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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2014, Volume 111, Issue 34, pp. E3514 - E3523
A challenge for microbial pathogens is to assure that their translocated effector proteins target only the correct host cell compartment during infection. The... 
X-ray crystallography | Membrane composition | Allosteric modulation | Pathogenic bacteria | COMPLEX | SMALL-ANGLE SCATTERING | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RAY SOLUTION SCATTERING | FAMILY | pathogenic bacteria | membrane composition | PNEUMOPHILA | LIPASE | SWITCH REGIONS | PROTEINS | allosteric modulation | INTERFACIAL ACTIVATION | rab5 GTP-Binding Proteins - genetics | Vesicular Transport Proteins - metabolism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Legionella pneumophila - genetics | rab5 GTP-Binding Proteins - metabolism | Endosomes - metabolism | Phospholipases A1 - genetics | Multiprotein Complexes - metabolism | Protein Structure, Quaternary | Protein Interaction Domains and Motifs | Phospholipases A1 - chemistry | Legionella pneumophila - enzymology | Legionella pneumophila - pathogenicity | Binding, Competitive | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Mutagenesis, Site-Directed | Vesicular Transport Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | Phospholipases A1 - metabolism | Recombinant Proteins - chemistry | Vesicular Transport Proteins - chemistry | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Host-Pathogen Interactions | Sequence Homology, Amino Acid | Multiprotein Complexes - chemistry | rab5 GTP-Binding Proteins - chemistry | Bacterial Proteins - metabolism | Protein Conformation | Amino Acid Substitution | Proteins | Amino acids | Bacteria | Mutation | Crystal structure | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 42, pp. 17337 - 17342
Rab5 is a small GTPase known to regulate vesicular trafficking during interphase. Here, we show that Rab5 also plays an unexpected role during mitotic... 
Endocytosis | Mitosis | Kinetochores | Microtubules | Cell nucleus | Cell lines | Nuclear membrane | Chromosomes | Anaphase | Daughter cells | EARLY ENDOCYTIC PATHWAY | MATRIX | ATTACHMENT | NETWORK | RAC | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | endocytosis | SPINDLE | RECEPTOR | mitosis | MITOTIC CHECKPOINT | Cell Line | RNA, Small Interfering - genetics | rab5 GTP-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Humans | Chromosomes, Human - metabolism | rab5 GTP-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - genetics | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | Microscopy, Confocal | Multiprotein Complexes - metabolism | Microtubules - metabolism | Microfilament Proteins - antagonists & inhibitors | Mitosis - physiology | RNA Interference | Chromosome Segregation - physiology | Luminescent Proteins - genetics | rab5 GTP-Binding Proteins - antagonists & inhibitors | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Luminescent Proteins - metabolism | Physiological aspects | Guanosine triphosphatase | Centromeres | Proteins | Cell division | Cellular biology | Ribonucleic acid--RNA | GTP-binding protein | Rab5 protein | Interphase | Nuclear membranes | Epistasis | Kinetics | Guanosinetriphosphatase | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 05/2003, Volume 161, Issue 3, pp. 609 - 624
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 16194 - 13
Rab5 is a small monomeric GTPase that mediates protein trafficking during endocytosis. Inactivation of Rab5 by GTP hydrolysis causes a conformational change... 
REGULATORY SUBUNIT | CATALYTIC SUBUNIT | SMALL GTPASE RAB5 | RECOGNITION | STRUCTURAL BASIS | PATHWAY | RAS | MULTIDISCIPLINARY SCIENCES | P110-BETA SUBUNIT | HUMAN INTERACTOME | CANCER | Proteins | Endocytosis | GTP | Arginine | Kinases | Protein transport | Binding sites | 1-Phosphatidylinositol 3-kinase | Guanosinetriphosphatase | Index Medicus
Journal Article
Current Molecular Medicine, ISSN 1566-5240, 2014, Volume 14, Issue 2, pp. 235 - 245
Uncontrolled endosome trafficking is a common feature of certain cancer cells, which has been acknowledged during the last decade. Migration and invasiveness... 
Integrin | Rab5 | Cell migration | Focal adhesion | focal adhesion | MEDICINE, RESEARCH & EXPERIMENTAL | SMALL GTPASE RAB5 | PHOSPHATIDYLINOSITOL 3-KINASE | ALPHA-V-BETA-3 INTEGRIN | LYSOSOMAL DEGRADATION | NUCLEOTIDE EXCHANGE FACTOR | CLATHRIN-DEPENDENT ENDOCYTOSIS | EXTRACELLULAR-MATRIX | EARLY ENDOSOMES | FOCAL ADHESION KINASE | GROWTH-FACTOR | integrin
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2004, Volume 279, Issue 23, pp. 24612 - 24623
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 8/2001, Volume 154, Issue 3, pp. 631 - 644
Phagosomal biogenesis is a fundamental biological process of particular significance for the function of phagocytic and antigen-presenting cells. The precise... 
Mycobacterium tuberculosis | Phagosomes | Antibodies | Infections | Macrophages | Latex | Phagocytosis | Cells | Endosomes | Phosphatidylinositols | EEA1 | LAM | hVPS34 | LBPA | Endosome | SMALL GTPASE RAB5 | EARLY ENDOSOME | CELL BIOLOGY | TUBERCULOSIS PHAGOSOME | endosome | DIRECT DELIVERY | MACROPHAGE INVASION MECHANISM | TRANS-GOLGI NETWORK | ENDOCYTIC MEMBRANE-FUSION | INFECTED MACROPHAGES | INTRACELLULAR TRAFFICKING | TYPHIMURIUM-CONTAINING VACUOLES | Lysophospholipids - metabolism | Tuberculosis, Pulmonary - metabolism | Phosphatidylinositol 3-Kinases - metabolism | rab5 GTP-Binding Proteins - metabolism | Phosphatidylinositol 3-Kinases - immunology | Microspheres | Phagosomes - immunology | Membrane Proteins - metabolism | Chromones - pharmacology | Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins | Macrophages - microbiology | Monoglycerides | Vesicular Transport Proteins | Cell Line | Microinjections | Macrolides | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Membrane Proteins - immunology | Glycosylation | Macrophages - cytology | Antibodies - pharmacology | Macrophages - metabolism | Tuberculosis, Pulmonary - immunology | Animals | Carrier Proteins - metabolism | Androstadienes - pharmacology | Qa-SNARE Proteins | Transport Vesicles - metabolism | Lipopolysaccharides - pharmacology | Anti-Bacterial Agents - pharmacology | Antigen presenting cells | Cell research | Research | Analysis | Phosphates | Pathogens | Bacteria | Tuberculosis | Cellular biology | Index Medicus | EEA1; endosome; hVPS34; LBPA; LAM
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e90384 - e90384
Rab5, the prototypical Rab GTPase and master regulator of the endocytic pathway, is encoded as three differentially expressed isoforms, Rab5A, Rab5B and Rab5C....