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Circulation research, ISSN 1524-4571, 2009, Volume 104, Issue 6, pp. 733 - 741
Vascular calcification is a major risk factor for cardiovascular morbidity and mortality... 
Vascular calcification | Smooth muscle cells | Genetic fate mapping | Lineage reprogramming | Runx2/Cbfa1 | WALL | CARDIAC & CARDIOVASCULAR SYSTEMS | vascular calcification | ATHEROSCLEROSIS | lineage reprogramming | genetic fate mapping | CARTILAGE | smooth muscle cells | IN-VITRO | DEFICIENT | CALCIFICATION | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | MATRIX-GLA-PROTEIN | HEMATOLOGY | EXPRESSION | Calcinosis - genetics | Vascular Diseases - pathology | Homeodomain Proteins - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Wnt Proteins - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Arteries - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Mice, Mutant Strains | Bone Morphogenetic Protein 2 - metabolism | Calcinosis - metabolism | Myocytes, Smooth Muscle - metabolism | Chondrocytes - metabolism | SOX9 Transcription Factor - metabolism | Bone Morphogenetic Protein 2 - genetics | Chondrocytes - pathology | RNA, Messenger - genetics | Vascular Diseases - genetics | Arteries - pathology | Transcription Factors - genetics | Down-Regulation - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Proteins - genetics | Transcription Factors - metabolism | Animals | Proteins - metabolism | Sp7 Transcription Factor | Stem Cells - pathology | Wnt3 Protein | Mice | Calcinosis - pathology | Vascular Diseases - metabolism | Wnt3A Protein | Cell Dedifferentiation - genetics | SOX9 Transcription Factor - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Cbfa1 | Runx2
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 7, pp. e11481 - 18
.... Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the target genes that are directly activated by Notch in the respective tissues... 
PROGENITOR CELLS | SKELETAL-MUSCLE | STEM-CELLS | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | HES | DOWN-REGULATION | MODEL | FATE | EXPRESSION | BINDING | Paired Box Transcription Factors - genetics | Cell Cycle - genetics | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | Myogenic Regulatory Factor 5 - genetics | Homeodomain Proteins - metabolism | Apoptosis - genetics | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Myogenic Regulatory Factor 5 - metabolism | Eye Proteins - genetics | Cell Differentiation - physiology | Repressor Proteins - metabolism | SOX9 Transcription Factor - metabolism | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Repressor Proteins - genetics | PAX6 Transcription Factor | Receptor, Notch1 - metabolism | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Animals | Eye Proteins - metabolism | Cell Cycle - physiology | Mice | Apoptosis - physiology | Receptor, Notch1 - genetics | Core Binding Factor Alpha 2 Subunit - genetics | SOX9 Transcription Factor - genetics | Paired Box Transcription Factors - metabolism | Analysis | Genes | Genetic research | Protein biosynthesis | Genetic transcription | DNA binding proteins | Tamoxifen | Cell differentiation | Embryonic stem cells | Protein binding | Transcription factors | Ontology | Sox9 protein | Genomics | Differentiation (biology) | Embryo cells | Decisions | Stem cell transplantation | Smooth muscle | Genomes | Biology | Biochemistry | Tissues | Proteins | Consortia | Allografts | Cell fate | Repressors | Cell cycle | Bioinformatics | Deoxyribonucleic acid--DNA | Biomedical engineering | Data analysis | Dendritic cells | Runx1 protein | Mammals | Gene expression | Signalling | Studies | Pax6 protein | Musculoskeletal system | Protein synthesis | Collaboration | Stem cells | Ligands | Notch protein | Binding sites | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
BMC cancer, ISSN 1471-2407, 2016, Volume 16, Issue 1, p. 53
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2016, Volume 126, Issue 5, pp. 1745 - 1758
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2015, Volume 148, Issue 5, pp. 1024 - 1034.e9
.... Secondary events, such as inflammation-induced signaling via the epidermal growth factor receptor (EGFR... 
Gastroenterology and Hepatology | Gene Regulation | Signal Transduction | ChIP | Mouse Model | CANCER-CELLS | ONCOGENIC KRAS | C-MYC | FACTOR RECEPTOR | K-RAS | INFLAMMATION | EPIDERMAL-GROWTH-FACTOR | MICE | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | PROGRESSION | Receptor, Epidermal Growth Factor - genetics | Carcinoma, Pancreatic Ductal - chemically induced | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Transcriptional Activation | Carcinoma, Pancreatic Ductal - metabolism | Pancreas, Exocrine - pathology | Male | Precancerous Conditions - metabolism | Pancreatic Ducts - pathology | Cyclosporine | Pancreatic Ducts - metabolism | Carcinoma, Pancreatic Ductal - genetics | Pancreatitis - genetics | Receptor, Epidermal Growth Factor - metabolism | Cell Transformation, Neoplastic - genetics | Cell Transdifferentiation | Pancreatic Neoplasms - chemically induced | Precancerous Conditions - pathology | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Cell Line | Tissue Culture Techniques | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Pancreatic Neoplasms - pathology | Gene Expression Regulation | Pancreatic Neoplasms - genetics | Pancreatitis - chemically induced | Carcinoma, Pancreatic Ductal - pathology | Cell Transformation, Neoplastic - metabolism | Precancerous Conditions - genetics | Mice, Knockout | Metaplasia | Animals | Pancreatitis - pathology | Pancreas, Exocrine - metabolism | Mutation | Pancreatitis - metabolism | Precancerous Conditions - chemically induced | Cell Transformation, Neoplastic - pathology | Ceruletide | NFATC Transcription Factors - deficiency | SOX9 Transcription Factor - genetics | NFATC Transcription Factors - genetics | Genetic transcription | Index Medicus | Abridged Index Medicus | NFATc1 | mouse model | signal transduction | transcriptional regulation | EGFR
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 9, pp. 6478 - 6487
.... In cancer cell lines, SOX9 silencing reduced cell proliferation and invasion, LRP6 and TCF4 transcription, and decreased Wnt/beta-catenin activation... 
SRY-RELATED GENE | INTESTINAL EPITHELIUM | WNT PROTEINS | AUTOSOMAL SEX REVERSAL | CAMPOMELIC DYSPLASIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMARY STEM-CELLS | BETA-CATENIN | TRANSCRIPTION FACTOR | GLAND DEVELOPMENT | CHONDROCYTE DIFFERENTIATION | Immunohistochemistry | Humans | Gene Expression Regulation, Neoplastic | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Wnt Proteins - metabolism | Breast Neoplasms - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Wnt Proteins - genetics | Female | Neoplasm Proteins - genetics | Wnt Signaling Pathway | Low Density Lipoprotein Receptor-Related Protein-6 - biosynthesis | Mammary Neoplasms, Animal - genetics | SOX9 Transcription Factor - metabolism | Transcription Factor 4 | Mammary Glands, Animal - pathology | Mammary Glands, Human - pathology | Mice, Transgenic | Transcription Factors - biosynthesis | Transcription Factors - genetics | beta Catenin - metabolism | beta Catenin - genetics | Mammary Neoplasms, Animal - pathology | Animals | Breast Neoplasms - genetics | Mammary Glands, Animal - metabolism | Breast Neoplasms - pathology | Mammary Neoplasms, Animal - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cell Line, Tumor | Mice | SOX9 Transcription Factor - genetics | Wnt Signaling | Molecular Bases of Disease | T-cell Factor (TCF) | Transcription Regulation | TCF4 | SOX9 | Wnt Pathway | Breast Cancer | LRP6
Journal Article
The Journal of cell biology, ISSN 0021-9525, 2012, Volume 198, Issue 5, pp. 799 - 813
Journal Article
Development (Cambridge), ISSN 0950-1991, 11/2011, Volume 138, Issue 22, pp. 4843 - 4852
The Lhx2 transcription factor plays essential roles in morphogenesis and patterning of ectodermal derivatives as well as in controlling stem cell activity... 
Skin | Wound healing | Stem cells | HOMEOSTASIS | INVOLVEMENT | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | MAINTENANCE | GENE | EXPRESSION | LINEAGE | WOUND REPAIR | CYCLE | LIM-Homeodomain Proteins - metabolism | Receptors, G-Protein-Coupled - metabolism | Embryo, Mammalian | Humans | LIM-Homeodomain Proteins - antagonists & inhibitors | Stem Cells - metabolism | Regeneration - genetics | Epidermis - injuries | Female | Wound Healing - genetics | Wound Healing - drug effects | Animals, Newborn | SOX9 Transcription Factor - metabolism | Epidermis - metabolism | Transcription Factors - physiology | Transcription Factor 4 | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Transcription Factors - metabolism | Hair Follicle - cytology | LIM-Homeodomain Proteins - genetics | Animals | Epidermis - physiology | Hair Follicle - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Stem Cells - physiology | Mice | Receptors, G-Protein-Coupled - genetics | SOX9 Transcription Factor - genetics | LIM-Homeodomain Proteins - physiology | Development and Stem Cells
Journal Article
PLoS genetics, ISSN 1553-7390, 09/2011, Volume 7, Issue 9, p. e1002265
Journal Article
Cell stem cell, ISSN 1934-5909, 2009, Volume 5, Issue 4, pp. 420 - 433
To examine transcription factor (TF) network(s), we created mouse ESC lines, in each of which 1 of 50 TFs tagged with a FLAG moiety is inserted into a ubiquitously controllable tetracycline-repressible locus... 
STEMCELL | SIGNALING PATHWAYS | DEVELOPMENTAL REGULATORS | CHROMATIN | EMBRYONIC STEM-CELLS | MOUSE | GENOME-WIDE | SELF-RENEWAL | PLURIPOTENCY | NANOG | EXPRESSION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | GATA3 Transcription Factor - genetics | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Immunoprecipitation | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | GATA3 Transcription Factor - physiology | Gene Regulatory Networks - physiology | SOX9 Transcription Factor - physiology | Cell Differentiation - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Chromatin Immunoprecipitation | Kruppel-Like Transcription Factors - metabolism | Cell Differentiation - physiology | GATA3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | SOX9 Transcription Factor - metabolism | Cell Line | Basic Helix-Loop-Helix Transcription Factors - physiology | Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Gene Regulatory Networks - genetics | Kruppel-Like Transcription Factors - physiology | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Proto-Oncogene Proteins - physiology | Mice | CDX2 Transcription Factor | Homeodomain Proteins - physiology | Kruppel-Like Transcription Factors - genetics | SOX9 Transcription Factor - genetics
Journal Article