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British Journal of Pharmacology, ISSN 0007-1188, 11/2005, Volume 146, Issue 6, pp. 834 - 845
In the spontaneously hypertensive rat (SHR) and aging Wistar–Kyoto rats (WKY), acetylcholine releases an endothelium‐derived contracting factor (EDCF) produced... 
TP receptors | spontaneously hypertensive rat | prostaglandins | Endothelium‐dependent contractions | endoperoxide | prostacyclin | Endoperoxide | Prostaglandins | Prostacyclin | Spontaneously hypertensive rat | Endothelium-dependent contractions | PROSTAGLANDIN-E SYNTHASE | CELLS | CYCLOOXYGENASE-2 | SPONTANEOUSLY HYPERTENSIVE-RATS | PLATELET-AGGREGATION | VASOCONSTRICTOR PROSTANOIDS | H-2 | VASCULAR SMOOTH-MUSCLE | ARTERIES | PHARMACOLOGY & PHARMACY | EXPRESSION | endothelium-dependent contractions | Prostaglandins - pharmacology | Rats, Inbred WKY | Nitrobenzenes - pharmacology | Salicylates - pharmacology | Aorta, Thoracic - drug effects | Prostaglandins I - metabolism | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Acetylcholine - pharmacology | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Imidazoles - pharmacology | Aorta, Thoracic - physiopathology | Sulfonamides - pharmacology | Vasoconstriction - drug effects | Hypertension - physiopathology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Prostaglandins I - pharmacology | Prostaglandins - classification | In Vitro Techniques | Thromboxane A2 - secretion | Prostaglandins - metabolism | Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2015, Volume 172, Issue 14, pp. 3687 - 3701
Background and Purpose In the aorta of adult spontaneously hypertensive (SHR), but not in that of normotensive Wistar‐Kyoto (WKY), rats, previous exposure to... 
Rats, Inbred SHR | Receptors, Adrenergic, alpha-1 - metabolism | Animals | Protein Kinase C-epsilon - metabolism | Rats | Rats, Inbred WKY | Male | Receptors, Thromboxane - metabolism | Aorta - metabolism | Research Papers
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2015, Volume 308, Issue 7, pp. 723 - 732
Testosterone has been added to hormone replacement therapy to treat sexual dysfunction in postmenopausal women. Whereas estrogen has been associated with... 
Testosterone | NADPH oxidase | Estrogen | ROS | Hypoactive sexual desire disorder | Cardiovascular disease | Angiotensin II | Endothelium | endothelium | cardiovascular disease | estrogen | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | testosterone | SPONTANEOUSLY HYPERTENSIVE-RATS | ANGIOTENSIN-II | MENOPAUSAL WOMEN | OVARIECTOMIZED RATS | hypoactive sexual desire disorder | SEXUAL DESIRE DISORDER | NITRIC-OXIDE PRODUCTION | angiotensin II | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | POSTMENOPAUSAL WOMEN | GENDER-DIFFERENCES | Estrogen Replacement Therapy | Estrogens, Conjugated (USP) - pharmacology | Phosphorylation | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Endothelium, Vascular - drug effects | Aorta - metabolism | RNA, Messenger - metabolism | Testosterone - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Dose-Response Relationship, Drug | Time Factors | NADPH Oxidases - genetics | Female | Aorta - physiopathology | Hypertension - genetics | Disease Models, Animal | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Ovariectomy | Endothelial Cells - metabolism | Aorta - drug effects | NADPH Oxidases - antagonists & inhibitors | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Vasoconstriction - drug effects | Hypertension - physiopathology | Hypertension - metabolism | Animals | Endothelium, Vascular - metabolism | Oxidative Stress - drug effects | Vasodilation - drug effects | Endothelial Cells - drug effects | Reactive oxygen species | Hormone therapy | Patient outcomes | Postmenopausal women | Aorta | Dosage and administration | Drug therapy | Sexual disorders | Health aspects | Methods
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2013, Volume 305, Issue 3, pp. H344 - H353
A contributing factor to increased peripheral resistance seen during hypertension is an increased production of endothelium-derived contractile factors... 
Cyclooxygenase | EDCF | ERK1/2 | cPLA | Endoplasmic reticulum stress | CYTOSOLIC PHOSPHOLIPASE A | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MESENTERIC-ARTERIES | ER STRESS | OLETF RATS | cyclooxygenase | endoplasmic reticulum stress | PROSTANOID RECEPTORS | UNFOLDED PROTEIN RESPONSE | GENE-EXPRESSION | RENAL-ARTERIES | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | Antihypertensive Agents - pharmacology | Epoprostenol - metabolism | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Rats, Inbred WKY | Endothelium, Vascular - drug effects | Hypertension - drug therapy | Male | Aorta - metabolism | Dinoprost - metabolism | Muscle, Smooth, Vascular - physiopathology | Dose-Response Relationship, Drug | Taurochenodeoxycholic Acid - pharmacology | Phenylbutyrates - pharmacology | tert-Butylhydroperoxide - pharmacology | Blood Pressure - drug effects | Membrane Proteins - metabolism | Aorta - physiopathology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Endoplasmic Reticulum Stress - drug effects | Acetylcholine - pharmacology | Aorta - drug effects | Cells, Cultured | Endothelium, Vascular - physiopathology | bcl-2-Associated X Protein - metabolism | Rats | Vasoconstriction - drug effects | Hypertension - physiopathology | Phospholipases A2, Cytosolic - metabolism | Hydrogen Peroxide - metabolism | Hypertension - metabolism | Thromboxane A2 - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Arachidonic Acid - pharmacology | Cyclooxygenase 1 - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Hypertension | Physiological aspects | Stress (Physiology) | Endoplasmic reticulum | Health aspects | Muscle contraction | cPLA2 | Vascular Biology and Microcirculation | ERK1
Journal Article
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 04/2016, Volume 43, Issue 4, pp. 450 - 458
Journal Article
Journal Article
Journal Article