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Aging Cell, ISSN 1474-9718, 12/2015, Volume 14, Issue 6, pp. 1045 - 1054
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 04/2009, Volume 46, Issue 8, pp. 1109 - 1118
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2004, Volume 318, Issue 4, pp. 998 - 1005
Several single gene mutations in mice that increase the murine life span have been identified, including the Pit-1 mutation which results in the Snell dwarf... 
Oxidative stress | 3-NPA | MAP kinase | Longevity | Snell dwarf | AP-1 | LIFE-SPAN | INDUCED APOPTOSIS | DROSOPHILA-MELANOGASTER | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUPEROXIDE DISMUTASE/CATALASE MIMETICS | 3-NITROPROPIONIC ACID | EXTENSION | CAENORHABDITIS-ELEGANS | BIOPHYSICS | longevity | C-JUN | oxidative stress
Journal Article
DIABETES, ISSN 0012-1797, 05/2005, Volume 54, Issue 5, pp. 1264 - 1276
Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing the ingestion, distribution, metabolism, and storage of... 
SNELL DWARF MOUSE | RAT HIPPOCAMPAL-NEURONS | BODY-WEIGHT | MESSENGER-RNA EXPRESSION | TRANSCRIPTION FACTOR FOXO1 | FOOD-INTAKE | JAPANESE-AMERICAN MEN | ENDOCRINOLOGY & METABOLISM | HYPOTHALAMIC ARCUATE NUCLEUS | ATP-SENSITIVE K | BETA-CELL FUNCTION
Journal Article
AGING-US, ISSN 1945-4589, 09/2010, Volume 2, Issue 9, pp. 582 - 596
Reactive oxygen species (ROS) and elevated levels of p38 MAPK activity accelerate physiological aging. This emphasizes the importance of understanding the... 
LIFE-SPAN | KINASE 1 ASK1 | signalosome | thioredoxin | DROSOPHILA-MELANOGASTER | PATHWAY ACTIVITY | 3-NITROPROPIONIC ACID | Klotho | PROTEIN-KINASES | CELL BIOLOGY | senescence | SNELL DWARF MOUSE | SIGNAL-TRANSDUCTION | CAENORHABDITIS-ELEGANS | REACTIVE OXYGEN | p38 | aging
Journal Article
BMB Reports, ISSN 1976-6696, 01/2019, Volume 52, Issue 1, pp. 70 - 85
Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have... 
Growth signaling | Mouse model | Longevity | Gene expression | OXIDATIVE STRESS | IGF-I | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIETARY RESTRICTION | LIFE-SPAN EXTENSION | WHITE ADIPOSE-TISSUE | LONG-LIVED SNELL | AMES DWARF MICE | INSULIN-RESISTANCE | GENE-EXPRESSION PROFILE | SEXUAL-DIMORPHISM | Invited Mini Review
Journal Article