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ACS Chemical Biology, ISSN 1554-8929, 01/2011, Volume 6, Issue 1, pp. 47 - 60
In the 12 years since the process of RNA interference (RNAi) was first discovered, great progress has been made in understanding its mechanism and exploiting... 
siRNA or miRNA seed sequence | RISC | microRNA (miRNA) | GENOME-WIDE RNAI | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | Short interfering RNA (siRNA) | FUNCTIONAL DISSECTION | MAMMALIAN-CELLS | DEPENDENT STIMULATION | SMALL INTERFERING RNAS | MESSENGER-RNAS | RNA Interference | RNAI off-target effect | GENE-EXPRESSION | C-ELEGANS | siRNA multiplicity validation | HIV-1 REPLICATION | RNA, Small Interfering - genetics | Gene Expression | Down-Regulation | Genomics | RNA, Messenger - genetics | Untranslated Regions | Validation Studies as Topic | Transcription, Genetic | MicroRNAs - genetics | RNA, Double-Stranded - chemistry | Genetic Techniques - standards | RNA, Small Interfering - metabolism | Short interfering RNA (siRNA): An endogenous or artificial (synthetic) small double strand RNA with perfect pairing of the two strands. One strand (called the guide strand) targets RISC to perfectly complementary mRNAs, resulting in endonucleolytic cleavage of the mRNA by the RISC component Ago2 | siRNA or miRNA seed sequence: The 5′ region of the guide strand of an siRNA or miRNA sequence, extending from nucleotides 2–7 (hexamer) or 2–8 (heptamer) | or mRNA decay | siRNA multiplicity validation: Validation of a gene-phenotype association by showing that the phenotype can be produced by multiple independent siRNAs that target different regions of the same mRNA | MicroRNA (miRNA): A mature endogenous small double strand RNA, often with imperfect pairing of the two strands, originating from processing of a precursor RNA molecule by cellular RNases. miRNAs target RISC complexes to sites that have imperfect sequence complementarity, and that are typically located in the 3′ untranslated region of the mRNA | RISC: The RNA-Induced Silencing Complexes are multi-protein complexes containing an Argonaute protein, a small single strand RNA and additional regulatory proteins | RNA interference: A cellular process that downregulates gene expression at a post-transcriptional step. One strand of a small double strand RNA (siRNA or miRNA) integrates in a protein complex called RISC and targets an mRNA with sequence complementarity for cleavage, translation inhibition and | RNAi off-target effect: Any effect of an RNAi-based treatment that is a consequence of reducing the expression of an unintended target
Journal Article
2004, 2nd ed., Methods in molecular biology, ISBN 1588292266, Volume 252., xv, 623
In this completely updated and expanded edition of a classic bench manual, hands-on experts take advantage of the latest advances in ribozyme, DNAzyme,... 
Small interfering RNA | Catalytic RNA | Cytology | Cell Biology | Life Sciences
Book
The Plant Journal, ISSN 0960-7412, 07/2011, Volume 67, Issue 2, pp. 292 - 304
Summary As important components of small RNA (smRNA) pathways, Argonaute (AGO) proteins mediate the interaction of incorporated smRNAs with their targets.... 
microRNA | nat‐siRNA | AGO4 | AGO1 | post‐transcriptional gene silencing | trans‐acting siRNAs | trans-acting siRNAs | post-transcriptional gene silencing | nat-siRNA | POLYMERASE-IV | SIRNA BIOGENESIS | MECHANISMS | IDENTIFICATION | PLANT SCIENCES | DIRECTED DNA-METHYLATION | ANTISENSE TRANSCRIPTS | MIRNA | ACCUMULATION | ARGONAUTE4 | Arabidopsis Proteins - genetics | Argonaute Proteins - metabolism | RNA, Plant - isolation & purification | Argonaute Proteins - genetics | Immunoprecipitation | Gene Library | Molecular Sequence Annotation | DNA-Directed RNA Polymerases - genetics | RNA, Plant - genetics | MicroRNAs - classification | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - isolation & purification | Arabidopsis Proteins - metabolism | MicroRNAs - isolation & purification | RNA Interference | Argonaute Proteins - isolation & purification | High-Throughput Nucleotide Sequencing | MicroRNAs - genetics | DNA-Directed RNA Polymerases - metabolism | Arabidopsis thaliana | Proteins | RNA | Developmental biology | Analysis | DNA polymerases | Green Revolution | Plant biology | Signal transduction | Flowers & plants | Ribonucleic acid--RNA | Gene silencing | Leaves | Post-transcription | Transcription | Roots | Conservation | Antisense | miRNA | siRNA | Flowers | DNA-directed RNA polymerase | Seedlings | Original
Journal Article
BMC Genomics, 09/2018, Volume 19
Journal Article
Biotechnology and bioengineering, ISSN 1097-0290, 2018, Volume 115, Issue 9, pp. 2280 - 2291
Journal Article