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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 44, pp. 16260 - 16265
Maintaining muscle size and fiber composition requires contractile activity. Increased activity stimulates expression of the transcriptional coactivator PGC-1α... 
Fasting | Messenger RNA | Transgenic animals | Genes | Muscles | Muscle fibers | Diabetes | Muscular atrophy | Skeletal muscle | Denervation | SIGNALING PATHWAYS | denervation | muscle fiber | mitochondria | MULTIDISCIPLINARY SCIENCES | RATS | fasting | EXERCISE | FOOD-DEPRIVATION | COACTIVATOR PGC-1 | GROWTH | DEGRADATION | EXPRESSION | energy metabolism | DENERVATION ATROPHY | UBIQUITIN-PROTEASOME PATHWAY
Journal Article
The Journal of Physiology, ISSN 0022-3751, 10/2014, Volume 592, Issue 20, pp. 4575 - 4589
Prolonged skeletal muscle inactivity causes muscle fibre atrophy. Redox imbalance has been considered one of the major triggers of skeletal muscle disuse... 
TIBIALIS ANTERIOR | SKELETAL-MUSCLE | GAMMA COACTIVATOR 1-ALPHA | OXIDATIVE STRESS | PHYSIOLOGY | MITOCHONDRIAL BIOGENESIS | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | UBIQUITIN LIGASES | PROTEIN-SYNTHESIS | NEUROSCIENCES | ANTIOXIDANT CAPACITY | Up-Regulation | Dynamins - metabolism | Superoxide Dismutase - genetics | Oxidative Stress | SKP Cullin F-Box Protein Ligases - genetics | Mitochondria, Muscle - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | RNA, Messenger - metabolism | Autophagy | Tripartite Motif Proteins | Chromans - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | NF-E2-Related Factor 2 - genetics | Muscular Atrophy - prevention & control | Muscle Fibers, Skeletal - physiology | Superoxide Dismutase - metabolism | Beclin-1 | Muscular Atrophy - metabolism | Catalase - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Dynamins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Antioxidants - pharmacology | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Catalase - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Antioxidants - therapeutic use | Animals | Chromans - therapeutic use | Hindlimb Suspension - adverse effects | NF-E2-Related Factor 2 - metabolism | Mice | Mitochondria, Muscle - drug effects | Superoxide Dismutase-1 | Ubiquitin-Protein Ligases - genetics | Index Medicus | Muscle
Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2007, Volume 585, Issue 1, pp. 203 - 215
Oxidative stress promotes controlled mechanical ventilation (MV)-induced diaphragmatic atrophy. Nonetheless, the signalling pathways responsible for oxidative... 
CHAIN MESSENGER-RNA | DISUSE ATROPHY | SKELETAL-MUSCLE | OXIDATIVE STRESS | VITAMIN-E | IN-VITRO | PHYSIOLOGY | SOLEUS MUSCLE | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | EXPRESSION | NEUROSCIENCES | Diaphragm - drug effects | Insulin - physiology | SKP Cullin F-Box Protein Ligases - genetics | Oxidative Stress - physiology | Insulin-Like Growth Factor I - genetics | Proto-Oncogene Proteins c-akt - genetics | Tripartite Motif Proteins | Chromans - pharmacology | Respiration, Artificial - adverse effects | Forkhead Transcription Factors - metabolism | Muscle Proteins - metabolism | Female | Muscular Atrophy - prevention & control | Diaphragm - metabolism | Muscular Atrophy - etiology | Diaphragm - physiopathology | Ubiquitin-Protein Ligases - metabolism | Rats | Proto-Oncogene Proteins c-akt - physiology | SKP Cullin F-Box Protein Ligases - metabolism | Antioxidants - pharmacology | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Muscle Proteins - genetics | Nerve Tissue Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Antioxidants - therapeutic use | Animals | Chromans - therapeutic use | Insulin-Like Growth Factor I - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Oxidative Stress - drug effects | Forkhead Box Protein O3 | Ubiquitin-Protein Ligases - genetics | Antioxidants | Physiological aspects | Protein kinases | Index Medicus | Respiratory
Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2006, Volume 576, Issue 3, pp. 923 - 933
Skeletal muscle size is tightly regulated by the synergy between anabolic and catabolic signalling pathways which, in humans, have not been well characterized.... 
TRANSCRIPTION FACTORS | INSULIN | ACTIVATION | PHYSIOLOGY | KINASE | ALPHA | TRANSLATION | PROTEIN-SYNTHESIS | EXPRESSION | UBIQUITIN-PROTEASOME PATHWAY | RESISTANCE-EXERCISE | Skeletal Muscle and Exercise
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2013, Volume 369, Issue 3, pp. 233 - 244
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6670 - 6670
Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid... 
SKELETAL-MUSCLE | HYPERTROPHY | HOMEOSTASIS | GENE | MULTIDISCIPLINARY SCIENCES | MASS | DEGRADATION | ATROGIN-1 | IDENTIFICATION | INVOLVE | EXPRESSION | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2008, Volume 358, Issue 13, pp. 1327 - 1335
Journal Article