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PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 6, pp. e11383 - e11383
.... Valproate, a widely used antiepileptic drug, has a number of targets including GABA transaminase, voltage-gated sodium channels, glycogen synthase kinase (GSK... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Neuroprotective Agents - therapeutic use | Brain Injuries - drug therapy | Rats | Male | Hippocampus - drug effects | Cognition - drug effects | Rats, Sprague-Dawley | Valproic Acid - pharmacology | Blotting, Western | Dose-Response Relationship, Drug | Hippocampus - metabolism | Animals | Neuroprotective Agents - pharmacology | Valproic Acid - administration & dosage | Valproic Acid - therapeutic use | Acetylation | Histones - metabolism | Neuroprotective Agents - administration & dosage | Blood-Brain Barrier | Disease Models, Animal | Brain | Synthesis | Glycogen | Neurons | GABA | Drug therapy, Combination | Permeability | Glutamate | Gene expression | Injuries | Blood transfusions | Histone deacetylase | Neuroprotection | Neurosciences | Traumatic brain injury | Hyperactivity | Memory | Transaminase | Cognitive ability | Neurobiology | Membrane permeability | Science | Neurosurgery | Antiepileptic agents | Memory tasks | γ-Aminobutyric acid | Head injuries | Blood-brain barrier | Ischemia | Rodents | Extravasation | Sodium channels (voltage-gated) | Behavior | Damage | Drug dosages | Edema | Immunoglobulins | 4-Aminobutyrate transaminase | Spatial analysis | Hydroxamic acid | Glycogen synthase kinase 3 | Valproic acid | Trauma | Signaling | Injury prevention | Sodium | Laboratory animals | Histone H3 | Hippocampus | Apoptosis | Spatial memory | Animal cognition | Index Medicus
Journal Article
Naunyn-Schmiedeberg's archives of pharmacology, ISSN 1432-1912, 10/2013, Volume 387, Issue 2, pp. 143 - 151
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2017, Volume 95, Issue 4, pp. 420 - 426
Drug-induced hepatotoxicity is one of the most commonly encountered obstacles in the field of medical practice. Sodium valproate (VPA... 
liver injury | sulforaphane | TNFα | hème oxygénase 1 | valproate de sodium | heme oxygenase-1 | lésions hépatiques | sodium valproate | Sodium valproate | Sulforaphane | Heme oxygenase-1 | Liver injury | Pharmacology & Pharmacy | Physiology | Life Sciences & Biomedicine | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Heme Oxygenase-1 - metabolism | Phytochemicals - therapeutic use | Glutathione - metabolism | Humans | Male | Alanine Transaminase - blood | Anticonvulsants - adverse effects | Isothiocyanates - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Valproic Acid - therapeutic use | Chemical and Drug Induced Liver Injury - pathology | Drug Evaluation, Preclinical | Valproic Acid - adverse effects | Chemical and Drug Induced Liver Injury - etiology | Anticarcinogenic Agents - therapeutic use | Brassica - chemistry | Disease Models, Animal | Liver Function Tests | Malondialdehyde - metabolism | Chemical and Drug Induced Liver Injury - prevention & control | Biomarkers - analysis | Anticonvulsants - therapeutic use | Rats | Rats, Sprague-Dawley | Antioxidants - therapeutic use | Animals | Aspartate Aminotransferases - blood | Epilepsy - drug therapy | Thiocyanates | Liver failure | Care and treatment | Health aspects | Prescription drugs | Liver diseases | Organic chemicals | Toxicity | Rodents | Index Medicus
Journal Article
International Journal of Trichology, ISSN 0974-7753, 7/2018, Volume 10, Issue 4, pp. 150 - 153
Valproate is a drug used in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis, and off label in many indications by various specialists... 
hair regeneration | valproate | hair | Hair loss | Online searching | Complications and side effects | Bipolar disorder | Internet/Web search services | Antipsychotic drugs | Database searching | Hair | Plasma | Pediatrics | Epilepsy | Migraine | Liver | Prophylaxis | Clinical trials | Gene expression | Kinases | Patients | Weight | Studies | Signal transduction | Regeneration | Side effects | Sodium | Search engines | Acidosis | Drug dosages | Review
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0176855 - e0176855
.... This report demonstrates that sodium valproate, a histone deacetylase inhibitor (HDACi), can increase the cytotoxicity of carboplatin in an additive and synergistic manner in DIPG cells in vitro... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Survival - drug effects | Adjuvants, Pharmaceutic - pharmacology | Apoptosis - drug effects | Humans | Cells, Cultured | Rats | Brain Stem Neoplasms - drug therapy | Hippocampus - drug effects | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Brain Stem Neoplasms - metabolism | Glioma - metabolism | Hippocampus - metabolism | Acetylation - drug effects | Animals | Drug Repositioning - methods | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Epigenesis, Genetic - drug effects | Glioma - drug therapy | Divalproex | Complications and side effects | Gliomas | Dosage and administration | Research | Drug therapy | Valproic acid | Slopes | Brain | Cell culture | Brain stem | Estrogens | Brain cancer | Radiation | Cytotoxicity | Cerebrospinal fluid | Cancer therapies | Blood | Anticancer properties | Proteins | Learning | Alterations | Blood-brain barrier | Surgery | Biocompatibility | Genetics | Diagnosis | Acetylation | Inhibition | Deoxyribonucleic acid--DNA | Medical research | Iodides | Lymphatic leukemia | Gene expression | Survival | Discrimination | Inhibitors | Sodium | Documents | Carboplatin | Mutation | Drugs | Surgical implants | Animal models | Chromatin | Drug delivery systems | Toxicity | Leukemia | Brain tumors | Clinical trials | Neurosurgery | Antiepileptic agents | Convection | Platinum | Modulation | DNA methylation | Children | Formulations | Effectiveness | Hematology | Buildings | Breast cancer | Pharmacology | Radiation therapy | Brain research | Cell death | Epigenetics | Skull | Genetic engineering | Annexin V | Methylation | Differentiation | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Practical neurology, ISSN 1474-7758, 06/2018, Volume 18, Issue 3, pp. 176 - 178
...), a regulatory body representing European Union member states, about the use of valproate in women of childbearing potential1 bring these age-old considerations into sharp relief... 
medicine | Pregnancy | Dose-response relationship (Biochemistry) | Divalproex | Safety and security measures | Laws, regulations and rules | Pregnant women | Analysis | Dosage and administration | Valproic acid | Health aspects | Drugs | Prevention | Autism | Neurology | Birth control | Sodium | Epilepsy | Patients | Age | Children & youth | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e98892 - e98892
.... We analyzed changes in miRNome and transcriptome during neural differentiation of mESCs exposed to the developmental neurotoxicant sodium valproate (VPA... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Neurotoxicity Syndromes - genetics | Neurons - cytology | Gene Regulatory Networks | Valproic Acid - toxicity | Cell Differentiation - genetics | Time Factors | Neurons - metabolism | Neurons - drug effects | Cell Line | Cell Survival - drug effects | Reproducibility of Results | Gene Expression Profiling - methods | Drug Discovery | GABA Agents - toxicity | Gene Expression Regulation - drug effects | Animals | Embryonic Stem Cells - drug effects | Signal Transduction - drug effects | Cell Differentiation - drug effects | Muscle Development - genetics | Neurotoxicity Syndromes - metabolism | Histone Deacetylase Inhibitors - pharmacology | Mice | MicroRNAs - genetics | In Vitro Techniques | Cluster Analysis | MicroRNA | Embryonic stem cells | Racial profiling | Myosin | Arsenic compounds | Drugs | Histone deacetylase | Decorin | Profiling | Toxicity | Genes | Embryo cells | Stem cell transplantation | Neurogenesis | Morphogenesis | Neurotoxicity | Calponin | Allografts | Developmental stages | Specifications | Coding | Risk assessment | miRNA | Trichostatin A | Sodium arsenite | Muscles | Exposure | Gene expression | Valproic acid | Ribonucleic acid--RNA | Chemicals | Myogenesis | Studies | Brain research | Sodium | MicroRNAs | Stem cells | Epigenetics | Sodium valproate | Differentiation | In vitro methods and tests | Non-coding RNA | Arsenite | Index Medicus | RNA | Ribonucleic acid
Journal Article