X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
shp2 (398) 398
index medicus (289) 289
humans (244) 244
animals (238) 238
protein tyrosine phosphatase, non-receptor type 11 - metabolism (173) 173
mice (144) 144
cell biology (137) 137
activation (132) 132
phosphorylation (130) 130
signal transduction (119) 119
biochemistry & molecular biology (117) 117
protein tyrosine phosphatase, non-receptor type 11 - genetics (113) 113
tyrosine (93) 93
ptpn11 (85) 85
phosphatases (84) 84
cancer (79) 79
protein-tyrosine-phosphatase (75) 75
female (68) 68
phosphatase (68) 68
article (67) 67
mutation (67) 67
oncology (67) 67
noonan-syndrome (65) 65
proteins (65) 65
male (64) 64
expression (60) 60
protein tyrosine phosphatase, non-receptor type 11 (51) 51
cells (50) 50
cell line, tumor (49) 49
protein tyrosine phosphatases - metabolism (49) 49
growth (47) 47
apoptosis (46) 46
kinases (46) 46
analysis (45) 45
research (45) 45
genetic aspects (43) 43
mice, knockout (40) 40
mutations (39) 39
leukemia (38) 38
pathway (37) 37
protein tyrosine phosphatase, non-receptor type 11 - antagonists & inhibitors (37) 37
cell line (36) 36
rats (34) 34
signal transduction - drug effects (34) 34
noonan syndrome (33) 33
protein tyrosine phosphatase (33) 33
signal transduction - physiology (33) 33
cells, cultured (32) 32
differentiation (32) 32
kinase (32) 32
mice, transgenic (32) 32
protein (32) 32
tyrosine-phosphatase shp2 (32) 32
extracellular signal-regulated map kinases - metabolism (31) 31
inhibition (31) 31
intracellular signaling peptides and proteins (31) 31
protein binding (31) 31
receptor (31) 31
in-vivo (30) 30
breast cancer (29) 29
genetics & heredity (28) 28
proliferation (28) 28
research article (28) 28
tyrosine-phosphatase (28) 28
biology (27) 27
cell proliferation (27) 27
enzyme activation (27) 27
enzyme inhibitors - pharmacology (27) 27
mice, inbred c57bl (27) 27
multidisciplinary sciences (27) 27
phosphoproteins - metabolism (27) 27
physiological aspects (27) 27
protein tyrosine phosphatases - genetics (27) 27
proto-oncogene proteins c-akt - metabolism (27) 27
binding (26) 26
gab1 (26) 26
gene expression (26) 26
hematology (26) 26
mouse model (26) 26
epidermal-growth-factor (25) 25
immunohistochemistry (24) 24
leopard-syndrome (24) 24
tyrosine phosphatase (24) 24
adult (23) 23
biophysics (23) 23
blotting, western (23) 23
health aspects (23) 23
inflammation (23) 23
middle aged (23) 23
signal-transduction (23) 23
tumors (23) 23
tyrosine-phosphatase shp-2 (23) 23
disease models, animal (22) 22
protein-tyrosine phosphatases (22) 22
ptp1b (22) 22
noonan syndrome - genetics (21) 21
phosphatidylinositol 3-kinases - metabolism (21) 21
acute myeloid-leukemia (20) 20
endocrinology & metabolism (20) 20
juvenile myelomonocytic leukemia (20) 20
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1781 - 1792
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein kinase (MAPK) pathway controlling cell growth, differentiation, and... 
CHEMISTRY, MEDICINAL | PTPN11 | TYROSINE-PHOSPHATASE SHP2
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2012, Volume 109, Issue 11, pp. 4257 - 4262
Noonan syndrome (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 (PTPN11), is characterized by... 
Phosphorylation | Phenotypes | Animal models | Phosphatases | Noonan syndrome | Growth hormones | Mice | Genetic mutation | Growth retardation | Binding sites | SIGNALING PATHWAYS | DEFECTS | signaling | ACTIVATED PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | TYROSINE-PHOSPHATASE SHP2 | HEIGHT | DELETION | PTPN11 SHP2 | growth hormone insensitivity | MALFORMATIONS | MOUSE MODEL | MUTATIONS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Noonan Syndrome - enzymology | ras Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | Noonan Syndrome - blood | Insulin-Like Growth Factor I - secretion | Mitogen-Activated Protein Kinase Kinases - metabolism | STAT5 Transcription Factor - metabolism | Janus Kinase 2 - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Binding Sites | Animals, Newborn | Insulin-Like Growth Factor I - biosynthesis | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Rats | Growth Hormone - pharmacology | Enzyme Activation - drug effects | Mutation - genetics | Noonan Syndrome - genetics | Biometry | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Gene mutations | Physiological aspects | Development and progression | Genetic aspects | Research | Growth factors | Health aspects | Phosphotransferases | Life Sciences | Biological Sciences
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2018, Volume 19, Issue 9
Journal Article
Pathology - Research and Practice, ISSN 0344-0338, 09/2019, p. 152621
Journal Article
Cancers, ISSN 2072-6694, 09/2019, Volume 11, Issue 9, p. 1381
BRAF V600 mutations have been found in 1–2% of non-small-cell lung cancer (NSCLC) patients, with Food and Drug Administration (FDA) approved treatment of... 
SHP2 | MEK | BRAF | PTPN11 | NSCLC | MAPK
Journal Article
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 2010, Volume 21, Issue 9, pp. 922 - 928
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2017, Volume 795, pp. 124 - 133
Shp2 is a classical non-receptor protein tyrosine phosphatase (PTP) involved in many human diseases such as Noonan syndrome and tumors, and identified as a... 
Demethylincisterol A | Shp2 inhibitor | Protein tyrosine phosphatase | Mechanism of action
Journal Article
06/2013
Tyrosyl phosphorylation plays an important role in many fundamental cellular processes, including cell growth, differentiation and proliferation. The levels of... 
SHP2 | Reactive oxygen species | 0379 | 0566 | 0992 | 0485 | Oxidation | 0307 | Protein-tyrosine phosphatases | Mass spectrometry | AP-MS | 0306
Dissertation
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1793 - 1802
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell... 
ALLOSTERIC-INHIBITION | CHEMISTRY, MEDICINAL | PTPN11 | TYROSINE-PHOSPHATASE SHP2 | MUTATIONS | IDENTIFICATION | DISCOVERY
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 02/2019, Volume 17, Issue 2, pp. 583 - 593
Melanoma is one of the most highly mutated cancer types. To identify functional drivers of melanoma, we searched for cross-species conserved mutations... 
SHP2 | ACTIVATION | INHIBITION | ONCOLOGY | PHOSPHORYLATION | KRAS | MUTATIONS | IDENTIFICATION | P53 | CELL BIOLOGY
Journal Article
Oncotarget, 10/2017, Volume 8, Issue 49, pp. 84776 - 84781
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 59, pp. 100242 - 100260
The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the... 
Phospho-ERK | SHP2 | Sulfatase | Wnt signaling | Chondroitin sulfate | GALACTOSE-6-SULFATASE | PROTEOGLYCANS | chondroitin sulfate | sulfatase | ARYLSULFATASE-B | C-MYC | TYROSINE-PHOSPHATASE SHP2 | SEQUENTIAL DEGRADATION | CELL BIOLOGY | MUCOPOLYSACCHARIDOSIS TYPE-VI | N-ACETYLGALACTOSAMINE-4-SULFATASE | phospho-ERK | EXPRESSION | PROGRESSION
Journal Article
by Jiang, L and Xu, WP and Chen, Y and Zhang, Y
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, ISSN 2169-1401, 2019, Volume 47, Issue 1, pp. 3231 - 3238
RAS mutations are frequent in non-small cell lung cancer (NSCLC). However, targeting RAS or the downstream/upstream effectors, such as tyrosine kinase... 
SHP2 | K-RAS MUTATIONS | MEK | MATERIALS SCIENCE, BIOMATERIALS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENGINEERING, BIOMEDICAL | Non-small cell lung cancer | stemness | RESISTANCE | KRAS | TYROSINE-PHOSPHATASE SHP2
Journal Article
Blood, ISSN 0006-4971, 09/2017, Volume 130, Issue 12, pp. 1471 - 1474
Journal Article
Phytochemistry, ISSN 0031-9422, 01/2020, Volume 169
A phytochemical investigation on the MeOH extract of the twigs and needles of the endangered plant led to the isolation and characterization of thirty-eight... 
Picea brachytyla (Franch.) E.Pritz | ATP citrate lyase (ACL) | Brachytylins | Pinaceae | SHP2 tyrosine phosphatase | Terpenoids | Endangered plant
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.