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Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9757, pp. 2018 - 2031
Summary Sickle-cell disease is one of the most common severe monogenic disorders in the world. Haemoglobin polymerisation, leading to erythrocyte rigidity and... 
Internal Medicine | FETAL-HEMOGLOBIN LEVELS | MEDICINE, GENERAL & INTERNAL | HOSPITAL ADMISSIONS | RISK-FACTORS | PULMONARY-HYPERTENSION | ACUTE CHEST SYNDROME | HYDROXYUREA THERAPY | NITRIC-OXIDE | ADHESION MOLECULES | ACUTE VASOOCCLUSIVE CRISIS | PLASMODIUM-FALCIPARUM MALARIA | Haplotypes | Antisickling Agents - therapeutic use | Acute Chest Syndrome - etiology | Acute Chest Syndrome - therapy | Humans | Pain Management | Hypertension, Pulmonary - therapy | Blood Transfusion | Anemia, Sickle Cell - epidemiology | Erythrocytes - pathology | Pain - etiology | Anemia, Sickle Cell - classification | Hemolysis | Severity of Illness Index | Gene Transfer Techniques | Iron Chelating Agents - therapeutic use | Disease Susceptibility | Anemia, Sickle Cell - complications | Africa | Hematopoietic Stem Cell Transplantation | Polymerization | Nervous System Diseases - therapy | Anemia, Sickle Cell - therapy | Heart Diseases - etiology | Mass Screening | Heart Diseases - therapy | Kidney Diseases - therapy | Nervous System Diseases - etiology | Hydroxyurea - therapeutic use | Anemia, Sickle Cell - blood | Anemia, Sickle Cell - diagnosis | Kidney Diseases - etiology | Hypertension, Pulmonary - etiology | Hematopoietic Stem Cells | Care and treatment | Sickle cell anemia | Hemoglobin | Development and progression | Diagnosis | Health aspects | Risk factors | Disease | Rodents | Nitric oxide | Mutation | Gene therapy | Epidemiology | Federal funding
Journal Article
Lancet, The, ISSN 0140-6736, 2017, Volume 390, Issue 10091, pp. 311 - 323
Summary Sickle cell disease is a common and life-threatening haematological disorder that affects millions of people worldwide. Abnormal sickle-shaped... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | PULMONARY-HYPERTENSION | CLINICAL-TRIAL | SUB-SAHARAN AFRICA | FETAL-HEMOGLOBIN | EARLY-CHILDHOOD MORTALITY | TRANSCRANIAL DOPPLER ULTRASONOGRAPHY | TRANSFUSION-TRANSMITTED INFECTIONS | IRON OVERLOAD | YOUNG-CHILDREN | Hemolysis | Antisickling Agents - therapeutic use | Pregnancy Complications, Hematologic - prevention & control | Stroke - prevention & control | Anemia, Sickle Cell - complications | Humans | Pregnancy | Anemia, Sickle Cell - therapy | Global Burden of Disease | Stem Cell Transplantation - methods | Stroke - etiology | Cerebrovascular Disorders - prevention & control | Point-of-Care Systems | Iron Overload - therapy | Female | Hydroxyurea - therapeutic use | Anemia, Sickle Cell - diagnosis | Chronic Disease | Early Diagnosis | Hemolytic Plaque Technique | Blood Transfusion - methods | Genetic Therapy - methods | Prevention | Transplantation | Diagnostic imaging | Sickle cell anemia | Mortality | Stem cells | Occlusion | Erythrocytes | Iron | Pain | Ischemia | Penicillin | Hemoglobin | Sickle cell disease | Genetic modification | Stroke | Hematology | Anemia | Vessels | Blood vessels | Medical screening | Disease control | Morbidity | Blood flow | Magnetic resonance imaging | Antibiotics | Medical prognosis | Diagnostic systems | Chelating agents | Gene therapy | Risk management
Journal Article
2011, ISBN 0691123179, 368
In the 1980s, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African... 
Clinical & internal medicine | Sickle cell anemia | Social aspects | Senegal | Services for | Genetic disorders | Sociology | Kinship | Anthropology | Genetic aspects | History | Patients | Health aspects
eBook
Journal Article
Journal Article
Human Genetics, ISSN 0340-6717, 11/2011, Volume 130, Issue 5, pp. 583 - 605
Dominant negative genetic disorders, in which a mutant allele of a gene causes disease in the presence of a second, normal copy, have been challenging since... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | PROLONGS SURVIVAL | SHORT INTERFERING RNA | ALZHEIMERS-DISEASE | IN-VIVO | GENETICS & HEREDITY | CHEMICAL-MODIFICATION | ALPHA-SYNUCLEIN | EXPRESSION PROFILES | BLOOD-BRAIN-BARRIER | HUNTINGTONS-DISEASE | MYOTONIC-DYSTROPHY | Parkinson Disease - therapy | Muscular Dystrophies - therapy | Humans | Anemia, Sickle Cell - drug therapy | Parkinson Disease - drug therapy | Spinocerebellar Ataxias - therapy | Genetic Diseases, Inborn - therapy | Molecular Targeted Therapy | Muscular Dystrophies - genetics | Amyotrophic Lateral Sclerosis - drug therapy | Huntington Disease - therapy | Neoplasms - therapy | Genes, Dominant | Neoplasms - genetics | RNA Interference | Spinocerebellar Ataxias - drug therapy | Huntington Disease - drug therapy | Spinocerebellar Ataxias - genetics | Amyotrophic Lateral Sclerosis - therapy | Amyotrophic Lateral Sclerosis - genetics | Alzheimer Disease - therapy | Muscular Dystrophies - drug therapy | Alzheimer Disease - drug therapy | Rats | Clinical Trials as Topic | Parkinson Disease - genetics | Neoplasms - drug therapy | Anemia, Sickle Cell - therapy | Point Mutation | Animals | Huntington Disease - genetics | Mice | Alzheimer Disease - genetics | Genetic Diseases, Inborn - drug therapy | Anemia, Sickle Cell - genetics | Genetic Therapy - methods | Enzymes | Gene mutations | Gene therapy | Catalytic RNA | Health aspects | Genes | Drugs | Parkinson's disease | Neurodegenerative diseases | Tumor cells | RNA-mediated interference | Amyotrophic lateral sclerosis | Antisense RNA | Drug delivery | Single-nucleotide polymorphism | Huntington's disease | Muscular dystrophy | Mutation | Ribozymes | Alzheimer's disease | Movement disorders | Cancer | Pharmaceuticals
Journal Article