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by Guo, YL and Ma, D and He, ZC and Xiong, J and Kuang, XY and Wang, WL and Yu, KL and Zhang, ZY and Wang, JS
BLOOD, ISSN 0006-4971, 11/2018, Volume 132
Conference Proceeding
International Journal of Cancer, ISSN 0020-7136, 10/2010, Volume 127, Issue 7, pp. 1517 - 1525
Journal Article
FEBS Letters, ISSN 0014-5793, 2012
Viral and bacterial infection activate several transcription factors including NF-κB and IRF3, which collaborate to induce type I interferons (IFNs). However,... 
Ubiquitination | Smurf2 | IFN-β | IRF3 | Macrophage
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 09/2018, Volume 430, Issue 18, pp. 3218 - 3233
Ubiquitin (Ub) ligases (E3s) catalyze the attachment of Ub chains to target proteins and thereby regulate a wide array of signal transduction pathways in... 
HECT domain | Smurf2 | thioester intermediate | Huwe1 | NMR spectroscopy | DOMAIN | COMPLEX | PROTEIN | POLYUBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAIN | AUTOINHIBITION | TUMOR-SUPPRESSOR | INSIGHTS | REVEALS
Journal Article
Journal Article
by Dong, S and Liu, J and Li, L and Wang, H and Ma, HC and Zhao, YT and Zhao, J
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, ISSN 0363-6143, 05/2019, Volume 316, Issue 5, pp. C632 - C640
Opioids are widely used for relieving clinical acute or chronic pain. The biological effects of opioids are through activating mu-opioid receptor 1 (MOR1).... 
ACTIVATION | PHYSIOLOGY | DAMGO | MECHANISM | PHOSPHORYLATION | DESENSITIZATION | INVOLVEMENT | TRAFFICKING | lung epithelial cells | protein stability | CELL BIOLOGY | MOR | INTERNALIZATION | ROLES | cell migration | Smurf2 | ARRESTINS | KINASES
Journal Article
Gene, ISSN 0378-1119, 02/2018, Volume 642, pp. 483 - 490
Chronic allograft dysfunction (CAD) is characterized by allograft kidney interstitial fibrosis, the underlying mechanism of which is unclear. Our aim was to... 
Smurf2 | TNF-α | EMT | CAD | FIBROSIS | PROTEIN | TNF-alpha | DOWN-REGULATION | UBIQUITIN-DEPENDENT DEGRADATION | RENAL-TRANSPLANTATION | PATHWAY | GENETICS & HEREDITY | SNON EXPRESSION | LIGASE | SNAIL | Index Medicus
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 429 - U192
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 05/2019, Volume 316, Issue 5, pp. C632 - C640
Opioids are widely used for relieving clinical acute or chronic pain. The biological effects of opioids are through activating μ-opioid receptor 1 (MOR1). Most... 
MOR | Protein stability | Lung epithelial cells | Smurf2 | DAMGO | Cell migration | Cell proliferation | Ubiquitin | Phosphorylation | Opioid receptors | Narcotics | Epithelial cells | Lung | Cell adhesion & migration | Ubiquitination | Pain | Internalization | Enkephalins | Proteasomes | Agonists | Ubiquitin-protein ligase
Journal Article
by Kim, JH and Ham, S and Lee, Y and Suh, GY and Lee, YS
CELL DEATH & DISEASE, ISSN 2041-4889, 01/2019, Volume 10
Transforming growth factor-beta (TGF-beta) acts as a key cytokine in epithelial-mesenchymal transition (EMT) and myofibroblast differentiation, which are... 
RENAL FIBROSIS | LUNG FIBROSIS | PROTEIN STABILITY | SMAD3 | NEGATIVE REGULATION | DOWN-REGULATION | TGF-BETA RECEPTOR | LIGASE SMURF2 | UBIQUITINATION REGULATORY FACTOR-2 | DEPENDENT DEGRADATION | CELL BIOLOGY
Journal Article
Frontiers in oncology, ISSN 2234-943X, 2018, Volume 8, p. 295
Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade essential for normal cellular functions and homeostasis maintenance.... 
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 09/2017, Volume 16, Issue 3, pp. 3308 - 3314
Journal Article
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 01/2012, Volume 113, Issue 1, pp. 238 - 246
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates a wide variety of cellular processes including proliferation,... 
DOMAIN | ANTAGONIST | SMURF2 | COLOCALIZATION ANALYSIS | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | IDENTIFICATION | HUMAN KERATINOCYTES | SMAD7 | CELL BIOLOGY | Degradation | BETA RECEPTOR | Co-receptor | SUPERFAMILY | TGF-ss | CD109 EXPRESSION
Journal Article
by Wang, J and Li, HY and Wang, HS and Su, ZB
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, ISSN 1015-8987, 2018, Volume 51, Issue 2, pp. 692 - 710
Background/Aims: Chronic respiratory conditions continue to plague millions of people worldwide. We aimed to elucidate the detailed mechanisms of microRNA-485... 
ALLERGIC INFLAMMATION | SUPPRESSOR | ACTIVATION | PHYSIOLOGY | MicroRNA-485 | CELL-PROLIFERATION | Proliferation | Chronic asthma | IDENTIFICATION | FIBROBLASTS | CELL BIOLOGY | TGF | INHIBITION | GENE | Smurf2 | EXPRESSION | ASSOCIATION | Smads signaling pathway | Apoptosis
Journal Article
Cell Reports, ISSN 2211-1247, 11/2018, Volume 25, Issue 7, pp. 1841 - 1855.e5
Signal transduction pathways stimulated by secreted growth factors are tightly regulated at multiple levels between the cell surface and the nucleus. The... 
SMAD2 | TGF-β | ESCRT machinery | signaling dynamics | receptor trafficking | epithelial-to-mesenchymal transition | EPITHELIAL-MESENCHYMAL TRANSITION | CELLS | SMADS | SMURF2 | UBIQUITIN LIGASE | I RECEPTOR | COMPLEXES | HD-PTP | CANCER PROGRESSION | ENDOCYTOSIS | CELL BIOLOGY
Journal Article
BBA - General Subjects, ISSN 0304-4165, 12/2018, Volume 1862, Issue 12, pp. 2902 - 2910
Journal Article