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shp2 (173) 173
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protein tyrosine phosphatase, non-receptor type 11 - metabolism (97) 97
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protein tyrosine phosphatase, non-receptor type 11 - genetics (79) 79
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activation (62) 62
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proto-oncogene proteins c-akt - metabolism (19) 19
ptpn11 mutations (19) 19
multidisciplinary sciences (17) 17
protein tyrosine phosphatases - genetics (17) 17
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extracellular signal-regulated map kinases - metabolism (16) 16
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protein tyrosine phosphatase, non-receptor type 11 (16) 16
protein tyrosine phosphatases - metabolism (16) 16
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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 5, pp. 629 - 639
The human gene , which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several... 
BREAST-CANCER | CELLS | ACTIVATION | HUMAN-DISEASE | ONCOLOGY | SHP2 TYROSINE PHOSPHATASE | INFLAMMATION | STAT3 | LIVER | MUTATIONS | DIFFERENTIATION | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Carcinoma, Hepatocellular - chemically induced | Liver - pathology | Hepatitis - enzymology | Liver - enzymology | Carcinoma, Hepatocellular - prevention & control | Humans | Hyperplasia | Lipopolysaccharides - administration & dosage | Adenoma, Liver Cell - pathology | Liver Neoplasms - chemically induced | Male | Necrosis | Liver - drug effects | Time Factors | Tumor Suppressor Proteins - deficiency | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine | Hepatitis - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Tumor Suppressor Proteins - genetics | STAT3 Transcription Factor - deficiency | Liver Neoplasms - pathology | Adenoma, Liver Cell - enzymology | Liver Neoplasms - enzymology | Cytokines - genetics | Interleukin-6 - administration & dosage | Adenoma, Liver Cell - genetics | STAT3 Transcription Factor - genetics | Cytokines - blood | Liver Neoplasms - prevention & control | Liver Regeneration | Tumor Suppressor Proteins - metabolism | Liver Neoplasms - genetics | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Inflammation Mediators - blood | Hepatitis - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - analysis | Carcinoma, Hepatocellular - enzymology | Mice, Knockout | Animals | Carcinoma, Hepatocellular - pathology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Tyrosine | Liver cancer | Development and progression | Phosphatases | Leukemia | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 954 - 960
The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth... 
MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC DUCTAL ADENOCARCINOMA | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | COLON-CANCER | SHP2 | INHIBITION | K-RAS | CELL LUNG-CARCINOMA | MOUSE MODEL | PROGRESSION | PHOSPHOTYROSINE PHOSPHATASE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Pancreatic Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Lung Neoplasms - pathology | Mutation - genetics | Carcinogenesis - metabolism | Disease Progression | Carcinogenesis - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Protein Kinase Inhibitors - therapeutic use | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Tyrosine | Care and treatment | Cellular signal transduction | Genetic aspects | Research | Gene expression | Cancer | Adenocarcinoma | Animal models | Xenotransplantation | Lung cancer | Phosphatase | Carcinogenesis | K-Ras protein | Proteins | Signal transduction | Carcinogens | Allosteric properties | Clonal deletion | Organoids | Dependence | Xenografts | Deletion | Protein-tyrosine kinase receptors | Inhibition | Pancreas | Protein-tyrosine kinase | MAP kinase | Tumor cell lines | Signaling | Transduction | Tumors | Protein-tyrosine-phosphatase | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7628, pp. 304 - 308
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1978 - 1985
Most ( ) mutant melanomas are sensitive to selective BRAF inhibitors, but mutant colon cancers are intrinsically resistant to these drugs because of feedback... 
COLON-CANCER | SHP2 PTPN11 | LUNG-CANCER | MEK INHIBITION | BRAF(V600E) INHIBITION | GROWTH | PROTEIN-TYROSINE PHOSPHATASES | RAF INHIBITORS | MUTATIONS | NOONAN-SYNDROME | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Genomic Library | ras Proteins - metabolism | Colonic Neoplasms - metabolism | MAP Kinase Signaling System | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Transduction, Genetic | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Genetic Vectors | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e109682 - e109682
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11, regulates signaling networks and cell fate in many tissues. Expression of... 
SIGNALS | CELLS | SHP2 | RECEPTOR | PTPN11 | MULTIDISCIPLINARY SCIENCES | Erythropoietin - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Leukemia - pathology | Nitriles - pharmacology | Erythroblasts - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Hematopoietic Stem Cells - pathology | Erythropoiesis - drug effects | Leukemia - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Antigens, CD - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Bone Marrow - metabolism | Proto-Oncogene Proteins c-kit - genetics | Receptors, Transferrin - genetics | Erythroblasts - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Leukemia - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Bone Marrow - drug effects | Erythropoiesis - genetics | Hematopoietic Stem Cells - drug effects | Butadienes - pharmacology | Signal Transduction | Leukemia - drug therapy | Hematopoietic Stem Cells - metabolism | Gene Expression Regulation, Leukemic | Receptors, Transferrin - metabolism | Animals | Bone Marrow - pathology | Alleles | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Erythroblasts - pathology | Glycoproteins | Erythropoiesis | Flow cytometry | Leukemia | Cellulose | Homology | AKT protein | Phosphatase | Experiments | Proteins | Signal transduction | Cell fate | Coding | Health care networks | Rodents | Animal tissues | Medical research | Immunoglobulins | Cytokines | Anemia | MEK inhibitors | Stat3 protein | Extracellular signal-regulated kinase | Variance analysis | Hemopoiesis | Signaling | Erythroblasts | Stem cells | Mutation | Cancer | Index Medicus
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 02/2019, Volume 17, Issue 2, pp. 583 - 593
Melanoma is one of the most highly mutated cancer types. To identify functional drivers of melanoma, we searched for cross-species conserved mutations... 
SHP2 | ACTIVATION | INHIBITION | ONCOLOGY | PHOSPHORYLATION | KRAS | MUTATIONS | IDENTIFICATION | P53 | CELL BIOLOGY
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 01/2012, Volume 302, Issue 1, pp. 231 - 243
The identification of mutations in PTPN11 (encoding the protein tyrosine phosphatase Shp2) in families with congenital heart disease has facilitated... 
Protein tyrosine phosphatase | Cell signaling | Mammalian target of rapamycin | LEOPARD-SYNDROME | TYROSINE PHOSPHATASE | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | CHAIN GENE PROMOTER | protein tyrosine phosphatase | NOONAN-SYNDROME | SHP2 MUTATIONS | mammalian target of rapamycin | cell signaling | CARDIAC-HYPERTROPHY | MOUSE MODEL | IN-VIVO | GROWTH | PERIPHERAL VASCULAR DISEASE | TRANSGENIC MICE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Age Factors | TOR Serine-Threonine Kinases - metabolism | Ventricular Function, Left | Cardiomyopathy, Hypertrophic - enzymology | Myocytes, Cardiac - enzymology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Transfection | Aging - genetics | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Animals, Newborn | Myocardial Contraction | Cardiomyopathy, Hypertrophic - genetics | Mutagenesis, Site-Directed | Cells, Cultured | Rats | Cell Size | Mice, Transgenic | Sirolimus - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Cardiomyopathy, Hypertrophic - physiopathology | Fibrosis | Mice | Protein Kinase Inhibitors - pharmacology | Cardiomyopathy, Hypertrophic - prevention & control | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Aging - metabolism | Cardiomyopathy, Hypertrophic - pathology | Cardiomyopathy, Hypertrophic | Gene mutations | Genetic aspects | Rapamycin | Dosage and administration | Cellular signal transduction | Drug therapy | Identification and classification | Risk factors | Signal transduction | Cardiovascular disease | Kinases | Gene expression | Rodents | Index Medicus
Journal Article
Human Mutation, ISSN 1059-7794, 03/2004, Volume 23, Issue 3, pp. 267 - 277
Noonan syndrome is a developmental disorder with dysmorphic facies, short stature, cardiac defects, and skeletal anomalies, which can be caused by missense... 
SHP2 | ERK2 | signal transduction | Noonan syndrome | GAB1 | MAPK1 | PTPN11 | SHP‐2 | epidermal growth factor | mitogen‐activated protein kinase | Signal transduction | Epidermal growth factor | SHP-2 | NS | Mitogen-activated protein kinase | MAP KINASE | RECEPTOR | mitogen-activated protein kinase | SH2-CONTAINING PHOSPHOTYROSINE PHOSPHATASE | EPIDERMAL-GROWTH-FACTOR | GENETICS & HEREDITY | PTPN11 MUTATIONS | SIGNAL-REGULATED KINASE | CELL | PROTEIN-TYROSINE-PHOSPHATASE | REQUIREMENT | CHO Cells - cytology | MAP Kinase Signaling System - physiology | Protein Binding - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | CHO Cells - enzymology | Noonan Syndrome - enzymology | Epidermal Growth Factor - physiology | Humans | Cercopithecus aethiops | Protein Tyrosine Phosphatases - metabolism | src Homology Domains - genetics | Phosphoproteins - metabolism | COS Cells - metabolism | Protein Tyrosine Phosphatases - immunology | COS Cells - enzymology | Mutation - physiology | Protein Tyrosine Phosphatases - genetics | MAP Kinase Signaling System - genetics | Mutagenesis, Site-Directed - genetics | CHO Cells - metabolism | Mutagenesis, Site-Directed - physiology | Protein Structure, Quaternary - physiology | Phosphoproteins - physiology | Antigen-Antibody Complex - metabolism | Protein Phosphatase 2 | Cell Division - genetics | Cell Line | Cricetinae | Intracellular Signaling Peptides and Proteins | Epidermal Growth Factor - metabolism | Mutation - genetics | src Homology Domains - physiology | COS Cells - cytology | Cell Division - physiology | Adaptor Proteins, Signal Transducing | Animals | Mitogen-Activated Protein Kinases - physiology | SH2 Domain-Containing Protein Tyrosine Phosphatases | Mitogen-Activated Protein Kinases - genetics | Protein Structure, Quaternary - genetics | Enzyme Activation - genetics | Enzyme Activation - physiology | Protein Binding - physiology | Protein Tyrosine Phosphatases - physiology | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 06/2015, Volume 29, Issue 6, pp. 1290 - 1300
Journal Article