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Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 376 - 379
The human APOBEC3 cytidine deaminases are potent inhibitors of diverse retroviruses, including human immunodeficiency virus-1 (HIV-1)(1-6). HIV-1 Vif forms an... 
COMPLEX | SOCS-BOX | PROTEIN | RUNT DOMAIN | MULTIDISCIPLINARY SCIENCES | ANTIVIRAL ACTIVITY | ENZYME APOBEC3G | DEGRADATION | VIRUS TYPE-1 VIF | BINDING | E3 UBIQUITIN LIGASE
Journal Article
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 07/2018, Volume 10, Issue 7
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to... 
INDUCIBLE SH2 PROTEIN | ACTIVATED T-CELLS | HEPATITIS-B-VIRUS | SOCS-BOX | JAK/STAT PATHWAY | DENDRITIC CELLS | IFN-GAMMA | HUMAN HEPATOCELLULAR-CARCINOMA | SH2-CONTAINING PROTEIN | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
Journal Article
by Zhao, GX and Gong, LY and Su, D and Jin, YJ and Guo, CC and Yue, MT and Yao, S and Qin, Z and Ye, Y and Tang, Y and Wu, QB and Zhang, J and Cui, BH and Ding, QR and Huang, HY and Hu, L and Chen, YT and Zhang, PY and Hu, GH and Chen, LN and Wong, KK and Gao, DM and Ji, HB
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 03/2019, Volume 129, Issue 3, pp. 972 - 987
Metastasis is the dominant cause of patient death in small-cell lung cancer (SCLC), and a better understanding of the molecular mechanisms underlying SCLC... 
MEDICINE, RESEARCH & EXPERIMENTAL | SOCS-BOX | SRC | MYC | MOUSE MODEL | GROWTH | DRIVES PROTEASOMAL DEGRADATION | POOR PROGNOSTIC-FACTOR | CUL5-RBX2 MODULES | EXPRESSION | CARCINOMA
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 371 - 375
Journal Article
IUBMB Life, ISSN 1521-6543, 04/2012, Volume 64, Issue 4, pp. spcone - spcone
The suppressor of cytokine signalling (SOCS) box was first identified in the SH2‐containing SOCS box family (cytokine‐inducible SH2‐containing protein,... 
proteasome | E3 ligase | SOCS box | cullin | ubiquitin
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 2011, Volume 22, Issue 1, pp. 33 - 41
The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins – p21Cip1/WAF1 , p27Kip1 , and p57Kip2 – that bind and... 
Pathology | BREAST-CANCER | UBIQUITIN-MEDIATED DEGRADATION | SOCS-BOX | P27 | PROTEASOMAL DEGRADATION | COP9 SIGNALOSOME | PROTEIN-KINASE | CELL-CYCLE | CUL5-RBX2 MODULES | G1 PHASE | CELL BIOLOGY | Ubiquitination | Animals | Humans | Substrate Specificity | Transcription, Genetic | Cyclin-Dependent Kinase Inhibitor Proteins - metabolism | Apoptosis | Ubiquitin | Ligases
Journal Article
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 09/2018, Volume 37, Issue 18
Multi-subunit cullin-RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended... 
SUPPRESSOR | COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES AUTOPHAGY | F-BOX PROTEINS | AMBRA1 | interleukin-6 | ubiquitin | CELL BIOLOGY | cullin-RING ligase | STRUCTURAL BASIS | HIV-1 VIF | COP9 SIGNALOSOME | IN-VIVO | HIV infection | E3 LIGASES
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 06/2010, Volume 84, Issue 11, pp. 5741 - 5750
The human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) potently restrict human immunodeficiency virus type 1 (HIV-1) replication, but they are... 
SOCS-BOX | PROTEIN | REPLICATION | VIROLOGY | HIV-1 VIF | CYTIDINE DEAMINASE APOBEC3H | ANTIVIRAL ACTIVITY | DEGRADATION | RESTRICTION | ANTIRETROVIRAL FACTOR | E3 UBIQUITIN LIGASE
Journal Article