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skp cullin f-box protein ligases - metabolism (488) 488
animals (470) 470
index medicus (417) 417
humans (337) 337
skp cullin f-box protein ligases - genetics (308) 308
muscle proteins - metabolism (258) 258
mice (225) 225
biochemistry & molecular biology (220) 220
male (212) 212
ubiquitin-protein ligases - metabolism (207) 207
tripartite motif proteins (184) 184
muscle proteins - genetics (183) 183
cell biology (177) 177
muscle, skeletal - metabolism (161) 161
phosphorylation (150) 150
ubiquitin (142) 142
ubiquitin-protein ligases - genetics (141) 141
proteolysis (138) 138
rats (136) 136
atrophy (134) 134
gene-expression (129) 129
physiology (127) 127
signal transduction (107) 107
cell line (105) 105
proteins (103) 103
muscle, skeletal - pathology (101) 101
ubiquitin - metabolism (99) 99
skeletal-muscle (96) 96
ligases (95) 95
muscular atrophy - metabolism (93) 93
skp cullin f-box protein ligases (93) 93
degradation (92) 92
female (90) 90
rna, messenger - metabolism (89) 89
ubiquitin ligases (88) 88
gene expression (87) 87
expression (82) 82
f-box proteins - metabolism (82) 82
research (82) 82
foxo transcription factors (79) 79
physiological aspects (78) 78
cell cycle proteins - metabolism (77) 77
proteasome endopeptidase complex - metabolism (76) 76
ubiquitination (76) 76
muscles (75) 75
amino acid sequence (72) 72
protein binding (71) 71
signal transduction - physiology (71) 71
molecular sequence data (69) 69
proto-oncogene proteins c-akt - metabolism (69) 69
article (68) 68
skp cullin f-box protein ligases - physiology (68) 68
activation (66) 66
mice, inbred c57bl (66) 66
muscle, skeletal - drug effects (66) 66
muscular atrophy - pathology (66) 66
f-box proteins (65) 65
cell cycle (62) 62
cells, cultured (61) 61
ubiquitin ligase (61) 61
atrogin-1 (57) 57
f-box proteins - genetics (57) 57
forkhead transcription factors - metabolism (57) 57
hypertrophy (57) 57
mutation (57) 57
skeletal muscle (57) 57
rats, sprague-dawley (56) 56
complex (55) 55
protein (55) 55
muscle fibers, skeletal - metabolism (53) 53
research article (53) 53
transcription factors - metabolism (51) 51
gene expression regulation (48) 48
oxidative stress (48) 48
rats, wistar (48) 48
transcription factors (48) 48
peptide synthases - metabolism (47) 47
time factors (47) 47
scf (46) 46
cancer (45) 45
cell cycle proteins - genetics (45) 45
f-box protein (45) 45
musculoskeletal system (45) 45
disease models, animal (44) 44
ubiquitin-protein ligases (44) 44
cell line, tumor (42) 42
pathway (42) 42
ubiquitins - metabolism (42) 42
endocrinology & metabolism (41) 41
hela cells (41) 41
mice, knockout (41) 41
models, biological (41) 41
forkhead box protein o3 (40) 40
multidisciplinary sciences (40) 40
muscular atrophy - genetics (40) 40
rna, messenger - genetics (40) 40
analysis (39) 39
transcription factors - genetics (39) 39
biology (38) 38
biophysics (38) 38
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Journal Article
Biogerontology, ISSN 1389-5729, 2013, Volume 14, Issue 3, pp. 303 - 323
During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle... 
Life Sciences | Sarcopenia | FoxO | Geriatrics/Gerontology | Ageing | mTOR | IGF1 | Akt | Developmental Biology | Cell Biology | LIFE-SPAN | IGF-I | ALPHA-V-BETA-3 INTEGRIN | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | GERIATRICS & GERONTOLOGY | GROWTH-HORMONE | MESSENGER-RNA | GENETIC-DETERMINANTS | FAST-TWITCH | CELL-CYCLE | S6 KINASE | Microtubule-Associated Proteins - genetics | SKP Cullin F-Box Protein Ligases - genetics | Humans | SKP Cullin F-Box Protein Ligases - physiology | Male | Forkhead Transcription Factors - physiology | Ubiquitin-Protein Ligases - physiology | Tripartite Motif Proteins | Young Adult | Aged, 80 and over | Adult | Female | Mice, Inbred DBA | Models, Animal | TOR Serine-Threonine Kinases - physiology | Muscle Proteins - physiology | Serpin E2 - physiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins c-akt - physiology | Muscle, Skeletal - physiology | Mice, Knockout | Microtubule-Associated Proteins - physiology | Muscle Proteins - genetics | Autophagy-Related Protein 7 | Sarcopenia - physiopathology | Serpin E2 - genetics | Animals | Aging - physiology | Insulin-Like Growth Factor I - physiology | Adolescent | Signal Transduction - physiology | Aged | Forkhead Box Protein O1 | Mice | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Muscles | Ligases | Proteolysis | Analysis | SKP Cullin F-Box Protein Ligases | Muscle Proteins | Aging | Serpin E2 | Signal Transduction | Biochemistry, Molecular Biology | Microtubule-Associated Proteins | Insulin-Like Growth Factor I | Proto-Oncogene Proteins c-akt | Ubiquitin-Protein Ligases | TOR Serine-Threonine Kinases | Muscle, Skeletal | Forkhead Transcription Factors | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Clinical Neurophysiology | Klinisk neurofysiologi | Klinisk medicin
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2410 - 2424
Cardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome system and is fundamental for cardiac adaptation to both... 
SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | SKP Cullin F-Box Protein Ligases - physiology | Male | Muscle Proteins - deficiency | Autophagy - physiology | Cardiomyopathies - etiology | Cardiomyopathies - physiopathology | Lysosomes - metabolism | Endosomal Sorting Complexes Required for Transport - antagonists & inhibitors | Electrocardiography | Muscle Proteins - physiology | Disease Models, Animal | Nerve Tissue Proteins - antagonists & inhibitors | SKP Cullin F-Box Protein Ligases - deficiency | Mice, Inbred C57BL | Endosomal Sorting Complexes Required for Transport - metabolism | Tachycardia, Ventricular - etiology | Cardiomyopathies - pathology | Unfolded Protein Response | Nerve Tissue Proteins - genetics | Mice, Knockout | Muscle Proteins - genetics | Nerve Tissue Proteins - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - physiology | Endoplasmic Reticulum Stress | Mice | Apoptosis - physiology | Proteasome Endopeptidase Complex - metabolism | Autophagy (Cytology) | Protein research | Cardiomyopathy | Heart cells | Physiological aspects | Heart diseases | Health aspects | Risk factors | Proteins | Heart | Enzymes | Protein synthesis | Rodents | Colleges & universities | Cardiomyocytes | Kinases | Autophagy | Age
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 7/2008, Volume 65, Issue 13, pp. 1977 - 2000
A signature feature of all living organisms is their utilization of proteins to construct molecular machineries that undertake the complex network of cellular... 
Life Sciences | Biochemistry, general | 26S proteasome | Life Sciences, general | F-box | ubiquitination | SCF | Biomedicine general | protein degradation | Cell Biology | Protein degradation | Ubiquitination | ANAPHASE-PROMOTING COMPLEX | GLR-1 GLUTAMATE RECEPTORS | VENTRAL NERVE CORD | BIOCHEMISTRY & MOLECULAR BIOLOGY | DROSOPHILA CIRCADIAN CLOCK | UBIQUITIN-LIGASE COMPLEX | SCF-BETA-TRCP | LEUCINE-RICH REPEAT | CELL BIOLOGY | PHOSPHORYLATION-DEPENDENT DEGRADATION | CONTROLS S-PHASE | I-KAPPA-B | Genomic Instability | Arabidopsis - physiology | Phosphorylation | Drosophila melanogaster - physiology | Arabidopsis - growth & development | SKP Cullin F-Box Protein Ligases - genetics | Multiprotein Complexes | SKP Cullin F-Box Protein Ligases - physiology | Drosophila melanogaster - genetics | Caenorhabditis elegans - physiology | Dimerization | Caenorhabditis elegans - growth & development | Caenorhabditis elegans - genetics | Synapses - physiology | F-Box Proteins - chemistry | Circadian Rhythm | SKP Cullin F-Box Protein Ligases - chemistry | Arabidopsis - genetics | Host-Pathogen Interactions | Animals | F-Box Proteins - physiology | Cell Cycle | Models, Biological | Drosophila melanogaster - growth & development | Protein Processing, Post-Translational | F-Box Proteins - genetics | Proteins | Proteolysis | Electric utilities | Cellular biology | Substrates
Journal Article
BLOOD, ISSN 0006-4971, 02/2012, Volume 119, Issue 5, pp. 1151 - 1161
Mixed lineage leukemia (MLL) is a key epigenetic regulator of normal hematopoietic development and chromosomal translocations involving MLL are one of the most... 
TRANSFORMATION | PR-SET7 | CHROMOSOMAL TRANSLOCATIONS | REGULATOR | PHOSPHORYLATION | INTERACTS | GENE-EXPRESSION | FUSION PROTEIN | EXECUTION | ANKYRIN REPEAT | HEMATOLOGY | Myeloid-Lymphoid Leukemia Protein - metabolism | Transcription Factors - chemistry | SKP Cullin F-Box Protein Ligases - genetics | Humans | Protein Processing, Post-Translational - genetics | SKP Cullin F-Box Protein Ligases - physiology | Multiprotein Complexes - genetics | Cullin Proteins - physiology | Leukemia - metabolism | Myeloid-Lymphoid Leukemia Protein - chemistry | Elongin | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | Leukemia - etiology | Transfection | Proteolysis | HEK293 Cells | Cullin Proteins - metabolism | Hematopoietic Stem Cells - physiology | Hematopoiesis - physiology | Suppressor of Cytokine Signaling Proteins - chemistry | Leukemia - genetics | Transcription Factors - physiology | Histone-Lysine N-Methyltransferase | Cells, Cultured | Suppressor of Cytokine Signaling Proteins - genetics | Hematopoiesis - genetics | Hematopoietic Stem Cells - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Transcription Factors - genetics | Protein Processing, Post-Translational - physiology | SKP Cullin F-Box Protein Ligases - chemistry | Multiprotein Complexes - physiology | Cullin Proteins - chemistry | Cullin Proteins - genetics | Transcription Factors - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | K562 Cells | Suppressor of Cytokine Signaling Proteins - physiology | Suppressor of Cytokine Signaling Proteins - metabolism | Hematopoiesis and Stem Cells
Journal Article
Journal Article