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International Journal of Biological Sciences, ISSN 1449-2288, 2012, Volume 8, Issue 9, pp. 1237 - 1247
Journal Article
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 08/2019, Volume 27, Issue 8, pp. 1197 - 1207
Transforming growth factor-β (TGF-β) is an important homeostatic regulator of cartilage. In contrast, interleukin-6 (IL-6) is a pro-inflammatory cytokine... 
TGF-β | Cartilage homeostasis | Cell signaling | IL-6 | STAT3 | ONCOSTATIN M | INTERLEUKIN-6 RECEPTOR | SYNOVIAL-FLUID | TRANSCRIPTION | RHEUMATOLOGY | RADIOGRAPHIC KNEE OSTEOARTHRITIS | CARTILAGE | TGF-beta | GROWTH-FACTOR-BETA | EPITHELIAL-CELLS | GENE-EXPRESSION | ORTHOPEDICS | SOLUBLE RECEPTOR
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1019 - 1031
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major... 
C-REACTIVE PROTEIN | INFLAMMATORY-RESPONSE | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis | of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across | INTERLEUKIN-6 | RESPIRATORY-DISTRESS-SYNDROME | PREDICTION | species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI | ACUTE-PHASE RESPONSE | ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis-associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-kappa B induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation | BLOCKADE | INHIBITOR | SEVERITY | Phosphorylation | Humans | NF-kappa B - metabolism | Pancreatitis - complications | Receptors, Interleukin-8B - antagonists & inhibitors | Benzenesulfonates - pharmacology | Interleukin-6 - physiology | Pancreatitis - immunology | Acute Lung Injury - metabolism | Chemokine CXCL1 - metabolism | STAT3 Transcription Factor - metabolism | Acinar Cells - metabolism | Aminosalicylic Acids - pharmacology | Signal Transduction | Mice, Inbred C57BL | Pancreas - pathology | Mice, Transgenic | Acute Lung Injury - pathology | Interleukin-6 - secretion | Animals | Myeloid Cells - secretion | Receptors, Interleukin-8B - metabolism | Myeloid Cells - metabolism | Acute Lung Injury - immunology | Pancreatitis - pathology | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | Pancreatitis - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Acute Lung Injury - etiology | Receptors, Interleukin-6 - metabolism | Lung diseases | Pancreatitis | Genetic aspects | Research | Health aspects | Risk factors | Interleukin-6 | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Surgery | Kirurgi
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 05/2014, Volume 18, Issue 5, pp. 495 - 512
Introduction: Increased IL-6 and soluble IL-6 receptor (sIL-6R) levels in depressed patients was first shown over 20 years ago. The pro-inflammatory effects of... 
inflammation | antidepressant | cytokines | oxidative and nitrosative stress | depression | tryptophan catabolites | IL-6 | Antidepressant | Oxidative and nitrosative stress | Tryptophan catabolites | Cytokines | Depression | Inflammation | C-REACTIVE PROTEIN | INFLAMMATORY RESPONSE SYSTEM | RANDOMIZED DOUBLE-BLIND | NECROSIS-FACTOR-ALPHA | BLOOD-BRAIN-BARRIER | SEROTONIN-IMMUNE INTERACTIONS | GUT BARRIER DYSFUNCTION | ACUTE-PHASE PROTEINS | SOLUBLE INTERLEUKIN-6 RECEPTOR | PHARMACOLOGY & PHARMACY | PITUITARY-ADRENAL AXIS | Autoimmunity | Depression - physiopathology | Meta-Analysis as Topic | Interleukin-6 - antagonists & inhibitors | Neurodegenerative Diseases - etiology | Humans | Depressive Disorder - drug therapy | Neuroimmunomodulation - physiology | Receptors, Interleukin-6 - antagonists & inhibitors | Depressive Disorder - etiology | Molecular Targeted Therapy | Depression - etiology | Depression - drug therapy | Tryptophan - blood | Zinc - physiology | Interleukin-6 - physiology | Antidepressive Agents - pharmacology | Hypothalamo-Hypophyseal System - physiopathology | Neurotransmitter Agents - physiology | Disease Models, Animal | Genetic Predisposition to Disease | Pituitary-Adrenal System - physiopathology | Interleukin-6 - genetics | Cytokines - secretion | Depressive Disorder - immunology | Bacterial Translocation | Receptors, Interleukin-6 - physiology | Animals | Neurodegenerative Diseases - physiopathology | Signal Transduction - drug effects | Depressive Disorder - physiopathology | Acute-Phase Reaction | Signal Transduction - physiology | T-Lymphocyte Subsets - secretion | Stress, Psychological - complications | Depression - immunology | Inflammation - physiopathology | Stress, Psychological - physiopathology
Journal Article