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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12675 - 12680
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2015, Volume 352, Issue 2, pp. 346 - 357
Journal Article
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 17, pp. 4602 - 4612
Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we... 
TUMOR-PROTEIN-53-INDUCED-NUCLEAR-PROTEIN-1 | NUCLEAR-PROTEIN 1 | ONCOLOGY | MAP KINASE | PROSTATE-CANCER | KINASE PHOSPHATASES MKPS | GENE-EXPRESSION | TUMOR-SUPPRESSOR | STRESS | P53-INDUCED NUCLEAR-PROTEIN-1 | CELL-DEATH | Prognosis | Humans | Lung Neoplasms - metabolism | Tumor Protein p73 - genetics | Gene Expression Profiling | Tumor Protein p73 - metabolism | Heat-Shock Proteins - genetics | Neoplasm Metastasis | Lung Neoplasms - secondary | Carcinoma, Hepatocellular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Dual-Specificity Phosphatases - genetics | Liver Neoplasms - pathology | Tumor Cells, Cultured | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Dual-Specificity Phosphatases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase Phosphatases - genetics | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Protein Array Analysis | Mice | Mice, Inbred BALB C | Carcinoma, Hepatocellular - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Liver | Extracellular signal-regulated kinase | Hepatocellular carcinoma | Metastasis | Metastases | Liver cancer | Signal transduction | Signaling | Stress response | Binding sites | Cellular stress response | Tumors | Apoptosis | Cancer | Liver Neoplasms | Lung Neoplasms | Life Sciences | Tumor Protein p73 | Heat-Shock Proteins | Mitogen-Activated Protein Kinase Phosphatases | Carcinoma, Hepatocellular | Dual-Specificity Phosphatases | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | Carrier Proteins
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2017, Volume 31, Issue 7, pp. 2963 - 2972
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e97675
Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to... 
3T3-L1 ADIPOCYTES | INDEPENDENT MECHANISM | ACTIVATION | RECOGNITION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | ENDOTOXEMIA | MICROBIOTA | NF-KAPPA-B | INDUCED INSULIN-RESISTANCE | INNATE IMMUNITY | Lipolysis - drug effects | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gonads - drug effects | Nod1 Signaling Adaptor Protein - deficiency | Adipose Tissue - cytology | Adipocytes - cytology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Adipocytes - drug effects | Adipose Tissue - metabolism | Gonads - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tissue Culture Techniques | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | 3T3-L1 Cells | Mice, Knockout | Gonads - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Adipocytes - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Peptidoglycan - pharmacology | Adipose Tissue - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Nod1 Signaling Adaptor Protein - genetics | Obesity | Metabolites | Insulin resistance | Inflammation | Lipase | Phosphotransferases | Protein binding | Protein kinase A | Pediatrics | Transcription factors | Adipose tissue | Pollution load | Lipids | Activation | Biochemistry | Hormones | Adipocytes | Glucose | Kinases | Defects | Proteins | Receptors | Microbiota | Nutrient loading | Rodents | Animal tissues | Bacteria | Inhibition | Nod1 protein | Endotoxemia | Explants | Cues | Pathogens | NF-κB protein | Oligomerization | Cytokines | Hyperlipidemia | Peptidoglycans | Extracellular signal-regulated kinase | c-Jun protein | Glycerol | MAP kinase | Metabolism | Insulin | Lipolysis | Ligands
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 381, Issue 3, pp. 675 - 683
Many intracellular signalling events are accompanied by generation of reactive oxygen species in cells. Oxidation of protein thiol groups is an emerging theme... 
Redox | Oxidative stress | Glutathionylation | Apoptosis signal-regulating kinase 1 (ASK1) | MEKK1 | S-thiolation | apoptosis signal-regulating kinase 1 (ASK1) | ACTIVATED PROTEIN-KINASE | glutathionylation | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYSTEINE SULFENIC ACID | redox | MENADIONE 2-METHYL-1,4-NAPHTHOQUINONE | CYTO-TOXICITY | TYROSINE-PHOSPHATASE 1B | ISOLATED HEPATOCYTES | REDOX REGULATION | CELL-MIGRATION | GROWTH-FACTOR | NF-KAPPA-B | oxidative stress | Catalytic Domain - drug effects | Oxidants - pharmacology | Lymph Nodes - pathology | Glutathione - metabolism | Humans | Oxidative Stress - physiology | Molecular Sequence Data | Male | Amino Acid Sequence - genetics | Alkylation | Lymph Nodes - enzymology | Mutation - physiology | Peptides - metabolism | MAP Kinase Kinase Kinase 1 - chemistry | Adenosine Triphosphate - metabolism | Binding Sites - physiology | Ethylmaleimide - pharmacology | Cysteine - metabolism | MAP Kinase Kinase Kinase 1 - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 - physiology | Dithiothreitol - pharmacology | MAP Kinase Kinase Kinase 1 - metabolism | Protein Structure, Tertiary | Prostatic Neoplasms - pathology | Oxidation-Reduction | Peptides - chemistry | Peptides - physiology | Enzyme Inhibitors - pharmacology | Amino Acid Sequence - physiology | Oxidants - antagonists & inhibitors | Valine - metabolism | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Oxidative Stress - drug effects | Amino Acid Substitution | TNF, tumour necrosis factor | cAPK, cyclic AMP-dependent protein kinase | CBD, chitin-binding domain | JNK, c-Jun N-terminal kinase | ERK kinase | DTT, dithiothreitol | MEKK1, MAPK (mitogen-activated protein kinase) | SAPK, stress-activated protein kinase | ASK1, apoptosis signal-regulating kinase 1 | EE epitope tag, MHEEEEYMPMEGPG (in the one-letter amino acid code) | SEK-KR, a catalytically inactive mutant of SEK in which K (lysine) has been mutated to arginine (R) | NEM, N-ethylmaleimide | GST, glutathione S-transferase | SNAP, S-nitroso-N-acetylpenicillamine | SEK, SAPK | IL1, interleukin 1 | ERK (extracellular-signal-regulated kinase) kinase kinase 1 | MS, tandem MS | LNCaP, lymph-node carcinoma of the prostate | HA, haemagglutinin | C1238V (etc.), Cys1238→Val (etc.) | MKK4, mitogen-activated protein kinase kinase 4 | NF-κB, nuclear factor NF-κB
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167071
Background Cigarette smoking plays an important role in the progression of chronic kidney disease (CKD). Nicotine, one of the major components of cigarette... 
ACETYLCHOLINE-RECEPTORS | CIGARETTE-SMOKING | NMDA RECEPTORS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | RENAL-FUNCTION | INJURY | DIABETIC-NEPHROPATHY | CHRONIC KIDNEY-DISEASE | CARDIOVASCULAR MORBIDITY | ROS PRODUCTION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Apoptosis - genetics | Male | Nicotinic Antagonists - pharmacology | Spin Labels | Reactive Oxygen Species - agonists | Nicotine - pharmacology | MAP Kinase Kinase 4 - metabolism | Cyclic N-Oxides - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Female | MAP Kinase Kinase 4 - antagonists & inhibitors | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Receptors, Nicotinic - metabolism | Podocytes - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Tissue Culture Techniques | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Nicotine - antagonists & inhibitors | Podocytes - cytology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Podocytes - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oxidative Stress - drug effects | Receptors, Nicotinic - genetics | Cell Line, Transformed | Mitogen-Activated Protein Kinase 1 - metabolism | Oxidative stress | Physiological aspects | Research | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking | Apoptosis | Cell proliferation | Reactive oxygen species | Phosphorylation | Laboratories | Syngeneic grafts | Downstream effects | Tempol | Acetylcysteine | Superoxide dismutase | Antagonists | mRNA | Medical schools | Antioxidants | Proteins | Receptors | Rodents | Mesangial cells | Localization | Medical research | Extracellular signal-regulated kinase | JNK protein | Superoxide | Permeability | Gene expression | Cigarette smoking | Signaling | Molecular modelling | Inhibitors | Acetylcholine receptors (nicotinic) | In vivo methods and tests | Kidney diseases | Diabetes | Kidney transplantation
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29622
GNAQ mutations at codon 209 have been recently identified in approximately 50% of uveal melanomas (UM) and are reported to be oncogenic through activating the... 
MULTIPLE-MYELOMA | PKC ISOFORMS | IN-VITRO | ACTIVATION | BETA INHIBITOR | CANCER CELLS | INDUCED APOPTOSIS | BRAF MUTATIONS | MULTIDISCIPLINARY SCIENCES | AKT PATHWAY | MAPK PATHWAY | Apoptosis - drug effects | Humans | Melanoma - enzymology | Molecular Sequence Data | Extracellular Signal-Regulated MAP Kinases - metabolism | Cyclin D1 | Uveal Neoplasms - enzymology | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Isoenzymes - metabolism | Protein Kinase C - metabolism | Indoles - pharmacology | Bromodeoxyuridine - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Uveal Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | GTP-Binding Protein alpha Subunits - genetics | Protein Kinase C - antagonists & inhibitors | Melanoma - pathology | Enzyme Activation - drug effects | Mutation - genetics | Uveal Neoplasms - drug therapy | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | GTP-Binding Protein alpha Subunits, Gq-G11 | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Isoenzymes - antagonists & inhibitors | Drug Screening Assays, Antitumor | Codon | Angiogenesis inhibitors | Protein kinases | Melanoma | Apoptosis | Phosphorylation | Protein kinase C | Bcl-2 protein | Leukemia | Metastasis | Kinases | Accumulation | Medical schools | Skin cancer | Anticancer properties | Proteins | Signal transduction | Tumorigenesis | Inhibition | Extracellular signal-regulated kinase | MAP kinase | Survivin | Signaling | Inhibitors | Womens health | Pancreatic cancer | Isoforms | Cyclin-dependent kinase inhibitor p27 | Antitumor activity | Sensitivity enhancement | Mutation | Viability
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 10/2017, Volume 15, Issue 10, pp. 1431 - 1444
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2014, Volume 34, Issue 7, pp. 1429 - 1436
OBJECTIVE—Mitogen-activated protein kinase pathways play an important role in neointima formation secondary to vascular injury, in part by promoting... 
neointima | mitogen-activated protein kinase kinase kinase | MLK3 | PROTEIN-KINASE | DOWN-REGULATION | PROLIFERATION | HYPERPLASIA | APOLIPOPROTEIN-E | IN-VIVO | NUCLEOTIDE EXCHANGE FACTOR | PERIPHERAL VASCULAR DISEASE | GENE-TRANSFER | HEMATOLOGY | SIGNAL-REGULATED KINASE | Cell Proliferation | Hyperplasia | Myocytes, Smooth Muscle - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Neointima | MAP Kinase Kinase Kinases - deficiency | Time Factors | rho-Associated Kinases - metabolism | Carotid Arteries - enzymology | Carotid Artery Injuries - genetics | Rho Guanine Nucleotide Exchange Factors - metabolism | Myocytes, Smooth Muscle - drug effects | Carotid Artery Injuries - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Animals | Carotid Artery Injuries - enzymology | rho GTP-Binding Proteins - metabolism | Carotid Arteries - pathology | Mice | Protein Kinase Inhibitors - pharmacology | Muscle, Smooth, Vascular - enzymology | cJun NH2-terminal kinase | p63RhoGEF | Rho-kinase | vascular smooth muscle cell | mixed-lineage kinase | RhoA
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 2, pp. 231 - 241
AS 160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4) translocation, but is widely expressed in insulin-insensitive... 
14-3-3 | Akt/protein kinase B (PKB) | GTPase-activating protein (GAP) | p90 ribosomal S6 kinase (RSK) | Akt substrate of 160 kDa (AS160) | Serum- and glucocorticoid-induced protein kinase (SGK) | MOUSE SKELETAL-MUSCLE | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | Akt substrate of 160kDa (AS160) | AKT SUBSTRATE | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | INSULIN-STIMULATED PHOSPHORYLATION | GLUT4 TRANSLOCATION | S6 KINASE | PROTEOMIC ANALYSIS | RAB-GAP | serum- and glucocorticoid-induced protein kinase (SGK) | Cell Line | Insulin-Like Growth Factor I - pharmacology | Phosphorylation | Humans | GTPase-Activating Proteins - metabolism | Insulin | Amino Acids | Aminoimidazole Carboxamide - pharmacology | Hypoglycemic Agents - pharmacology | 14-3-3 Proteins - metabolism | Ribonucleotides - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Protein Binding | Epidermal Growth Factor - pharmacology | Binding Sites | ACC, acetyl-CoA carboxylase | AGC kinase, protein kinase A | AICAR, 5-amino-4-imidazolecarboxamide1-β-D-ribofuranoside | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | TOS motif, mTOR signalling motif | PAS, phospho-Akt substrate | pSer, phosphorylated serine | TSC, tuberous sclerosis complex | AS160, Akt substrate of 160 kDa | PKB, protein kinase B (also known as Akt) | AMPK, AMP-activated protein kinase | RSK, p90 ribosomal S6 kinase | DSP, dithiobis(succinimidyl propionate) | protein kinase C-family | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase B (PKB) | IGF-1, insulin-like growth factor-1 | Akt substrate of 160 kDa (AS160) | GLUT4, glucose transporter 4 | protein kinase G | mTOR, mammalian target of rapamycin | TORC1, mTOR–raptor (regulatory associated protien of mTOR) complex | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | GST, glutathione S-transferase | PKC, protein kinase C | PP2A, protein phosphatase 2A | Akt | SGK, serum- and glucocorticoid-induced protein kinase | HA, haemagglutinin | GSV, GLUT4 storage vesicle | p70S6K, p70 S6 kinase | PTB, phosphotyrosine binding domain | pThr, phosphorylated threonine | GAP, GTPase-activating protein | HEK-293, human embryonic kidney-293 | IRAP, insulin-responsive aminopeptidase | Rheb, Ras enriched in brain | MAPK, mitogen-activated protein kinase
Journal Article