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Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 4759 - 4771
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 35, pp. 15473 - 15478
Disregulated Wnt/β-catenin signaling has been linked to various human diseases, including cancers. Inhibitors of oncogenic Wnt signaling are likely to have a... 
Phosphorylation | Propellers | HEK293 cells | Stem cells | Antibodies | Wnt proteins | Modulated signal processing | Heterologous transplantation | Tumors | Cancer | Antibody therapeutics | antibody therapeutics | STEM-CELLS | ACTIVATION | PATHWAY | EPIGENETIC INACTIVATION | MULTIDISCIPLINARY SCIENCES | MUTATION | DISEASE | RECEPTOR-RELATED PROTEIN-5 | BONE-MASS | cancer | SOST | LDL-Receptor Related Proteins - metabolism | Wnt1 Protein - genetics | Humans | Immunoblotting | Green Fluorescent Proteins - genetics | Wnt1 Protein - metabolism | Wnt Proteins - metabolism | LDL-Receptor Related Proteins - genetics | Neoplasms, Experimental - pathology | Wnt Proteins - genetics | Protein Binding - drug effects | Antibodies - immunology | Female | Cell Line | Green Fluorescent Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 | Neoplasms, Experimental - prevention & control | beta Catenin - metabolism | beta Catenin - genetics | Antibodies - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Ligands | Wnt3 Protein | Mice | Mammary Tumor Virus, Mouse - genetics | Wnt3A Protein | LDL-Receptor Related Proteins - immunology | Cell Transformation, Viral | Viral antibodies | Proteins | Control | Ligands (Biochemistry) | Health aspects | Carcinogenesis | Biological Sciences
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 04/2009, Volume 13, Issue 4, pp. 485 - 496
Background: There is a need to develop new bone anabolic agents because current bone regeneration regimens have limitations. The Wingless-type MMTV integration... 
Osteoporosis | Sfrp1 | Sclerostin | GSK-3 | SOST | Dkk1 | OSTEOBLAST DIFFERENTIATION | GLYCOGEN-SYNTHASE KINASE-3 | BETA-CATENIN | NEGATIVE REGULATOR | DKK1-MEDIATED INHIBITION | IN-VIVO | RECEPTOR-RELATED PROTEIN-5 | PHARMACOLOGY & PHARMACY | FRIZZLED-RELATED PROTEIN-1 | HEALTHY POSTMENOPAUSAL WOMEN | VAN-BUCHEM-DISEASE | Bone Morphogenetic Proteins - antagonists & inhibitors | Bone Morphogenetic Proteins - physiology | Humans | Glycogen Synthase Kinase 3 beta | Osteoporosis - drug therapy | LDL-Receptor Related Proteins - genetics | Intercellular Signaling Peptides and Proteins - physiology | beta Catenin - biosynthesis | Membrane Proteins - deficiency | Bone Diseases - drug therapy | Membrane Proteins - physiology | LDL-Receptor Related Proteins - deficiency | Intercellular Signaling Peptides and Proteins - deficiency | Drug Evaluation, Preclinical | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Low Density Lipoprotein Receptor-Related Protein-5 | Membrane Proteins - genetics | Osteoblasts - drug effects | Osteoblasts - physiology | Osteogenesis - drug effects | Bone Resorption - drug therapy | Intercellular Signaling Peptides and Proteins - genetics | Bone Diseases - physiopathology | Organ Specificity | Regeneration - physiology | LDL-Receptor Related Proteins - physiology | beta Catenin - genetics | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Genetic Markers - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Wnt Proteins - physiology | Wnt Proteins - antagonists & inhibitors | Fractures, Bone - drug therapy
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2012, Volume 417, Issue 2, pp. 830 - 835
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 03/2004, Volume 199, Issue 6, pp. 805 - 814
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0142058
Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored.... 
COLON-CANCER | IN-VITRO | GENE | SECRETED WNT ANTAGONIST | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | RECEPTOR-RELATED PROTEIN-5 | BONE METASTASIS | CELL-GROWTH | BETA-CATENIN | VAN-BUCHEM-DISEASE | Wnt3A Protein - metabolism | Neoplasm Transplantation | Coculture Techniques | Humans | Bone Neoplasms - secondary | Male | Membrane Proteins - pharmacology | Bone Neoplasms - pathology | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Heterografts | Prostatic Neoplasms - genetics | Neoplasm Invasiveness - pathology | Membrane Proteins - metabolism | Osteoblasts - cytology | Bone Morphogenetic Proteins - genetics | Bone Morphogenetic Proteins - pharmacology | Osteolysis - pathology | Prostatic Neoplasms - pathology | Membrane Proteins - genetics | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Mice, Knockout | Animals | Wnt Signaling Pathway - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Genetic Markers - genetics | Cell Line, Tumor | Mice | Neoplasm Invasiveness - genetics | Osteoblasts - metabolism | Care and treatment | Patient outcomes | Development and progression | Genetic aspects | Research | Diagnosis | Prostate cancer | Tropism | Biotechnology | Wnt protein | Laboratories | Colorectal cancer | Cardiovascular disease | SOST protein | Biology | Metastasis | Osteolysis | Osteoblasts | Metastases | Cell adhesion & migration | Proteins | Liver cancer | Biomedical materials | Biocompatibility | Life sciences | Bone density | Elongation | Heparan sulfate | Invasiveness | Pseudopodia | Breast cancer | Gene expression | Signaling | Bone cancer | Ligands | In vivo methods and tests | Mutation | Bone | Dkk1 protein | Prostate | Cancer | Tumors | 60 APPLIED LIFE SCIENCES
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0180393
Although dipeptidyl peptidase-4 inhibitors, a class of antidiabetic drugs, have various pleiotropic effects, it remains undetermined whether gemigliptin has a... 
PHOSPHATE | ARTERIAL MEDIAL CALCIFICATION | OXIDATIVE STRESS | IN-VITRO | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | OSTEOBLASTIC DIFFERENTIATION | CATENIN | UREMIC RATS | AKT | RUNX2 GENE-EXPRESSION | Reactive Oxygen Species - metabolism | Transcription Factor Pit-1 - metabolism | Calcium - metabolism | NADPH Oxidases - metabolism | Male | Core Binding Factor Alpha 1 Subunit - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Aorta, Abdominal - drug effects | Vascular Calcification - metabolism | Transcription Factor Pit-1 - genetics | Renal Insufficiency, Chronic - genetics | NADPH Oxidases - genetics | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Transcription Factor Pit-1 - antagonists & inhibitors | Phosphates - pharmacology | Wnt Signaling Pathway | Muscle, Smooth, Vascular - drug effects | Rats | Pyrimidines - pharmacology | Vascular Calcification - pathology | Rats, Sprague-Dawley | Reactive Oxygen Species - antagonists & inhibitors | Frizzled Receptors - genetics | Renal Insufficiency, Chronic - chemically induced | Muscle, Smooth, Vascular - metabolism | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Renal Insufficiency, Chronic - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Myocytes, Smooth Muscle - metabolism | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Adenine | Frizzled Receptors - metabolism | Vascular Calcification - prevention & control | NADPH Oxidase 4 | Piperidones - pharmacology | Renal Insufficiency, Chronic - pathology | Phosphatidylinositol 3-Kinases - genetics | Muscle, Smooth, Vascular - pathology | Animals | Phosphates - antagonists & inhibitors | Primary Cell Culture | Core Binding Factor Alpha 1 Subunit - genetics | Complications and side effects | Chronic kidney failure | Calcification | Genetic aspects | Hypoglycemic agents | Dosage and administration | Research | Drug therapy | Calcification (ectopic) | Phosphates | Drugs | Oxidative stress | Reactive oxygen species | Transcription factors | Nephrology | Wnt protein | Calcium | Frizzled protein | Oxidase | AKT protein | Smooth muscle | SOST protein | Kinases | NAD(P)H oxidase | Proteins | Signal transduction | Pit1 protein | Biomedical materials | NOX4 protein | Phosphate | Rodents | Aorta | Attenuation | Biocompatibility | Cbfa-1 protein | Oxygen | Peptidase | Internal medicine | Diabetes mellitus | Markers | Gene expression | 1-Phosphatidylinositol 3-kinase | Calcium phosphates | Medicine | Studies | Inhibitors | Kidney diseases | Diabetes | Dkk1 protein | Differentiation
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