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Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 283 - 293
The atherogenic cytokine IL-6 (interleukin-6) induces pro-inflammatory gene expression in VECs (vascular endothelial cells) by activating the JAK (Janus... 
Flavanoid | Suppressor of cytokine signalling 3 (SOCS3) | Interleukin-6 (IL-6) | Gene expression | Janus kinase/signal transducer and activator of transcription (JAK/STAT) | Endothelium, Vascular - cytology | AMP-Activated Protein Kinases - metabolism | Interleukin-6 - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Cercopithecus aethiops | Flavonoids - antagonists & inhibitors | Endothelium, Vascular - drug effects | Promoter Regions, Genetic - drug effects | Interleukin-6 Receptor alpha Subunit - metabolism | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - cytology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Cell Line | Human Umbilical Vein Endothelial Cells - drug effects | Cytokine Receptor gp130 - metabolism | AMP-Activated Protein Kinases - antagonists & inhibitors | Cells, Cultured | Suppressor of Cytokine Signaling Proteins - genetics | Mutant Proteins - metabolism | Recombinant Proteins - agonists | Gene Expression Regulation - drug effects | Suppressor of Cytokine Signaling 3 Protein | Animals | Cytokine Receptor gp130 - antagonists & inhibitors | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Flavonoids - metabolism | Suppressor of Cytokine Signaling Proteins - agonists | Mice | Protein Kinase Inhibitors - pharmacology | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Mutant Proteins - agonists | MEK, MAPK | suppressor of cytokine signalling 3 (SOCS3) | ACC, acetyl-CoA carboxylase | SH, Src homology | flavanoid | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | RT, reverse transcription | ERK kinase | interleukin-6 (IL-6) | PDE, phosphodiesterase | ERK, extracellular-signal-regulated kinase | IL-6R, IL-6 receptor | Janus kinase | CK2, casein kinase 2 | TNFα, tumour necrosis factor α | HUVEC, human umbilical vein endothelial cell | PKC, protein kinase C | STAT3, signal transducer and activator of transcription 3 | SOCS, suppressor of cytokine signalling | VEC, vascular endothelial cell | STAT | DMEM, Dulbecco’s modified Eagle’s medium | JAK, Janus kinase | IL, interleukin | signal transducer and activator of transcription (JAK | VASP, vasodilator-stimulated phosphoprotein | MCP-1, monocyte chemotactic protein-1 | gene expression | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Scandinavian Journal of Immunology, ISSN 0300-9475, 11/2016, Volume 84, Issue 5, pp. 299 - 309
Although the specific events dictating systemic lupus erythematosus (SLE) pathology remain unclear, abundant evidence indicates a critical role for... 
IMMUNITY | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | TYPE-1 DIABETES SUSCEPTIBILITY | DENDRITIC CELLS | SOCS PROTEINS | IFN-GAMMA | GENE-EXPRESSION | INDUCTION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | RNA, Messenger - immunology | Humans | Middle Aged | Male | Case-Control Studies | CD3 Complex - genetics | Leukocytes, Mononuclear - immunology | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Suppressor of Cytokine Signaling 1 Protein - immunology | Steroids - therapeutic use | Suppressor of Cytokine Signaling 3 Protein - immunology | Suppressor of Cytokine Signaling 1 Protein - genetics | Leukocytes, Mononuclear - drug effects | Signal Transduction | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Suppressor of Cytokine Signaling 3 Protein - genetics | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Antibodies - pharmacology | Leukocytes, Mononuclear - pathology | Animals | Histocompatibility Antigens Class II - immunology | Lupus Erythematosus, Systemic - genetics | Adolescent | CD3 Complex - immunology | Lipopolysaccharides - pharmacology | Aged | Mice | Histocompatibility Antigens Class II - genetics | Primary Cell Culture | Lupus Erythematosus, Systemic - pathology | Interferon-gamma - pharmacology | Systemic lupus erythematosus | RNA | Analysis | Development and progression | Interferon | Biological response modifiers | Drug therapy | Health aspects | Autoimmunity | kinase | STAT | signal transducers and activators of transcription (Jak | signal transduction | biomarkers | Janus kinase | lupus | tolerance
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2010, Volume 185, Issue 10, pp. 6226 - 6233
Journal Article
DIABETOLOGIA, ISSN 0012-186X, 09/2010, Volume 53, Issue 9, pp. 1935 - 1946
Aims/hypothesis Suppressor of cytokine signalling (SOCS) proteins are powerful inhibitors of pathways involved in survival and function of pancreatic beta... 
Glucose intolerance | Pancreatic beta cell | Transgenic mice | SOCS | Insulin secretion | PROINSULIN CONVERSION | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | RISK LOCI | IN-VIVO | GROWTH | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | MICE | SECRETION | Proinsulin maturation | GENOME-WIDE ASSOCIATION
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2006, Volume 7, Issue 2, pp. 148 - 155
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 11/2011, Volume 90, Issue 5, pp. 845 - 854
Journal Article