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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 47, pp. 19444 - 19449
Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-function variants of sodium channel Na(v)1.7 have recently been found in... 
patch clamp | dorsal root ganglia | NERVE | RAT | MULTIDISCIPLINARY SCIENCES | DRG NEURONS | SMALL FIBER NEUROPATHY | INJURY | SODIUM-CHANNEL | SENSORY NEURONS | DENSITY | ERYTHROMELALGIA | EXPRESSION
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 06/2012, Volume 18, Issue 6, pp. 926 - 926
This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic metabolite methylglyoxal. We found that concentrations of plasma... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | FOREBRAIN | SENSITIVE METHOD | RAT | ROOT GANGLION NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-FLOW | CELL BIOLOGY | PERIPHERAL NEUROPATHY | RESISTANT SODIUM-CHANNELS | EXPRESSION | GLYOXALASE-I
Journal Article
PAIN, ISSN 0304-3959, 10/2012, Volume 153, Issue 10, pp. 2017 - 2030
A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal... 
GENE-RELATED PEPTIDE | C fiber | PRIMARY AFFERENT NEURONS | tdTomato | DRG NEURONS | VGSC | SPINAL-CORD | Scn10a | DORSAL-ROOT GANGLION | NEUROSCIENCES | CLINICAL NEUROLOGY | Nociceptive | NEUROPATHIC PAIN | ANESTHESIOLOGY | INFLAMMATORY PAIN | PRIMARY SENSORY NEURONS | RESISTANT SODIUM-CHANNELS | SUBSTANCE-P | C-LTM
Journal Article
NEUROSCIENCE, ISSN 0306-4522, 01/2017, Volume 340, pp. 279 - 290
We examined the contribution of the sodium channel isoform Na(v)1.8 to retinal function using the specific blocker A803467. We found that A803467 has little... 
RABBIT RETINA | B-WAVE | oscillatory potentials | NEUROSCIENCES | ACETYLCHOLINE-RECEPTORS | sodium channels | retina | AXON INITIAL SEGMENT | GANGLION-CELLS | electroretinogram | NEURONS | MOUSE RETINA | DIRECTIONAL SELECTIVITY | starburst amacrine cells | Na(v)1.8
Journal Article
Circulation research, ISSN 0009-7330, 2012, Volume 111, Issue 3, pp. 333 - 343
Rationale: The SCN10A gene encodes the neuronal sodium channel isoform Na(V)1.8. Several recent genome-wide association studies have linked SCN10A to PR... 
cardiac electrophysiology | COMMON VARIANTS | CARDIAC & CARDIOVASCULAR SYSTEMS | autonomic nervous system | RAT | GATED SODIUM-CHANNELS | DRG NEURONS | SINOATRIAL NODE | SENSORY NEURONS | TETRODOTOXIN-RESISTANT | SCN10A | PR INTERVAL | sodium channels | PERIPHERAL VASCULAR DISEASE | HEART-RATE | QRS DURATION | HEMATOLOGY
Journal Article
Journal of Neurology Neurosurgery and Psychiatry, ISSN 0022-3050, 05/2014, Volume 85, Issue 5, pp. 499 - 505
Objective Painful small fibre neuropathy (SFN) represents a significant public health problem, with no cause apparent in one-half of cases (termed idiopathic,... 
SURGERY | RAT | GANGLION NEURONS | PSYCHIATRY | NOCICEPTORS | GATED SODIUM-CHANNEL | SENSORY NEURONS | CLINICAL NEUROLOGY | SCN10A | EXTREME PAIN DISORDER | EXPRESSION | NA+ CURRENT | SARCOIDOSIS
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 06/2019, Volume 33, Issue 6, pp. 7315 - 7330
Voltage-dependent sodium (Na-V) 1.8 channels regulate action potential generation in nociceptive neurons, identifying them as putative analgesic targets. Here,... 
PROTEIN-KINASE-A | LOCALIZATION | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | INDUCED INTERNALIZATION | nociception | SCHIZOPHRENIA | ACTIVATED POTASSIUM CHANNELS | CELL BIOLOGY | sodium channels | potassium channels | DYSREGULATION | BIOLOGY | peptidomimetics | trafficking | EXPRESSION
Journal Article
PHARMACEUTICAL RESEARCH, ISSN 0724-8741, 09/2019, Volume 36, Issue 9
PurposePitt Hopkins Syndrome (PTHS) is a rare genetic disorder caused by mutations of a specific gene, transcription factor 4 (TCF4), located on chromosome 18.... 
MENTAL-RETARDATION | GATED SODIUM-CHANNELS | TRAFFICKING | repurposing | Na(v)1 | CHEMISTRY, MULTIDISCIPLINARY | HAPLOINSUFFICIENCY | K(v)7 | Pitt Hopkins syndrome | MODELS | KCNQ1 | PHARMACOLOGY & PHARMACY | high throughput screen | TCF4 | TRANSCRIPTION FACTOR
Journal Article
JOURNAL OF PHYSIOLOGY-LONDON, ISSN 0022-3751, 05/2018, Volume 596, Issue 10, pp. 1863 - 1872
Voltage-gated sodium (Na-V) channel gating is a complex phenomenon which involves a distinct contribution of four integral voltage-sensing domains (VSDI,... 
SKELETAL-MUSCLE | PHYSIOLOGY | DOMAIN IV | DETERMINANTS | PHARMACOLOGY | GATED SODIUM-CHANNELS | ALPHA-SCORPION TOXIN | K+ CHANNEL | NEUROSCIENCES | FAST INACTIVATION | MODULATION
Journal Article
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, ISSN 1569-9048, 12/2019, Volume 270
Cough in respiratory diseases is attributed to the activation of airway C-fibers by inflammation. Inflammatory mediators can act on multiple receptors... 
NaV1.8 | PHYSIOLOGY | PAIN | Bronchopulmonary C-fibers | RESPIRATORY SYSTEM | CONDUCTION | Vagus nerve | Cough | Voltage-gated sodium channels
Journal Article
MOLECULAR PAIN, ISSN 1744-8069, 06/2019, Volume 15
Chronic pain is a significant unmet medical problem. Current research regarding sodium channel function in pathological pain is advancing with the hope that it... 
PHOSPHORYLATION | GATED SODIUM-CHANNELS | DOWN-REGULATION | IDENTIFICATION | DORSAL-ROOT GANGLION | DRUG TARGETS | NEUROSCIENCES | Nav1.7 | nociceptors | SPINAL SENSORY NEURONS | neuropathic pain | hyperexcitability | sodium channel | dorsal root ganglion | inflammatory pain | voltage-gated sodium channels | EXPRESSION | RESISTANT NA+ CURRENT | Nav1.8
Journal Article
JOURNAL OF NEUROPHYSIOLOGY, ISSN 0022-3077, 05/2016, Volume 115, Issue 5, pp. 2536 - 2555
Firing patterns differ between subpopulations of vestibular primary afferent neurons. The role of sodium (Na-V) channels in this diversity has not been... 
PHYSIOLOGY | HUMAN VENTRICULAR MYOCYTES | DORSAL-ROOT GANGLIA | RESISTANT NA+ CHANNELS | action potential | NEUROSCIENCES | vestibular afferent | FIRING PROPERTIES | HAIR-CELLS | TTX-RESISTANT | vestibular ganglion | sodium channel | CALCIUM-CHANNELS | FUNCTIONAL EXPRESSION | Na(V)1.5 | SMALL DRG NEURONS | Na(V)1.8 | tetrodotoxin | PRIMARY SENSORY NEURONS
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 01/2019, Volume 27, Issue 1, pp. 230 - 239
The voltage gated sodium channel Na(V)1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported... 
CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Neuropathic pain | SCN10A | POTENT | PF-06305591 | Benzimidazole | Na(V)1.8 | INHIBITORS | MUTATIONS | Voltage gated sodium channel | Inflammatory pain
Journal Article
Journal Article
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