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Current pharmaceutical design, ISSN 1381-6128, 2018, Volume 24, Issue 32, pp. 3767 - 3777
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 954 - 960
The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth... 
MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC DUCTAL ADENOCARCINOMA | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | COLON-CANCER | SHP2 | INHIBITION | K-RAS | CELL LUNG-CARCINOMA | MOUSE MODEL | PROGRESSION | PHOSPHOTYROSINE PHOSPHATASE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Pancreatic Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Lung Neoplasms - pathology | Mutation - genetics | Carcinogenesis - metabolism | Disease Progression | Carcinogenesis - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Protein Kinase Inhibitors - therapeutic use | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Tyrosine | Care and treatment | Cellular signal transduction | Genetic aspects | Research | Gene expression | Cancer | Adenocarcinoma | Animal models | Xenotransplantation | Lung cancer | Phosphatase | Carcinogenesis | K-Ras protein | Proteins | Signal transduction | Carcinogens | Allosteric properties | Clonal deletion | Organoids | Dependence | Xenografts | Deletion | Protein-tyrosine kinase receptors | Inhibition | Pancreas | Protein-tyrosine kinase | MAP kinase | Tumor cell lines | Signaling | Transduction | Tumors | Protein-tyrosine-phosphatase | Index Medicus
Journal Article
06/2013
Tyrosyl phosphorylation plays an important role in many fundamental cellular processes, including cell growth, differentiation and proliferation. The levels of... 
SHP2 | Reactive oxygen species | 0379 | 0566 | 0992 | 0485 | Oxidation | 0307 | AP-MS | Protein-tyrosine phosphatases | Mass spectrometry | 0306
Dissertation
Journal Article
by Chen, C and Liang, F and Chen, B and Sun, ZY and Xue, TD and Yang, RL and Luo, DQ
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 01/2017, Volume 795, pp. 124 - 133
Shp2 is a classical non-receptor protein tyrosine phosphatase (PTP) involved in many human diseases such as Noonan syndrome and tumors, and identified as a... 
Demethylincisterol A | ACTIVATION | Protein tyrosine phosphatase | CELLS IN-VITRO | DRUG DISCOVERY | PTPN11 | NOONAN-SYNDROME | BREAST-CANCER | Shp2 inhibitor | POOR-PROGNOSIS | GROWTH | THERAPEUTIC TARGETS | PHARMACOLOGY & PHARMACY | Mechanism of action | PROGRESSION
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2017, Volume 795, pp. 124 - 133
Shp2 is a classical non-receptor protein tyrosine phosphatase (PTP) involved in many human diseases such as Noonan syndrome and tumors, and identified as a... 
Demethylincisterol A | Shp2 inhibitor | Protein tyrosine phosphatase | Mechanism of action
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2018, Volume 19, Issue 9
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 795, pp. 124 - 133
Shp2 is a classical non-receptor protein tyrosine phosphatase (PTP) involved in many human diseases such as Noonan syndrome and tumors, and identified as a... 
Shp2 inhibitor | Mechanism of action | Protein tyrosine phosphatase | Demethylincisterol A3 | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2013, Volume 12, Issue 9, pp. 1738 - 1748
Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine... 
SIGNAL-TRANSDUCTION | HEMATOPOIETIC-CELLS | SOMATIC PTPN11 MUTATIONS | OF-FUNCTION MUTATION | MOLECULAR-DYNAMICS | COLONY-STIMULATING FACTOR | ONCOLOGY | JUVENILE MYELOMONOCYTIC LEUKEMIA | GENERAL FORCE-FIELD | ACUTE MYELOID-LEUKEMIA | NOONAN-SYNDROME | Catalytic Domain - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Leukemia, Myeloid - pathology | Noonan Syndrome - pathology | Indoles - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Indoles - pharmacology | Triazines - chemistry | Molecular Structure | Tumor Cells, Cultured | Drug Evaluation, Preclinical | Child | Cell Line | Triazines - metabolism | Triazines - pharmacology | Catalytic Domain - genetics | Enzyme Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Enzyme Inhibitors - analysis | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Signal Transduction - genetics | Gene Knockout Techniques | Noonan Syndrome - drug therapy | Leukemia, Myeloid - drug therapy | Animals | Signal Transduction - drug effects | Cell Proliferation - drug effects | Mice | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Indoles - chemistry | Drug Screening Assays, Antitumor | Index Medicus | Inhibitor | PTPN11 (SHP2) | Phosphatase | Drug development | Leukemia
Journal Article
BMC Cancer, ISSN 1471-2407, 06/2014, Volume 14, Issue 1, pp. 442 - 442
Background: Tumor invasion and metastasis represent a major unsolved problem in cancer pathogenesis. Recent studies have indicated the involvement of... 
Extracellular signal-related kinase | Src-homology 2 domain-containing tyrosine phosphatase 2 | Metastasis | Oral cancer | Invasion | TUMOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | E-CADHERIN | NOONAN-SYNDROME | BREAST-CANCER | SHP2 PTPN11 | ONCOLOGY | GROWTH-FACTOR | MUTATIONS | SQUAMOUS-CELL CARCINOMAS | EXPRESSION | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Up-Regulation | Humans | Gene Expression Regulation, Neoplastic | Mouth Neoplasms - metabolism | Cell Movement - genetics | MAP Kinase Signaling System | Neoplasm Metastasis | Lung Neoplasms - secondary | Nuclear Proteins - genetics | Mouth Neoplasms - genetics | Snail Family Transcription Factors | Disease Models, Animal | Lung Neoplasms - genetics | Neoplasm Invasiveness | Nuclear Proteins - metabolism | Transcription Factors - genetics | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Mouth Neoplasms - pathology | Mice | Enzyme Activation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Twist-Related Protein 1 - metabolism | Tyrosine | Care and treatment | Patient outcomes | Physiological aspects | Development and progression | Genetic aspects | Research | Diagnosis | Intermediate filament proteins | Health aspects | Mouth cancer | Index Medicus
Journal Article
Journal Article