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1. Full Text Fulminant bilateral acute retinal necrosis complicated with secondary herpes simplex type-1 viral encephalitis A case report
by Ye, LQ and Ding, XS and Shen, SS and Wang, J and Wu, JM and Chen, YX
MEDICINE, ISSN 0025-7974, 08/2019, Volume 98, Issue 35, p. e17001
Rationale: Acute retinal necrosis (ARN), which is characterized by peripheral necrotizing retinitis, severe retinal arteritis, and progressive inflammatory... 
herpes simplex virus | Steroid | MEDICINE, GENERAL & INTERNAL | VIRUS | encephalitis | acute retinal necrosis syndrome | RETINITIS | polymerase chain reaction | Encephalitis | Complications and side effects | Retinal diseases | Risk factors
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2. Full Text Does porphyrin suppres the apoptotic and necrotic effects of bovine herpes virus type-1(BoHV-1) and herpes simplex virus type-1(HSV-1)?
by Yavuz, Beyza and Yazici, Zafer
Pakistan Journal of Pharmaceutical Sciences, ISSN 1011-601X, 09/2016, Volume 29, Issue 5, pp. 1633 - 1637
In this study, antiviral effect of porphyrin was investigated. Cooper strain of Bovine Herpes Virus type 1(BoHV-1) and Kos strain of Herpes Simplex Virus... 
Bovine Herpes Virus 1 | Herpes Simplex Virus 1 | Porphyrin | Apoptosis | Necrosis | Antiviral Agents - pharmacology | Cytopathogenic Effect, Viral - drug effects | Apoptosis - drug effects | Cercopithecus aethiops | Herpesvirus 1, Bovine - pathogenicity | Porphyrins - pharmacology | Herpesvirus 1, Human - drug effects | Host-Pathogen Interactions | Animals | Time Factors | Dogs | Madin Darby Canine Kidney Cells | Vero Cells | Herpesvirus 1, Human - pathogenicity | Herpesvirus 1, Bovine - drug effects | Antiviral agents | Care and treatment | Analysis | Herpes simplex | Physiological aspects | Herpes simplex virus
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3. Full Text Herpes simplex virus type-1 attachment inhibition by functionalized graphene oxide
by Sametband, Matias and Kalt, Inna and Gedanken, Aharon and Sarid, Ronit
ACS Applied Materials and Interfaces, ISSN 1944-8244, 01/2014, Volume 6, Issue 2, pp. 1228 - 1235
Graphene oxide and its derivatives have lately been the subject of increased attention in the field of bioscience and biotechnology. In this article, we report... 
functionalization | herpes simplex virus | virus inhibition | graphene oxide | plaque assay reduction | ENTRY | ASSAY | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOSHEETS | NANOSCIENCE & NANOTECHNOLOGY | HEPARAN-SULFATE | INFECTION | PROTEINS | CELL | DIAGNOSTICS | Graphite - administration & dosage | Antiviral Agents - chemistry | Heparitin Sulfate - chemistry | Nanostructures - administration & dosage | Humans | Oxides - chemistry | Nanostructures - chemistry | Graphite - chemistry | Antiviral Agents - administration & dosage | Oxides - administration & dosage | Herpesvirus 1, Human - drug effects
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4. Full Text Autophagy interaction with herpes simplex virus type-1 infection
by O'Connell, Douglas and Liang, Chengyu
Autophagy, ISSN 1554-8627, 03/2016, Volume 12, Issue 3, pp. 451 - 459
More than 50% of the U.S. population is infected with herpes simplex virus type-I (HSV-1) and global infectious estimates are nearly 90%. HSV-1 is normally... 
herpes simplex virus | neurodegeneration | autophagy | ICP34.5 | immune evasion | IMMUNE-RESPONSE | LATENT INFECTION | ALZHEIMERS-DISEASE | AXONAL-TRANSPORT | NEURODEGENERATIVE DISEASES | CELL BIOLOGY | ANTIVIRAL DEFENSE | ENDOGENOUS VIRAL-ANTIGENS | PROTEIN-KINASE PKR | CENTRAL-NERVOUS-SYSTEM | TRANSGENIC MICE | Neurons - pathology | Herpes Simplex - virology | Herpesvirus 1, Human - physiology | Nerve Degeneration - virology | Herpes Simplex - pathology | Humans | Risk Factors | Autophagy | Nerve Degeneration - pathology
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5. Full Text Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation
by Piacentini, Roberto and Li Puma, Domenica Donatella and Ripoli, Cristian and Marcocci, Maria Elena and De Chiara, Giovanna and Garaci, Enrico and Teresa Palamara, Anna and Grassi, Claudio
Scientific Reports, ISSN 2045-2322, 10/2015, Volume 5, Issue 1, p. 15444
Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer's Disease (AD)... 
TAU PHOSPHORYLATION | CHANNEL | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | INTRACELLULAR ACCUMULATION | A-BETA | GENE-EXPRESSION | PRECURSOR PROTEIN | TRANSGENIC MODEL | BRAIN | Neurons - pathology | Neurons - virology | Glycogen Synthase Kinase 3 - biosynthesis | Synaptic Transmission - genetics | Humans | Risk Factors | Cerebral Cortex - pathology | Gene Expression Regulation | Cerebral Cortex - virology | Synapsins - genetics | Alzheimer Disease - pathology | Alzheimer Disease - virology | Synaptophysin - genetics | Animals | Glycogen Synthase Kinase 3 - genetics | Synaptophysin - biosynthesis | Amyloid beta-Peptides - metabolism | Synapsins - biosynthesis | Mice | Neurons - metabolism | Alzheimer Disease - genetics | Herpesvirus 1, Human - pathogenicity
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6. Full Text Human Pharmacokinetic and Dosimetry Studies of [18F]FHBG: A Reporter Probe for Imaging Herpes Simplex Virus Type-1 Thymidine Kinase Reporter Gene Expression
by Yaghoubi, Shahriar and Barrio, Jorge R and Dahlbom, Magnus and Iyer, Meera and Namavari, Mohammad and Satyamurthy, Nagichettiar and Goldman, Robin and Herschman, Harvey R and Phelps, Michael E and Gambhir, Sanjiv S
The Journal of Nuclear Medicine, ISSN 0161-5505, 08/2001, Volume 42, Issue 8, pp. 1225 - 1234
9-[4-[F-18]fluoro-3-(hydroxymethyl)butyl]guanine ([F-18]FHBG) has been used as a reporter probe to image expression of herpes simplex virus type-1 thymidine... 
9-[4- | F]fluoro-3-(hydroxymethyl) butyl]guanine | Dosimetry | Herpes simplex virus type-1 thymidine kinase | PET | PENCICLOVIR | PROTEIN | dosimetry | RECONSTRUCTION | LIVING ANIMALS | herpes simplex virus type-1 thymidine kinase | 9-[4-[F-18]fluoro-3-(hydroxymethyl)butyl]guanine | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | REPLICATION | GANCICLOVIR | ASSAYS | MESOTHELIOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiopharmaceuticals - pharmacokinetics | Thymidine Kinase - genetics | Guanine - analogs & derivatives | Guanine - pharmacokinetics | Humans | Male | Calibration | Tissue Distribution | Herpesvirus 1, Human - enzymology | Image Processing, Computer-Assisted | Gene Expression Regulation, Enzymologic - genetics | Thymidine Kinase - biosynthesis | Adult | Female | Radiometry | Guanine - adverse effects | Radiopharmaceuticals - adverse effects | Tomography, Emission-Computed | Genes, Reporter
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7. Full Text Risk factors for herpes simplex virus type-1 infection and reactivation: Cross-sectional studies among EPIC-Norfolk participants
by Forbes, H and Warne, B and Doelken, L and Brenner, N and Waterboer, T and Luben, R and Wareham, NJ and Warren-Gash, C and Gkrania-Klotsas, E
PLOS ONE, ISSN 1932-6203, 05/2019, Volume 14, Issue 5, pp. e0215553 - e0215553
Background The prevalence of, and risk factors for, herpes simplex virus type-1 (HSV-1) infection and reactivation in older individuals are poorly understood.... 
POPULATION | NUTRITION | SEROPREVALENCE | CANCER | MULTIDISCIPLINARY SCIENCES | Herpesvirus diseases | Analysis | Herpes | Research | Herpes simplex virus | Risk factors | Prevalence studies (Epidemiology) | Immunoglobulin G | Herpes simplex | Viruses | Population studies | Infections | Activation | Epidemiology | Data dictionaries | Ethics | Questionnaires | Aging | Population | Children | Cross sections | Public health | Medical research | Antigens | Risk analysis | Primary care | Environmental conditions | Medicine | Ulcers | Herpes viruses | Kidney diseases | Cancer
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8. Full Text Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1
by Gescher, Kirsten and Hensel, Andreas and Hafezi, Wali and Derksen, Andrea and Kühn, Joachim
Antiviral Research, ISSN 0166-3542, 2011, Volume 89, Issue 1, pp. 9 - 18
The polyphenole-enriched acetone–water extract R2 from the aerial parts of L. containing high amounts of oligomeric and polymeric proanthocyanidins and... 
Penetration | Rumex acetosa | Epicatechin-3-O-gallate | Galloylation | Antiviral | Attachment | Herpes simplex virus type-1 | Organotypic skin model | Proanthocyanidins | ENTRY | COLORIMETRIC ASSAY | MEDICINES | VIROLOGY | PHARMACOLOGY & PHARMACY | MEDIATORS | CELL | BINDING | EXTRACT | Thiazoles - metabolism | Antiviral Agents - pharmacology | Cell Survival | Plant Extracts - pharmacology | Humans | Cercopithecus aethiops | Rumex - chemistry | Viral Plaque Assay | Plant Extracts - isolation & purification | Herpesvirus 1, Human - drug effects | Virus Attachment - drug effects | Microbial Sensitivity Tests | Herpesvirus 1, Human - physiology | Animals | Tetrazolium Salts - metabolism | Proanthocyanidins - pharmacology | Inhibitory Concentration 50 | Antiviral Agents - isolation & purification | Skin - virology | Vero Cells | Organ Culture Techniques | Proanthocyanidins - isolation & purification | Adenoviridae - drug effects | Virus diseases | Proteins | Antiviral agents | Analysis | Herpes simplex | Health aspects | Herpes simplex virus | Isoflavones
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9. Full Text Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains
by Wagner, Bettina and Wimer, Christine and Freer, Heather and Osterrieder, Nikolaus and Erb, Hollis N
Veterinary Immunology and Immunopathology, ISSN 0165-2427, 2011, Volume 143, Issue 1, pp. 116 - 124
The recent increase in incidence, morbidity, and mortality of neurological disease induced by equine herpesvirus type 1 (EHV-1) has suggested a change of... 
Pregnancy | Neonate | Innate immune response | Cytokine | Horse | Herpesvirus | SIMPLEX-VIRUS TYPE-1 | IL-10 PRODUCTION | RECEPTOR | HORSES | NEUROLOGIC DISEASE | THOROUGHBRED FOALS | IMMUNOLOGY | PLASMACYTOID DENDRITIC CELLS | GAMMA SYNTHESIS | EHV-1 | VETERINARY SCIENCES | T-CELLS | Animals, Newborn | Pregnancy Complications, Infectious - virology | Horses - immunology | Species Specificity | Interferon-alpha - biosynthesis | Herpesviridae Infections - veterinary | Immune Tolerance | Herpesviridae Infections - virology | Horse Diseases - virology | Leukocytes, Mononuclear - virology | Pregnancy Complications, Infectious - immunology | Pregnancy Complications, Infectious - veterinary | Herpesvirus 1, Equid - classification | Interleukin-4 - biosynthesis | Animals | Herpesvirus 1, Equid - immunology | Leukocytes, Mononuclear - immunology | Herpesvirus 1, Equid - pathogenicity | Female | Interleukin-10 - biosynthesis | Horses - virology | Horse Diseases - immunology | Herpesviridae Infections - immunology
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10. Full Text Silencing status epilepticus-induced BDNF expression with herpes simplex virus type-1 based amplicon vectors
by Falcicchia, Chiara and Trempat, Pascal and Binaschi, Anna and Perrier-Biollay, Coline and Roncon, Paolo and Soukupova, Marie and Berthommé, Hervé and Simonato, Michele
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0150995
Brain-derived neurotrophic factor (BDNF) has been found to produce pro-but also anti-epileptic effects. Thus, its validity as a therapeutic target must be... 
CONVERGENT TRANSCRIPTION | SPONTANEOUS SEIZURES | MESSENGER-RNAS | DOUBLE-STRANDED-RNA | CAENORHABDITIS-ELEGANS | TEMPORAL-LOBE EPILEPSY | GENETIC INTERFERENCE | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | RAT FOREBRAIN | MAMMALIAN-CELLS | Brain-Derived Neurotrophic Factor - genetics | Gene Transfer Techniques | Gene Expression | Genetic Vectors - administration & dosage | Humans | Gene Silencing | Cercopithecus aethiops | Rats | Status Epilepticus - drug therapy | Male | Status Epilepticus - genetics | DNA, Antisense - genetics | Genetic Vectors - genetics | Behavior, Animal | Hippocampus - metabolism | Animals | Plasmids - genetics | Cell Line, Tumor | Herpesvirus 1, Human - genetics | Transgenes | Gene Order | Vero Cells | Disease Models, Animal | Brain-derived neurotrophic factor | Analysis | Physiological aspects | Influence | Research | Gene expression | Status epilepticus | Health aspects | Herpes simplex virus | Brain | Neurosciences | Transcription | Epilepsy | Science | Herpes simplex | Viruses | Antisense | Genomes | Kinases | Inoculation | Rodents | Deoxyribonucleic acid--DNA | Expression vectors | Cytomegalovirus | Gene transfer | Therapeutic applications | Cloning | Pharmacology | Insects | Plasmids | Herpes viruses | In vivo methods and tests | Hippocampus | Deoxyribonucleic acid | DNA
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11. Full Text Detection of herpes simplex virus type-1 in patients with fibrotic lung diseases
by Lasithiotaki, Ismini and Antoniou, Katerina M and Vlahava, Virginia-Maria and Karagiannis, Konstantinos and Spandidos, Demetrios A and Siafakas, Nikolaos M and Sourvinos, George
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 12, p. e27800
The current study intends to investigate i) the incidence of herpes viruses including Herpes Simplex Virus type-1 (HSV-1), Cytomegalovirus (CMV) and Human... 
ACTIVATION | EPITHELIAL-CELLS | GAMMAHERPESVIRUS | DNA | INFLAMMATION | BIOLOGY | EBV | INFECTION | MICE | IDIOPATHIC PULMONARY-FIBROSIS | EPSTEIN-BARR-VIRUS | Cytomegalovirus - isolation & purification | Lung - pathology | Bronchoalveolar Lavage Fluid - virology | Humans | Gene Expression Regulation | Pulmonary Fibrosis - immunology | Pulmonary Fibrosis - genetics | Wound Healing | Immunity, Innate | Lung - virology | Pulmonary Fibrosis - virology | Pulmonary Fibrosis - metabolism | Herpesvirus 1, Human - pathogenicity | Herpesvirus 1, Human - isolation & purification | Infection | Care and treatment | Lung diseases | Genes | Herpes simplex | Genetic transcription | Vascular endothelial growth factor | Health aspects | Growth factors | Herpes simplex virus | CC chemokine receptors | Cell culture | Regulators | Pathogenesis | Lung cancer | Incidence | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Deoxyribonucleic acid--DNA | Wound healing | Cytokines | CCR7 protein | Bronchus | Cultures | Gene expression | Patients | CXCR4 protein | Studies | Polymerase chain reaction | Pulmonary fibrosis | Herpes viruses | Infertility | Fibrosis | Biological properties | Fibroblast growth factor | Biotechnology | Pneumonia | Transcription | Laboratories | Viruses | Infections | Kinases | Biological samples | Medical schools | Bronchoalveolar lavage | Alveoli | Cytomegalovirus | Sarcoidosis | Markers | Gelatinase B | Virology | Gelatinase A | Hypotheses | Biopsy | Chemokines | Viral infections | Acquired immune deficiency syndrome | AIDS | Human immunodeficiency virus | Deoxyribonucleic acid | HIV
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12. Full Text Herpes simplex virus type-1 infection affects the expression of extracellular matrix components in human nucleus pulposus cells
by Alpantaki, Kalliopi and Zafiropoulos, Alexandros and Tseliou, Melpomeni and Vasarmidi, Eirini and Sourvinos, George
Virus Research, ISSN 0168-1702, 01/2019, Volume 259, pp. 10 - 17
Intervertebral disc (IVD) degeneration has a complex multifactorial origin and it is tightly associated with changes in the secretion of proteoglycans and... 
Lytic infection | Intervertebral disc degeneration | Extracellular matrix | HSV-1 | Proteoglycans | Non-productive infection | Intervertebral Disc Degeneration - etiology | Cell Line | Intervertebral Disc - cytology | Gene Expression | Nucleus Pulposus - metabolism | Humans | Extracellular Matrix - metabolism | Magnetic Resonance Imaging - methods | Proteoglycans - metabolism | Intervertebral Disc Degeneration - diagnostic imaging | Intervertebral Disc - metabolism | Nucleus Pulposus - cytology | Herpes Simplex - genetics | Herpesvirus 1, Human | Intervertebral Disc Degeneration - metabolism | Herpes Simplex - metabolism | Intervertebral Disc Degeneration - pathology | Herpes Simplex - virology | Animals | Biomarkers | Microscopy, Fluorescence | Medical research | Collagen | Analysis | Genetic research | Medicine, Experimental | Herpes simplex | Hyaluronic acid | Health aspects | Herpes simplex virus
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13. Full Text Transient reversal of episome silencing precedes VP16-dependent transcription during reactivation of latent HSV-1 in neurons
by Kim, Ju Youn and Mandarino, Angelo and Chao, Moses V and Mohr, Ian and Wilson, Angus C
PLoS Pathogens, ISSN 1553-7366, 02/2012, Volume 8, Issue 2, p. e1002540
Herpes simplex virus type-1 (HSV-1) establishes latency in peripheral neurons, creating a permanent source of recurrent infections. The latent genome is... 
MACROMOLECULAR-SYNTHESIS | ACTIVATION DOMAIN | LYTIC INFECTION | MICROBIOLOGY | TRIGEMINAL GANGLIA | EARLY PROMOTERS | HERPES-SIMPLEX-VIRUS | HOST-CELL FACTOR | VIROLOGY | EARLY GENE-EXPRESSION | IMMEDIATE-EARLY TRANSCRIPTION | TYPE-1 MUTANT | PARASITOLOGY | Animals, Newborn | Amino Acid Sequence | Neurons - virology | Herpesvirus 1, Human - metabolism | Virus Replication - genetics | Cells, Cultured | Molecular Sequence Data | Rats | Rats, Sprague-Dawley | Virus Latency - physiology | Sequence Homology | Herpesvirus 1, Human - physiology | Animals | Time Factors | Models, Biological | Herpes Simplex Virus Protein Vmw65 - metabolism | Plasmids - genetics | Herpes Simplex Virus Protein Vmw65 - physiology | Herpesvirus 1, Human - genetics | Neurons - metabolism | Transcription, Genetic - genetics | Gene Silencing - physiology | Virus Replication - physiology | Virus Latency - genetics | Physiological aspects | Protein biosynthesis | Genetic aspects | Research | Genetic transcription | Gene expression | Health aspects | Herpes simplex virus | Proteins | Microbiology | Microscopy | Neurons | Viruses | Genomes | RNA polymerase | Experiments
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14. Full Text Transient viral-mediated overexpression of -calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell leads to long-lasting functional upregulation of -amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors: Dopamine type-1 receptor and protein kinase A dependence
by Singer, B.F and Loweth, J.A and Neve, R.L and Vezina, P
European Journal of Neuroscience, ISSN 0953-816X, 04/2010, Volume 31, Issue 7, pp. 1243 - 1251
Calcium/calmodulin-dependent protein kinase II (CaMKII) activity is necessary for the long-lasting expression of locomotor sensitization and enhanced... 
Protein kinase A | Locomotion | Dopamine type-1 receptor | Sensitization | Rat | Herpes simplex virus | Phenols | Neurosciences | Hydroxides | Glutamate | Protein kinases
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15. Full Text Recent observations on HIV type-1 infection in the genital tract of men and women
by Coombs, RW and Reichelderfer, PS and Landay, AL
AIDS, ISSN 0269-9370, 03/2003, Volume 17, Issue 4, pp. 455 - 480
HIV-1 | semen | cervix | SEXUALLY-TRANSMITTED DISEASES | INFECTIOUS DISEASES | HUMAN SEMINAL PLASMA | sexual transmission | VITAMIN-A-DEFICIENCY | AIDS | NECROSIS-FACTOR-ALPHA | virus shedding | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | LEUKOCYTE PROTEASE INHIBITOR | TIGHT EPITHELIAL BARRIERS | HERPES-SIMPLEX VIRUS | VIROLOGY | genitalia | ACTIVE ANTIRETROVIRAL THERAPY | mucous membrane | female | FEMALE REPRODUCTIVE-TRACT | male
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