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Cancer Discovery, ISSN 2159-8274, 09/2018, Volume 8, Issue 9, pp. 1096 - 1111
Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but molecular characterization is not yet standard in clinical care. We... 
HETEROGENEITY | MEK | INHIBITION | ONCOLOGY | DUCTAL ADENOCARCINOMA | SUBTYPES | RESISTANCE | SOMATIC ERCC2 MUTATIONS | BRAF | SIGNATURE | FIBROBLASTS
Journal Article
by Robertson, A. Gordon and Kim, Jaegil and Al-Ahmadie, Hikmat and Bellmunt, Joaquim and Guo, Guangwu and Cherniack, Andrew D and Hinoue, Toshinori and Laird, Peter W and Hoadley, Katherine A and Akbani, Rehan and Castro, Patricia and Castro, Mauro A.A and Gibb, Ewan A and Kanchi, Rupa S and Gordenin, Dmitry A and Shukla, Sachet A and Sanchez-Vega, Francisco and Hansel, Donna E and Czerniak, Bogdan A and Reuter, Victor E and Su, Xiaoping and de Sa Carvalho, Benilton and Chagas, Vinicius S and Mungall, Andrew J and Mungall, Karen L and Sadeghi, Sara and Pedamallu, Chandra Sekhar and Lu, Yiling and Klimczak, Leszek J and Zhang, Jiashan (Julia) and Zhang, Jiexin and Choo, Caleb and Ojesina, Akinyemi I and Bullman, Susan and Leraas, Kristen M and Lichtenberg, Tara M and Wu, Ye and Wu, Catherine J and Schultz, Nikolaus and Schultz, Nicholaus and Getz, Gad and Meyerson, Matthew and Mills, Gordon B and McConkey, David J and Albert, Monique and Alexopoulou, Iakovina and Ally, Adrian and Antic, Tatjana and Aron, Manju and Balasundaram, Miruna and Bartlett, John and Baylin, Stephen B and Beaver, Allison and Birol, Inanc and Boice, Lori and Bootwalla, Moiz S and Bowen, Jay and Bowlby, Reanne and Brooks, Denise and Broom, Bradley M and Bshara, Wiam and Burks, Eric and Cárcano, Flavio M and Carlsen, Rebecca and Carvalho, Benilton S and Carvalho, Andre L and Castle, Eric P and Catto, James W and Chesla, David W and Chuah, Eric and Chudamani, Sudha and Cortessis, Victoria K and Cottingham, Sandra L and Crain, Daniel and Curley, Erin and Daneshmand, Siamak and Demchok, John A and Dhalla, Noreen and Djaladat, Hooman and Eckman, John and Egea, Sophie C and Engel, Jay and Felau, Ina and Ferguson, Martin L and Gardner, Johanna and Gastier-Foster, Julie M and Gerken, Mark and Gomez-Fernandez, Carmen R and Harr, Jodi and Hartmann, Arndt and Herbert, Lynn M and Ho, Thai H and Holt, Robert A and Hutter, Carolyn M and Jones, Steven J.M and Jorda, Merce and Kahnoski, Richard J and Kasaian, Katayoon and Kwiatkowski, David J and Lai, Phillip H and ... and TCGA Res Network and TCGA Research Network
Cell, ISSN 0092-8674, 10/2017, Volume 171, Issue 3, pp. 540 - 556.e25
Journal Article
EUROPEAN UROLOGY, ISSN 0302-2838, 02/2019, Volume 75, Issue 2, pp. 231 - 239
Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is the standard of care for patients with muscle-invasive... 
Neoadjuvant chemotherapy | SURVIVAL | Muscle-invasive bladder cancer | SUBTYPES | SOMATIC ERCC2 MUTATIONS | Bladder cancer | TUMORS | PREDICT | HIGH-RISK | ERCC2 | Non-muscle-invasive bladder cancer | UROLOGY & NEPHROLOGY | Radical cystectomy | CORRELATE
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 04/2019, Volume 25, Issue 8, pp. 2458 - 2470
Purpose: The purpose of this study is to characterize the mutational landscape across the spectrum of urothelial carcinoma (UC) to identify mutational features... 
SURVIVAL | BLADDER-CANCER | SIGNATURES | VARIANTS | ONCOLOGY | SUBTYPES | DNA-DAMAGE | GENE ALTERATIONS | SOMATIC ERCC2 MUTATIONS | FGFR3 MUTATIONS | GENOME
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 06/2019, Volume 37, Issue 18, pp. 1547 - 1557
PURPOSE Novel sensitive methods for early detection of relapse and for monitoring therapeutic efficacy may have a huge impact on risk stratification,... 
CIRCULATING TUMOR DNA | NEOADJUVANT CHEMOTHERAPY | CISPLATIN | ONCOLOGY | TREATMENT RESPONSE | SOMATIC ERCC2 MUTATIONS | CLONAL EVOLUTION | RECURRENCE | LIQUID BIOPSIES | CANCER
Journal Article
Journal Article
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 08/2018, Volume 15, Issue 8, pp. 495 - 509
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2193 - 11
Despite continued widespread use, the genomic effects of cisplatin-based chemotherapy and implications for subsequent treatment are incompletely characterized.... 
CTLA-4 BLOCKADE | PLUS CISPLATIN | SIGNATURES | MULTIDISCIPLINARY SCIENCES | INTRATUMOR HETEROGENEITY | RANDOMIZED-TRIAL | SOMATIC ERCC2 MUTATIONS | BRANCHED EVOLUTION | CLONAL EVOLUTION | INTERSTRAND CROSS-LINKS | LONG-TERM-SURVIVAL | Humans | Middle Aged | Carcinoma - mortality | Male | Urinary Bladder - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Urinary Bladder Neoplasms - genetics | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | Carcinoma - pathology | Urinary Bladder - surgery | Carcinoma - drug therapy | Urinary Bladder Neoplasms - mortality | Neoplasm Invasiveness | Clonal Evolution - drug effects | Survival Rate | Treatment Outcome | Transcriptome - genetics | Cisplatin - pharmacology | Urinary Bladder Neoplasms - drug therapy | Urinary Bladder Neoplasms - surgery | Whole Exome Sequencing | Cystectomy | Drug Resistance, Neoplasm - genetics | Cisplatin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoadjuvant Therapy - methods | Carcinoma - genetics | Aged | Biomarkers, Tumor - genetics | Mutation | Cohort Studies | Drug Resistance, Neoplasm - drug effects | Cell survival | Invasiveness | Gene regulation | Spatial discrimination | Clinical trials | Muscles | Bladder | Gene expression | Bladder cancer | Cisplatin | Heterogeneity | Chemotherapy | Immune checkpoint | Urinary bladder | Spatial heterogeneity | Biomarkers | Bioindicators | Tumors | Cancer
Journal Article