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Journal of Medicinal Chemistry, ISSN 0022-2623, 2010, Volume 53, Issue 3, pp. 951 - 965
Journal Article
Science, ISSN 0036-8075, 9/2013, Volume 341, Issue 6152, pp. 1387 - 1390
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2006, Volume 49, Issue 23, pp. 6819 - 6832
Journal Article
Cell Stem Cell, ISSN 1934-5909, 11/2009, Volume 5, Issue 5, pp. 491 - 503
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 19, pp. 5576 - 5581
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2017, Volume 56, Issue 9, pp. 2423 - 2428
Small‐molecule inhibition of the interaction between the KRas oncoprotein and the chaperone PDE6δ impairs KRas spatial organization and signaling in cells.... 
Ras protein | drug design | structure–activity relationships | PDEδ | medicinal chemistry | ACTIVATION | NUCLEOTIDE EXCHANGE | SMALL MOLECULES | PDE delta | ONCOGENIC KRAS | IDENTIFICATION | PLASMA-MEMBRANE | RAS ONCOGENES | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | structure-activity relationships | K-RAS | MODULATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 6, pp. 1812 - 1824
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 137, pp. 176 - 195
Recent years have seen much effort to discover new chemotypes of BRD4 inhibitors. Interestingly, some kinase inhibitors have been demonstrated to be potent... 
BI-2536 | Dihydroquinoxalin-2(1H)-one | BRD4 inhibitor | Kinase | TARGET | CHEMISTRY, MEDICINAL | ACETYLATION | DRUG DISCOVERY | C-MYC | BROMODOMAIN LIGANDS | SMALL-MOLECULE INHIBITORS | READER | BINDING | BRD4 | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Cell Cycle Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Quinoxalines - pharmacology | Protein Kinase Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Quinoxalines - chemical synthesis | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Protein Kinase Inhibitors - chemical synthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Quinoxalines - chemistry | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Neoplasms, Experimental - drug therapy | Anisotropy | Drug therapy, Combination | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1377 - 1392
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2017, Volume 27, Issue 13, pp. 2962 - 2966
Journal Article
2011, Current topics in microbiology and immunology, ISBN 9783642170836, Volume 348., x, 174
In this volume, the editors have collected the knowledgeable insights of researchers who have achieved success in addressing the difficult problem of... 
Protein-protein interactions | Enzyme inhibitors | Medicine: General Issues | Biomedicine general | Biomedicine
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