X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (35226) 35226
Book Chapter (301) 301
Dissertation (127) 127
Conference Proceeding (51) 51
Newsletter (40) 40
Magazine Article (26) 26
Reference (23) 23
Book / eBook (21) 21
Publication (16) 16
Web Resource (12) 12
Newspaper Article (11) 11
Book Review (6) 6
Government Document (4) 4
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (20868) 20868
humans (11984) 11984
male (7903) 7903
rats (7680) 7680
neurosciences (6800) 6800
sodium channels (6227) 6227
sodium channels - metabolism (5691) 5691
female (5654) 5654
physiology (4867) 4867
mice (4710) 4710
sodium channels - physiology (4513) 4513
sodium channels - genetics (4358) 4358
sodium channels - drug effects (4095) 4095
biochemistry & molecular biology (4086) 4086
patch-clamp techniques (3676) 3676
sodium-channels (3636) 3636
mutation (3567) 3567
pharmacology & pharmacy (3246) 3246
electrophysiology (3024) 3024
sodium - metabolism (2997) 2997
ion channels (2815) 2815
neurons (2796) 2796
cells, cultured (2745) 2745
sodium channel (2737) 2737
research (2698) 2698
rats, sprague-dawley (2671) 2671
tetrodotoxin - pharmacology (2662) 2662
in vitro techniques (2625) 2625
sodium-channel (2575) 2575
sodium channel blockers - pharmacology (2569) 2569
expression (2430) 2430
sodium (2352) 2352
molecular sequence data (2341) 2341
cell biology (2312) 2312
amino acid sequence (2192) 2192
physiological aspects (2128) 2128
analysis (2121) 2121
kinetics (2094) 2094
membrane potentials - drug effects (2068) 2068
cardiac & cardiovascular systems (2039) 2039
clinical neurology (2037) 2037
dose-response relationship, drug (1956) 1956
adult (1917) 1917
action potentials - drug effects (1737) 1737
cells (1729) 1729
biophysics (1711) 1711
neurons - drug effects (1674) 1674
neurons - physiology (1674) 1674
membrane potentials - physiology (1657) 1657
cell line (1654) 1654
potassium channels (1630) 1630
pain (1621) 1621
multidisciplinary sciences (1599) 1599
proteins (1568) 1568
time factors (1556) 1556
epilepsy (1538) 1538
action potentials - physiology (1523) 1523
neurons - metabolism (1481) 1481
middle aged (1453) 1453
calcium - metabolism (1442) 1442
rats, wistar (1434) 1434
genetic aspects (1426) 1426
activation (1409) 1409
rat (1405) 1405
amiloride - pharmacology (1356) 1356
channels (1310) 1310
na+ channel (1294) 1294
mutations (1280) 1280
disease models, animal (1276) 1276
research article (1276) 1276
sodium channels - chemistry (1263) 1263
action potentials (1238) 1238
ion channel gating - physiology (1238) 1238
ion channel gating - drug effects (1205) 1205
epithelial sodium-channel (1202) 1202
na+ channels (1185) 1185
sodium channel blockers (1181) 1181
gene expression (1176) 1176
tetrodotoxin (1169) 1169
brain (1156) 1156
ion channel gating (1149) 1149
epithelial sodium channels - metabolism (1144) 1144
phenotype (1142) 1142
mechanisms (1141) 1141
calcium (1140) 1140
inactivation (1140) 1140
nervous system (1117) 1117
sensory neurons (1107) 1107
mice, inbred c57bl (1098) 1098
membrane potentials (1093) 1093
currents (1051) 1051
calcium channels (1017) 1017
inhibition (1006) 1006
neurology (1006) 1006
xenopus laevis (1005) 1005
epithelial sodium channels (991) 991
biology (989) 989
toxicology (987) 987
electrocardiography (982) 982
electric stimulation (981) 981
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (34909) 34909
Japanese (435) 435
Chinese (269) 269
Russian (169) 169
French (144) 144
German (123) 123
Spanish (84) 84
Portuguese (24) 24
Italian (18) 18
Hungarian (16) 16
Polish (16) 16
Korean (12) 12
Ukrainian (9) 9
Danish (8) 8
Czech (7) 7
Dutch (5) 5
Swedish (5) 5
Norwegian (4) 4
Turkish (4) 4
Finnish (3) 3
Slovak (3) 3
Hebrew (2) 2
Indonesian (1) 1
Romanian (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 7, p. e0180154
Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel... 
TARGET | DYE | KV1.3 | NA(V)1.7 | MODULATORS | MULTIDISCIPLINARY SCIENCES | EXTREME PAIN DISORDER | PATCH-CLAMP | MUTATIONS | Cricetulus | High-Throughput Screening Assays - instrumentation | NAV1.3 Voltage-Gated Sodium Channel - genetics | NAV1.1 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.4 Voltage-Gated Sodium Channel - metabolism | Kv1.3 Potassium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Patch-Clamp Techniques - methods | Kv1.3 Potassium Channel - deficiency | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - genetics | Drug Evaluation, Preclinical | Transgenes | Potassium Channel Blockers - pharmacology | CHO Cells | High-Throughput Screening Assays - methods | Gene Expression | NAV1.4 Voltage-Gated Sodium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - genetics | Rats | Sodium Channel Blockers - pharmacology | Membrane Potentials - physiology | Animals | T-Lymphocytes - cytology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | NAV1.7 Voltage-Gated Sodium Channel - metabolism | NAV1.6 Voltage-Gated Sodium Channel - genetics | Sodium Channels - genetics | Primary Cell Culture | Patch-Clamp Techniques - instrumentation | Ion channels | Information management | Drug discovery | T cells | Modules | Electrophysiology | Patching | Lymphocytes T | Boundaries | Assaying | Channels | Step voltage | Immunology | Pain | Lymphocytes | Sodium channels (voltage-gated) | Physiology | Potassium channels (voltage-gated) | Gold | Platforms | Data points | Automation | Cloning | Pharmacology | Sodium | Antigen-presenting cells | Ligands | Mutation | Recording | Potassium
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 5/2016, Volume 113, Issue 21, pp. 5856 - 5861
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2018, Volume 293, Issue 43, pp. 16546 - 16558
Journal Article
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 07/2015, Volume 1848, Issue 7, pp. 1545 - 1551
With the ultimate goal of detailed structural analysis of mammalian and particularly human voltage-gated sodium channels (VGSCs), we have investigated the... 
Radioligand-binding assay | Human voltage-gated sodium channel | Membrane protein stability | Rat VGSC | Structural biology | Electrophorus electricus | RAT SKELETAL-MUSCLE | ELECTROPHORUS-ELECTRICUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | RECEPTOR | MECHANISMS | MICROSCOPY | BIOPHYSICS | NA+ CHANNEL | SAXITOXIN | MEMBRANE-PROTEINS | BINDING | Temperature | Cricetulus | Detergents - chemistry | Humans | Crystallography, X-Ray | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - chemistry | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - ultrastructure | Membrane Proteins - ultrastructure | Voltage-Gated Sodium Channels - ultrastructure | HEK293 Cells | Membrane Proteins - metabolism | NAV1.3 Voltage-Gated Sodium Channel - ultrastructure | NAV1.2 Voltage-Gated Sodium Channel - ultrastructure | CHO Cells | Toxins, Biological - pharmacology | Cricetinae | Solubility | Benchmarking - methods | Rats | Cryoelectron Microscopy | NAV1.2 Voltage-Gated Sodium Channel - chemistry | Animals | Membrane Proteins - chemistry | Protein Stability - drug effects | Toxins, Biological - metabolism | NAV1.3 Voltage-Gated Sodium Channel - chemistry | Eels - metabolism | Voltage-Gated Sodium Channels - chemistry | Voltage-Gated Sodium Channels - metabolism | Benchmarks | Detergents, Synthetic | Analysis | Eels
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8428 - 8433
Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms... 
Sodium channels | Bromine | Maps | Sodium | Channel blockers | Crystals | Atoms | Binding sites | Crystal structure | Local anesthetics | Pharmacology | QUALITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | NA+ CHANNELS | MOLECULAR DETERMINANTS | INHIBITION | LOCAL-ANESTHETICS | LIDOCAINE | pharmacology | DRUGS | crystal structure | STATE-DEPENDENT BLOCK | BINDING | Humans | NAV1.1 Voltage-Gated Sodium Channel - genetics | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - chemistry | Ion Channel Gating - physiology | HEK293 Cells | Sodium Channels - metabolism | Membrane Potentials - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Triazines - metabolism | Triazines - pharmacology | Alphaproteobacteria - metabolism | Bacterial Proteins - genetics | Models, Molecular | Sodium Channel Blockers - metabolism | Sodium Channel Blockers - pharmacology | Binding Sites - genetics | Membrane Potentials - physiology | Alphaproteobacteria - chemistry | Sequence Homology, Amino Acid | Alphaproteobacteria - genetics | Ion Channel Gating - genetics | Sodium Channels - chemistry | Bacterial Proteins - metabolism | Sodium Channels - genetics | Mutation | Ion Channel Gating - drug effects | Physiological aspects | Prokaryotes | Biological Sciences
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 34, pp. 24316 - 24331
Voltage-gated sodium channel (NaV) trafficking is incompletely understood. Post-translational modifications of NaVs and/or auxiliary subunits and... 
SPINAL SENSORY NEURONS | NEUROPATHIC PAIN | TRAUMATIC BRAIN-INJURY | RESPONSE MEDIATOR PROTEIN-2 | ROOT GANGLION NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SLOW INACTIVATION | ANTICONVULSANT LACOSAMIDE | SUMO MODIFICATION | GROWTH CONE COLLAPSE | NAV1.3 Voltage-Gated Sodium Channel - genetics | Humans | NAV1.1 Voltage-Gated Sodium Channel - genetics | Multienzyme Complexes - metabolism | Protein Transport - physiology | NAV1.1 Voltage-Gated Sodium Channel - metabolism | Protein Transport - drug effects | Sumoylation - physiology | Mutation, Missense | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Sumoylation - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Cysteine Endopeptidases - metabolism | SUMO-1 Protein - genetics | HEK293 Cells | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | Sensory Receptor Cells - metabolism | Cell Differentiation - physiology | Endopeptidases - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Conjugating Enzymes - genetics | Multienzyme Complexes - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Endopeptidases - genetics | Sensory Receptor Cells - cytology | Cell Differentiation - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | NAV1.7 Voltage-Gated Sodium Channel - metabolism | SUMO-1 Protein - metabolism | Sodium Channels - genetics | Catecholamines - pharmacology | Amino Acid Substitution | Signaling | Patch Clamp Electrophysiology | Signal Transduction | Post-translational Modification | Trafficking | CRMP2 | Sodium Channels | Sumoylation | NaV1.1 | NaV1.7
Journal Article
蛋白质与细胞:英文版, ISSN 1674-800X, 2017, Volume 8, Issue 6, pp. 401 - 438
Journal Article