-X Protein - genetics | Dose-Response Relationship, Drug | bcl-X Protein - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Caspase 3 - genetics | Leukemia, Myeloid, Acute - drug therapy | Flavonoids - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Janus Kinase 2 - antagonists & inhibitors | STAT3 Transcription Factor - genetics | Leukemia, Myeloid, Acute - pathology | Janus Kinase 2 - genetics | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Poly(ADP-ribose) Polymerases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Plant Roots - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Flavonoids - isolation & purification | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | STAT3 Transcription Factor - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - isolation & purification | Proteins | Tyrosine | Chemotherapy | Phosphatases | Medicine, Botanic | Medicine, Herbal | Sugars | Cancer | Apoptosis | Monosaccharides | Cell proliferation | SHP-1 protein | Leukemia | Multiple myeloma | Kinases | Inactivation | Phosphatase | ADP | Experiments | Caspase-3 | Cancer therapies | Anticancer properties | Time dependence | Human papillomavirus | Epidermal growth factor | Bcl-x protein | Ribose | Janus kinase 2 | Cell cycle | Localization | Medical research | Deactivation | Cytokines | Pervanadate | Myeloid leukemia | Stat3 protein | Poly(ADP-ribose) polymerase | Caspase | siRNA | Survivin | Medicine | Polymerase | DNA nucleotidylexotransferase | Signaling | Flavonoids | Sodium | Acute myeloid leukemia | Protein-tyrosine-phosphatase | Herbs | survivin | Roots | pervanadate | Tumor cell lines
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2001, Volume 98, Issue 24, pp. 13866 - 13871
PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains two tyrosine residues in the cytoplasmic region. Studies on... 
Proteins | Molecules | Biological Sciences | Phosphorylation | Receptors | Phosphatases | B lymphocytes | Cell lines | Ligands | Chimeras | Growth retardation | P62(DOK) | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | ANTIGEN-RECEPTOR | MICE | SHP-1 | EXPRESSION | MEMBER | FAMILY | LYMPHOCYTES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Calcium - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Receptors, Antigen, B-Cell - metabolism | Antigens, CD - genetics | Receptors, IgG - metabolism | Antigens, CD - metabolism | Phosphotyrosine - metabolism | Receptors, IgG - genetics | Cell Division | Antigens, Surface - metabolism | Tumor Cells, Cultured | Protein Phosphatase 2 | Signal Transduction | Receptors, KIR | Antigens, Surface - genetics | Intracellular Signaling Peptides and Proteins | src Homology Domains | Tyrosine - metabolism | Animals | Apoptosis Regulatory Proteins | SH2 Domain-Containing Protein Tyrosine Phosphatases | Programmed Cell Death 1 Receptor | Mice | Receptors, Immunologic - genetics | Mitogen-Activated Protein Kinase 3 | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Receptors, Immunologic - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Protein tyrosine kinase | Immunoglobulins | Cellular signal transduction | B cells | phosphotyrosine | thyrosine phosphatase | Fc receptors | SH2 domain | PD-1 protein
Journal Article
CELLS, ISSN 2073-4409, 04/2019, Volume 8, Issue 4, p. 345
The antigen-mediated activation of mast cells initiates signaling events leading to their degranulation, to the release of inflammatory mediators, and to the... 
LYN | GAMMA-TUBULIN COMPLEXES | SYK | PHOSPHORYLATION | CENTROSOME | cell activation | KINASE | microtubule nucleation | RECEPTOR | tubulin complexes | CELL BIOLOGY | bone marrow-derived mast cells | DEGRANULATION | FYN | SHP-1 tyrosine phosphatase | CYCLE | γ-tubulin complexes
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2000, Volume 165, Issue 3, pp. 1344 - 1351
Src homology region 2 (SH2) domain-containing phosphatase-1 (SXIP-1) is a cytosolic protein tyrosine phosphatase containing two SH2 domains in its NH2... 
SIGNAL-TRANSDUCTION | SLP-76 | VIABLE MOTHEATEN | SUBSTRATE | MOTH-EATEN | MICE | IMMUNOLOGY | SHP-1 | ANTIGEN RECEPTOR | TYROSINE-PHOSPHATASE | LYMPHOCYTE-ACTIVATION | Phosphorylation |