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International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 12, pp. 2681 - 2688
A variety of immunoregulatory signals to effector T cells from monocytes, macrophages and regulatory T cells act through cyclic adenosine monophosphate. In the... 
T cell receptor | C-terminal Src kinase | T cell | Ezrin | Cyclic adenosine monophosphate | Csk binding protein | PTPs | Ezrin/radixin/moesin (ERM) binding protein of 50 kDa | nuclear factor κB | linker for activation of T cells | protein tyrosine phosphatases | NF-κB | PI3K | protein tyrosine kinases | ITAMs | adenylyl cyclase | phosphatidylinositol 3 kinase | SLP-76 | PKA | Gads | PKC | PTKs | guanine nucleotide exchange factors | SH2 domain-containing leukocyte protein of 76 kDa | nuclear factor of activated T cells | phospholipase Cγ1 | growth factor receptor bound protein-2 | GPCR | TCR | EBP50 | AKAP | cAMP | phosphoprotein associated with glycosphingolipid-enriched membrane microdomains (GEMs) | immunoreceptor tyrosine-based activation motifs | NFAT | Cbp | PDE | Src homology 2 | Grb-related adaptor downstream of Shc | Csk | protein kinase A | protein kinase C | A kinase anchoring protein | G protein-coupled receptor | GEFs | PLCγ1 | APC | cyclic adenosine monophosphate | PAG | antigen presenting cell | Grb2 | phosphodiesterase | SH2 | LAT | PROTEIN-KINASE-A | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | P50(CSK) TYROSINE KINASE | CELL BIOLOGY | MEMBRANE MICRODOMAINS | TRANSMEMBRANE ADAPTER | BIOPHYSICS | ADENOSINE-MONOPHOSPHATE | NEGATIVE REGULATION | LIPID RAFTS | ANTIGEN-RECEPTOR | TERMINAL-SRC-KINASE | Cyclic AMP-Dependent Protein Kinases - metabolism | T-Lymphocytes, Regulatory - metabolism | Lymphocyte Activation | Membrane Microdomains - metabolism | Humans | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Phosphoproteins - metabolism | Sodium-Hydrogen Exchangers - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Models, Immunological | Animals | T-Lymphocytes - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | T-Lymphocytes - immunology | Membrane Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cyclic AMP - metabolism
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2005, Volume 391, Issue 2, pp. 153 - 166
The activation of signalling pathways by ligand engagement with transmembrane receptors is responsible for determining many aspects of cellular function and... 
T-cell receptor | Ubiquitin | Receptor tyrosine kinase | E3 ligase | Cbl | Thymocyte | BIOCHEMISTRY & MOLECULAR BIOLOGY | thymocyte | receptor tyrosine kinase | ubiquitin | Protein Structure, Tertiary | Proto-Oncogene Proteins c-cbl - genetics | Proto-Oncogene Proteins c-cbl - metabolism | Animals | Signal Transduction | Substrate Specificity | Proto-Oncogene Proteins c-cbl - chemistry | Proto-Oncogene Proteins c-cbl - immunology | PLC, phospholipase C | SH, Src homology | TCR, T-cell receptor | IL-2, interleukin 2 | PI3K, phosphoinositide 3-kinase | PTK, protein tyrosine kinase | EGF, epidermal growth factor | TKB, tyrosine-kinase-binding | Review | Sli-1, suppressor of lineage defect-1 | UBA, ubiquitin-associated | WASP, Wiskott–Aldrich syndrome protein | PTB, phosphotyrosine-binding | Ubc, ubiquitin-conjugating | GLUT4, glucose transporter 4 | BMMC, bone-marrow-derived mast cell | KPD, Komeda diabetes-prone | HECT, homologous with E6AP C-terminus | SLAP, Src-like adaptor protein | CIN85, Cbl-interacting protein of 85 kDa | CTLA-4, cytotoxic T-lymphocyte-associated protein 4 | PKC, protein kinase C | ZAP-70, ζ-associated protein of 70 kDa | SLP-76, SH2 domain-containing leucocyte protein of 76 kDa | FcεRI, high-affinity IgE receptor | NFAT, nuclear factor of activated T-cells | GRAIL, gene related to anergy in lymphocytes | RIP-gp, rat insulin promoter glycoprotein | hSpry2, human Sprouty 2 | RTK, receptor tyrosine kinase | SEM-5, sex muscle abnormal 5 | DP, double positive | LAT, linker for activation of T-cells | APS, adaptor molecule containing pleckstrin homology and Src homology 2 domains | MAIDS, murine AIDS | PDGF, platelet-derived growth factor | BLNK, B-cell linker
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2013, Volume 454, Issue 1, pp. 109 - 121
Distinct signalling pathways producing diverse cellular outcomes can utilize similar subsets of proteins. For example, proteins from the TCR (T-cell receptor)... 
Integrin | Outside-in signalling | Extracellular-signal-regulated kinase (ERK) | T-cell co-stimulation | Early signalling complex | Time Factors | Antigens, CD - biosynthesis | Integrin alpha4beta1 - physiology | Jurkat Cells | Humans | Interleukin-2 Receptor alpha Subunit - biosynthesis | Signal Transduction - physiology | Lectins, C-Type - biosynthesis | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Receptors, Antigen, T-Cell - physiology | Lck, lymphocyte-specific kinase | MEK, MAPK | TCR, T-cell receptor | ESC, early signalling complex | ECM, extracellular matrix | GDS, guanine nucleotide dissociation stimulator | ZAP-70, ζ-chain-associated protein of 70 kDa | ERK kinase | extracellular-signal-regulated kinase (ERK) | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | CXCR4, CXC chemokine receptor 4 | SLP-76, SH2-domain-containing leukocyte protein of 76 kDa | FTI, farnesyl transferase inhibitor | integrin | PBMC, peripheral blood mononuclear cell | LFA-1, lymphocyte-function-associated antigen 1 | VCAM-1, vascular cell adhesion molecule-1 | IFNαR, interferon-α receptor | early signalling complex | outside-in signalling | RBD, Rap1-binding domain | LAT, linker for activation of T-cells | SH2, Src homology 2 | VLA-4, very late antigen-4 | MAPK, mitogen-activated protein kinase
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e32398
Journal Article