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1. Full Text Synthesis of stereochemically diverse cyclic analogs of tubulysins
by Park, Yunjeong and Bae, Song Yi and Hah, Jung-Mi and Lee, Sang Kook and Ryu, Jae-Sang
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2015, Volume 23, Issue 21, pp. 6827 - 6843
The synthesis of tubulysin analogs containing stereochemically diverse cyclic Tuv moieties is described. A tetrahydropyranyl moiety was incorporated into the... 
Hetero Diels–Alder reaction | Antitumor agents | Peptides | Tubulysin | Asymmetric catalysis | Hetero Diels-Alder reaction | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DANISHEFSKYS | CHEMISTRY, ORGANIC | BOND FORMATION | SIMPLIFIED PRETUBULYSIN DERIVATIVES | ANTICANCER | N-METHYLAMINO ACIDS | BIOLOGICAL EVALUATION | RACEMIZATION | INHIBITORS | CYTOTOXICITY | MYXOBACTERIA | Antineoplastic Agents - metabolism | Oligopeptides - chemical synthesis | Tubulin - metabolism | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Catalysis | Oligopeptides - metabolism | Tubulin - chemistry | Antineoplastic Agents - chemistry | Cycloaddition Reaction | Oligopeptides - chemistry | Drugstores | Enantiomers | Tubulins | Aldehydes | Pharmacy
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2. Full Text Fabrication of QDNVM-based comparator
by Karmakar, S and Gogna, M and Jain, F
MICRO & NANO LETTERS, ISSN 1750-0443, 08/2019, Volume 14, Issue 9, pp. 947 - 951
This work presents the fabrication of 1 bit comparator circuit based on quantum dot gate non-volatile memory (QDNVM) for both analogue-to-digital and... 
reference voltage source | word length 1 | random-access storage | digital-to-analogue converters | MATERIALS SCIENCE, MULTIDISCIPLINARY | gate region | 0 bit | NANOSCIENCE & NANOTECHNOLOGY | analogue-digital conversion | digital-to-analogue signal processing applications | simplified comparator circuit | BIT ADC | QDNVM-based comparator | analogue-to-digital converters | semiconductor quantum dots | digital-analogue conversion | quantum dot gate nonvolatile memory | comparators (circuits) | comparator circuit | Digital to analog conversion | Circuits | Quantum dots | Analogue | Product design | Digital to analog converters | Comparators | Signal processing | Infrared radiation | Threshold voltage | Analog to digital conversion | Comparator circuits | Analog to digital converters
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3. Full Text Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs
by Niphakis, Micah J and Gay, Bryant C and Hong, Kwon Ho and Bleeker, Nicholas P and Georg, Gunda I
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2012, Volume 20, Issue 19, pp. 5893 - 5900
Tylophorine and many related phenanthropiperidine alkaloids are extraordinarily potent anti-proliferative agents. Despite their impressive anti-cancer... 
Tylophorine | Cytotoxicity | Synthesis | Phenanthropiperidine | Simplified analogs | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CELL-GROWTH | INHIBITION | (S)-(+)-TYLOPHORINE | PHENANTHROINDOLIZIDINE | DERIVATIVES | ALKALOIDS | NF-kappa B - antagonists & inhibitors | Alkaloids - pharmacology | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Phenanthrenes - chemistry | Phenanthrenes - pharmacology | Indolizines - chemistry | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Alkaloids - chemistry | Indolizines - pharmacology
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4. Full Text An evolutionary-based methodology for symbolic simplification of analog circuits using genetic algorithm and simulated annealing
by Shokouhifar, Mohammad and Jalali, Ali
Expert Systems With Applications, ISSN 0957-4174, 02/2015, Volume 42, Issue 3, pp. 1189 - 1201
In this paper, an evolutionary-based multi-objective criterion is introduced for simplified symbolic small-signal analysis of analog circuits containing... 
Analog circuits | Simplified symbolic analysis | Modified nodal analysis | Multi-objective optimization | Genetic algorithm | Simulated annealing | OPERATIONS RESEARCH & MANAGEMENT SCIENCE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE | ENGINEERING, ELECTRICAL & ELECTRONIC | Annealing | Algorithms | Analysis | Methods | Simplification | Methodology | Criteria | Genetic algorithms | Matlab
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5. Full Text Enhanced cellular uptake by "pharmaceutically oriented devices" of new simplified analogs of Linezolid with antimicrobial activity
by Parisi, Ortensia Ilaria and Fiorillo, Marco and Caruso, Anna and Cappello, Anna Rita and Saturnino, Carmela and Puoci, Francesco and Panno, Antonella and Dolce, Vincenza and El-Kashef, Hussein and Sinicropi, Maria Stefania
International Journal of Pharmaceutics, ISSN 0378-5173, 01/2014, Volume 461, Issue 1-2, pp. 163 - 170
The aim of the present study was to enhance cellular uptake of simplified analogs of Linezolid by their incorporation into suitable delivery devices in order... 
Enhanced cellular uptake | Drug carriers | Antimicrobial activity | Oxazolidinones | Simplified analogs of Linezolid | 2-OXAZOLIDINONES | ANTIBIOTICS | MICROSPHERES | ENDOCYTOSIS | ANTIBACTERIAL ACTIVITY | PRECIPITATION POLYMERIZATION | NANOSPHERES | PHARMACOLOGY & PHARMACY | EMULSIONS | BETA-LACTAMS | Linezolid | Emulsions | Anti-Infective Agents - pharmacology | Escherichia coli - drug effects | Acetamides - pharmacology | Saccharomyces cerevisiae - drug effects | Oxazolidinones - administration & dosage | Drug Delivery Systems | Oxazolidinones - chemistry | Microbial Sensitivity Tests | Nanoparticles | Acetamides - chemistry | Anti-Infective Agents - administration & dosage | Oxazolidinones - pharmacology | Anti-Infective Agents - chemistry | Polymers - chemistry | Acetamides - administration & dosage
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6. Full Text The Quest for a Simple Bioactive Analog of Paclitaxel as a Potential Anticancer Agent
by Kingston, David G. I and Snyder, James P
Accounts of Chemical Research, ISSN 0001-4842, 08/2014, Volume 47, Issue 8, pp. 2682 - 2691
Paclitaxel (PTX), introduced into the clinic in 1991, has revealed itself as an effective antimicrotubule drug for treatment of a range of otherwise... 
BETA-TUBULIN | SIMPLIFIED TAXOL ANALOGS | DESIGN | NATURAL-PRODUCTS | BIOLOGICAL EVALUATION | HYDROPHOBIC COLLAPSE | RECENT PROGRESS | T-TAXOL | CONFORMATION | NOVO CYTOTOXIC ALKALOIDS | CHEMISTRY, MULTIDISCIPLINARY | Paclitaxel - metabolism | Taxoids - chemistry | Paclitaxel - analogs & derivatives | Water - metabolism | Taxoids - metabolism | Antineoplastic Agents - chemistry | Antineoplastic Agents - metabolism | Thermodynamics | Tubulin - metabolism | Water - chemistry | Protein Binding | Tubulin - chemistry | Binding Sites | Antimitotic agents | Research | Chemical properties | Antineoplastic agents | Paclitaxel
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7. Full Text Enhanced cellular uptake by “pharmaceutically oriented devices” of new simplified analogs of Linezolid with antimicrobial activity
by Parisi, Ortensia Ilaria and Fiorillo, Marco and Caruso, Anna and Cappello, Anna Rita and Saturnino, Carmela and Puoci, Francesco and Panno, Antonella and Dolce, Vincenza and El-Kashef, Hussein and Sinicropi, Maria Stefania
International Journal of Pharmaceutics, ISSN 0378-5173, 01/2014, Volume 461, Issue 1-2, pp. 163 - 170
The aim of the present study was to enhance cellular uptake of simplified analogs of Linezolid by their incorporation into suitable delivery devices in order... 
Enhanced cellular uptake | Drug carriers | Antimicrobial activity | Oxazolidinones | Simplified analogs of Linezolid
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8. Full Text Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation
by Zhao, Jielu and Bane, Susan and Snyder, James P and Hu, Haipeng and Mukherjee, Kamalika and Slebodnick, Carla and Kingston, David G.I
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2011, Volume 19, Issue 24, pp. 7664 - 7678
A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been... 
Bioactive conformation | Tubulin | Antiproliferative activity | Taxol | Paclitaxel | X-ray | Simplified paclitaxel | T-Taxol | Modeling | BETA-TUBULIN | CHEMISTRY, MEDICINAL | MICROTUBULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | C-RING | AMINO-ACIDS | BINDING-SITE | BACCATIN-III | NOVO CYTOTOXIC ALKALOIDS | STEREOCONTROLLED SYNTHESIS | PINENE PATH | Antineoplastic Agents, Phytogenic - chemical synthesis | Paclitaxel - pharmacology | Paclitaxel - chemical synthesis | Humans | Molecular Conformation | Paclitaxel - analogs & derivatives | Models, Molecular | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Neoplasms - drug therapy | Paclitaxel - chemistry | Tubulin - metabolism | Drug Design | Cell Line, Tumor | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Tubulins | Analysis | bioactive conformation
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9. Design and synthesis of pyrazol-bridged simplified vinblastine analogues
by Guo, Cuiping and Peng, Qunlong and Pan, Long and Zhang, Dongmei and Chen, Heru
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 12/2014, Volume 34, Issue 12, pp. 2505 - 2510
Simplified design | Pharmacophore similarity | Drug synthesis | Antitumor | Vinca alkaloids analogues
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10. Synthesis of oxygen-bridged decahydroazulene derivatives: Simplified analogues of biologically active natural products
by Abe, Hideki and Tezuka, Akira and Kobayashi, Toyoharu and Ito, Hisanaka
Heterocycles, ISSN 0385-5414, 2014, Volume 88, Issue 1, pp. 651 - 662
Decahydroazulene derivatives having an ether bridge were synthesized. They are structurally simplified analogues of the biologically active guaiane... 
Structurally Simplified Analogue | ENANTIOSELECTIVE SYNTHESIS | Oxygen-Bridged Decahydroazulene Derivative | CHEMISTRY, ORGANIC | Orientalol F | Intramolecular Aldol Condensation | Englerin A
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11. Full Text Capecitabine plus oxaliplatin (XELOX) versus 5‐fluorouracil/leucovorin plus oxaliplatin (FOLFOX‐6) as first‐line treatment for metastatic colorectal cancer
by Ducreux, Michel and Bennouna, Jaafar and Hebbar, Mohamed and Ychou, Marc and Lledo, Gérard and Conroy, Thierry and Adenis, Antoine and Faroux, Roger and Rebischung, Christine and Bergougnoux, Loic and Kockler, Leila and Douillard, Jean‐Yves and French Anticanc Ctr FNCLCC and GI Group of the French Anti-Cancer Centers
International Journal of Cancer, ISSN 0020-7136, 02/2011, Volume 128, Issue 3, pp. 682 - 690
A regimen consisting of 5‐fluorouracil/leucovorin plus oxaliplatin (FOLFOX‐6) is widely used in France in the first‐line treatment of metastatic colorectal... 
capecitabine | metastatic colorectal cancer | oxaliplatin | 5‐fluorouracil/leucovorin | 5-fluorouracil/leucovorin | SURVIVAL | SOLID TUMORS | FLUOROURACIL | ORAL CAPECITABINE | 2ND-LINE THERAPY | FINAL REPORT | ONCOLOGY | HIGH-DOSE LEUCOVORIN | RANDOMIZED PHASE-III | SIMPLIFIED BIMONTHLY LEUCOVORIN | CONTINUOUS-INFUSION | Leucovorin - administration & dosage | Capecitabine | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Male | Young Adult | Neoplasm Metastasis | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Rectal Neoplasms - pathology | Rectal Neoplasms - drug therapy | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Treatment Outcome | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colonic Neoplasms - pathology | Aged | Colorectal Neoplasms - pathology | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Index Medicus
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12. Full Text Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A(2A) Adenosine Receptor Inverse Agonists with Antinociceptive Activity
by Varano, F and Catarzi, D and Vincenzi, F and Betti, M and Falsini, M and Ravani, A and Borea, PA and Colotta, V and Varani, K
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2016, Volume 59, Issue 23, pp. 10564 - 10576
In this study, we describe the design and synthesis of new N-5-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamines (2-18) and their pharmacological... 
NEUROPATHIC PAIN | CHEMISTRY, MEDICINAL | BIOCHEMICAL-CHARACTERIZATION | SIMPLIFIED ANALOGS | HYPERALGESIA | STRUCTURE-AFFINITY RELATIONSHIPS | BLOCKADE | BINDING | ANTAGONISTS. SYNTHESIS | DELETION | SKELETON
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13. Full Text Duplex Formation of the Simplified Nucleic Acid GNA
by Schlegel, Mark K and Peritz, Adam E and Kittigowittana, Krisada and Zhang, Lilu and Meggers, Eric
ChemBioChem, ISSN 1439-4227, 05/2007, Volume 8, Issue 8, pp. 927 - 932
Glycol nucleic acid (GNA) has an acyclic backbone of propylene glycol nucleosides that are connected by phosphodiester bonds. This paper characterizes the... 
duplex formation | GNA | nucleic acids | simplified backbone | acyclic backbone | DNA | Acyclic backbone | Duplex formation | Nucleic acids | Simplified backbone | simplified-backbone | OLIGODEOXYNUCLEOTIDES | CHEMISTRY, MEDICINAL | ARTIFICIAL DNA-BASE | NUCLEOSIDE ANALOGS | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | THYMINE | OLIGONUCLEOTIDES | CHEMICAL ETIOLOGY | NUCLEOTIDE ANALOGS | ALIPHATIC ANALOGS | DERIVATIVES | Thermodynamics | DNA - chemistry | Nucleic Acids - chemical synthesis | Nucleosides - chemistry | Temperature | Nucleic Acids - chemistry | Stereoisomerism | Sensitivity and Specificity | Propylene Glycols - chemistry | Organophosphates - chemistry | Nucleic Acid Conformation | Circular Dichroism - methods
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14. Full Text Automated Design of Analog Circuits Accelerated by Use of Simplified MOS Model and Reuse of Genetic Operations(Analog Circuits and Related SoC Integration Technologies)
by UNNO Naoyuki and FUJII Nobuo
IEICE transactions on electronics, ISSN 0916-8524, 06/2007, Volume 90, Issue 6, pp. 1291 - 1298
This paper presents an automated design of linear and non-linear differential analog circuits accelerated by reuse of genetic operations. The system first... 
genetic algorithm | simplified element | synthesis of analog differential circuits | SEARCH | reuse of genetic operations | design automation | ENGINEERING, ELECTRICAL & ELECTRONIC
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15. Full Text Streamlined Syntheses of (−)-Dictyostatin, 16-Desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-Desmethyl-25,26-dihydrodictyostatin
by Zhu, Wei and Jiménez, María and Jung, Won-Hyuk and Camarco, Daniel P and Balachandran, Raghavan and Vogt, Andreas and Day, Billy W and Curran, Dennis P
Journal of the American Chemical Society, ISSN 0002-7863, 07/2010, Volume 132, Issue 26, pp. 9175 - 9187
The dictyostatins are a promising class of potential anti-cancer drugs because they are powerful microtubule-stabilizing agents, but the complexity of their... 
DISCODERMOLIDE | NATURAL-PRODUCTS | METATHESIS APPROACH | BIOLOGICAL EVALUATION | FRAGMENT | CARBOXYLIC ESTERS | POTENT ANALOG | SIMPLIFIED ANALOGS | MICROTUBULE-STABILIZING MACROLIDE | STEREOSELECTIVE-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | Lithium - chemistry | Macrolides - chemistry | Macrolides - chemical synthesis | Humans | Cell Line, Tumor | Macrolides - pharmacology | Cell Proliferation - drug effects | Carbon - chemistry | Esterification | Lactones - chemistry | Antimitotic agents | Analysis | Methyl groups | Chemical properties | Ring formation (Chemistry) | Antineoplastic agents | Structure | Statins
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16. Full Text Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates
by Nicolaou, K. C and Erande, Rohan D and Yin, Jun and Vourloumis, Dionisios and Aujay, Monette and Sandoval, Joseph and Munneke, Stefan and Gavrilyuk, Julia
Journal of the American Chemical Society, ISSN 0002-7863, 03/2018, Volume 140, Issue 10, pp. 3690 - 3711
Improved, streamlined total syntheses of natural tubulysins such as V (Tb45) and U (Tb46) and pretubulysin D (PTb-D43), and their application to the synthesis... 
ANTICANCER ACTIVITY | N-METHYL TUBULYSIN | ANALOGS | AMINO-ACIDS | SIMPLIFIED PRETUBULYSIN DERIVATIVES | STEREOSELECTIVE-SYNTHESIS | INHIBITORS | ANGIOCOCCUS-DISCIFORMIS | ACID-ESTERS | CHEMISTRY, MULTIDISCIPLINARY | NATURAL TUBULYSINS | Drugs | Chemotherapy | Drug delivery systems | Lysine | Analysis | Chemical properties | Chemical synthesis | Cancer | Vehicles
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17. Full Text FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study
by Christophe Tournigand and Thierry André and Emmanuel Achille and Gérard Lledo and Michel Flesh and Dominique Mery-Mignard and Emmanuel Quinaux and Corinne Couteau and Marc Buyse and Gérard Ganem and Bruno Landi and Philippe Colin and Christophe Louvet and Aimery de Gramont
Journal of Clinical Oncology, ISSN 0732-183X, 01/2004, Volume 22, Issue 2, pp. 229 - 237
Purpose In metastatic colorectal cancer, phase III studies have demonstrated the superiority of fluorouracil (FU) with leucovorin (LV) in combination with... 
TRIAL | 1ST-LINE TREATMENT | 2ND-LINE THERAPY | ONCOLOGY | HIGH-DOSE LEUCOVORIN | FLUOROURACIL FAILURE | IRINOTECAN | OXALIPLATIN | SIMPLIFIED BIMONTHLY LEUCOVORIN | CONTINUOUS-INFUSION | 5-FLUOROURACIL REGIMEN | Leucovorin - administration & dosage | Injections, Intravenous | Drug Administration Schedule | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colorectal Neoplasms - drug therapy | Survival Analysis | Adult | Camptothecin - administration & dosage | Female | Aged | Infusions, Intravenous | Colorectal Neoplasms - pathology | Camptothecin - analogs & derivatives
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18. Full Text Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug
by Kikumori, Masayuki and Yanagita, Ryo C and Irie, Kazuhiro
Tetrahedron, ISSN 0040-4020, 12/2014, Volume 70, Issue 52, pp. 9776 - 9782
10-Methyl-aplog-1 ( ), a simplified analog of tumor-promoting aplysiatoxin, is a potential lead for cancer therapy that exhibits marked and selective growth... 
Protein kinase C | Simplified analog | Anticancer | Aplysiatoxin | Phorbol ester | ANALOG | TUMOR-PROMOTING APLYSIATOXIN | HOMOALLYLIC ALCOHOLS | CHEMISTRY, ORGANIC | BRYOSTATIN-1 | Antimitotic agents | Antineoplastic agents | Surgical implants | Biomedical materials | Toxicity | In vivo testing | In vivo tests | Biocompatibility | Hydroxyl groups | Cancer
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19. Full Text Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A Multicenter Study of the Gruppo Oncologico Dell'Italia Meridionale
by Colucci, Giuseppe and Gebbia, Vittorio and Paoletti, Giancarlo and Giuliani, Francesco and Caruso, Michele and Gebbia, Nicola and Cartenì, Giacomo and Agostara, Biagio and Pezzella, Giuseppe and Manzione, Luigi and Borsellino, Nicola and Misino, Andrea and Romito, Sante and Durini, Ernesto and Cordio, Stefano and Di Seri, Marisa and Lopez, Massimo and Maiello, Evaristo and Gruppo Oncologico Dell'Italia Meridionale
Journal of Clinical Oncology, ISSN 0732-183X, 2005, Volume 23, Issue 22, pp. 4866 - 4875
Purpose We performed this phase III study to compare the irinotecan, leucovorin (LV), and fluorouracil (FU) regimen (FOLFIRI) versus the oxaliplatin, LV, and... 
1ST-LINE TREATMENT | 2ND-LINE THERAPY | ONCOLOGY | HIGH-DOSE LEUCOVORIN | FLUOROURACIL FAILURE | OXALIPLATIN | SIMPLIFIED BIMONTHLY LEUCOVORIN | CONTINUOUS-INFUSION | FOLINIC ACID | 5-FLUOROURACIL REGIMEN | PLUS FLUOROURACIL | Leucovorin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Treatment Outcome | Disease Progression | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colorectal Neoplasms - drug therapy | Survival Analysis | Adult | Camptothecin - administration & dosage | Female | Aged | Infusions, Intravenous | Colorectal Neoplasms - pathology | Camptothecin - analogs & derivatives
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20. Full Text Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A(3) and A(2A) subtypes
by Poli, D and Falsini, M and Varano, F and Betti, M and Varani, K and Vincenzi, F and Pugliese, AM and Pedata, F and Dal Ben, D and Thomas, A and Palchetti, I and Bettazzi, F and Catarzi, D and Colotta, V
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 01/2017, Volume 125, pp. 611 - 628
The imidazo[1,2-a]pyrazine ring system has been chosen as a new decorable core skeleton for the design of novel adenosine receptor (AR) antagonists targeting... 
Adenosine receptor antagonists | CHEMISTRY, MEDICINAL | G protein-coupled receptors | CRYSTAL-STRUCTURE | Ligand-receptor modeling studies | SIMPLIFIED ANALOGS | STRUCTURE-AFFINITY RELATIONSHIPS | OXYGEN-GLUCOSE DEPRIVATION | CONFORMATIONAL ENERGIES | LIGANDS | Bicyclic heteroaromatic systems | HIGHLY POTENT | Imidazopyrazines | PHARMACOLOGICAL EVALUATION | DERIVATIVES | MOLECULAR-FORCE FIELD
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