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Science, ISSN 0036-8075, 8/2012, Volume 337, Issue 6098, pp. 1094 - 1097
Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock... 
Molecules | Carbazoles | Hepatocytes | HEK293 cells | Chronobiology | Genes | REPORTS | Cell lines | Luminescence | Fibroblasts | Resins | HOMEOSTASIS | CHEMICAL BIOLOGY | METABOLISM | RHYTHMS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PERIOD | DEGRADATION | MAMMALIAN CIRCADIAN CLOCK | OSCILLATIONS | REVEALS | Glucose-6-Phosphatase - genetics | Carbazoles - chemistry | Gluconeogenesis - drug effects | Humans | Molecular Sequence Data | Hepatocytes - metabolism | Phosphoenolpyruvate Carboxykinase (GTP) - genetics | Proteolysis - drug effects | Sulfonamides - isolation & purification | Liver - drug effects | HEK293 Cells | Cryptochromes - agonists | Hepatocytes - drug effects | Cryptochromes - metabolism | Carbazoles - isolation & purification | Amino Acid Sequence | Circadian Clocks - drug effects | Sulfonamides - chemistry | Liver - metabolism | Sulfonamides - pharmacology | Animals | Gluconeogenesis - genetics | Small Molecule Libraries | Protein Stability - drug effects | Cell Line, Tumor | Liver - cytology | Mice | Carbazoles - pharmacology | 3T3 Cells | Circadian rhythms | Ubiquitin | Molecular dynamics | Physiological aspects | Research | Proteins | Biochemistry | Circadian rhythm | Molecular biology | Index Medicus | Biotechnology | Biomedical materials | Medical services | Disorders | Derivatives | Chemical compounds | Culture | Biological clocks
Journal Article
Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5954, pp. 853 - 858
Virtually all of the 560 human proteases are stored as inactive proenyzmes and are strictly regulated. We report the identification and characterization of the... 
Executioners | T lymphocytes | Molecules | HEK293 cells | B lymphocytes | Cell lines | Cytochromes | Reports | Kidney cells | Viability | Apoptosis | APOPTOSIS | IN-VITRO | CYSTEINE PROTEASE | DOMAIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DEATH | INDUCTION | CASPASE ACTIVATION | ALLOSTERIC SITE | Enzyme Activators - pharmacology | Caspase 6 - metabolism | Pyridines - chemistry | Caspase 3 - chemistry | Granzymes - metabolism | Humans | Caspase 3 - metabolism | Enzyme Precursors - genetics | Imidazoles - chemistry | Benzopyrans - metabolism | Enzyme Activators - metabolism | Small Molecule Libraries - metabolism | Benzopyrans - chemistry | Enzyme Activators - chemistry | Caspase 3 - genetics | Enzyme Precursors - antagonists & inhibitors | Molecular Structure | Benzopyrans - pharmacology | Imidazoles - metabolism | Catalytic Domain | Biocatalysis | Enzyme Inhibitors - metabolism | Enzyme Precursors - chemistry | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Caspase Inhibitors | Small Molecule Libraries - chemistry | Enzyme Precursors - metabolism | Animals | Pyridines - metabolism | Mutagenesis | Caspase 6 - genetics | Cell Line, Tumor | Mice | Pyridines - pharmacology | Enzyme Activation | Kinetics | Caspase 6 - chemistry | Cell Line, Transformed | Chemical properties | Research | Zymogens | Proteases | Identification and classification | Enzymes | Biochemistry | Molecular biology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6124, pp. 1216 - 1219
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 11, pp. 8340 - 8351
Journal Article
Cancer Science, ISSN 1347-9032, 06/2016, Volume 107, Issue 6, pp. 791 - 802
Transcriptional co‐activator with PDZ ‐binding motif ( TAZ ) plays versatile roles in cell proliferation and differentiation. It is phosphorylated by large... 
GFP | Hippo pathway | Drug screening | TAZ | phosphorylation | Phosphorylation | YES-ASSOCIATED PROTEIN | YAP ACTIVATION | CELL-BASED ASSAY | HIPPO SIGNALING PATHWAY | PROLIFERATION | CANCER | EPITHELIAL-MESENCHYMAL TRANSITION | EFFECTOR YAP | ONCOLOGY | DIFFERENTIATION | Ethanolamines - pharmacology | Small Molecule Libraries - pharmacology | Transcription, Genetic - drug effects | Transcription Factors - chemistry | ortho-Aminobenzoates - pharmacology | Drug Evaluation, Preclinical - standards | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Cytoplasm - metabolism | Green Fluorescent Proteins - genetics | Thiourea - pharmacology | Recombinant Fusion Proteins - metabolism | ortho-Aminobenzoates - analysis | Cell Nucleus - metabolism | Time Factors | Protein Binding - drug effects | HEK293 Cells | Phosphorylation - drug effects | PDZ Domains - drug effects | Thiourea - analysis | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Drug Evaluation, Preclinical - methods | Green Fluorescent Proteins - metabolism | Small Molecule Libraries - analysis | Pyridines - analysis | Transcription Factors - antagonists & inhibitors | Heterocyclic Compounds, 3-Ring - analysis | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Dobutamine - pharmacology | Ethanolamines - analysis | Amino Acid Motifs | Transcription Factors - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Pyridines - pharmacology | Cell Nucleus - drug effects | Phosphoric Monoester Hydrolases - metabolism | Cytoplasm - drug effects | Thiourea - analogs & derivatives | Cell differentiation | Genetic aspects | Genetic transcription | Cell proliferation | Immunoglobulins | Transcription | Mesenchyme | Therapeutic applications | Drug development | Kinases | Phosphatase | Stomach cancer | Proteins | Gene amplification | Cell activation | Antitumor agents | Osteosarcoma | Medical prognosis | Tumor suppressor genes | Localization | Cytoplasm | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e46364 - e46364
Chronic inflammation is a major contributing factor in the pathogenesis of many age-associated diseases. One central protein that regulates inflammation is... 
LIFE-SPAN | ACETYLATION | PHOSPHORYLATION | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DNA-DAMAGE | DEPENDENT GENE-EXPRESSION | CELL-SURVIVAL | CYTOKINE RELEASE | SMALL-MOLECULE ACTIVATORS | Inflammation - chemically induced | Sirtuin 1 - metabolism | Transcription Factor RelA - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Male | Benzimidazoles - chemistry | Sirtuin 1 - genetics | Transcription Factor RelA - genetics | Inflammation - metabolism | Inflammation - drug therapy | Tumor Necrosis Factor-alpha - immunology | Acetylation | Interleukin-12 - biosynthesis | Cell Line | Anti-Inflammatory Agents - pharmacology | Inflammation - immunology | Animals | Anti-Inflammatory Agents - chemistry | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Small Molecule Libraries | Interleukin-12 - immunology | Lipopolysaccharides - pharmacology | Benzimidazoles - pharmacology | Thiazoles - chemistry | Mice | Mice, Inbred BALB C | Protein Processing, Post-Translational | Thiazoles - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Pathogenesis | Arthritis | Kinases | Lipopolysaccharides | Proteins | Reduction | Rodents | Transcription activation | Post-translation | Aging | Chronic obstructive pulmonary disease | Synaptotagmin | Age | Chronic illnesses | NF-κB protein | Antiinflammatory agents | Cytokines | Secretion | Interleukin 12 | Pharmacology | Inflammation | Tumor necrosis factor-α | Metabolism | Gene expression | Chemical compounds | SIRT1 protein | NAD | Signaling | Deacetylation | New classes | Kidney diseases | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 05/2017, Volume 24, Issue 5, pp. 903 - 916
Ubiquitin is a key component of the regulatory network that maintains gene expression in eukaryotes, yet the molecular mechanism(s) by which non-degradative... 
MONOUBIQUITINATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | MDM2 | NUCLEAR EXPORT | IRF-1 | SMALL-MOLECULE ANTAGONISTS | PROMOTER | P53 POLYUBIQUITINATION | LIGASE | CELL BIOLOGY | Chromatin - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Transcriptional Activation | Ubiquitin - metabolism | Crystallography, X-Ray | Melanocytes - metabolism | Proto-Oncogene Proteins c-mdm2 - chemistry | Trans-Activators - chemistry | Tumor Suppressor Protein p53 - genetics | Thermodynamics | Ubiquitination | Interferon Regulatory Factor-1 - chemistry | Melanocytes - cytology | Melanocytes - drug effects | Trans-Activators - genetics | Protein Domains | Proto-Oncogene Proteins c-mdm2 - metabolism | Chromatin - chemistry | Lymphocytes - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Imidazoles - pharmacology | Lymphocytes - cytology | Ubiquitin - genetics | DNA - metabolism | Piperazines - pharmacology | Interferon Regulatory Factor-1 - genetics | DNA - genetics | DNA - chemistry | Lymphocytes - drug effects | Cell Line, Tumor | Protein Binding | Trans-Activators - metabolism | Tumor Suppressor Protein p53 - chemistry | Ubiquitin-Protein Ligases - genetics | Interferon Regulatory Factor-1 - metabolism | Index Medicus | Original Paper
Journal Article
Journal Article
Journal of Molecular Cell Biology, ISSN 1674-2788, 03/2019, Volume 11, Issue 3, pp. 245 - 254
Drugging the p53 pathway has been a goal for both academics and pharmaceutical companies since the designation of p53 as the guardian of the genome'. Through... 
Cell biology | Small molecule | Cancer therapy | Cancer | P53 | cancer therapy | small molecule | cell biology | MULTICENTER PHASE-II | NUCLEAR EXPORT | cancer | BREQUINAR SODIUM | p53
Journal Article