X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (33262) 33262
Publication (4689) 4689
Book Chapter (276) 276
Conference Proceeding (81) 81
Book Review (74) 74
Dissertation (52) 52
Newsletter (28) 28
Reference (13) 13
Newspaper Article (11) 11
Data Set (9) 9
Magazine Article (7) 7
Book / eBook (3) 3
Web Resource (3) 3
Government Document (1) 1
Presentation (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (19232) 19232
animals (16733) 16733
humans (14894) 14894
extracellular signal-regulated map kinases - metabolism (14436) 14436
extracellular signal-regulated kinase (12675) 12675
phosphorylation (11188) 11188
signal transduction (9376) 9376
mice (8842) 8842
kinases (6944) 6944
cell biology (6601) 6601
apoptosis (6569) 6569
activation (6556) 6556
proteins (6175) 6175
male (6002) 6002
rats (5840) 5840
biochemistry & molecular biology (5712) 5712
expression (5642) 5642
cell line, tumor (4888) 4888
cells, cultured (4750) 4750
map kinase (4692) 4692
oncology (4466) 4466
gene expression (4226) 4226
female (4202) 4202
cancer (4168) 4168
cell proliferation (4119) 4119
signal transduction - drug effects (4095) 4095
cell line (3426) 3426
neurosciences (3233) 3233
research article (3215) 3215
inhibition (3158) 3158
inflammation (3078) 3078
signal-regulated kinase (3073) 3073
rodents (3051) 3051
phosphorylation - drug effects (3027) 3027
article (3003) 3003
medicine (2986) 2986
multidisciplinary sciences (2963) 2963
proto-oncogene proteins c-akt - metabolism (2959) 2959
akt protein (2881) 2881
erk (2800) 2800
signaling (2752) 2752
research (2685) 2685
cell proliferation - drug effects (2652) 2652
science (2587) 2587
apoptosis - drug effects (2522) 2522
analysis (2518) 2518
pharmacology & pharmacy (2457) 2457
proliferation (2420) 2420
blotting, western (2416) 2416
cells (2401) 2401
map kinase signaling system - drug effects (2396) 2396
gene-expression (2361) 2361
rats, sprague-dawley (2350) 2350
enzyme activation (2324) 2324
oxidative stress (2309) 2309
extracellular signal-regulated map kinases - antagonists & inhibitors (2204) 2204
immunology (2162) 2162
physiology (2160) 2160
p38 mitogen-activated protein kinases - metabolism (2115) 2115
activated protein-kinase (2103) 2103
biology (2035) 2035
pathway (1982) 1982
in-vitro (1981) 1981
growth (1974) 1974
mice, inbred c57bl (1956) 1956
pathways (1936) 1936
physiological aspects (1934) 1934
tumors (1929) 1929
enzyme inhibitors - pharmacology (1914) 1914
signal transduction - physiology (1911) 1911
protein kinases (1896) 1896
enzyme activation - drug effects (1889) 1889
map kinase signaling system (1884) 1884
cell cycle (1879) 1879
cell growth (1825) 1825
cytokines (1817) 1817
mitogen-activated protein kinases - metabolism (1808) 1808
nf-kappa-b (1801) 1801
dose-response relationship, drug (1795) 1795
differentiation (1790) 1790
health aspects (1782) 1782
medicine, research & experimental (1752) 1752
transcription factors (1685) 1685
time factors (1679) 1679
metastasis (1646) 1646
mutation (1640) 1640
phosphatidylinositol 3-kinases - metabolism (1627) 1627
mitogen-activated protein kinase 1 - metabolism (1611) 1611
genetic aspects (1581) 1581
extracellular signal-regulated map kinases - genetics (1576) 1576
cell migration (1558) 1558
in-vivo (1541) 1541
cell survival - drug effects (1519) 1519
disease models, animal (1495) 1495
nf-kappa b - metabolism (1482) 1482
protein kinase inhibitors - pharmacology (1459) 1459
protein (1455) 1455
immunohistochemistry (1448) 1448
transfection (1448) 1448
mitogen-activated protein kinase 3 - metabolism (1443) 1443
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (33033) 33033
Chinese (307) 307
Japanese (127) 127
Korean (33) 33
French (17) 17
Russian (16) 16
Spanish (7) 7
German (4) 4
Polish (4) 4
Ukrainian (2) 2
Danish (1) 1
Persian (1) 1
Portuguese (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Diabetes, ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 514 - 525
The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation. In some conditions, certain white adipose... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins
Journal Article
Oncogene, ISSN 0950-9232, 05/2007, Volume 26, Issue 22, pp. 3291 - 3310
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 836 - 842
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1080 - 1094
The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to... 
targeted therapy | Ras | therapeutic sensitivity | Raf | resistance | ERK | ABROGATE CYTOKINE DEPENDENCY | INITIATION-FACTOR 4E | ACUTE MYELOID-LEUKEMIA | KINASE INHIBITOR PROTEIN | DRUG-INDUCED APOPTOSIS | BONE-MARROW MICROENVIRONMENT | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | MURINE HEMATOPOIETIC-CELLS | HEMATOLOGY | SIGNAL-REGULATED KINASE | ras Proteins - genetics | MAP Kinase Signaling System - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Apoptosis - drug effects | raf Kinases - antagonists & inhibitors | Humans | Neoplasm Proteins - physiology | Mitogen-Activated Protein Kinase Kinases - physiology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - genetics | Gene Expression Regulation, Leukemic - genetics | raf Kinases - physiology | MAP Kinase Signaling System - genetics | Drug Design | Antineoplastic Agents - pharmacology | Extracellular Signal-Regulated MAP Kinases - physiology | Neoplasm Proteins - genetics | raf Kinases - genetics | ras Proteins - physiology | Cell Division - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Cell Division - drug effects | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | Models, Biological | Phosphatidylinositol 3-Kinases - physiology | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Extracellular signal-regulated kinases | Leukemia | Physiological aspects | Genetic aspects | Research | Drug therapy | Health aspects | Mitogen-activated protein kinases | Cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article