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slc7a11 (52) 52
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Cell Reports, ISSN 2211-1247, 10/2016, Volume 17, Issue 2, pp. 366 - 373
Although previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, and senescence does not completely abrogate its tumor suppression... 
acetylation | tumor suppression | ferroptosis | transcription | deacetylation | SLC7A11 | p53 | metabolic regulation | APOPTOSIS | RESPONSES | ACTIVATION | INAUHZIN | GROWTH | CELL-CYCLE ARREST | METABOLIC-REGULATION | ABSENCE | NOXA | P53 | CELL BIOLOGY | Index Medicus | metabolic regulation Transcription | SLC7A11 and tumor suppression
Journal Article
Oncotarget, 08/2018, Volume 9, Issue 64, pp. 32280 - 32297
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 12/2016, Volume 14, Issue 12, pp. 1229 - 1242
Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor in adults. Several studies have shown that glioma cells up-regulate the... 
chemoresistance | glutathione | glioma | metabolism | SLC7A11 | oxidative stress
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 08/2019
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 10/2012, Volume 18, Issue 19, pp. 5427 - 5437
Purpose: (4S)-4-(3-[F-18]fluoropropyl)-L-glutamate (BAY 94-9392, alias [F-18]FSPG) is a new tracer to image x(C)(-) transporter activity with positron emission... 
CYSTINE | GAMMA-GLUTAMYL-TRANSPEPTIDASE | METABOLISM | ONCOLOGY | GLUTATHIONE | RESISTANCE | SLC7A11 | EXCHANGE | PLASMA-MEMBRANE | EXPRESSION | CD44
Journal Article
Oncotarget, ISSN 1949-2553, 08/2018, Volume 9, Issue 64, pp. 32280 - 32297
About 3 million US cancer patients and 1.7 million EU cancer patients received multiple doses of radiation therapy (RT) in 2012, with treatment duration... 
Journal Article
Amino Acids, ISSN 0939-4451, 1/2012, Volume 42, Issue 1, pp. 231 - 246
The oxidative stress-inducible cystine/glutamate exchange system, system x c − , transports one molecule of cystine, the oxidized form of cysteine, into cells... 
Biochemistry, general | 4F2 | Neurobiology | xCT | Cystine/cysteine redox cycle | Slc7a11 | Glutamate | Life Sciences | Analytical Chemistry | Life Sciences, general | Biochemical Engineering | Proteomics | Glutathione | XCT
Journal Article
Autophagy, ISSN 1554-8627, 12/2018, Volume 14, Issue 12, pp. 2173 - 2175
Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a... 
BECN1 | autophagy | ferroptosis | AMPK | cancer | SLC7A11 | chemotherapy | phosphorylation | redox | CELL BIOLOGY | Index Medicus
Journal Article
Current Biology, ISSN 0960-9822, 08/2018, Volume 28, Issue 15, pp. 2388 - 2399.e5
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X . However, key... 
BECN1 | cancer therapy | autophagy | ferroptosis | autosis | AMPK | SLC7A11 | lipid peroxidation | phosphorylation | necroptosis
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 10/2019, Volume 236, pp. 110529 - 110529
Red tilapia has become more popular for aquaculture production in China in recent years. However, the pigmentation differentiation that has resulted from the... 
Skin color differentiation | slc7a11 | RNA interference | Red tilapia | Localization | Expression | Index Medicus
Journal Article
Current Biology, ISSN 0960-9822, 08/2018, Volume 28, Issue 15, pp. 2388 - 2399.e5
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X . However, key... 
BECN1 | cancer therapy | autophagy | ferroptosis | autosis | AMPK | SLC7A11 | lipid peroxidation | phosphorylation | necroptosis | BECLIN 1 | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES AUTOPHAGY | KINASE | AUTOPHAGIC CELL-DEATH | DEGRADATION | INDUCTION | PROTEINS | PROTECTS | CELL BIOLOGY
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2019, Volume 18, Issue 8, pp. 773 - 783
SLC7A11 (or xCT) imports extracellular cystine into cells to promote glutathione synthesis, thus inhibiting ferroptosis. SLC7A11 expression is tightly... 
H2A ubiquitination | ferroptosis | SLC7A11 | PRC1 | BAP1 | COMPLEX | INHIBITION | TRANSPORTER GENE | CHECKPOINT | ANTIPORTER | POLYCOMB | CELL-DEATH | CELL BIOLOGY
Journal Article
Molecular & Cellular Oncology, ISSN 2372-3556, 01/2019, Volume 6, Issue 1, pp. 1536845 - 1536845
The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development... 
tumor suppression | H2A ubiquitination | metabolism | ferroptosis | SLC7A11 | BAP1
Journal Article
eLife, ISSN 2050-084X, 05/2014, Volume 3, Issue 3, pp. e02523 - e02523
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2012, Volume 14, Issue 3, pp. 276 - 286
Journal Article
The World Journal of Biological Psychiatry, ISSN 1562-2975, 05/2019, Volume 20, Issue 5, pp. 381 - 392
Objectives: The cystine/glutamate antiporter (system xc-) is believed to contribute to nonvesicular glutamate release from glial cells in various brain areas.... 
system xc | slc7a11 | Depression | glutamate | N-acetylcysteine | OXIDATIVE STRESS | PSYCHIATRY | INVOLVEMENT | X(C)(-) | RAT MODEL | ANTIDEPRESSANT-LIKE ACTIVITY | TRANSMISSION | DOUBLE-BLIND | ANTAGONISTS
Journal Article
JOURNAL OF PSYCHIATRIC RESEARCH, ISSN 0022-3956, 01/2016, Volume 72, pp. 58 - 63
Background: The cystine/glutamate antiporter system x(c)(-), playing a critical role in the regulation of glutamate release, might be implicated in the... 
OXIDATIVE STRESS | TRANSPORTER | PSYCHIATRY | System x(c)(-) | Schizophrenia | SLC3A2 | SLC7A11 | PLASMA-MEMBRANE | CYSTINE | D-SERINE | CYSTINE/GLUTAMATE ANTIPORTER | D-ASPARTATE | GENE-EXPRESSION | EXCHANGE | glutamate | BLOOD
Journal Article