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03/2013
Purpose: To formulate and characterize nanoparticles containing silybin, and evaluate their activity against carbon tetrachloride (CCl4)-induced liver... 
Nanoparticles | Hepatoprotective activity | Pharmacodynamics | Silybin | Pharmacokinetics
Web Resource
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 05/2014, Volume 10, Issue 1, pp. 1047 - 1063
Methods were developed and optimized for the preparation of the 2,3-cis- and the 10,11-cis-isomers of silybin by the Lewis acid catalyzed (BF3 center dot OEt2)... 
10,11-cis-silybin | Silybin | 2,3-cis-silybin | Silymarin | Isomerization | Silibinin | silymarin | ASYMMETRIC-SYNTHESIS | silibinin | CHROMOPHORE | isomerization | silybin | CHEMISTRY, ORGANIC | FLAVONOIDS | NEOLIGNANS | DIASTEREOISOMERS | CIRCULAR-DICHROISM | ABSOLUTE-CONFIGURATION | MARIANUM MILK THISTLE | FLAVONOLIGNANS | CONSTITUENTS
Journal Article
09/2012
Purpose: To investigate the effect of β-glucuronidase on the extraction efficiency of silymarin (mainly as silybin) from spiked human plasma using a sensitive... 
Extraction Efficiency | β-glucuronidase | Silymarin | Silybin | HPLC
Web Resource
Journal of China Pharmaceutical University, ISSN 1000-5048, 04/2018, Volume 49, Issue 2, pp. 202 - 208
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 05/2019, Volume 20, Issue 9, p. 2190
Silybin is a flavonolignan extracted from (milk thistle) with hepatoprotective, antioxidant, and anti-inflammatory activity. Several studies have shown that... 
miRNAs | sorafenib | silybin | PTEN | apoptosis | ceramides | hepatocarcinoma
Journal Article
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 01/2018, Volume 825, pp. 15 - 18
Journal Article
Yaoxue Xuebao, ISSN 0513-4870, 05/2016, Volume 51, Issue 5, pp. 813 - 820
Journal Article
Natural Product Communications, ISSN 1934-578X, 2017, Volume 12, Issue 2, pp. 175 - 178
Silymarin, the active constituent of Silybum marianum (milk thistle), and its main component, silybin, are products with well-known hepatoprotective,... 
Estrogen receptor | ADME/Tox properties | Silymarin | Silybins | CHEMISTRY, MEDICINAL | METABOLISM | FOOD SCIENCE & TECHNOLOGY | KNOWLEDGE | ESTROGEN | SYSTEMS | TOXICITY | DERIVATIVES | Silybin - toxicity | Humans | Models, Molecular | Silybin - chemistry | Molecular Docking Simulation | Silybin - pharmacokinetics | Intestinal Absorption
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 04/2018, Volume 59, Issue 17, pp. 1666 - 1669
Synthesis of 2,3-dehydrosilybin and 19- -demethyl-2,3-dehydrosilybin is reported starting from naturally abundant flavonolignan silybin using metal-pyridine/I... 
Silybin | 19-O-Demethyl-2,3-dehydrosilybin | Synthesis | Metal chelating | 2,3-Dehydrosilybin | Antitumor
Journal Article
Journal of Functional Foods, ISSN 1756-4646, 04/2015, Volume 14, pp. 570 - 580
The flavonolignan silybin (isolated from the fruits of the milk thistle, ), is a mixture of two diastereoisomers and has anticancer, chemoprotective,... 
Silybin | Silymarin | Benzofuranone | Silybin glucuronide | Silybin sulfate | Silibinin | ANTIOXIDANT ACTIVITY | FOOD SCIENCE & TECHNOLOGY | GLUCURONIDATION | MASS-SPECTROMETRY | PERFORMANCE LIQUID-CHROMATOGRAPHY | MARIANUM | IN-VITRO | ISOSILYBIN | MILK THISTLE | SILIBININ DIASTEREOMERS | SILYMARIN FLAVONOLIGNANS
Journal Article
LWT - Food Science and Technology, ISSN 0023-6438, 09/2015, Volume 63, Issue 1, pp. 77 - 84
The potential of nanoemulsion delivery systems to carry silybin from silymarin extract was studied. To this purpose, sunflower oil, extra virgin olive oil and... 
Delivery system | Invitro bioaccessibility | Stability | Nanoemulsion | Silybin
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2018, Volume 146, pp. 93 - 107
A series of neuroprotective hybrid compounds was synthesized by conjugation of the flavonolignan silibinin with natural phenolic acids, such as ferulic,... 
Silybin | FRAP assay | Stability | HT-22 cells | Esterification | NEURONAL CELL-LINE | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | NEURODEGENERATIVE DISEASES | SILYBIN DIASTEREOISOMERS | HT-22 cells | IN-VITRO | MILK THISTLE | FERULIC ACID | PROSTATE-CANCER | DRUG-INTERACTION | Esters | Peptides | Diastereomers | Health aspects | Index Medicus
Journal Article
The Journal of Supercritical Fluids, ISSN 0896-8446, 05/2015, Volume 100, pp. 105 - 109
Milk thistle is a plant that has been used medicinally for over 2000 years. It has been used for the treatment of many diseases such as cancer, liver, kidney,... 
Silybin A | Supercritical extraction | Silybin B | Milk thistle seeds | YIELD | LEAVES | COSOLVENT | CHEMISTRY, PHYSICAL | RESPONSE-SURFACE METHODOLOGY | MARIANUM | ENGINEERING, CHEMICAL | CO2 EXTRACTION | SILYMARIN | OPTIMIZATION | FLUID EXTRACTION | Petroleum mining | Milk
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