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Journal Article
by Chen, HC and Tian, JW and He, WJ and Guo, ZJ
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 02/2015, Volume 137, Issue 4, pp. 1539 - 1547
The low selectivity of currently available photosensitizers, which causes the treatment-related toxicity and side effects on adjacent normal tissues, is a... 
ACTIVATION | SOLID TUMORS | PRODRUG | PHOTOSENSITIZER | RESISTANCE | SENSOR | SINGLET OXYGEN GENERATION | MECHANISMS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e33788
Background: To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of... 
EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | TGF-BETA | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | CLINICAL-IMPLICATIONS | HER2 STATUS | STEM-CELL | PROGNOSTIC-SIGNIFICANCE | NF-KAPPA-B | RT-QPCR | Microarray Analysis - methods | Microfluidic Analytical Techniques | Humans | Gene Expression Regulation, Neoplastic | Neoplastic Cells, Circulating - metabolism | Gene Expression Profiling | Breast Neoplasms - metabolism | Lymphoma - blood | Single-Cell Analysis - instrumentation | Neoplasm Metastasis | Breast Neoplasms - genetics | Single-Cell Analysis - methods | Breast Neoplasms - blood | Cell Line, Tumor | Female | Care and treatment | Genes | Breast cancer | Genetic transcription | Metastasis | Transforming growth factors | Analysis | Stem cells | Genetic aspects | Drug discovery | Health aspects | Microfluidics | Cancer | Bioengineering | Therapy | Biotechnology | Motility | Profiling | Transcription | Mesenchyme | S100A4 protein | Genomes | Biochemistry | Kinases | Blood | Subgroups | Metastases | Heterogeneity | Epidermal growth factor | Rodents | Surgery | Electrical engineering | Medical research | Antigens | Tumor cells | Feasibility studies | Tumor cell lines | Gene expression | Patients | Contamination | CXCR4 protein | Medicine | White blood cells | Blood circulation | Biopsy | Pancreatic cancer | Cell lines | Breast | Solid tumors | Molecular biology | Prostate | Tumors
Journal Article
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 09/2015, Volume 230, Issue 9, pp. 2281 - 2298
We determined whether the multi‐kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra... 
CANCER-CELLS | PDE5 INHIBITORS ENHANCE | IN-VITRO | PHYSIOLOGY | CYCLIC-GMP | SIGNALING PATHWAY | PROTEIN-KINASE-G | NITRIC-OXIDE SYNTHASE | DOWN-REGULATION | LEUKEMIA-CELLS | CD95 ACTIVATION | CELL BIOLOGY | Niacinamide - analogs & derivatives | Piperazines - administration & dosage | Gene Expression Regulation, Enzymologic - drug effects | Apoptosis - drug effects | Neoplasm Proteins - biosynthesis | Humans | Phosphodiesterase 5 Inhibitors - administration & dosage | Purines - administration & dosage | Cyclic Nucleotide Phosphodiesterases, Type 5 - biosynthesis | Gene Knockdown Techniques | Hep G2 Cells | Neoplasms - drug therapy | Niacinamide - administration & dosage | Drug Synergism | Sildenafil Citrate | Xenograft Model Antitumor Assays | Neoplasms - genetics | Phenylurea Compounds - administration & dosage | Signal Transduction - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Cell Proliferation - drug effects | Neoplasms - pathology | Sulfonamides - administration & dosage | Anti-impotence agents | Impotence | Liver | Colorectal cancer | Tumors | TOR protein | Multiplexing | Drugs | Fibroblast growth factor | Phosphorylation | Toxicity | AKT protein | Lethality | Kinases | FADD protein | Liver cancer | Colon cancer | Xenografts | Biocompatibility | Colon | Inhibition | Viagra | Phosphodiesterase | Killing | ErbB-1 protein | Tumor cells | CD95 antigen | Extracellular signal-regulated kinase | Caspase | JNK protein | Caspase-8 | Signaling | Inhibitors | Hepatocytes | Cell death | Biomarkers | Sildenafil | Solid tumors | Index Medicus | Original | Original s
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e67466
Background: Epithelial cell adhesion molecule (EpCAM)-based enumeration of circulating tumor cells (CTC) has prognostic value in patients with solid tumors,... 
BREAST-CANCER | SURVIVAL | IMPACT | MULTIDISCIPLINARY SCIENCES | PERIPHERAL-BLOOD | PROGRESSION | CLINICAL-SIGNIFICANCE | Prognosis | Prospective Studies | Neoplastic Cells, Circulating - pathology | Cell Count | Humans | Lung Neoplasms - metabolism | Middle Aged | Neoplastic Cells, Circulating - metabolism | Lung Neoplasms - pathology | Male | Tissue Array Analysis - methods | Small Cell Lung Carcinoma - blood | Epithelial Cell Adhesion Molecule | Small Cell Lung Carcinoma - metabolism | Aged, 80 and over | Antigens, Neoplasm - metabolism | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Cell Adhesion Molecules - metabolism | Small Cell Lung Carcinoma - pathology | Cell Line, Tumor | Carcinoma, Non-Small-Cell Lung - blood | Aged | Lung Neoplasms - blood | Medical research | Care and treatment | Medicine, Experimental | Metastasis | Comparative analysis | Lung cancer, Non-small cell | Prostate cancer | Biotechnology | Epithelial cells | Lung cancer | Oncology | Statistical methods | Metastases | Cell adhesion molecules | Engineering | Colon cancer | Cell adhesion | Peripheral blood | Clusters | Life sciences | Colon | Enumeration | Statistical analysis | Research & development--R&D | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Statistics | Patients | Chemotherapy | Sampling methods | Solid tumors | Median (statistics) | Prostate | Tumors | Cancer | Research & development | R&D
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0126653
KRAS is the most commonly mutated oncogene in human cancers and is associated with poor prognosis and drug resistance. Let-7 is a family of tumor suppressor... 
LUNG-CANCER | RIBONUCLEOTIDE REDUCTASE | TO-MESENCHYMAL TRANSITION | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | RESISTANCE | HMGA2 | EXPRESSION | III BETA-TUBULIN | GEMCITABINE | PANCREATIC-CANCER CELLS | Cell Cycle - genetics | Paclitaxel - pharmacology | Drug Resistance, Multiple | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Cell Survival - genetics | Apoptosis - genetics | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Epithelial-Mesenchymal Transition - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Transfection | MCF-7 Cells | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Cell Proliferation - genetics | Tubulin - biosynthesis | Signal Transduction - genetics | Mutation - genetics | Proto-Oncogene Proteins p21(ras) - biosynthesis | Neoplasms - drug therapy | Cell Line, Tumor | MicroRNAs - genetics | Ribonucleoside Diphosphate Reductase - biosynthesis | Deoxycytidine - analogs & derivatives | Chemotherapy | Pharmacology, Experimental | Oncology, Experimental | Tumor suppressor genes | Genetic aspects | Research | Properties | Drug resistance | Methods | Cancer | Gemcitabine | Mesenchyme | Toxicity | Lung cancer | Cytotoxicity | AKT protein | Metastasis | Kinases | Cancer therapies | K-Ras protein | Proteins | Cell growth | Ribonucleotide reductase | Tubulin | Penicillin | Cell cycle | Paclitaxel | Pharmaceutical sciences | Tumor cells | MiRNA | Extracellular signal-regulated kinase | Breast cancer | Gene expression | 1-Phosphatidylinositol 3-kinase | Signaling | MicroRNAs | Pancreatic cancer | Solid tumors | Mutation | Tumors | Apoptosis | Reductase
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2992 - 13
Journal Article
Journal Article