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1. Full Text Actinic keratoses: Natural history and risk of malignant transformation in the veterans affairs topical tretinoin chemoprevention trial
by Criscione, Vincent D and Weinstock, Martin A and Naylor, Mark F and Luque, Claudia and Eide, Melody J and Bingham, Stephen F and Dept Vet Affairs Topical Tretinoin and Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group and for the Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group
Cancer, ISSN 0008-543X, 06/2009, Volume 115, Issue 11, pp. 2523 - 2530
BACKGROUND: Actinic keratoses (AKs) are established as direct precursors of squamous cell carcinoma (SCC), but there is significant controversy regarding the... 
Squamous cell carcinoma | Basal cell carcinoma | Actinic keratoses | Nonmelanoma skin cancer | Epidemiology | actinic keratoses | RELIABILITY | PREVALENCE | SOLAR KERATOSES | epidemiology | NONMELANOMA SKIN-CANCER | ONCOLOGY | QUEENSLAND | FREQUENCY | nonmelanoma skin cancer | SQUAMOUS-CELL CARCINOMA | basal cell carcinoma | VATTC TRIAL | ASSOCIATION | squamous cell carcinoma | Carcinoma, Squamous Cell - epidemiology | Humans | Middle Aged | Male | Risk | Carcinoma, Basal Cell - epidemiology | Skin Neoplasms - epidemiology | Disease Progression | Time Factors | Aged, 80 and over | Adult | Female | Precancerous Conditions - pathology | Aged | Keratosis, Actinic - pathology | Actinic keratosis | Complications and side effects | Patient outcomes | Development and progression | Research | Risk factors
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2. Full Text Prevalence and risk factors of actinic keratoses in Germany – analysis of multisource data
by Schaefer, I and Augustin, M and Spehr, C and Reusch, M and Kornek, T
Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, 03/2014, Volume 28, Issue 3, pp. 309 - 313
Background In Europe, only few and inconsistent data on the prevalence and treatment of actinic keratoses (AK) are available. Objectives To determine the... 
POPULATION | COST | NONMELANOMA SKIN-CANCER | COHORT | CARE | SOLAR KERATOSES | DERMATOLOGY | Young Adult | Keratosis, Actinic - epidemiology | Prevalence | Humans | Middle Aged | Risk Factors | Adolescent | Adult | Female | Male | Aged | Germany - epidemiology | Sunburn | Melanoma | Prevalence studies (Epidemiology) | Keratosis
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3. Full Text Guidelines for the management of actinic keratoses
by de Berker, D and McGregor, J.M and Hughes, B.R and Brit Assoc Dermatol Therapy Guidel and British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and on behalf of the British Association of Dermatologists Therapy Guidelines and Audit Subcommittee
British Journal of Dermatology, ISSN 0007-0963, 02/2007, Volume 156, Issue 2, pp. 222 - 230
Summary These guidelines stemmed from a consensus meeting held by the British Photobiology Group (BPG) in 1999. Following this meeting one of the authors... 
treatment | guidelines | actinic keratosis | Actinic keratosis | Treatment | Guidelines | RANDOMIZED-CONTROLLED-TRIAL | TRANSPLANT RECIPIENTS | SOLAR KERATOSES | DERMATOLOGY | TOPICAL PHOTODYNAMIC THERAPY | SQUAMOUS-CELL CARCINOMA | DOUBLE-BLIND | 5-PERCENT IMIQUIMOD CREAM | TRICHLOROACETIC-ACID | 2.5-PERCENT HYALURONAN GEL | SKIN-CANCER | Skin Neoplasms - therapy | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Photochemotherapy - methods | Humans | Keratosis - therapy | Risk Factors | Antineoplastic Agents - therapeutic use | Skin Neoplasms - etiology | Administration, Cutaneous | Keratosis - diagnosis | Surgical Procedures, Operative - methods | Ultraviolet Rays - adverse effects
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4. Full Text A randomised study of topical 5 imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up
by Krawtchenko, N and Roewert-Huber, J and Ulrich, M and Mann, I and Sterry, W and Stockfleth, E
British Journal of Dermatology, ISSN 0007-0963, 12/2007, Volume 157, Issue s2, pp. 34 - 40
Summary Background  Actinic keratoses (AK) frequently occur on sun-exposed skin and are considered as in situ squamous cell carcinoma. To date, no treatment... 
5-fluorouracil | actinic keratoses | comparative study | cryosurgery | imiquimod | field cancerisation | 5‐fluorouracil | Field cancerisation | 5-Fluorouracil | Cryosurgery | Actinic keratoses | Imiquimod | Comparative study | EFFICACY | PERSPECTIVE | SOLAR KERATOSIS | FLUOROURACIL | FORMULATION | DERMATOLOGY | TRIAL | THERAPY | CREAM | SQUAMOUS-CELL CARCINOMA | DOUBLE-BLIND | Neoplasms, Radiation-Induced - surgery | Skin Neoplasms - drug therapy | Follow-Up Studies | Humans | Middle Aged | Carcinoma, Squamous Cell - surgery | Male | Antineoplastic Agents - therapeutic use | Keratosis - drug therapy | Fluorouracil - therapeutic use | Fluorouracil - adverse effects | Antineoplastic Agents - adverse effects | Aged, 80 and over | Female | Immunocompetence | Skin Neoplasms - surgery | Esthetics | Treatment Outcome | Neoplasms, Radiation-Induced - drug therapy | Ultraviolet Rays - adverse effects | Carcinoma, Squamous Cell - drug therapy | Aged | Cryosurgery - adverse effects | Aminoquinolines - therapeutic use | Aminoquinolines - adverse effects | Medical research | Algorithms | Surgery | Patient outcomes | Medicine, Experimental | Comparative analysis | Fluorouracil | Keratosis
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5. Full Text Methyl aminolaevulinate–photodynamic therapy: a review of clinical trials in the treatment of actinic keratoses and nonmelanoma skin cancer
by Lehmann, P
British Journal of Dermatology, ISSN 0007-0963, 05/2007, Volume 156, Issue 5, pp. 793 - 801
Summary Methyl aminolaevulinate–photodynamic therapy (MAL‐PDT) has advanced the management of nonmelanoma skin cancer (NMSC), providing a treatment option for... 
actinic keratoses | basal cell carcinoma | Bowen's disease | photodynamic therapy | review | methyl aminolaevulinate | Methyl aminolaevulinate | Basal cell carcinoma | Photodynamic therapy | Review | Actinic keratoses | SURGERY | TOPICAL APPLICATION | CRYOTHERAPY | RANDOMIZED MULTICENTER | SOLAR KERATOSES | DERMATOLOGY | BASAL-CELL CARCINOMA | 5-AMINOLEVULINIC ACID | Skin Neoplasms - drug therapy | Photosensitizing Agents - therapeutic use | Photochemotherapy - methods | Bowen's Disease - drug therapy | Humans | Aminolevulinic Acid - analogs & derivatives | Carcinoma, Basal Cell - drug therapy | Treatment Outcome | Aminolevulinic Acid - therapeutic use | Keratosis - drug therapy | Clinical trials | Care and treatment | Melanoma | Cancer | Skin cancer | Keratosis
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6. Full Text Treatment of Actinic Keratoses: A Randomized Split-Site Approach Comparison of Sequential 5-Fluorouracil and 5-Aminolevulinic Acid Photodynamic Therapy to 5-Aminolevulinic Acid Photodynamic Monotherapy
by Pei, Susan and Kaminska, Edidiong C.N and Tsoukas, Maria M
Dermatologic Surgery, ISSN 1076-0512, 09/2017, Volume 43, Issue 9, pp. 1170 - 1175
BACKGROUNDActinic keratoses (AKs) are skin lesions resulting from sun exposure and carry a risk of developing into squamous cell carcinoma. Current therapies... 
TRIAL | SURGERY | TOPICAL FLUOROURACIL | CREAM | MALIGNANT-TRANSFORMATION | CRYOTHERAPY | SQUAMOUS-CELL CARCINOMA | SOLAR KERATOSES | IMIQUIMOD | DERMATOLOGY | Esthetics | Photosensitizing Agents - therapeutic use | Humans | Middle Aged | Male | Photosensitizing Agents - adverse effects | Treatment Outcome | Aminolevulinic Acid - therapeutic use | Dermatologic Agents - therapeutic use | Aminolevulinic Acid - adverse effects | Dermatologic Agents - adverse effects | Fluorouracil - therapeutic use | Fluorouracil - adverse effects | Keratosis, Actinic - drug therapy | Aged, 80 and over | Female | Aged | Drug Therapy, Combination | Actinic keratosis | Treatment outcome | Care and treatment | Usage | Patient outcomes | Analysis | Dosage and administration | Research | Comparative analysis | Photochemotherapy | Fluorouracil | Cancer | Index Medicus
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7. Full Text Actinic keratoses: non-invasive diagnosis for field cancerisation
by Ulrich, M and Maltusch, A and Rowert-Huber, J and Gonzalez, S and Sterry, W and Stockfleth, E and Astner, S
British Journal of Dermatology, ISSN 0007-0963, 05/2007, Volume 156, Issue s3, pp. 13 - 17
Summary Background  Actinic keratoses (AKs) are among the most common cutaneous malignancies and have previously been classified as in situ squamous cell... 
reflectance confocal microscopy | actinic keratoses | non-invasive imaging | non-melanoma skin cancer | field cancerisation | non‐melanoma skin cancer | non‐invasive imaging | HUMAN SKIN | MOHS MICROGRAPHIC SURGERY | SCANNING LASER MICROSCOPY | SOLAR KERATOSES | DERMATOLOGY | CONFOCAL REFLECTANCE MICROSCOPY | BASAL-CELL CARCINOMA | IN-VIVO | CONTRAST | REAL-TIME | Skin Neoplasms - pathology | Sunlight - adverse effects | Humans | Precancerous Conditions - pathology | Biopsy, Needle | Keratosis - pathology | Microscopy, Confocal - methods | Disease Progression | Skin - pathology | Development and progression | Diagnosis | Keratosis
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8. Full Text Optimal treatment of actinic keratoses
by Uhlenhake, EE
CLINICAL INTERVENTIONS IN AGING, ISSN 1176-9092, 2013, Volume 8, pp. 29 - 35
The most compelling reason and primary goal of treating actinic keratoses is to prevent malignant transformation into invasive squamous cell carcinoma, and... 
photodynamic therapy | FLUOROURACIL | actinic keratosis | SOLAR KERATOSES | GERIATRICS & GERONTOLOGY | CONTROLLED-TRIALS | topical chemotherapy | 5-FLUOROURACIL | IMIQUIMOD 5-PERCENT CREAM | NONMELANOMA SKIN-CANCER | SQUAMOUS-CELL CARCINOMA | DOUBLE-BLIND | field therapy | INGENOL MEBUTATE GEL | Precancerous Conditions - therapy | Keratosis, Actinic - therapy | Photochemotherapy - methods | Humans | Aging | Keratosis, Actinic - prevention & control | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Cryotherapy - methods | Precancerous Conditions - prevention & control | Sunscreening Agents - administration & dosage | Actinic keratosis | Photodynamic therapy | Field therapy | Topical chemotherapy | Prevention | Care and treatment | Squamous cell carcinoma | Skin | Research | Medicine, Preventive | Health aspects | Preventive health services | Disease prevention | Chemotherapy | Sunburn & sun tanning | Skin cancer | Review
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9. Full Text Actinic keratoses show variable histological basal growth patterns – a proposed classification adjustment
by Schmitz, L and Gambichler, T and Gupta, G and Stücker, M and Stockfleth, E and Szeimies, R.M and Dirschka, T
Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, 05/2018, Volume 32, Issue 5, pp. 745 - 751
Background Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now,... 
SQUAMOUS-CELL CARCINOMA | SOLAR KERATOSIS | PERSPECTIVE | TREATMENT ALGORITHM | PROGRESSION | DERMATOLOGY | Epidermis - pathology | Facial Dermatoses - classification | Humans | Middle Aged | Male | Facial Dermatoses - pathology | Epidermis - growth & development | Keratinocytes - pathology | Keratosis, Actinic - classification | Aged, 80 and over | Female | Aged | Retrospective Studies | Keratosis, Actinic - pathology | Medicine, Experimental | Medical research | Analysis | Keratosis
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10. Full Text Actinic keratoses
by Callen, Jeffrey P and Bickers, David R and Moy, Ronald L
Journal of the American Academy of Dermatology, ISSN 0190-9622, 1997, Volume 36, Issue 4, pp. 650 - 653
Actinic keratoses are cutaneous neoplasms displaying chromosomal abnormalities that occur primarily on sun-exposed skin surfaces. These premalignant lesions... 
K GA DERMATOLOGY & VENEREAL DISEASES | DERMATOLOGY & VENEREAL DISEASES | SKIN-CANCER | SOLAR KERATOSES | P53 | Cocarcinogenesis | Neoplasms, Radiation-Induced - therapy | Precancerous Conditions - etiology | Carcinoma, Squamous Cell - etiology | Precancerous Conditions - therapy | Skin Neoplasms - therapy | Humans | Neoplasms, Radiation-Induced - etiology | Carcinoma, Squamous Cell - therapy | Skin Neoplasms - etiology | Squamous cell carcinoma | Tumor proteins | Radiation | Keratosis
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11. Full Text Clinical findings using ingenol mebutate gel to treat actinic keratoses
by Martin, George, MD and Swanson, Neil, MD
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2012, Volume 68, Issue 1, pp. S39 - S48
Actinic keratosis (AK) is a common ultraviolet light–induced skin lesion found on sun-exposed skin areas generally in older, fair-skinned people. It is part of... 
Dermatology | local skin response | ingenol mebutate | field cancerization | field therapy | actinic keratosis | PROTEIN-KINASE-C | RANDOMIZED CONTROLLED-TRIAL | TRANSPLANT RECIPIENTS | SOLAR KERATOSES | DERMATOLOGY | P53 MUTATIONS | NONMELANOMA SKIN-CANCER | REGULAR SUNSCREEN USE | IMMUNOCOMPETENT PATIENTS | SQUAMOUS-CELL CARCINOMAS | BASAL-CELL | Skin Neoplasms - pathology | Diterpenes - therapeutic use | Keratinocytes - pathology | Keratosis, Actinic - drug therapy | Humans | Female | Male | Aged | Clinical Trials as Topic | Skin - pathology | Medical research | Squamous cell carcinoma | Medicine, Experimental | Skin | Health aspects | Keratosis | Skin cancer | Index Medicus
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12. Full Text Treatment options for actinic keratoses
by McIntyre, William J and Downs, Michael R and Bedwell, Sondra A
American Family Physician, ISSN 0002-838X, 09/2007, Volume 76, Issue 5, pp. 667 - 672
Actinic keratoses are rough, scaly lesions that commonly occur on sun-exposed areas of the skin. The prevalence of the condition increases with age. Actinic... 
MEDICINE, GENERAL & INTERNAL | IMIQUIMOD 5-PERCENT CREAM | PHOTODYNAMIC THERAPY | CLINICAL-TRIAL | VEHICLE-CONTROLLED TRIALS | PARALLEL-GROUP | SQUAMOUS-CELL CARCINOMA | DOUBLE-BLIND | FLUOROURACIL | SKIN-CANCER | SOLAR KERATOSES | Prevalence | Cryosurgery | Humans | Aminoquinolines - administration & dosage | Chemexfoliation | Antineoplastic Agents - administration & dosage | Keratosis - diagnosis | Photochemotherapy | Curettage | Fluorouracil - administration & dosage | Skin Neoplasms - prevention & control | Keratosis - therapy | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Diclofenac - administration & dosage | Administration, Topical | Keratosis - epidemiology | Actinic keratosis | Care and treatment | Dermatology | Surgery | Formulae, receipts, prescriptions | Dermatologic agents | Dosage and administration | Skin | Methods
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13. Full Text Fractional erbium: YAG laser‐assisted photodynamic therapy for facial actinic keratoses: a randomized, comparative, prospective study
by Ko, D.‐Y and Jeon, S.‐Y and Kim, K.‐H and Song, K.‐H
Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, 11/2014, Volume 28, Issue 11, pp. 1529 - 1539
Background Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is effective for treating multiple actinic keratoses (AKs). Ablative fractional laser... 
MULTICENTER | TOPICAL METHYL-AMINOLEVULINATE | ACID | FLUORESCENCE | 5-AMINOLEVULINATE | YTTRIUM-ALUMINUM-GARNET | DOUBLE-BLIND | SKIN | CELL CARCINOMA | SOLAR KERATOSES | DERMATOLOGY | Recurrence | Prospective Studies | Photosensitizing Agents - therapeutic use | Photochemotherapy - methods | Humans | Middle Aged | Male | Photosensitizing Agents - adverse effects | Patient Satisfaction | Time Factors | Female | Face | Republic of Korea | Severity of Illness Index | Lasers, Solid-State - therapeutic use | Photochemotherapy - adverse effects | Keratosis, Actinic - ethnology | Treatment Outcome | Aminolevulinic Acid - therapeutic use | Lasers, Solid-State - adverse effects | Aminolevulinic Acid - adverse effects | Asian Continental Ancestry Group | Keratosis, Actinic - drug therapy | Aminolevulinic Acid - analogs & derivatives | Aged | Keratosis, Actinic - surgery | Rare earth metals | Care and treatment | Comparative analysis | Light-emitting diodes | Photochemotherapy | Lasers in medicine | Keratosis | Cancer
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14. Full Text Epidemiology of actinic keratoses and squamous cell carcinoma
by Salasche, Stuart J
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2000, Volume 42, Issue 1, pp. S4 - S7
Objective: The purpose of this article was to review the frequency; distribution, and determinants of actinic keratoses (AKs) and squamous cell carcinoma... 
MARYLAND WATERMEN | AUSTRALIA | LIP | NONMELANOMA SKIN-CANCER | PUVA | RISK | ASSOCIATION | EXPOSURE | SOLAR KERATOSES | DERMATOLOGY | Photosensitivity Disorders - epidemiology | Carcinoma, Squamous Cell - epidemiology | Skin Neoplasms - epidemiology | Humans | Keratosis - epidemiology | Epidemiology | Squamous cell carcinoma
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15. Full Text Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses
by Ulrich, M and Krueger-Corcoran, D and Roewert-Huber, J and Sterry, W and Stockfleth, E and Astner, S
Dermatology, ISSN 1018-8665, 01/2010, Volume 220, Issue 1, pp. 15 - 24
Background: Actinic keratoses (AK) represent cutaneous carcinoma in situ and have previously been evaluated by ref