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Publication DateGenes and Development, ISSN 0890-9369, 12/2004, Volume 18, Issue 24, pp. 3055 - 3065
The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit...
SOCS-box protein | VHL-box protein | E3 ubiquitin ligase | Cullin | RNA-POLYMERASE-II | DEVELOPMENTAL BIOLOGY | F-BOX | ELONGIN BC COMPLEX | U-BOX | DEPENDENT PROTEOLYSIS | GENETICS & HEREDITY | TUMOR-SUPPRESSOR PROTEIN | DEGRADATION | RING FINGER | HIF-ALPHA | TRANSCRIPTION FACTOR-SIII | Immunoprecipitation | Models, Chemical | Humans | Molecular Sequence Data | Suppressor of Cytokine Signaling 1 Protein | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | Suppressor of Cytokine Signaling Proteins | RNA Interference | Mass Spectrometry | Tumor Suppressor Proteins - genetics | Cullin Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Cullin Proteins - genetics | Sequence Alignment | Carrier Proteins - metabolism | Proteins - metabolism | Protein Binding | Von Hippel-Lindau Tumor Suppressor Protein | Gene Components | Ubiquitin-Protein Ligases - genetics | Genetic research | Research | Protein kinases | Von Hippel-Lindau disease | Research Papers
SOCS-box protein | VHL-box protein | E3 ubiquitin ligase | Cullin | RNA-POLYMERASE-II | DEVELOPMENTAL BIOLOGY | F-BOX | ELONGIN BC COMPLEX | U-BOX | DEPENDENT PROTEOLYSIS | GENETICS & HEREDITY | TUMOR-SUPPRESSOR PROTEIN | DEGRADATION | RING FINGER | HIF-ALPHA | TRANSCRIPTION FACTOR-SIII | Immunoprecipitation | Models, Chemical | Humans | Molecular Sequence Data | Suppressor of Cytokine Signaling 1 Protein | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | Suppressor of Cytokine Signaling Proteins | RNA Interference | Mass Spectrometry | Tumor Suppressor Proteins - genetics | Cullin Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Cullin Proteins - genetics | Sequence Alignment | Carrier Proteins - metabolism | Proteins - metabolism | Protein Binding | Von Hippel-Lindau Tumor Suppressor Protein | Gene Components | Ubiquitin-Protein Ligases - genetics | Genetic research | Research | Protein kinases | Von Hippel-Lindau disease | Research Papers
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Loading RightsNature Immunology, ISSN 1529-2908, 02/2006, Volume 7, Issue 2, pp. 148 - 155
Toll-like receptor (TLR) signals that initiate innate immune responses to pathogens must be tightly regulated to prevent excessive inflammatory damage to the...
BRUTONS TYROSINE KINASE | INDUCED STAT INHIBITOR | ACTIVATION | SOCS PROTEINS | PHOSPHORYLATION | LIPOPOLYSACCHARIDE | TRANSDUCTION | BOX | IMMUNOLOGY | NF-KAPPA-B | TLR4 | Phosphorylation | Humans | Proteolipids - metabolism | Transcriptional Activation | Ubiquitin - metabolism | Suppressor of Cytokine Signaling 1 Protein | Suppressor of Cytokine Signaling Proteins - deficiency | Transcription Factor RelA - genetics | Proteolipids - immunology | Myelin and Lymphocyte-Associated Proteolipid Proteins | Mice, Inbred CBA | Myelin Proteins - immunology | Membrane Transport Proteins - metabolism | Toll-Like Receptors - metabolism | Carrier Proteins - immunology | Repressor Proteins - metabolism | Cell Line | Signal Transduction | Suppressor of Cytokine Signaling Proteins - immunology | Repressor Proteins - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Carrier Proteins - genetics | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Transcription Factor RelA - metabolism | Repressor Proteins - immunology | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Membrane Transport Proteins - immunology | Myelin Proteins - metabolism
BRUTONS TYROSINE KINASE | INDUCED STAT INHIBITOR | ACTIVATION | SOCS PROTEINS | PHOSPHORYLATION | LIPOPOLYSACCHARIDE | TRANSDUCTION | BOX | IMMUNOLOGY | NF-KAPPA-B | TLR4 | Phosphorylation | Humans | Proteolipids - metabolism | Transcriptional Activation | Ubiquitin - metabolism | Suppressor of Cytokine Signaling 1 Protein | Suppressor of Cytokine Signaling Proteins - deficiency | Transcription Factor RelA - genetics | Proteolipids - immunology | Myelin and Lymphocyte-Associated Proteolipid Proteins | Mice, Inbred CBA | Myelin Proteins - immunology | Membrane Transport Proteins - metabolism | Toll-Like Receptors - metabolism | Carrier Proteins - immunology | Repressor Proteins - metabolism | Cell Line | Signal Transduction | Suppressor of Cytokine Signaling Proteins - immunology | Repressor Proteins - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Carrier Proteins - genetics | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Transcription Factor RelA - metabolism | Repressor Proteins - immunology | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Membrane Transport Proteins - immunology | Myelin Proteins - metabolism
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Loading RightsInternational Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue...
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
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Loading RightsBiochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are...
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
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Loading RightsJournal of Molecular Biology, ISSN 0022-2836, 10/2016, Volume 428, Issue 21, pp. 4330 - 4344
RanBPM and RanBP10 are non-canonical members of the Ran binding protein family that lack the Ran binding domain and do not associate with Ran GTPase . Rather,...
RanBPM/RanBP10 | SPRY domain | crystal structure | DDX-4 | scaffolding protein | ANDROGEN RECEPTOR | COMPLEX | SOCS-BOX | RECOGNITION | PHOSPHORYLATION | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNE | GENE | PATHWAY | Adaptor Proteins, Signal Transducing - chemistry | Microtubule-Associated Proteins - chemistry | B30.2-SPRY Domain | Guanine Nucleotide Exchange Factors - genetics | Microtubule-Associated Proteins - genetics | Cytoskeletal Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Models, Molecular | Crystallography, X-Ray | Nuclear Proteins - metabolism | Cytoskeletal Proteins - chemistry | Nuclear Proteins - chemistry | Germ Cells - physiology | Guanine Nucleotide Exchange Factors - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Cytoskeletal Proteins - metabolism | Protein Conformation | Adaptor Proteins, Signal Transducing - metabolism | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | Guanine Nucleotide Exchange Factors - chemistry | Proteins | RNA | Crystals | Tryptophan | Structure | Protein-protein interactions | Protein binding | Index Medicus
RanBPM/RanBP10 | SPRY domain | crystal structure | DDX-4 | scaffolding protein | ANDROGEN RECEPTOR | COMPLEX | SOCS-BOX | RECOGNITION | PHOSPHORYLATION | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNE | GENE | PATHWAY | Adaptor Proteins, Signal Transducing - chemistry | Microtubule-Associated Proteins - chemistry | B30.2-SPRY Domain | Guanine Nucleotide Exchange Factors - genetics | Microtubule-Associated Proteins - genetics | Cytoskeletal Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Models, Molecular | Crystallography, X-Ray | Nuclear Proteins - metabolism | Cytoskeletal Proteins - chemistry | Nuclear Proteins - chemistry | Germ Cells - physiology | Guanine Nucleotide Exchange Factors - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Cytoskeletal Proteins - metabolism | Protein Conformation | Adaptor Proteins, Signal Transducing - metabolism | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | Guanine Nucleotide Exchange Factors - chemistry | Proteins | RNA | Crystals | Tryptophan | Structure | Protein-protein interactions | Protein binding | Index Medicus
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Loading RightsGenes and Development, ISSN 0890-9369, 12/1998, Volume 12, Issue 24, pp. 3872 - 3881
The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a...
Protein degradation | SOCS box | SOCS-1 | Jak/STAT signaling | Elongin BC complex | RNA-POLYMERASE-II | ACTIVATION | PROTEIN | TUMOR-SUPPRESSOR GENE | DEVELOPMENTAL BIOLOGY | F-BOX | IDENTIFICATION | INDUCED STAT INHIBITOR | ELONGATION | PRODUCT | GENETICS & HEREDITY | protein degradation | TRANSCRIPTION FACTOR-SIII | Consensus Sequence | Protein-Tyrosine Kinases - metabolism | Repressor Proteins | Molecular Sequence Data | Suppressor of Cytokine Signaling 1 Protein | ras Proteins - metabolism | Suppressor of Cytokine Signaling Proteins | Recombinant Fusion Proteins - metabolism | Ankyrins - chemistry | Elongin | Janus Kinase 2 | ras Proteins - chemistry | Carrier Proteins - chemistry | Proto-Oncogene Proteins | Binding Sites | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Cell Line | Signal Transduction | Enzyme Stability | Gene Expression Regulation | Rats | Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Suppressor of Cytokine Signaling 3 Protein | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Ankyrins - metabolism | Protein Binding | Transcription Factors - isolation & purification | Mice | Mutation | Proteins - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Tumor suppressor genes | Cellular signal transduction | Separation | Observations | Jak | Research Paper | STAT signaling
Protein degradation | SOCS box | SOCS-1 | Jak/STAT signaling | Elongin BC complex | RNA-POLYMERASE-II | ACTIVATION | PROTEIN | TUMOR-SUPPRESSOR GENE | DEVELOPMENTAL BIOLOGY | F-BOX | IDENTIFICATION | INDUCED STAT INHIBITOR | ELONGATION | PRODUCT | GENETICS & HEREDITY | protein degradation | TRANSCRIPTION FACTOR-SIII | Consensus Sequence | Protein-Tyrosine Kinases - metabolism | Repressor Proteins | Molecular Sequence Data | Suppressor of Cytokine Signaling 1 Protein | ras Proteins - metabolism | Suppressor of Cytokine Signaling Proteins | Recombinant Fusion Proteins - metabolism | Ankyrins - chemistry | Elongin | Janus Kinase 2 | ras Proteins - chemistry | Carrier Proteins - chemistry | Proto-Oncogene Proteins | Binding Sites | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Cell Line | Signal Transduction | Enzyme Stability | Gene Expression Regulation | Rats | Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Suppressor of Cytokine Signaling 3 Protein | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Ankyrins - metabolism | Protein Binding | Transcription Factors - isolation & purification | Mice | Mutation | Proteins - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Tumor suppressor genes | Cellular signal transduction | Separation | Observations | Jak | Research Paper | STAT signaling
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Loading RightsGenes and Development, ISSN 0890-9369, 12/2001, Volume 15, Issue 23, pp. 3104 - 3117
Although MDM2 plays a major role in regulating the stability of the p53 tumor suppressor protein, other poorly understood MDM2-independent pathways also exist....
Protein degradation | Ubiquitination | Adenovirus | Cullin complexes | NEDD8 | Elongin B | Elongin C | P53 | TRANSCRIPTIONAL ACTIVATION | LIGASE ACTIVITY | 55-KILODALTON PROTEIN | UBIQUITIN-LIKE PROTEIN | NUCLEAR EXPORT | DEVELOPMENTAL BIOLOGY | elongin B | elongin C | ELONGIN BC COMPLEX | CELL BIOLOGY | DEPENDENT PROTEOLYSIS | ubiquitination | GENETICS & HEREDITY | TUMOR-SUPPRESSOR PROTEIN | INFECTED-CELLS | p53 adenovirus | protein degradation | SOCS-BOX MOTIF | Temperature | Molecular Weight | Humans | Multiprotein Complexes | Ubiquitin - metabolism | Ligases - chemistry | Elongin | Adenovirus E4 Proteins - metabolism | Tumor Cells, Cultured | Adenovirus E1B Proteins - metabolism | CHO Cells | Cell Line | Cricetinae | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ligases - metabolism | Adenovirus E1B Proteins - chemistry | Blotting, Western | Macromolecular Substances | Transcription Factors - metabolism | Ubiquitin-Protein Ligases | Microscopy, Confocal | Animals | Carrier Proteins - metabolism | Models, Biological | Protein Binding | Mice | Proteins | Ubiquitin | Genetic research | Physiological aspects | Analysis | Adenoviruses | E1B55K protein | cullin | Rbx1 protein | E1B-55K protein | E4orf6 protein | Cul5 protein | adenovirus | Research Paper | p53
Protein degradation | Ubiquitination | Adenovirus | Cullin complexes | NEDD8 | Elongin B | Elongin C | P53 | TRANSCRIPTIONAL ACTIVATION | LIGASE ACTIVITY | 55-KILODALTON PROTEIN | UBIQUITIN-LIKE PROTEIN | NUCLEAR EXPORT | DEVELOPMENTAL BIOLOGY | elongin B | elongin C | ELONGIN BC COMPLEX | CELL BIOLOGY | DEPENDENT PROTEOLYSIS | ubiquitination | GENETICS & HEREDITY | TUMOR-SUPPRESSOR PROTEIN | INFECTED-CELLS | p53 adenovirus | protein degradation | SOCS-BOX MOTIF | Temperature | Molecular Weight | Humans | Multiprotein Complexes | Ubiquitin - metabolism | Ligases - chemistry | Elongin | Adenovirus E4 Proteins - metabolism | Tumor Cells, Cultured | Adenovirus E1B Proteins - metabolism | CHO Cells | Cell Line | Cricetinae | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ligases - metabolism | Adenovirus E1B Proteins - chemistry | Blotting, Western | Macromolecular Substances | Transcription Factors - metabolism | Ubiquitin-Protein Ligases | Microscopy, Confocal | Animals | Carrier Proteins - metabolism | Models, Biological | Protein Binding | Mice | Proteins | Ubiquitin | Genetic research | Physiological aspects | Analysis | Adenoviruses | E1B55K protein | cullin | Rbx1 protein | E1B-55K protein | E4orf6 protein | Cul5 protein | adenovirus | Research Paper | p53
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Loading RightsCell, ISSN 0092-8674, 2006, Volume 124, Issue 1, pp. 105 - 117
The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses...
SV5 V | SOCS-BOX | SIMIAN-VIRUS-5 | BETA-PROPELLERS | STAT1 | CRYSTAL-STRUCTURE | TOMATO HOMOLOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | BINDING-PROTEIN | GENOME STABILITY | CELL BIOLOGY | Protein Structure, Tertiary | DNA-Binding Proteins - physiology | Mutagenesis, Site-Directed | Humans | Crystallization | Models, Molecular | Crystallography, X-Ray | Cullin Proteins - physiology | Ubiquitin-Protein Ligases - chemistry | Ubiquitin-Protein Ligases - physiology | Viral Structural Proteins - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Cullin Proteins - genetics | Viral Structural Proteins - genetics | Viral Structural Proteins - physiology | Genes, Viral | Protein Conformation | Ubiquitin-Protein Ligases - genetics | Proteins | Ubiquitin | Paramyxoviruses | Research | Chemical properties | Structure | Virus diseases | Biological response modifiers | Ligases | Crystals
SV5 V | SOCS-BOX | SIMIAN-VIRUS-5 | BETA-PROPELLERS | STAT1 | CRYSTAL-STRUCTURE | TOMATO HOMOLOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | BINDING-PROTEIN | GENOME STABILITY | CELL BIOLOGY | Protein Structure, Tertiary | DNA-Binding Proteins - physiology | Mutagenesis, Site-Directed | Humans | Crystallization | Models, Molecular | Crystallography, X-Ray | Cullin Proteins - physiology | Ubiquitin-Protein Ligases - chemistry | Ubiquitin-Protein Ligases - physiology | Viral Structural Proteins - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Cullin Proteins - genetics | Viral Structural Proteins - genetics | Viral Structural Proteins - physiology | Genes, Viral | Protein Conformation | Ubiquitin-Protein Ligases - genetics | Proteins | Ubiquitin | Paramyxoviruses | Research | Chemical properties | Structure | Virus diseases | Biological response modifiers | Ligases | Crystals
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