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PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 9, p. e73875
Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein... 
TRANSCRIPTION FACTORS | HEART | RESVERATROL | LONGEVITY | PROMOTES CELL-SURVIVAL | ACTIVATION | DEACETYLASE | MULTIDISCIPLINARY SCIENCES | SIR2-ALPHA | SIRTUINS | EXPRESSION | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Superoxide Dismutase - genetics | Cell Proliferation | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Humans | Apoptosis - genetics | Stilbenes - pharmacology | Sirtuin 1 - genetics | Antimycin A - pharmacology | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Forkhead Transcription Factors - metabolism | Superoxide Dismutase - metabolism | Cell Line | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | Enzyme Activation - drug effects | Forkhead Transcription Factors - genetics | Hydrogen Peroxide - metabolism | Animals | Forkhead Box Protein O1 | Mice | Forkhead Box Protein O3 | Niacinamide | Oxidative stress | Ionizing radiation | Resveratrol | DNA binding proteins | Tumor proteins | Apoptosis | NADPH | Transcription factors | p53 Protein | Superoxide dismutase | Kinases | Modulators | Muscular dystrophy | Proteins | Mitochondria | FOXO1 protein | Rodents | Antimycin A | Aging | FOXO4 protein | Forkhead protein | FOXO3 protein | Heart failure | Immunoglobulins | Cell survival | Pharmacology | siRNA | Survival | SIRT1 protein | NAD | Medicine | Deacetylation | Cell death | Tumor suppressor genes | Nicotinamide | Mutation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 31, pp. 13736 - 13741
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 10/2005, Volume 16, Issue 10, pp. 4623 - 4635
Sir2 is a NAD+-dependent protein deacetylase that extends lifespan in yeast and worms. This study examines seven human proteins homologous to Sir2 (SIRT1... 
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173002
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2003, Volume 100, Issue 19, pp. 10794 - 10799
Journal Article
Journal Article
Aging, ISSN 1945-4589, 2010, Volume 2, Issue 7, pp. 415 - 431
SIRT1 is increasingly recognized as a critical regulator of stress responses, replicative senescence, inflammation, metabolism, and aging. SIRT1 expression is... 
Post-transcriptional regulation | Reprogramming | miRNAs | Differentiation | SIRT1 | Mouse embryonic stem cells | LIFE-SPAN | differentiation | post-transcriptional regulation | DNA-DAMAGE | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | reprogramming | LUNG-CANCER | CAENORHABDITIS-ELEGANS | MICE | mouse embryonic stem cells | STRESS | HISTONE DEACETYLASE | SIR2-ALPHA PROTEIN | CALORIE RESTRICTION | MICRORNA
Journal Article
Journal Article