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1. Full Text The use of porcine small intestinal submucosa to enhance the healing of the medial collateral ligament––a functional tissue engineering study in rabbits
by Musahl, Volker and Abramowitch, Steven D and Gilbert, Thomas W and Tsuda, Eiichi and Wang, James H-C and Badylak, Stephen F and Woo, Savio L-Y
Journal of Orthopaedic Research, ISSN 0736-0266, 2004, Volume 22, Issue 1, pp. 214 - 220
Introduction : Small intestinal submucosa (SIS) from porcine has been successfully used as a collagen scaffold for the repair of various tissues, including... 
Mechanical properties | Healing | Functional tissue engineering | Small intestinal submucosa | Medial collateral ligament | SYSTEM | COLLAGEN | INJURIES | RECONSTRUCTION | BEHAVIOR | functional tissue engineering | DOG-MODEL | medial collateral ligament | small intestinal submucosa | ANTERIOR CRUCIATE LIGAMENT | mechanical properties | healing | BIOMATERIAL | REPAIR | IN-VIVO | ORTHOPEDICS | Tensile Strength | Rabbits | Medial Collateral Ligament, Knee - injuries | Intestinal Mucosa - transplantation | Stress, Mechanical | Medial Collateral Ligament, Knee - physiology | Intestine, Small - transplantation | Biomechanical Phenomena | Animals | Medial Collateral Ligament, Knee - surgery | Swine | Female | Weight-Bearing | Wound Healing - physiology | Tissue Engineering
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2. Full Text Decellularization of Bovine Small Intestinal Submucosa
by Parmaksiz, Mahmut and Parmaksiz, Mahmut and Elçin, Ayşe Eser and Elçin, Ayşe Eser and Elçin, Yaşar Murat and Elçin, Yaşar Murat
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2018, Volume 1577, pp. 129 - 138
Decellularization technology promises to overcome some of the significant limitations in the regenerative medicine field by providing functional biocompatible... 
Bioactive materials | Bovine | Regenerative medicine | Decellularization | Extracellular matrix (ECM) | Small intestinal submucosa (SIS) | Xenogenic biomaterials | Intestinal Mucosa - cytology | Intestine, Small - chemistry | Animals | Tissue Engineering - methods | Intestine, Small - cytology | Cattle | DNA - analysis | Spectrophotometry - methods | Intestinal Mucosa - chemistry | Extracellular Matrix - chemistry | Tissue Scaffolds - chemistry
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3. Full Text Diverse preparation methods for small intestinal submucosa (SIS): Decellularization, components, and structure
by Ji, Yanhui and Zhou, Jinge and Sun, Tingfang and Tang, Kai and Xiong, Zekang and Ren, Zhengwei and Yao, Sheng and Chen, Kaifang and Yang, Fan and Zhu, Fengzhao and Guo, Xiaodong
Journal of Biomedical Materials Research Part A, ISSN 1549-3296, 03/2019, Volume 107, Issue 3, pp. 689 - 697
The native extracellular matrix (ECM) biomaterial derived from small intestinal submucosa (SIS) is widely applied in tissue engineering for tissue repair and... 
small intestinal submucosa | extracellular matrix | decellularization | BIOLOGIC SCAFFOLDS | STERILIZATION | MATERIALS SCIENCE, BIOMATERIALS | ENHANCE | ENGINEERING, BIOMEDICAL | GROWTH | TISSUES | ECM | EXTRACELLULAR-MATRIX HYDROGELS | Analysis | Methods | Biological products | Regeneration | Organic chemistry | Surgical implants | Biomedical materials | Intestine | Tissue engineering | Biocompatibility | Extracellular matrix | Research | Microstructure | Biomaterials
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4. Full Text Identification and characterization of bioactive factors in bladder submucosa matrix
by Chun, So Young and Lim, Grace Jeong and Kwon, Tae Gyun and Kwak, Eun Kyoung and Kim, Bup Wan and Atala, Anthony and Yoo, James J
Biomaterials, ISSN 0142-9612, 2007, Volume 28, Issue 29, pp. 4251 - 4256
Abstract In spite of long term clinical use of decellularized bladder submucosa matrix (BSM), little is known about the active factors within this material. In... 
Advanced Basic Science | Dentistry | Bladder submucosa matrix (BSM) | Extracellular matrix | Decellularized scaffold | Bioactive factors | Growth factors | COLLAGEN MATRIX | SMALL-INTESTINAL SUBMUCOSA | MATERIALS SCIENCE, BIOMATERIALS | FACTOR DELIVERY | TGF-BETA | growth factors | ENGINEERING, BIOMEDICAL | REGENERATION | bladder submucosa matrix (BSM) | FIBROBLAST-GROWTH-FACTOR | RELEASE | REPAIR | ACELLULAR MATRIX | EXTRACELLULAR-MATRIX | bioactive factors | extracellular matrix | decellularized scaffold | Intercellular Signaling Peptides and Proteins - analysis | Animals | Cell-Free System - metabolism | Urinary Bladder - metabolism | Swine | Extracellular Matrix - metabolism | Materials Testing | Biological Factors - analysis | Extracellular Matrix Proteins - analysis | Mucous Membrane - metabolism
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5. Full Text Small intestinal submucosa extracellular matrix (CorMatrix®) in cardiovascular surgery: a systematic review
by Mosala Nezhad, Zahra and Poncelet, Alain and de Kerchove, Laurent and Gianello, Pierre and Fervaille, Caroline and El Khoury, Gebrine
Interactive CardioVascular and Thoracic Surgery, ISSN 1569-9293, 06/2016, Volume 22, Issue 6, pp. 839 - 850
Extracellular matrix (ECM) derived from small intestinal submucosa (SIS) is widely used in clinical applications as a scaffold for tissue repair. Recently,... 
Cardiovascular surgery | Extracellular matrix | CorMatrix | Tissue engineering | Small intestinal submucosa | LONG-TERM | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | CAROTID-ARTERY | BIOPROSTHETIC TRICUSPID-VALVE | GRAFT | SURGICAL-TREATMENT | PULMONARY VALVE | CLINICAL-EXPERIENCE | REPAIR | RESPIRATORY SYSTEM | VASCULAR RECONSTRUCTIVE SURGERY | GROWTH-FACTOR | Animals | Tissue Engineering - methods | Intestine, Small - cytology | Extracellular Matrix - transplantation | Humans | Prostheses and Implants | Prosthesis Design | Intestine, Small - transplantation | Cardiovascular Diseases - surgery | STATE-OF-THE-ART
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6. Full Text The incorporation of poly(lactic- co -glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials
by Mondalek, Fadee G and Lawrence, Benjamin J and Kropp, Bradley P and Grady, Brian P and Fung, Kar-Ming and Madihally, Sundar V and Lin, Hsueh-Kung
Biomaterials, ISSN 0142-9612, 2007, Volume 29, Issue 9, pp. 1159 - 1166
Abstract Small intestinal submucosa (SIS) derived from porcine small intestine has been intensively studied for its capacity in repairing and regenerating... 
Advanced Basic Science | Dentistry | Biocompatibility | Scaffold | Porosity | Nanoparticle | Small intestinal submucosa | CELLS | MATERIALS SCIENCE, BIOMATERIALS | MOLECULAR-WEIGHT | AUGMENTATION | biocompatibility | ENGINEERING, BIOMEDICAL | porosity | TISSUE REPLACEMENT APPLICATIONS | nanoparticle | RELEASE | small intestinal submucosa | DELIVERY | REPAIR | BLADDER REGENERATION | scaffold | IN-VIVO | DOG | Intestine, Small - ultrastructure | Cell Proliferation | Nanoparticles - chemistry | Biocompatible Materials - chemistry | Humans | Wound Healing | Swine | Cell Line | Intestine, Small - chemistry | Microscopy, Electron, Scanning | Lactic Acid - chemistry | Tissue Engineering - methods | Intestinal Mucosa - ultrastructure | Nanoparticles - ultrastructure | Materials Testing | Permeability | Intestinal Mucosa - chemistry | Particle Size | Regeneration | Urea | Biomechanical Phenomena | Animals | Endothelial Cells - cytology | Polyglycolic Acid - chemistry | Polymers - chemistry
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7. Full Text Bladder regeneration in a canine model using hyaluronic acid‐poly(lactic‐co‐glycolic‐acid) nanoparticle modified porcine small intestinal submucosa
by Roth, Christopher C and Mondalek, Fadee G and Kibar, Yusuf and Ashley, Richard A and Bell, Cardin H and Califano, John A and Madihally, Sundar V and Frimberger, Dominic and Lin, Hsueh‐Kung and Kropp, Bradley P
BJU International, ISSN 1464-4096, 07/2011, Volume 108, Issue 1, pp. 148 - 155
OBJECTIVE To determine if hyaluronic acid (HA) can be incorporated into porcine small intestinal submucosa (SIS) through poly (lactide-co-glycolide-acid)... 
nanotechnology | tissue engineering | small intestinal submucosa | extracellular matrix | ACID | UROLOGY & NEPHROLOGY | SCAFFOLDS | Intestinal Mucosa | Tissue Engineering - methods | Extracellular Matrix | Intestine, Small | Hyaluronic Acid - pharmacokinetics | Regeneration - physiology | Adjuvants, Immunologic - pharmacokinetics | Lactic Acid - pharmacokinetics | Animals | Polyglycolic Acid - pharmacokinetics | Nanoparticles - therapeutic use | Swine | Dogs | Biocompatible Materials - pharmacokinetics | Urinary Bladder - physiology | Usage | Biological products | Hyaluronic acid | Analysis
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8. Full Text Histologic examination of decellularized porcine intestinal submucosa extracellular matrix (CorMatrix) in pediatric congenital heart surgery
by Woo, Jennifer S and Fishbein, Michael C and Reemtsen, Brian
Cardiovascular Pathology, ISSN 1054-8807, 2015, Volume 25, Issue 1, pp. 12 - 17
Abstract Background CorMatrix is a decellularized porcine small intestinal submucosa extracellular matrix that has gained attention as a promising alternative... 
Pathology | Congenital heart disease | Small intestinal submucosa extracellular matrix | CorMatrix | REPAIR | CARDIAC & CARDIOVASCULAR SYSTEMS | PRELIMINARY EXPERIENCE | GRAFT | VALVE | TERM | PATHOLOGY | SCAFFOLD | Inflammation - pathology | Heart Defects, Congenital - surgery | Humans | Heart Septum - pathology | Child, Preschool | Infant | Male | Cardiac Surgical Procedures - adverse effects | Heart Valves - pathology | Necrosis | Heart Valves - surgery | Heterografts | Calcinosis - etiology | Female | Heart Septum - surgery | Child | Databases, Factual | Heart Defects, Congenital - pathology | Intestinal Mucosa - transplantation | Treatment Outcome | Inflammation - etiology | Foreign-Body Reaction - pathology | Extracellular Matrix - transplantation | Adolescent | Fibrosis | Los Angeles | Calcinosis - pathology | Extracellular Matrix - pathology | Foreign-Body Reaction - etiology | Intestinal Mucosa - pathology | Pediatrics | Genetic disorders | Analysis | Surgery
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9. Full Text Small intestinal submucosa for anular defect closure: Long-term response in an in vivo sheep model
by Ledet, Eric H and Jeshuran, Winston and Glennon, Joseph C and Shaffrey, Christopher and De Deyne, Patrick and Belden, Cliff and Kallakury, Bhaskar and Carl, Allen L
Spine, ISSN 0362-2436, 06/2009, Volume 34, Issue 14, pp. 1457 - 1463
Study Design. After undergoing anulotomy, lumbar intervertebral discs from sheep were treated with small intestinal submucosa (SIS) and assessed functionally... 
Sheep | Anulotomy | Lumbar spine | Discectomy | SIS | Small intestinal submucosa | SURGERY | RECONSTRUCTION | COLLATERAL LIGAMENT | small intestinal submucosa | discectomy | CLINICAL NEUROLOGY | BIOMATERIAL | REPAIR | DISKECTOMY | anulotomy | LUMBAR DISC HERNIATION | lumbar spine | INTERVERTEBRAL DISC | EXTRACELLULAR-MATRIX | SCAFFOLDS | ORTHOPEDICS | sheep | Intervertebral Disc - ultrastructure | Intestine, Small - chemistry | Microscopy, Electron, Scanning | Lumbar Vertebrae - diagnostic imaging | Bone Screws | Biocompatible Materials - chemistry | Intervertebral Disc - surgery | Intestinal Mucosa - transplantation | Diskectomy - methods | Male | Intestinal Mucosa - chemistry | Intestine, Small - transplantation | Radiography | Lumbar Vertebrae - surgery | Animals | Swine | Titanium | Intervertebral Disc Displacement - therapy | Biocompatible Materials - therapeutic use | Intervertebral Disc - drug effects | Intervertebral Disc Displacement - surgery | Diskectomy - instrumentation
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10. Full Text Transplantation of Isl1+ cardiac progenitor cells in small intestinal submucosa improves infarcted heart function
by Wang, Lingjun and Meier, Elizabeth M and Tian, Shuo and Lei, Ienglam and Liu, Liu and Xian, Shaoxiang and Lam, Mai T and Wang, Zhong
Stem Cell Research and Therapy, ISSN 1757-6512, 10/2017, Volume 8, Issue 1, pp. 230 - 10
Background: Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial... 
Heart regeneration | Myocardial infarction | Cardiac progenitor cell | Small intestinal submucosa | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | MATRIX | STEM-CELLS | MULTIPOTENT | RAT | REGENERATION | CARDIOMYOCYTES | PATCH | DELIVERY | CELL BIOLOGY | ACUTE MYOCARDIAL-INFARCTION | Transplantation | Research | Health aspects | Heart attack | Risk factors | Stem cells | Heart failure | Heart attacks | Wound healing | Syngeneic grafts | Heart transplantation | Stem cell transplantation | Cardiomyocytes | Contraction | Endothelial cells | Studies | Biomedical materials | Intestine | Collagen | Vitamin C | Bone marrow | Myocardium | Extracellular matrix | Biocompatibility | Ventricle | Heart diseases
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11. Full Text Small Intestinal Submucosa (SIS) Graft Urethroplasty: Short-term Results
by Palminteri, Enzo and Berdondini, Elisa and Colombo, Fulvio and Austoni, Edoardo
European Urology, ISSN 0302-2838, 2006, Volume 51, Issue 6, pp. 1695 - 1701
Abstract Objective We evaluated the use of small intestinal submucosa (SIS) graft in penile and bulbar urethroplasties. Methods From 2003 to 2004, 20 men (mean... 
Urology | Small intestinal submucosa (SIS) | Urethra | Urethral stricture | Tissue engineering | COLLAGEN MATRIX | REPLACEMENT | small intestinal submucosa (SIS) | tissue engineering | REPAIR | ACELLULAR MATRIX | RECONSTRUCTION | REGENERATION | urethral stricture | UROLOGY & NEPHROLOGY | CANINE URETHRA | urethra | Urethra - surgery | Follow-Up Studies | Humans | Middle Aged | Urologic Surgical Procedures, Male - methods | Intestinal Mucosa - transplantation | Male | Transplantation, Autologous | Treatment Outcome | Intestine, Small - transplantation | Urethral Stricture - surgery | Penis | Adult | Aged | Political corruption
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12. Full Text A Comparative Analysis of Expanded Polytetrafluoroethylene and Small Intestinal Submucosa—Implications for Patch Repair in Ventral Herniorrhaphy
by Rauth, Thomas P., M.D and Poulose, Benjamin K., M.D and Nanney, Lillian B., Ph.D and Holzman, Michael D., M.D
Journal of Surgical Research, ISSN 0022-4804, 2007, Volume 143, Issue 1, pp. 43 - 49
Background Small intestinal submucosa and expanded polytetrafluoroethylene are commonly used as adjuncts to repair in ventral herniorrhaphy. Despite their... 
Surgery | laparoscopic herniorrhaphy | ventral herniorrhaphy | neovascularity | herniorrhaphy | porcine | contraction | expanded polytetrafluoroethylene | small intestinal submucosa | SiS | ePTFE | MESH REPAIR | SURGERY | SUTURE | STRENGTH | MODEL | expanded | DIAPHRAGMATIC-HERNIA | polytetrafluoroethylene | TERM-FOLLOW-UP | Intestinal Mucosa - metabolism | Hernia, Ventral - surgery | Intestinal Mucosa - blood supply | Intestine, Small - blood supply | Intestinal Mucosa - surgery | Collagen - metabolism | Polytetrafluoroethylene - therapeutic use | Laparoscopy - methods | Animals | Intestine, Small - surgery | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Swine | Female | Biocompatible Materials - therapeutic use | Hernia, Ventral - metabolism | Intestine, Small - metabolism | Comparative analysis | Polytetrafluoroethylene | Fluorine compounds
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13. Full Text Tissue engineered esophagus by copper——small intestinal submucosa graft for esophageal repair in a canine model
by TAN Bo WANG Min CHEN Xi HOU JiangLong CHEN XiaoHe WANG Yue LI-LING Jesse XIE HuiQi
中国科学：生命科学英文版, ISSN 1674-7305, 2014, Volume 57, Issue 2, pp. 248 - 255
Acellular porcine small intestinal submucosa（SIS）has been used for esophagoplasty with success in a canine model.However,it did not lead to complete... 
猪小肠 | 食管 | 组织工程化 | 比格犬 | 修复 | 食道 | 模型 | 移植 | Life Sciences | Life Sciences, general | copper | re-epithelialization | muscle regeneration | small intestinal submucosa | esophagus | re-vascularization | MUCOSAL EPITHELIAL-CELLS | RECONSTRUCTION | REGENERATION | SHEETS | TRANSPLANTATION | REPLACEMENT | BIOSCAFFOLD | ENHANCE | BIOLOGY | GENERATION | Immunohistochemistry | Animals | Swine | Dogs | Male | Models, Animal | Esophagus - surgery | Intestine, Small - transplantation | Tissue Engineering | Tissue engineering | Analysis
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14. Full Text Crosslinking decreases the hemocompatibility of decellularized, porcine small intestinal submucosa
by Glynn, Jeremy J and Polsin, Elizabeth G and Hinds, Monica T
Acta Biomaterialia, ISSN 1742-7061, 03/2015, Volume 14, pp. 96 - 103
Decellularized tissues have been widely used as scaffolds for biomedical applications due to their presentation of adhesion peptide sequences and growth... 
SIS (small intestinal submucosa) | Platelets | Hemocompatibility | Coagulation | Fibrinogen | NONHUMAN-PRIMATES | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | THROMBIN-GENERATION | ARTERIAL THROMBOSIS | CLOT STRUCTURE | WHOLE-BLOOD | EXTRACELLULAR-MATRIX | HEMOSTASIS | SCAFFOLD MATERIAL | TISSUE FACTOR | Intestinal Mucosa - metabolism | Glycosaminoglycans - metabolism | Cross-Linking Reagents - pharmacology | Prothrombin Time | Male | Materials Testing | Biocompatible Materials - pharmacology | Heparin Lyase - pharmacology | Intestinal Mucosa - drug effects | Polysaccharide-Lyases - pharmacology | Hyaluronoglucosaminidase - pharmacology | Papio | Animals | Blood Coagulation - drug effects | Partial Thromboplastin Time | Intestine, Small - drug effects | Fibrinogen - metabolism | Chondroitinases and Chondroitin Lyases - pharmacology | Intestine, Small - metabolism | Thromboplastin - metabolism | Blood Platelets - drug effects | Sus scrofa | Crosslinked polymers | Anticoagulants | Pathways | Crosslinking | Devices | Scaffolds | Blood
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